Incidental Mutation 'R0184:Dab2ip'
| ID |
23925 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab2ip
|
| Ensembl Gene |
ENSMUSG00000026883 |
| Gene Name |
disabled 2 interacting protein |
| Synonyms |
2310011D08Rik, AIP1 |
| MMRRC Submission |
038449-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.353)
|
| Stock # |
R0184 (G1)
|
| Quality Score |
192 |
|
Status
|
Validated
(trace)
|
| Chromosome |
2 |
| Chromosomal Location |
35558266-35730994 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 35718791 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 579
(R579H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000068832
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065001]
[ENSMUST00000091010]
[ENSMUST00000112983]
[ENSMUST00000112986]
[ENSMUST00000112987]
[ENSMUST00000112992]
[ENSMUST00000135741]
[ENSMUST00000145698]
|
| AlphaFold |
Q3UHC7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000065001
AA Change: R579H
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000068832
Gene: ENSMUSG00000026883
AA Change: R579H
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
10 |
139 |
3.63e-2 |
SMART |
|
C2
|
149 |
245 |
1.34e-7 |
SMART |
|
RasGAP
|
255 |
592 |
1.08e-126 |
SMART |
|
low complexity region
|
604 |
616 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
629 |
694 |
4e-29 |
BLAST |
|
low complexity region
|
733 |
745 |
N/A |
INTRINSIC |
|
low complexity region
|
780 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
873 |
N/A |
INTRINSIC |
|
coiled coil region
|
961 |
1095 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000091010
AA Change: R644H
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000088532
Gene: ENSMUSG00000026883
AA Change: R644H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
39 |
N/A |
INTRINSIC |
|
PH
|
73 |
204 |
5.58e-3 |
SMART |
|
C2
|
214 |
310 |
1.34e-7 |
SMART |
|
RasGAP
|
320 |
657 |
1.08e-126 |
SMART |
|
low complexity region
|
669 |
681 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
694 |
759 |
4e-29 |
BLAST |
|
low complexity region
|
798 |
810 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
938 |
N/A |
INTRINSIC |
|
coiled coil region
|
1026 |
1160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112981
|
| SMART Domains |
Protein: ENSMUSP00000108605
Gene: ENSMUSG00000026883
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PH
|
2 |
80 |
6e-35 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112983
AA Change: R520H
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000108607
Gene: ENSMUSG00000026883
AA Change: R520H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
18 |
N/A |
INTRINSIC |
|
C2
|
90 |
186 |
1.34e-7 |
SMART |
|
RasGAP
|
196 |
533 |
1.08e-126 |
SMART |
|
low complexity region
|
545 |
557 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
570 |
635 |
3e-29 |
BLAST |
|
low complexity region
|
674 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
746 |
N/A |
INTRINSIC |
|
low complexity region
|
796 |
814 |
N/A |
INTRINSIC |
|
coiled coil region
|
902 |
1036 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112986
AA Change: R616H
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108610
Gene: ENSMUSG00000026883
AA Change: R616H
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
45 |
176 |
5.58e-3 |
SMART |
|
C2
|
186 |
282 |
1.34e-7 |
SMART |
|
RasGAP
|
292 |
629 |
1.08e-126 |
SMART |
|
low complexity region
|
641 |
653 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
666 |
731 |
4e-29 |
BLAST |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
842 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
910 |
N/A |
INTRINSIC |
|
coiled coil region
|
998 |
1129 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112987
AA Change: R587H
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000108611
Gene: ENSMUSG00000026883
AA Change: R587H
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
16 |
147 |
5.58e-3 |
SMART |
|
C2
|
157 |
253 |
1.34e-7 |
SMART |
|
RasGAP
|
263 |
600 |
1.08e-126 |
SMART |
|
low complexity region
|
612 |
624 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
637 |
702 |
4e-29 |
BLAST |
|
low complexity region
|
741 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
813 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112992
AA Change: R644H
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000108616
Gene: ENSMUSG00000026883
AA Change: R644H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
39 |
N/A |
INTRINSIC |
|
PH
|
73 |
204 |
5.58e-3 |
SMART |
|
C2
|
214 |
310 |
1.34e-7 |
SMART |
|
RasGAP
|
320 |
657 |
1.08e-126 |
SMART |
|
low complexity region
|
669 |
681 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
694 |
759 |
4e-29 |
BLAST |
|
low complexity region
|
798 |
810 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
938 |
N/A |
INTRINSIC |
|
Pfam:DUF3498
|
986 |
1108 |
3.3e-61 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000124098
AA Change: R537H
|
| SMART Domains |
Protein: ENSMUSP00000119058
Gene: ENSMUSG00000026883
AA Change: R537H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
36 |
N/A |
INTRINSIC |
|
C2
|
108 |
204 |
1.34e-7 |
SMART |
|
RasGAP
|
214 |
551 |
1.08e-126 |
SMART |
|
low complexity region
|
563 |
575 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
588 |
653 |
3e-29 |
BLAST |
|
low complexity region
|
692 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
814 |
832 |
N/A |
INTRINSIC |
|
coiled coil region
|
919 |
1053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135741
AA Change: R587H
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000122341
Gene: ENSMUSG00000026883
AA Change: R587H
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
16 |
147 |
5.58e-3 |
SMART |
|
C2
|
157 |
253 |
1.34e-7 |
SMART |
|
RasGAP
|
263 |
600 |
1.08e-126 |
SMART |
|
low complexity region
|
612 |
624 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
637 |
702 |
4e-29 |
BLAST |
|
low complexity region
|
741 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
813 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1100 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145698
|
| SMART Domains |
Protein: ENSMUSP00000114915
Gene: ENSMUSG00000026883
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PH
|
1 |
79 |
3e-18 |
BLAST |
|
low complexity region
|
80 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
135 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000156669
AA Change: R269H
|
| SMART Domains |
Protein: ENSMUSP00000121506
Gene: ENSMUSG00000026883
AA Change: R269H
| Domain | Start | End | E-Value | Type |
|---|
|
RasGAP
|
1 |
283 |
1.97e-88 |
SMART |
|
low complexity region
|
295 |
307 |
N/A |
INTRINSIC |
|
Pfam:DUF3498
|
317 |
594 |
2.9e-78 |
PFAM |
|
Pfam:DUF3498
|
591 |
712 |
4.2e-70 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.6%
- 20x: 93.9%
|
| Validation Efficiency |
66% (50/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses. Mice homozygous for a gene trap allele exhibit delayed Purkinje cell dendritogenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
C |
A |
3: 124,419,250 (GRCm38) |
V131F |
probably damaging |
Het |
| Adam28 |
T |
C |
14: 68,637,373 (GRCm38) |
D285G |
probably benign |
Het |
| Akr1c13 |
A |
G |
13: 4,194,056 (GRCm38) |
E36G |
probably damaging |
Het |
| Antxr2 |
A |
G |
5: 97,980,030 (GRCm38) |
L214S |
probably damaging |
Het |
| Arhgap26 |
T |
A |
18: 38,617,673 (GRCm38) |
D46E |
unknown |
Het |
| Armc9 |
T |
C |
1: 86,198,370 (GRCm38) |
L61P |
probably damaging |
Het |
| Bicc1 |
C |
A |
10: 71,079,215 (GRCm38) |
R73L |
probably benign |
Het |
| Calm2 |
T |
C |
17: 87,435,841 (GRCm38) |
N43S |
probably benign |
Het |
| Cct7 |
A |
G |
6: 85,461,554 (GRCm38) |
D105G |
probably null |
Het |
| Cdk18 |
T |
C |
1: 132,118,538 (GRCm38) |
N215D |
probably benign |
Het |
| Cep126 |
T |
C |
9: 8,103,395 (GRCm38) |
T205A |
probably benign |
Het |
| Cfap57 |
A |
T |
4: 118,599,012 (GRCm38) |
I495N |
probably damaging |
Het |
| Cyp2b9 |
T |
A |
7: 26,187,007 (GRCm38) |
C152* |
probably null |
Het |
| Dnah8 |
T |
C |
17: 30,683,683 (GRCm38) |
V905A |
probably benign |
Het |
| Eif4h |
C |
A |
5: 134,625,375 (GRCm38) |
D134Y |
possibly damaging |
Het |
| Espl1 |
T |
A |
15: 102,299,216 (GRCm38) |
S372T |
probably benign |
Het |
| Fat2 |
T |
A |
11: 55,296,288 (GRCm38) |
H1244L |
probably damaging |
Het |
| Fbxo11 |
T |
A |
17: 88,008,673 (GRCm38) |
N443I |
probably benign |
Het |
| Git2 |
G |
A |
5: 114,739,037 (GRCm38) |
T128M |
possibly damaging |
Het |
| Gm10985 |
T |
A |
3: 53,845,258 (GRCm38) |
Y21N |
probably damaging |
Het |
| Gm12790 |
A |
T |
4: 101,967,614 (GRCm38) |
Y152* |
probably null |
Het |
| Heatr5a |
T |
C |
12: 51,909,969 (GRCm38) |
D1115G |
probably benign |
Het |
| Hipk2 |
T |
C |
6: 38,718,931 (GRCm38) |
N726S |
possibly damaging |
Het |
| Hrg |
T |
C |
16: 22,953,771 (GRCm38) |
|
probably null |
Het |
| Iars |
T |
G |
13: 49,722,212 (GRCm38) |
S792A |
probably benign |
Het |
| Igf1r |
A |
G |
7: 68,226,193 (GRCm38) |
N1301S |
possibly damaging |
Het |
| Il22 |
A |
T |
10: 118,205,606 (GRCm38) |
I75F |
probably damaging |
Het |
| Ilkap |
T |
C |
1: 91,376,305 (GRCm38) |
|
probably benign |
Het |
| Ints13 |
A |
T |
6: 146,555,044 (GRCm38) |
Y435N |
probably benign |
Het |
| Ints8 |
A |
C |
4: 11,218,637 (GRCm38) |
S797A |
probably benign |
Het |
| Itgad |
T |
A |
7: 128,189,231 (GRCm38) |
D405E |
probably benign |
Het |
| Itgam |
A |
T |
7: 128,086,058 (GRCm38) |
I448F |
probably damaging |
Het |
| Klk1 |
C |
T |
7: 44,228,749 (GRCm38) |
T41I |
possibly damaging |
Het |
| Mcrip1 |
T |
C |
11: 120,544,884 (GRCm38) |
M1V |
probably null |
Het |
| Mdga1 |
A |
G |
17: 29,852,442 (GRCm38) |
Y128H |
probably damaging |
Het |
| Mtor |
G |
T |
4: 148,464,971 (GRCm38) |
R604L |
probably benign |
Het |
| Olfr1170 |
A |
T |
2: 88,224,780 (GRCm38) |
L84* |
probably null |
Het |
| Olfr656 |
T |
C |
7: 104,618,240 (GRCm38) |
V187A |
probably damaging |
Het |
| Pcdhb7 |
T |
A |
18: 37,343,390 (GRCm38) |
D526E |
probably benign |
Het |
| Pip4k2a |
T |
C |
2: 18,889,128 (GRCm38) |
D139G |
probably damaging |
Het |
| Pkp3 |
A |
C |
7: 141,088,367 (GRCm38) |
N536T |
probably benign |
Het |
| Pla2g4c |
T |
A |
7: 13,356,220 (GRCm38) |
S524T |
probably benign |
Het |
| Pno1 |
T |
C |
11: 17,211,127 (GRCm38) |
E69G |
probably benign |
Het |
| Pold1 |
C |
T |
7: 44,541,715 (GRCm38) |
V231M |
probably benign |
Het |
| Poli |
A |
G |
18: 70,522,731 (GRCm38) |
S248P |
probably damaging |
Het |
| Ppox |
C |
T |
1: 171,279,552 (GRCm38) |
S138N |
probably damaging |
Het |
| Psg20 |
T |
C |
7: 18,685,976 (GRCm38) |
E6G |
probably null |
Het |
| Rbmx |
C |
T |
X: 57,391,566 (GRCm38) |
|
probably null |
Het |
| Rln1 |
T |
A |
19: 29,331,936 (GRCm38) |
K148* |
probably null |
Het |
| Rnf213 |
C |
T |
11: 119,414,521 (GRCm38) |
T526I |
probably damaging |
Het |
| Rps6kc1 |
A |
T |
1: 190,799,093 (GRCm38) |
V904E |
probably null |
Het |
| Sf3b2 |
T |
A |
19: 5,283,672 (GRCm38) |
I633F |
probably damaging |
Het |
| Sfswap |
T |
A |
5: 129,507,189 (GRCm38) |
I189N |
probably damaging |
Het |
| Smarca2 |
T |
A |
19: 26,692,249 (GRCm38) |
Y973* |
probably null |
Het |
| Spink5 |
G |
A |
18: 44,003,198 (GRCm38) |
D559N |
probably benign |
Het |
| Spty2d1 |
C |
T |
7: 46,997,574 (GRCm38) |
V536I |
possibly damaging |
Het |
| Tbx3 |
T |
C |
5: 119,675,562 (GRCm38) |
I221T |
probably damaging |
Het |
| Tcf20 |
T |
A |
15: 82,852,300 (GRCm38) |
D1650V |
probably damaging |
Het |
| Thsd7b |
A |
G |
1: 129,430,964 (GRCm38) |
K45R |
probably benign |
Het |
| Tirap |
A |
G |
9: 35,189,194 (GRCm38) |
S65P |
probably benign |
Het |
| Trim25 |
C |
T |
11: 88,999,640 (GRCm38) |
P51L |
probably damaging |
Het |
| Trim61 |
T |
C |
8: 65,014,417 (GRCm38) |
N64S |
probably benign |
Het |
| Twf1 |
T |
A |
15: 94,581,067 (GRCm38) |
|
probably null |
Het |
| Ubr4 |
A |
C |
4: 139,445,262 (GRCm38) |
T1692P |
probably damaging |
Het |
| Usp3 |
A |
G |
9: 66,562,581 (GRCm38) |
M86T |
probably damaging |
Het |
| Utrn |
T |
C |
10: 12,667,618 (GRCm38) |
D1762G |
probably benign |
Het |
| V1rd19 |
T |
A |
7: 24,003,207 (GRCm38) |
F33I |
probably benign |
Het |
| Vmn2r52 |
T |
C |
7: 10,159,338 (GRCm38) |
S625G |
probably damaging |
Het |
| Vmn2r90 |
G |
A |
17: 17,726,877 (GRCm38) |
W472* |
probably null |
Het |
| Vrk2 |
C |
A |
11: 26,550,046 (GRCm38) |
A56S |
probably damaging |
Het |
| Yeats2 |
C |
T |
16: 20,203,685 (GRCm38) |
P620S |
possibly damaging |
Het |
| Zbtb21 |
C |
T |
16: 97,950,513 (GRCm38) |
D171N |
probably damaging |
Het |
| Zeb1 |
A |
T |
18: 5,766,808 (GRCm38) |
I440F |
probably damaging |
Het |
| Zfp292 |
A |
G |
4: 34,819,563 (GRCm38) |
I253T |
probably damaging |
Het |
|
| Other mutations in Dab2ip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00509:Dab2ip
|
APN |
2 |
35,720,013 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00799:Dab2ip
|
APN |
2 |
35,707,775 (GRCm38) |
missense |
probably benign |
0.25 |
|
IGL00902:Dab2ip
|
APN |
2 |
35,717,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00929:Dab2ip
|
APN |
2 |
35,708,877 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL03052:Dab2ip
|
UTSW |
2 |
35,643,897 (GRCm38) |
missense |
probably benign |
0.27 |
|
R0097:Dab2ip
|
UTSW |
2 |
35,718,916 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R0137:Dab2ip
|
UTSW |
2 |
35,692,376 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1195:Dab2ip
|
UTSW |
2 |
35,718,745 (GRCm38) |
splice site |
probably benign |
|
|
R1195:Dab2ip
|
UTSW |
2 |
35,718,745 (GRCm38) |
splice site |
probably benign |
|
|
R1388:Dab2ip
|
UTSW |
2 |
35,721,256 (GRCm38) |
intron |
probably benign |
|
|
R1442:Dab2ip
|
UTSW |
2 |
35,710,256 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1496:Dab2ip
|
UTSW |
2 |
35,718,791 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1665:Dab2ip
|
UTSW |
2 |
35,720,278 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1909:Dab2ip
|
UTSW |
2 |
35,718,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3625:Dab2ip
|
UTSW |
2 |
35,643,891 (GRCm38) |
nonsense |
probably null |
|
|
R3819:Dab2ip
|
UTSW |
2 |
35,713,210 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4333:Dab2ip
|
UTSW |
2 |
35,661,620 (GRCm38) |
makesense |
probably null |
|
|
R4869:Dab2ip
|
UTSW |
2 |
35,720,037 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4894:Dab2ip
|
UTSW |
2 |
35,730,527 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R5035:Dab2ip
|
UTSW |
2 |
35,709,941 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5180:Dab2ip
|
UTSW |
2 |
35,720,491 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R5425:Dab2ip
|
UTSW |
2 |
35,709,991 (GRCm38) |
missense |
probably benign |
0.25 |
|
R5513:Dab2ip
|
UTSW |
2 |
35,710,254 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5579:Dab2ip
|
UTSW |
2 |
35,715,327 (GRCm38) |
nonsense |
probably null |
|
|
R5829:Dab2ip
|
UTSW |
2 |
35,707,775 (GRCm38) |
unclassified |
probably benign |
|
|
R5840:Dab2ip
|
UTSW |
2 |
35,727,499 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5890:Dab2ip
|
UTSW |
2 |
35,715,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6057:Dab2ip
|
UTSW |
2 |
35,692,255 (GRCm38) |
nonsense |
probably null |
|
|
R6235:Dab2ip
|
UTSW |
2 |
35,723,087 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6360:Dab2ip
|
UTSW |
2 |
35,710,266 (GRCm38) |
missense |
probably benign |
0.38 |
|
R6571:Dab2ip
|
UTSW |
2 |
35,712,890 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6813:Dab2ip
|
UTSW |
2 |
35,730,473 (GRCm38) |
nonsense |
probably null |
|
|
R7262:Dab2ip
|
UTSW |
2 |
35,622,286 (GRCm38) |
splice site |
probably null |
|
|
R7883:Dab2ip
|
UTSW |
2 |
35,720,206 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R8127:Dab2ip
|
UTSW |
2 |
35,644,126 (GRCm38) |
critical splice donor site |
probably benign |
|
|
R8313:Dab2ip
|
UTSW |
2 |
35,727,428 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8387:Dab2ip
|
UTSW |
2 |
35,719,858 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8422:Dab2ip
|
UTSW |
2 |
35,707,755 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8560:Dab2ip
|
UTSW |
2 |
35,713,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9263:Dab2ip
|
UTSW |
2 |
35,712,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9342:Dab2ip
|
UTSW |
2 |
35,723,093 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R9353:Dab2ip
|
UTSW |
2 |
35,708,839 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9423:Dab2ip
|
UTSW |
2 |
35,709,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9551:Dab2ip
|
UTSW |
2 |
35,715,318 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R9563:Dab2ip
|
UTSW |
2 |
35,719,903 (GRCm38) |
nonsense |
probably null |
|
|
X0011:Dab2ip
|
UTSW |
2 |
35,723,085 (GRCm38) |
nonsense |
probably null |
|
|
Z1176:Dab2ip
|
UTSW |
2 |
35,708,868 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCCACCTCCTTGATGAAGTAGG -3'
(R):5'- TTCCCAAAGAGCAGAGGCATTCC -3'
Sequencing Primer
(F):5'- GCTACCAGAGATGCCTCTTG -3'
(R):5'- AGAGGCATTCCTCCTTCAAG -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation