Incidental Mutation 'R2195:Or8k32'
ID 238313
Institutional Source Beutler Lab
Gene Symbol Or8k32
Ensembl Gene ENSMUSG00000075179
Gene Name olfactory receptor family 8 subfamily K member 32
Synonyms GA_x6K02T2Q125-48024195-48023254, MOR189-1, Olfr1079
MMRRC Submission 040197-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R2195 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86368310-86369257 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86369247 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 2 (E2G)
Ref Sequence ENSEMBL: ENSMUSP00000151072 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099882] [ENSMUST00000111582] [ENSMUST00000216480]
AlphaFold Q8VF52
Predicted Effect probably benign
Transcript: ENSMUST00000099882
AA Change: E4G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000097467
Gene: ENSMUSG00000075179
AA Change: E4G

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 37 175 1.2e-7 PFAM
Pfam:7tm_1 43 292 7.1e-32 PFAM
Pfam:7tm_4 141 285 1.3e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111582
AA Change: E2G

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000107208
Gene: ENSMUSG00000075179
AA Change: E2G

DomainStartEndE-ValueType
Pfam:7tm_4 33 308 1.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 37 175 1.2e-7 PFAM
Pfam:7tm_1 43 292 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216480
AA Change: E2G

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago2 A T 15: 72,991,318 (GRCm39) V540E probably benign Het
Cep295 T A 9: 15,243,617 (GRCm39) Q1613L probably damaging Het
Cib3 A T 8: 72,958,257 (GRCm39) I160N probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Coq10b T A 1: 55,100,457 (GRCm39) L47Q probably damaging Het
Impg2 T C 16: 56,080,497 (GRCm39) V767A probably benign Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Kmt2e T C 5: 23,707,194 (GRCm39) probably null Het
Marf1 T C 16: 13,929,563 (GRCm39) D1681G probably benign Het
Nid1 G T 13: 13,650,788 (GRCm39) V442L probably damaging Het
Or13a21 T C 7: 139,999,138 (GRCm39) T183A possibly damaging Het
Ppfia1 T C 7: 144,069,844 (GRCm39) N363S probably damaging Het
Stxbp2 A G 8: 3,684,615 (GRCm39) probably null Het
Tnf A G 17: 35,420,089 (GRCm39) probably null Het
Zkscan7 T C 9: 122,724,686 (GRCm39) F552L possibly damaging Het
Other mutations in Or8k32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01109:Or8k32 APN 2 86,368,674 (GRCm39) missense probably benign 0.12
IGL02289:Or8k32 APN 2 86,368,792 (GRCm39) missense probably benign 0.07
IGL02794:Or8k32 APN 2 86,368,492 (GRCm39) missense possibly damaging 0.80
R1498:Or8k32 UTSW 2 86,368,902 (GRCm39) missense probably benign 0.00
R1923:Or8k32 UTSW 2 86,368,857 (GRCm39) missense probably damaging 1.00
R2211:Or8k32 UTSW 2 86,368,857 (GRCm39) missense probably damaging 1.00
R2925:Or8k32 UTSW 2 86,368,891 (GRCm39) missense probably damaging 1.00
R4370:Or8k32 UTSW 2 86,368,764 (GRCm39) missense possibly damaging 0.78
R4430:Or8k32 UTSW 2 86,368,731 (GRCm39) missense probably damaging 0.98
R4678:Or8k32 UTSW 2 86,369,077 (GRCm39) missense possibly damaging 0.95
R4790:Or8k32 UTSW 2 86,369,224 (GRCm39) missense possibly damaging 0.63
R4996:Or8k32 UTSW 2 86,368,615 (GRCm39) missense probably benign 0.02
R5905:Or8k32 UTSW 2 86,369,113 (GRCm39) missense possibly damaging 0.91
R5984:Or8k32 UTSW 2 86,368,512 (GRCm39) missense probably damaging 1.00
R6028:Or8k32 UTSW 2 86,369,113 (GRCm39) missense possibly damaging 0.91
R6878:Or8k32 UTSW 2 86,369,109 (GRCm39) missense probably damaging 1.00
R7579:Or8k32 UTSW 2 86,368,872 (GRCm39) missense probably damaging 0.98
R7942:Or8k32 UTSW 2 86,368,566 (GRCm39) missense probably benign 0.42
R8079:Or8k32 UTSW 2 86,368,725 (GRCm39) missense possibly damaging 0.60
R8465:Or8k32 UTSW 2 86,368,731 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGGTGTTTGCAGCCTTGATTCC -3'
(R):5'- CCAAAGATGCATACGTATGTCTTTG -3'

Sequencing Primer
(F):5'- CACTATGGTGAGGATGATCATGCC -3'
(R):5'- TGTGTGCACAGAAGTGTATATACACC -3'
Posted On 2014-10-02