Incidental Mutation 'R2192:Fam186a'
ID 238243
Institutional Source Beutler Lab
Gene Symbol Fam186a
Ensembl Gene ENSMUSG00000045350
Gene Name family with sequence similarity 186, member A
Synonyms LOC380973, 1700030F18Rik
MMRRC Submission 040194-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R2192 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 99816229-99864942 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99838192 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 2684 (D2684G)
Ref Sequence ENSEMBL: ENSMUSP00000097783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100209]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000100209
AA Change: D2684G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097783
Gene: ENSMUSG00000045350
AA Change: D2684G

DomainStartEndE-ValueType
low complexity region 10 21 N/A INTRINSIC
Blast:FBG 44 222 4e-48 BLAST
coiled coil region 292 340 N/A INTRINSIC
low complexity region 423 443 N/A INTRINSIC
low complexity region 446 458 N/A INTRINSIC
low complexity region 632 644 N/A INTRINSIC
low complexity region 702 713 N/A INTRINSIC
internal_repeat_2 743 1156 1.05e-58 PROSPERO
internal_repeat_1 833 1270 7.71e-59 PROSPERO
low complexity region 1271 1285 N/A INTRINSIC
low complexity region 1289 1300 N/A INTRINSIC
low complexity region 1309 1323 N/A INTRINSIC
low complexity region 1327 1338 N/A INTRINSIC
low complexity region 1347 1361 N/A INTRINSIC
low complexity region 1365 1376 N/A INTRINSIC
low complexity region 1384 1395 N/A INTRINSIC
low complexity region 1403 1414 N/A INTRINSIC
low complexity region 1423 1437 N/A INTRINSIC
low complexity region 1441 1452 N/A INTRINSIC
low complexity region 1460 1471 N/A INTRINSIC
low complexity region 1479 1490 N/A INTRINSIC
low complexity region 1498 1509 N/A INTRINSIC
low complexity region 1518 1532 N/A INTRINSIC
low complexity region 1536 1547 N/A INTRINSIC
low complexity region 1555 1566 N/A INTRINSIC
low complexity region 1574 1585 N/A INTRINSIC
internal_repeat_1 1586 1981 7.71e-59 PROSPERO
internal_repeat_2 1737 2197 1.05e-58 PROSPERO
low complexity region 2367 2378 N/A INTRINSIC
low complexity region 2549 2564 N/A INTRINSIC
low complexity region 2644 2655 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104255
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177831
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180309
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra1d A T 2: 131,403,289 (GRCm39) M267K probably damaging Het
Aen T C 7: 78,555,793 (GRCm39) probably null Het
Ano2 A G 6: 125,992,502 (GRCm39) D825G probably damaging Het
Bdh2 T C 3: 135,001,025 (GRCm39) S142P probably damaging Het
Celsr1 A G 15: 85,800,924 (GRCm39) L2507P possibly damaging Het
Ces3a T C 8: 105,782,212 (GRCm39) F308S probably benign Het
Cfap47 C T X: 78,454,218 (GRCm39) R1646Q probably damaging Het
Chd4 T A 6: 125,082,320 (GRCm39) M603K probably damaging Het
Cit T C 5: 116,106,068 (GRCm39) V984A probably benign Het
Clstn3 A T 6: 124,436,166 (GRCm39) D194E probably damaging Het
Ctdp1 T C 18: 80,492,696 (GRCm39) R600G probably benign Het
Ctnnd1 C T 2: 84,439,907 (GRCm39) G801D probably damaging Het
Dgkg A G 16: 22,407,049 (GRCm39) F179L probably damaging Het
Dlg3 G A X: 99,817,827 (GRCm39) D379N probably damaging Het
Drd2 G T 9: 49,314,571 (GRCm39) R267S probably benign Het
Dsg1b T C 18: 20,542,675 (GRCm39) *1061Q probably null Het
Dvl1 G A 4: 155,932,273 (GRCm39) V28I possibly damaging Het
Edc3 T C 9: 57,620,826 (GRCm39) V49A probably damaging Het
Ern1 G A 11: 106,300,750 (GRCm39) T548I probably benign Het
Fam20a A G 11: 109,565,449 (GRCm39) M454T probably benign Het
Fbp2 A G 13: 63,006,056 (GRCm39) M19T possibly damaging Het
Frmd4b A T 6: 97,464,577 (GRCm39) C47S probably damaging Het
Gtf2h1 T A 7: 46,464,747 (GRCm39) I388N possibly damaging Het
Hectd4 T C 5: 121,453,206 (GRCm39) V571A possibly damaging Het
Helz2 T A 2: 180,870,841 (GRCm39) K2832* probably null Het
Herc1 T A 9: 66,372,688 (GRCm39) D3081E probably damaging Het
Hmcn1 A T 1: 150,591,566 (GRCm39) S1878T probably damaging Het
Iars1 A G 13: 49,841,605 (GRCm39) probably null Het
Il17rd A T 14: 26,816,835 (GRCm39) K180M probably damaging Het
Ints6l T A X: 55,550,110 (GRCm39) H678Q probably benign Het
Khdrbs1 A G 4: 129,613,830 (GRCm39) probably null Het
Lce3a A C 3: 92,832,837 (GRCm39) S88A unknown Het
Lgals12 C T 19: 7,578,606 (GRCm39) probably null Het
Lnpk T C 2: 74,399,373 (GRCm39) T57A probably benign Het
Lrp2bp C T 8: 46,466,206 (GRCm39) T105I probably benign Het
Lrrc4c C G 2: 97,459,657 (GRCm39) N94K possibly damaging Het
Mag A T 7: 30,600,066 (GRCm39) Y571* probably null Het
Mbd1 T A 18: 74,410,449 (GRCm39) D583E probably damaging Het
Mill1 T A 7: 17,998,544 (GRCm39) Y251* probably null Het
Mllt10 T C 2: 18,211,871 (GRCm39) I928T probably benign Het
Ms4a18 T C 19: 10,991,029 (GRCm39) T22A probably benign Het
Mtmr14 T C 6: 113,257,700 (GRCm39) F250L probably damaging Het
Mtmr3 A T 11: 4,449,032 (GRCm39) W244R probably damaging Het
Myorg A G 4: 41,497,704 (GRCm39) I642T probably damaging Het
Nat10 C A 2: 103,556,522 (GRCm39) E885D probably benign Het
Nbeal1 T A 1: 60,321,054 (GRCm39) L2055H probably damaging Het
Necab3 T A 2: 154,388,999 (GRCm39) I192F possibly damaging Het
Nedd4 T A 9: 72,650,000 (GRCm39) N783K probably damaging Het
Nf2 A T 11: 4,749,899 (GRCm39) W61R probably damaging Het
Nox4 T A 7: 87,023,588 (GRCm39) F491L probably benign Het
Omt2b G A 9: 78,235,457 (GRCm39) probably benign Het
Or4c125 A T 2: 89,170,009 (GRCm39) Y212* probably null Het
Or4c127 T A 2: 89,832,774 (GRCm39) I8N probably damaging Het
Or8i2 A G 2: 86,852,855 (GRCm39) V11A probably benign Het
Osbpl5 A T 7: 143,247,596 (GRCm39) Y723* probably null Het
Otop2 T C 11: 115,217,757 (GRCm39) S198P possibly damaging Het
Pgam5 T G 5: 110,413,785 (GRCm39) H126P probably damaging Het
Phip A T 9: 82,753,868 (GRCm39) N1625K probably damaging Het
Phospho2 T A 2: 69,626,451 (GRCm39) Y202* probably null Het
Pkd1l3 T A 8: 110,347,156 (GRCm39) H176Q unknown Het
Plxdc2 A G 2: 16,570,147 (GRCm39) R109G probably damaging Het
Prorsd1 T C 11: 29,463,592 (GRCm39) K57E probably benign Het
Rnf150 A T 8: 83,591,020 (GRCm39) R128W probably damaging Het
Samm50 G A 15: 84,084,625 (GRCm39) probably null Het
Skint6 A T 4: 112,722,909 (GRCm39) Y889* probably null Het
Slc35b1 T C 11: 95,276,640 (GRCm39) Y40H probably damaging Het
Speg A G 1: 75,394,371 (GRCm39) H1722R probably damaging Het
Suz12 T C 11: 79,913,024 (GRCm39) L356P probably damaging Het
Tln2 T G 9: 67,262,503 (GRCm39) I585L probably damaging Het
Trim2 G A 3: 84,098,225 (GRCm39) Q359* probably null Het
Ttc28 T C 5: 111,371,362 (GRCm39) Y635H probably damaging Het
Ttn C T 2: 76,543,549 (GRCm39) E33146K probably damaging Het
Vcp G T 4: 42,982,547 (GRCm39) T715K probably benign Het
Vmn1r230 T A 17: 21,067,355 (GRCm39) N181K probably benign Het
Vmn2r17 T A 5: 109,582,144 (GRCm39) M511K possibly damaging Het
Wdfy3 C T 5: 102,055,408 (GRCm39) R1554Q possibly damaging Het
Zfp112 A T 7: 23,824,863 (GRCm39) Q277L probably damaging Het
Zfp850 T C 7: 27,684,620 (GRCm39) E42G probably damaging Het
Zfp976 G A 7: 42,262,695 (GRCm39) P381S probably damaging Het
Zzef1 A T 11: 72,800,982 (GRCm39) probably null Het
Other mutations in Fam186a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00588:Fam186a APN 15 99,825,572 (GRCm39) splice site probably benign
IGL03047:Fam186a UTSW 15 99,843,589 (GRCm39) missense unknown
R0172:Fam186a UTSW 15 99,852,768 (GRCm39) missense unknown
R0194:Fam186a UTSW 15 99,839,644 (GRCm39) missense possibly damaging 0.92
R0381:Fam186a UTSW 15 99,840,055 (GRCm39) missense probably damaging 0.97
R0799:Fam186a UTSW 15 99,839,893 (GRCm39) missense probably damaging 1.00
R1295:Fam186a UTSW 15 99,837,670 (GRCm39) splice site probably benign
R1366:Fam186a UTSW 15 99,841,270 (GRCm39) missense possibly damaging 0.89
R1519:Fam186a UTSW 15 99,845,536 (GRCm39) missense unknown
R1592:Fam186a UTSW 15 99,838,199 (GRCm39) missense probably benign 0.01
R1636:Fam186a UTSW 15 99,839,539 (GRCm39) missense unknown
R1719:Fam186a UTSW 15 99,840,227 (GRCm39) missense possibly damaging 0.54
R1759:Fam186a UTSW 15 99,864,762 (GRCm39) nonsense probably null
R1856:Fam186a UTSW 15 99,838,183 (GRCm39) missense possibly damaging 0.82
R2131:Fam186a UTSW 15 99,831,557 (GRCm39) unclassified probably benign
R2239:Fam186a UTSW 15 99,852,745 (GRCm39) missense unknown
R2251:Fam186a UTSW 15 99,842,978 (GRCm39) missense probably benign 0.02
R2902:Fam186a UTSW 15 99,843,049 (GRCm39) missense possibly damaging 0.73
R3037:Fam186a UTSW 15 99,841,675 (GRCm39) missense probably damaging 0.99
R3744:Fam186a UTSW 15 99,845,416 (GRCm39) missense unknown
R4021:Fam186a UTSW 15 99,839,680 (GRCm39) missense possibly damaging 0.66
R4183:Fam186a UTSW 15 99,831,566 (GRCm39) unclassified probably benign
R4238:Fam186a UTSW 15 99,841,523 (GRCm39) missense probably benign 0.05
R4667:Fam186a UTSW 15 99,842,413 (GRCm39) missense possibly damaging 0.92
R4817:Fam186a UTSW 15 99,831,419 (GRCm39) unclassified probably benign
R4835:Fam186a UTSW 15 99,843,689 (GRCm39) missense unknown
R4837:Fam186a UTSW 15 99,838,678 (GRCm39) missense unknown
R4897:Fam186a UTSW 15 99,843,158 (GRCm39) missense possibly damaging 0.66
R4902:Fam186a UTSW 15 99,844,723 (GRCm39) missense unknown
R4950:Fam186a UTSW 15 99,839,534 (GRCm39) missense unknown
R4995:Fam186a UTSW 15 99,842,980 (GRCm39) missense probably benign 0.27
R5062:Fam186a UTSW 15 99,842,527 (GRCm39) missense possibly damaging 0.66
R5124:Fam186a UTSW 15 99,840,977 (GRCm39) missense possibly damaging 0.90
R5133:Fam186a UTSW 15 99,853,374 (GRCm39) missense unknown
R5424:Fam186a UTSW 15 99,843,644 (GRCm39) missense unknown
R5624:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5628:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5637:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5639:Fam186a UTSW 15 99,844,931 (GRCm39) missense unknown
R5652:Fam186a UTSW 15 99,843,253 (GRCm39) missense possibly damaging 0.79
R5673:Fam186a UTSW 15 99,839,628 (GRCm39) missense possibly damaging 0.90
R5799:Fam186a UTSW 15 99,864,705 (GRCm39) nonsense probably null
R5965:Fam186a UTSW 15 99,842,978 (GRCm39) missense probably benign 0.37
R6044:Fam186a UTSW 15 99,839,878 (GRCm39) missense probably damaging 0.97
R6077:Fam186a UTSW 15 99,840,584 (GRCm39) missense possibly damaging 0.46
R6120:Fam186a UTSW 15 99,838,244 (GRCm39) missense probably benign 0.00
R6185:Fam186a UTSW 15 99,845,530 (GRCm39) missense unknown
R6186:Fam186a UTSW 15 99,845,206 (GRCm39) missense unknown
R6242:Fam186a UTSW 15 99,837,788 (GRCm39) missense unknown
R6351:Fam186a UTSW 15 99,839,623 (GRCm39) missense probably damaging 0.97
R6368:Fam186a UTSW 15 99,841,198 (GRCm39) missense possibly damaging 0.66
R6369:Fam186a UTSW 15 99,845,212 (GRCm39) missense unknown
R6559:Fam186a UTSW 15 99,842,356 (GRCm39) missense possibly damaging 0.46
R6855:Fam186a UTSW 15 99,852,756 (GRCm39) missense unknown
R6867:Fam186a UTSW 15 99,843,731 (GRCm39) missense unknown
R6957:Fam186a UTSW 15 99,844,357 (GRCm39) missense unknown
R6961:Fam186a UTSW 15 99,838,082 (GRCm39) missense probably benign 0.16
R6994:Fam186a UTSW 15 99,840,347 (GRCm39) missense probably benign 0.35
R6996:Fam186a UTSW 15 99,853,374 (GRCm39) missense unknown
R7062:Fam186a UTSW 15 99,831,521 (GRCm39) unclassified probably benign
R7064:Fam186a UTSW 15 99,839,557 (GRCm39) missense unknown
R7173:Fam186a UTSW 15 99,843,531 (GRCm39) missense unknown
R7244:Fam186a UTSW 15 99,844,273 (GRCm39) missense unknown
R7270:Fam186a UTSW 15 99,842,033 (GRCm39) missense possibly damaging 0.66
R7410:Fam186a UTSW 15 99,844,826 (GRCm39) nonsense probably null
R7437:Fam186a UTSW 15 99,840,775 (GRCm39) missense probably damaging 1.00
R7475:Fam186a UTSW 15 99,845,395 (GRCm39) missense unknown
R7487:Fam186a UTSW 15 99,840,017 (GRCm39) missense possibly damaging 0.66
R7526:Fam186a UTSW 15 99,839,796 (GRCm39) missense possibly damaging 0.83
R7650:Fam186a UTSW 15 99,837,788 (GRCm39) missense unknown
R7658:Fam186a UTSW 15 99,837,725 (GRCm39) missense unknown
R7663:Fam186a UTSW 15 99,842,950 (GRCm39) missense probably benign 0.00
R7703:Fam186a UTSW 15 99,852,678 (GRCm39) missense unknown
R7814:Fam186a UTSW 15 99,842,545 (GRCm39) missense possibly damaging 0.92
R7958:Fam186a UTSW 15 99,841,189 (GRCm39) missense probably damaging 0.99
R7970:Fam186a UTSW 15 99,831,467 (GRCm39) missense unknown
R8076:Fam186a UTSW 15 99,841,351 (GRCm39) missense possibly damaging 0.83
R8087:Fam186a UTSW 15 99,839,725 (GRCm39) missense possibly damaging 0.46
R8130:Fam186a UTSW 15 99,841,914 (GRCm39) frame shift probably null
R8239:Fam186a UTSW 15 99,839,191 (GRCm39) missense unknown
R8246:Fam186a UTSW 15 99,838,428 (GRCm39) missense unknown
R8446:Fam186a UTSW 15 99,845,335 (GRCm39) missense unknown
R8469:Fam186a UTSW 15 99,845,186 (GRCm39) missense unknown
R8676:Fam186a UTSW 15 99,845,023 (GRCm39) missense unknown
R8790:Fam186a UTSW 15 99,841,024 (GRCm39) missense possibly damaging 0.90
R8808:Fam186a UTSW 15 99,842,604 (GRCm39) missense possibly damaging 0.83
R8848:Fam186a UTSW 15 99,838,034 (GRCm39) missense possibly damaging 0.83
R9083:Fam186a UTSW 15 99,843,079 (GRCm39) missense probably benign 0.27
R9106:Fam186a UTSW 15 99,844,107 (GRCm39) small deletion probably benign
R9116:Fam186a UTSW 15 99,840,472 (GRCm39) missense possibly damaging 0.95
R9156:Fam186a UTSW 15 99,841,159 (GRCm39) missense possibly damaging 0.46
R9227:Fam186a UTSW 15 99,853,384 (GRCm39) missense unknown
R9250:Fam186a UTSW 15 99,845,330 (GRCm39) missense unknown
R9282:Fam186a UTSW 15 99,839,879 (GRCm39) missense probably damaging 0.97
R9495:Fam186a UTSW 15 99,844,766 (GRCm39) missense unknown
R9514:Fam186a UTSW 15 99,844,766 (GRCm39) missense unknown
R9521:Fam186a UTSW 15 99,841,471 (GRCm39) missense probably damaging 0.97
R9553:Fam186a UTSW 15 99,844,561 (GRCm39) missense unknown
R9641:Fam186a UTSW 15 99,838,244 (GRCm39) missense probably benign 0.00
R9655:Fam186a UTSW 15 99,840,973 (GRCm39) missense probably damaging 0.99
R9661:Fam186a UTSW 15 99,842,492 (GRCm39) missense possibly damaging 0.66
R9673:Fam186a UTSW 15 99,841,024 (GRCm39) missense possibly damaging 0.90
R9762:Fam186a UTSW 15 99,842,393 (GRCm39) missense possibly damaging 0.66
X0021:Fam186a UTSW 15 99,843,316 (GRCm39) missense probably benign 0.00
Z1088:Fam186a UTSW 15 99,843,875 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GTGTCCAGGGCTTGTCTATC -3'
(R):5'- ATCCTTTCACAGCAGAGGCC -3'

Sequencing Primer
(F):5'- GCCCTTTTCAGAAGTTGAGATC -3'
(R):5'- TTTCACAGCAGAGGCCCTACC -3'
Posted On 2014-10-02