Incidental Mutation 'R2190:Adgrg5'
ID 238038
Institutional Source Beutler Lab
Gene Symbol Adgrg5
Ensembl Gene ENSMUSG00000061577
Gene Name adhesion G protein-coupled receptor G5
Synonyms Gpr114, PGR27, LOC382045
MMRRC Submission 040192-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2190 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 95650322-95669908 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 95660579 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 73 (I73F)
Ref Sequence ENSEMBL: ENSMUSP00000074155 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074570] [ENSMUST00000128308] [ENSMUST00000153448] [ENSMUST00000166802]
AlphaFold Q3V3Z3
Predicted Effect probably damaging
Transcript: ENSMUST00000074570
AA Change: I73F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074155
Gene: ENSMUSG00000061577
AA Change: I73F

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 87 95 N/A INTRINSIC
GPS 181 234 4.7e-13 SMART
Pfam:7tm_2 240 494 2.1e-36 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000128308
AA Change: I69F

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000120217
Gene: ENSMUSG00000061577
AA Change: I69F

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 83 91 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142991
Predicted Effect probably benign
Transcript: ENSMUST00000153448
SMART Domains Protein: ENSMUSP00000122780
Gene: ENSMUSG00000061577

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000166802
AA Change: I73F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000132628
Gene: ENSMUSG00000061577
AA Change: I73F

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 87 95 N/A INTRINSIC
GPS 181 234 1.37e-14 SMART
Pfam:7tm_2 241 495 1.3e-36 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 A T 8: 111,766,785 (GRCm39) T56S probably damaging Het
Acbd6 A T 1: 155,500,652 (GRCm39) H204L probably damaging Het
Acnat2 T A 4: 49,383,551 (GRCm39) M1L probably benign Het
Ankrd52 A G 10: 128,219,487 (GRCm39) T474A probably benign Het
Arid3a A G 10: 79,782,365 (GRCm39) D252G possibly damaging Het
Aspg G T 12: 112,091,322 (GRCm39) E501D probably damaging Het
Bicral A G 17: 47,136,049 (GRCm39) I387T probably damaging Het
Bub1 T C 2: 127,652,645 (GRCm39) N574S probably benign Het
Casr G A 16: 36,315,778 (GRCm39) T764M probably damaging Het
Ccdc60 A G 5: 116,295,639 (GRCm39) S259P probably damaging Het
Ccne2 A T 4: 11,197,241 (GRCm39) N181I probably benign Het
Chd4 A G 6: 125,091,260 (GRCm39) D89G probably benign Het
Col25a1 C T 3: 130,378,364 (GRCm39) P606S probably damaging Het
Dcc A G 18: 71,680,491 (GRCm39) S582P possibly damaging Het
Dlg4 A G 11: 69,933,430 (GRCm39) D619G probably damaging Het
Elavl2 C T 4: 91,152,331 (GRCm39) V129I probably benign Het
Epha3 A G 16: 63,366,552 (GRCm39) I965T probably benign Het
Fbxw16 G A 9: 109,265,739 (GRCm39) S360L probably damaging Het
Fgf14 T C 14: 124,221,330 (GRCm39) Y158C probably damaging Het
Gm44511 A G 6: 128,803,163 (GRCm39) I16T possibly damaging Het
Has2 C A 15: 56,531,183 (GRCm39) V511F probably benign Het
Heatr5b G A 17: 79,109,185 (GRCm39) R1025C probably damaging Het
Hsd17b12 T C 2: 93,864,408 (GRCm39) Y233C probably benign Het
Il36rn A T 2: 24,170,831 (GRCm39) I43F probably damaging Het
Inpp5b T A 4: 124,678,988 (GRCm39) I465N probably damaging Het
Irak2 T A 6: 113,663,904 (GRCm39) N423K probably damaging Het
Itga2 C A 13: 115,007,141 (GRCm39) V396L probably benign Het
Itprid1 A G 6: 55,874,685 (GRCm39) T212A possibly damaging Het
Lipo2 A T 19: 33,725,969 (GRCm39) N94K probably damaging Het
Lrrc37a T C 11: 103,390,869 (GRCm39) T1519A possibly damaging Het
Macf1 A G 4: 123,353,005 (GRCm39) V1558A probably benign Het
Mocos C A 18: 24,797,114 (GRCm39) H91Q probably benign Het
Myh14 G A 7: 44,310,487 (GRCm39) T132I probably damaging Het
Nlrp2 A T 7: 5,322,237 (GRCm39) D803E possibly damaging Het
Ntsr2 T A 12: 16,704,018 (GRCm39) I173N probably damaging Het
Or14c43 A G 7: 86,115,573 (GRCm39) Y318C possibly damaging Het
Or5b105 T G 19: 13,079,857 (GRCm39) K270N probably damaging Het
Pitx3 T C 19: 46,125,486 (GRCm39) Y86C probably damaging Het
Pkp1 T C 1: 135,807,709 (GRCm39) S520G probably benign Het
Pygo1 C T 9: 72,852,529 (GRCm39) Q239* probably null Het
Rab13 A G 3: 90,130,851 (GRCm39) E68G probably damaging Het
Rfx7 A G 9: 72,525,201 (GRCm39) E797G probably benign Het
Slc5a1 T C 5: 33,261,937 (GRCm39) probably null Het
Slco1c1 A G 6: 141,508,893 (GRCm39) T518A probably benign Het
Spint1 A G 2: 119,068,661 (GRCm39) I132V probably benign Het
Stard9 T A 2: 120,544,601 (GRCm39) I4514N probably benign Het
Tenm3 T G 8: 48,848,579 (GRCm39) S87R probably damaging Het
Thap4 G T 1: 93,678,381 (GRCm39) P135Q probably damaging Het
Tmed9 A G 13: 55,741,156 (GRCm39) E57G probably benign Het
Tnrc18 C T 5: 142,761,644 (GRCm39) V594I unknown Het
Trmt1 A T 8: 85,416,470 (GRCm39) K64* probably null Het
Usf2 A G 7: 30,654,606 (GRCm39) V198A probably damaging Het
Usp14 A T 18: 10,007,835 (GRCm39) C168S probably damaging Het
Vav3 C A 3: 109,470,130 (GRCm39) T525K probably damaging Het
Vmn1r52 A G 6: 90,156,151 (GRCm39) I152V probably benign Het
Vmn2r81 A G 10: 79,104,085 (GRCm39) D236G possibly damaging Het
Wdr19 G A 5: 65,401,509 (GRCm39) V975I possibly damaging Het
Other mutations in Adgrg5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01340:Adgrg5 APN 8 95,664,257 (GRCm39) missense probably damaging 1.00
IGL02617:Adgrg5 APN 8 95,660,610 (GRCm39) missense probably benign 0.01
R0483:Adgrg5 UTSW 8 95,660,136 (GRCm39) missense possibly damaging 0.73
R0539:Adgrg5 UTSW 8 95,665,260 (GRCm39) missense probably damaging 1.00
R0580:Adgrg5 UTSW 8 95,663,972 (GRCm39) critical splice donor site probably null
R0650:Adgrg5 UTSW 8 95,660,785 (GRCm39) critical splice donor site probably null
R0652:Adgrg5 UTSW 8 95,660,785 (GRCm39) critical splice donor site probably null
R0828:Adgrg5 UTSW 8 95,668,413 (GRCm39) splice site probably null
R1546:Adgrg5 UTSW 8 95,668,258 (GRCm39) missense probably benign 0.27
R1567:Adgrg5 UTSW 8 95,664,326 (GRCm39) missense probably damaging 0.97
R1695:Adgrg5 UTSW 8 95,664,373 (GRCm39) missense probably damaging 1.00
R1753:Adgrg5 UTSW 8 95,668,680 (GRCm39) missense possibly damaging 0.65
R1852:Adgrg5 UTSW 8 95,664,428 (GRCm39) missense probably damaging 1.00
R2018:Adgrg5 UTSW 8 95,661,108 (GRCm39) missense probably damaging 1.00
R2051:Adgrg5 UTSW 8 95,668,695 (GRCm39) missense probably benign 0.01
R2299:Adgrg5 UTSW 8 95,665,204 (GRCm39) missense possibly damaging 0.88
R2568:Adgrg5 UTSW 8 95,660,649 (GRCm39) missense probably damaging 0.99
R4283:Adgrg5 UTSW 8 95,664,326 (GRCm39) missense probably benign 0.21
R4512:Adgrg5 UTSW 8 95,660,652 (GRCm39) missense possibly damaging 0.90
R4825:Adgrg5 UTSW 8 95,668,362 (GRCm39) missense possibly damaging 0.77
R5422:Adgrg5 UTSW 8 95,660,580 (GRCm39) missense probably damaging 1.00
R5427:Adgrg5 UTSW 8 95,661,730 (GRCm39) missense probably benign 0.27
R6186:Adgrg5 UTSW 8 95,660,652 (GRCm39) missense possibly damaging 0.90
R6522:Adgrg5 UTSW 8 95,668,696 (GRCm39) missense probably benign 0.13
R6608:Adgrg5 UTSW 8 95,668,348 (GRCm39) missense probably damaging 1.00
R6810:Adgrg5 UTSW 8 95,660,570 (GRCm39) missense probably damaging 0.97
R6816:Adgrg5 UTSW 8 95,668,311 (GRCm39) missense probably damaging 0.99
R7214:Adgrg5 UTSW 8 95,660,646 (GRCm39) missense
R7686:Adgrg5 UTSW 8 95,664,430 (GRCm39) missense
R7955:Adgrg5 UTSW 8 95,664,325 (GRCm39) missense
R9383:Adgrg5 UTSW 8 95,661,162 (GRCm39) missense
R9653:Adgrg5 UTSW 8 95,663,864 (GRCm39) missense
R9729:Adgrg5 UTSW 8 95,668,133 (GRCm39) missense
X0027:Adgrg5 UTSW 8 95,663,966 (GRCm39) missense probably benign 0.07
Z1176:Adgrg5 UTSW 8 95,661,779 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGGCTCTAAGACTTGCGTGG -3'
(R):5'- GAGAGGCCATAGAGCACTTC -3'

Sequencing Primer
(F):5'- CTCTAAGACTTGCGTGGGGGAC -3'
(R):5'- GAGGCCATAGAGCACTTCCTCTTTC -3'
Posted On 2014-10-02