Incidental Mutation 'R2189:Icosl'
ID 237977
Institutional Source Beutler Lab
Gene Symbol Icosl
Ensembl Gene ENSMUSG00000000732
Gene Name icos ligand
Synonyms GL50, B7h, GL50-B, ICOS-L, B7RP-1, LICOS, B7-H2
MMRRC Submission 040191-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R2189 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 77904921-77915359 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 77909759 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 235 (T235A)
Ref Sequence ENSEMBL: ENSMUSP00000101032 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105393]
AlphaFold Q9JHJ8
Predicted Effect possibly damaging
Transcript: ENSMUST00000105393
AA Change: T235A

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000101032
Gene: ENSMUSG00000000732
AA Change: T235A

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
IG 47 161 4.67e-4 SMART
Pfam:C2-set_2 165 253 5.2e-9 PFAM
transmembrane domain 280 299 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217675
Predicted Effect unknown
Transcript: ENSMUST00000219038
AA Change: T231A
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219633
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene exhibit defects in the humoral immune response associated with an impaired interactions between T and B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan G C 7: 78,747,839 (GRCm39) G870A probably damaging Het
Adamtsl2 T C 2: 26,971,750 (GRCm39) W12R probably benign Het
Bsph1 G A 7: 13,204,254 (GRCm39) probably null Het
Celsr1 G T 15: 85,863,431 (GRCm39) H1200Q possibly damaging Het
Clptm1 A T 7: 19,371,070 (GRCm39) Y355* probably null Het
Cry2 T C 2: 92,242,037 (GRCm39) E572G possibly damaging Het
Dlk1 G A 12: 109,420,975 (GRCm39) probably null Het
Eral1 A G 11: 77,966,657 (GRCm39) V201A probably benign Het
Esrp1 A T 4: 11,357,603 (GRCm39) M503K probably benign Het
Fam83e G T 7: 45,371,607 (GRCm39) M1I probably null Het
Flt4 G A 11: 49,526,525 (GRCm39) A835T probably benign Het
H2bc15 A G 13: 21,938,447 (GRCm39) D52G probably damaging Het
Hdac4 T C 1: 91,903,244 (GRCm39) S562G probably null Het
Itga6 A G 2: 71,655,961 (GRCm39) D295G probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lipa A T 19: 34,502,199 (GRCm39) L15Q probably benign Het
Mcc T C 18: 44,667,297 (GRCm39) E218G possibly damaging Het
Mdga2 A G 12: 66,519,970 (GRCm39) probably null Het
Mmadhc A C 2: 50,178,958 (GRCm39) C153W probably damaging Het
Myh1 A G 11: 67,112,430 (GRCm39) D1799G probably damaging Het
Nlrp1b T A 11: 71,060,621 (GRCm39) Q729L probably damaging Het
Ofcc1 T A 13: 40,333,924 (GRCm39) Q389L probably benign Het
Or52b2 A G 7: 104,986,809 (GRCm39) V38A probably benign Het
Or5m5 A G 2: 85,814,412 (GRCm39) D76G probably damaging Het
Or5p4 A T 7: 107,680,243 (GRCm39) M81L possibly damaging Het
Or5p50 T C 7: 107,421,822 (GRCm39) I285V probably benign Het
Pml T C 9: 58,142,157 (GRCm39) N225S probably benign Het
Rnf213 A G 11: 119,321,187 (GRCm39) E1215G probably benign Het
Scap T A 9: 110,206,761 (GRCm39) I402N probably damaging Het
Sgsm2 A G 11: 74,743,908 (GRCm39) L886P probably damaging Het
Sugct T C 13: 17,836,851 (GRCm39) I104V probably benign Het
Tmem200c A G 17: 69,147,681 (GRCm39) Q88R probably damaging Het
Tnfrsf1a T A 6: 125,334,768 (GRCm39) L14Q probably benign Het
Tnk2 C T 16: 32,490,239 (GRCm39) L381F probably damaging Het
Ubr2 C T 17: 47,254,290 (GRCm39) V1454I probably benign Het
V1ra8 A C 6: 90,179,944 (GRCm39) D49A probably damaging Het
Vmn2r5 A C 3: 64,417,014 (GRCm39) M48R probably benign Het
Yars1 A G 4: 129,099,982 (GRCm39) I227V probably damaging Het
Zfp850 C A 7: 27,688,480 (GRCm39) R576L probably benign Het
Zfpm2 T A 15: 40,964,579 (GRCm39) F223I possibly damaging Het
Other mutations in Icosl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00980:Icosl APN 10 77,907,805 (GRCm39) missense probably damaging 1.00
IGL02540:Icosl APN 10 77,905,370 (GRCm39) critical splice donor site probably null
R0304:Icosl UTSW 10 77,911,156 (GRCm39) missense probably benign
R0512:Icosl UTSW 10 77,907,800 (GRCm39) missense possibly damaging 0.77
R0584:Icosl UTSW 10 77,907,709 (GRCm39) missense possibly damaging 0.82
R0711:Icosl UTSW 10 77,909,775 (GRCm39) missense probably damaging 1.00
R2005:Icosl UTSW 10 77,907,787 (GRCm39) missense possibly damaging 0.63
R2006:Icosl UTSW 10 77,907,787 (GRCm39) missense possibly damaging 0.63
R3417:Icosl UTSW 10 77,907,869 (GRCm39) missense possibly damaging 0.46
R4423:Icosl UTSW 10 77,907,707 (GRCm39) missense possibly damaging 0.92
R5183:Icosl UTSW 10 77,905,319 (GRCm39) unclassified probably benign
R5579:Icosl UTSW 10 77,909,597 (GRCm39) missense probably damaging 0.99
R6388:Icosl UTSW 10 77,905,366 (GRCm39) missense possibly damaging 0.96
R7336:Icosl UTSW 10 77,909,707 (GRCm39) nonsense probably null
R7921:Icosl UTSW 10 77,909,786 (GRCm39) missense probably benign 0.02
R7921:Icosl UTSW 10 77,909,574 (GRCm39) missense probably benign 0.01
R8733:Icosl UTSW 10 77,909,697 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGAACGTACCTACACCTG -3'
(R):5'- AGTTCTTGTGACAGGCCAGAG -3'

Sequencing Primer
(F):5'- TACACCTGCATGTCCAAGAATG -3'
(R):5'- CTCTCTGATAGGGATCATCTGTAAG -3'
Posted On 2014-10-02