Incidental Mutation 'R2209:Zfp84'
ID 239251
Institutional Source Beutler Lab
Gene Symbol Zfp84
Ensembl Gene ENSMUSG00000046185
Gene Name zinc finger protein 84
Synonyms KRAB18, C86188, Zfp69, 2210410P13Rik, 4633401C23Rik
MMRRC Submission 040211-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2209 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 29467977-29479246 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 29476607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 433 (I433N)
Ref Sequence ENSEMBL: ENSMUSP00000032802 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032802]
AlphaFold Q9D654
Predicted Effect probably damaging
Transcript: ENSMUST00000032802
AA Change: I433N

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000032802
Gene: ENSMUSG00000046185
AA Change: I433N

DomainStartEndE-ValueType
KRAB 14 74 9.09e-36 SMART
ZnF_C2H2 249 271 1.67e-2 SMART
ZnF_C2H2 277 299 1.43e-1 SMART
ZnF_C2H2 305 327 5.81e-2 SMART
ZnF_C2H2 333 355 1.95e-3 SMART
ZnF_C2H2 361 383 8.6e-5 SMART
ZnF_C2H2 389 411 2.32e-1 SMART
ZnF_C2H2 417 439 3.89e-3 SMART
ZnF_C2H2 445 467 1.69e-3 SMART
ZnF_C2H2 473 495 9.58e-3 SMART
ZnF_C2H2 501 523 1.38e-3 SMART
ZnF_C2H2 529 551 1.58e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158514
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik A G 8: 120,884,227 (GRCm39) E330G possibly damaging Het
Apob A C 12: 8,057,752 (GRCm39) D2078A probably benign Het
Arhgap21 T A 2: 20,854,331 (GRCm39) Q1681L probably damaging Het
Arsb A G 13: 93,998,609 (GRCm39) T306A probably benign Het
Brpf3 G A 17: 29,047,394 (GRCm39) D1053N probably damaging Het
Cenpf A T 1: 189,384,795 (GRCm39) I2495N probably benign Het
Col12a1 T C 9: 79,599,634 (GRCm39) K840E possibly damaging Het
Cry1 A G 10: 84,982,619 (GRCm39) L269P probably damaging Het
Cyp21a1 C A 17: 35,021,701 (GRCm39) E289* probably null Het
Dcp2 A T 18: 44,538,581 (GRCm39) K215* probably null Het
Dnaaf11 A G 15: 66,321,400 (GRCm39) I247T probably benign Het
Ecm2 A G 13: 49,683,632 (GRCm39) N537D probably damaging Het
Emid1 G A 11: 5,085,407 (GRCm39) T113M probably benign Het
Exoc8 C T 8: 125,622,918 (GRCm39) W483* probably null Het
Fes A T 7: 80,030,031 (GRCm39) N582K probably damaging Het
Flnb G T 14: 7,905,507 (GRCm38) E1086* probably null Het
Flnc T A 6: 29,455,844 (GRCm39) D2058E possibly damaging Het
Gatb G A 3: 85,561,112 (GRCm39) D543N probably benign Het
Gm14412 A G 2: 177,009,229 (GRCm39) V9A probably damaging Het
Gm4884 T C 7: 40,692,745 (GRCm39) V238A possibly damaging Het
Igfbp5 A G 1: 72,913,096 (GRCm39) V68A possibly damaging Het
Igflr1 T A 7: 30,267,222 (GRCm39) I330N probably damaging Het
Il1r2 A G 1: 40,154,298 (GRCm39) T222A probably benign Het
Krt87 T C 15: 101,330,989 (GRCm39) E419G probably benign Het
Lman2 A G 13: 55,499,315 (GRCm39) S187P probably damaging Het
Mrpl38 T C 11: 116,029,288 (GRCm39) E76G possibly damaging Het
Mtx3 A G 13: 92,984,112 (GRCm39) I130V probably benign Het
Naf1 T G 8: 67,313,188 (GRCm39) probably benign Het
Nkx2-1 T G 12: 56,580,293 (GRCm39) M216L probably benign Het
Notch1 C A 2: 26,350,019 (GRCm39) V2374L probably benign Het
Nrxn2 A G 19: 6,543,037 (GRCm39) D1087G probably benign Het
Nudt8 T C 19: 4,051,902 (GRCm39) F171S probably damaging Het
Or5an1 T G 19: 12,261,224 (GRCm39) F271V probably benign Het
Pds5a A T 5: 65,785,357 (GRCm39) C916* probably null Het
Phyhip A T 14: 70,699,334 (GRCm39) N46Y probably damaging Het
Pomt1 A G 2: 32,140,874 (GRCm39) Y502C possibly damaging Het
Prkcg A C 7: 3,352,097 (GRCm39) probably benign Het
Prl8a6 C T 13: 27,619,369 (GRCm39) E118K probably benign Het
Prpf39 T C 12: 65,104,689 (GRCm39) probably null Het
Ptprb A G 10: 116,205,262 (GRCm39) H2159R probably damaging Het
Ripor2 A T 13: 24,885,595 (GRCm39) D571V probably damaging Het
Rps19 C T 7: 24,584,552 (GRCm39) L34F probably benign Het
Rusc1 A G 3: 88,996,128 (GRCm39) S145P probably damaging Het
Scn4a T A 11: 106,230,051 (GRCm39) T586S probably damaging Het
Slc7a12 A G 3: 14,546,124 (GRCm39) S90G possibly damaging Het
Specc1l A G 10: 75,082,410 (GRCm39) D619G probably damaging Het
Src A G 2: 157,304,710 (GRCm39) D143G probably benign Het
Sst T C 16: 23,708,558 (GRCm39) N91S probably benign Het
Stxbp5l T A 16: 37,036,398 (GRCm39) I406F probably damaging Het
Thsd1 T A 8: 22,748,887 (GRCm39) I525N probably damaging Het
Ticam2 A T 18: 46,693,467 (GRCm39) F207I probably damaging Het
Tsc22d1 C A 14: 76,656,180 (GRCm39) N31K probably damaging Het
Tspan10 T C 11: 120,336,989 (GRCm39) V253A probably benign Het
Ttc33 A G 15: 5,237,924 (GRCm39) K99R possibly damaging Het
Vmn1r63 T A 7: 5,806,212 (GRCm39) N140I probably damaging Het
Yju2b C T 8: 84,990,498 (GRCm39) V45I probably benign Het
Zbtb25 A G 12: 76,395,903 (GRCm39) *440Q probably null Het
Zfhx4 T A 3: 5,461,978 (GRCm39) C1218S probably damaging Het
Other mutations in Zfp84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01768:Zfp84 APN 7 29,476,091 (GRCm39) missense probably benign 0.16
IGL03022:Zfp84 APN 7 29,474,759 (GRCm39) splice site probably benign
R0666:Zfp84 UTSW 7 29,476,276 (GRCm39) missense probably damaging 1.00
R0781:Zfp84 UTSW 7 29,470,797 (GRCm39) start codon destroyed probably null 0.02
R1110:Zfp84 UTSW 7 29,470,797 (GRCm39) start codon destroyed probably null 0.02
R1353:Zfp84 UTSW 7 29,475,600 (GRCm39) missense probably benign 0.02
R1495:Zfp84 UTSW 7 29,476,728 (GRCm39) nonsense probably null
R1496:Zfp84 UTSW 7 29,476,039 (GRCm39) missense possibly damaging 0.53
R1681:Zfp84 UTSW 7 29,476,825 (GRCm39) missense probably damaging 1.00
R1827:Zfp84 UTSW 7 29,476,768 (GRCm39) missense possibly damaging 0.91
R1854:Zfp84 UTSW 7 29,474,796 (GRCm39) missense possibly damaging 0.84
R2843:Zfp84 UTSW 7 29,474,758 (GRCm39) splice site probably null
R2844:Zfp84 UTSW 7 29,474,758 (GRCm39) splice site probably null
R4691:Zfp84 UTSW 7 29,476,505 (GRCm39) missense probably damaging 1.00
R5453:Zfp84 UTSW 7 29,475,722 (GRCm39) missense possibly damaging 0.82
R5474:Zfp84 UTSW 7 29,476,514 (GRCm39) missense probably damaging 1.00
R5578:Zfp84 UTSW 7 29,474,856 (GRCm39) missense possibly damaging 0.93
R5646:Zfp84 UTSW 7 29,475,818 (GRCm39) missense probably benign 0.05
R5963:Zfp84 UTSW 7 29,476,378 (GRCm39) missense probably damaging 1.00
R6830:Zfp84 UTSW 7 29,475,911 (GRCm39) missense probably benign 0.00
R8129:Zfp84 UTSW 7 29,475,862 (GRCm39) missense probably benign 0.00
R8138:Zfp84 UTSW 7 29,474,797 (GRCm39) missense probably damaging 0.99
R9180:Zfp84 UTSW 7 29,474,873 (GRCm39) missense probably damaging 0.97
R9401:Zfp84 UTSW 7 29,476,297 (GRCm39) missense probably damaging 1.00
R9489:Zfp84 UTSW 7 29,476,264 (GRCm39) missense possibly damaging 0.89
R9555:Zfp84 UTSW 7 29,476,102 (GRCm39) missense probably damaging 0.99
R9605:Zfp84 UTSW 7 29,476,264 (GRCm39) missense possibly damaging 0.89
V3553:Zfp84 UTSW 7 29,476,672 (GRCm39) missense probably benign 0.36
Z1186:Zfp84 UTSW 7 29,470,805 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GCCTTTAACAAGAGTGCCAACC -3'
(R):5'- CCTCTGGTGCAGAATGAGAG -3'

Sequencing Primer
(F):5'- TGCGGAAAGACCTTCACTTG -3'
(R):5'- CCTCTGGTGCAGAATGAGAGTTTTAC -3'
Posted On 2014-10-15