Incidental Mutation 'R2211:Arhgap21'
| ID |
239352 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
040213-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.443)
|
| Stock # |
R2211 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
20847919-20968881 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20881640 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 242
(M242K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133851
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000174584]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114594
AA Change: M246K
PolyPhen 2
Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
AA Change: M246K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141298
AA Change: M252K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
AA Change: M252K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154230
AA Change: M252K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
AA Change: M252K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156142
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000173194
AA Change: M242K
PolyPhen 2
Score 0.564 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
AA Change: M242K
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174584
AA Change: M81K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
AA Change: M81K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A430078G23Rik |
T |
C |
8: 3,387,680 (GRCm38) |
S268P |
possibly damaging |
Het |
| Adam18 |
A |
G |
8: 24,628,155 (GRCm38) |
S34P |
probably damaging |
Het |
| Adam23 |
T |
A |
1: 63,573,129 (GRCm38) |
|
probably benign |
Het |
| Adcy10 |
A |
T |
1: 165,518,212 (GRCm38) |
I277F |
probably damaging |
Het |
| Arfgef3 |
A |
T |
10: 18,592,245 (GRCm38) |
S1736T |
possibly damaging |
Het |
| Astn1 |
A |
G |
1: 158,657,306 (GRCm38) |
R4G |
probably benign |
Het |
| AU041133 |
G |
A |
10: 82,150,921 (GRCm38) |
C135Y |
probably damaging |
Het |
| Cdc42bpb |
A |
G |
12: 111,301,854 (GRCm38) |
V53A |
probably benign |
Het |
| Cdh23 |
T |
C |
10: 60,466,004 (GRCm38) |
D428G |
possibly damaging |
Het |
| Cebpa |
T |
C |
7: 35,120,466 (GRCm38) |
S350P |
probably damaging |
Het |
| Cftr |
A |
G |
6: 18,214,280 (GRCm38) |
M152V |
probably null |
Het |
| Cpa4 |
A |
G |
6: 30,583,650 (GRCm38) |
N255S |
possibly damaging |
Het |
| Ddx51 |
T |
A |
5: 110,655,768 (GRCm38) |
D343E |
probably damaging |
Het |
| Dnah7a |
T |
C |
1: 53,479,773 (GRCm38) |
I2942V |
probably benign |
Het |
| Dnajc1 |
G |
T |
2: 18,392,475 (GRCm38) |
A9E |
probably damaging |
Het |
| Dpysl5 |
G |
A |
5: 30,791,597 (GRCm38) |
D399N |
probably damaging |
Het |
| Edem3 |
A |
G |
1: 151,804,702 (GRCm38) |
D526G |
possibly damaging |
Het |
| Emc10 |
G |
A |
7: 44,493,192 (GRCm38) |
R109W |
probably damaging |
Het |
| Etaa1 |
G |
A |
11: 17,952,686 (GRCm38) |
Q84* |
probably null |
Het |
| Fabp3 |
C |
T |
4: 130,312,387 (GRCm38) |
T57I |
probably benign |
Het |
| Fam149a |
G |
A |
8: 45,341,009 (GRCm38) |
T674I |
probably damaging |
Het |
| Fam98a |
A |
G |
17: 75,538,945 (GRCm38) |
|
probably null |
Het |
| Fat4 |
A |
G |
3: 38,891,527 (GRCm38) |
N1523S |
possibly damaging |
Het |
| Fbxw10 |
A |
G |
11: 62,867,535 (GRCm38) |
T529A |
probably damaging |
Het |
| Gzf1 |
C |
T |
2: 148,684,950 (GRCm38) |
A447V |
probably damaging |
Het |
| Hap1 |
G |
A |
11: 100,354,724 (GRCm38) |
T138M |
probably benign |
Het |
| Hic1 |
T |
A |
11: 75,169,384 (GRCm38) |
R46W |
possibly damaging |
Het |
| Id4 |
T |
A |
13: 48,261,802 (GRCm38) |
L102Q |
probably damaging |
Het |
| Il3ra |
T |
C |
14: 14,355,029 (GRCm38) |
C271R |
probably benign |
Het |
| Ints4 |
T |
C |
7: 97,509,750 (GRCm38) |
I443T |
possibly damaging |
Het |
| Lmln |
A |
G |
16: 33,109,778 (GRCm38) |
E535G |
probably benign |
Het |
| Lrrtm4 |
A |
G |
6: 80,022,640 (GRCm38) |
H345R |
probably benign |
Het |
| Ltbp3 |
T |
C |
19: 5,753,962 (GRCm38) |
I834T |
possibly damaging |
Het |
| Mnd1 |
C |
A |
3: 84,134,109 (GRCm38) |
C62F |
probably benign |
Het |
| Ms4a18 |
C |
A |
19: 10,997,305 (GRCm38) |
V341L |
probably benign |
Het |
| Nbr1 |
T |
C |
11: 101,567,264 (GRCm38) |
|
probably null |
Het |
| Nf1 |
T |
C |
11: 79,444,064 (GRCm38) |
M914T |
probably benign |
Het |
| Notch3 |
T |
A |
17: 32,147,978 (GRCm38) |
H861L |
probably benign |
Het |
| Nup58 |
A |
G |
14: 60,232,640 (GRCm38) |
F341L |
probably damaging |
Het |
| Ogfod2 |
C |
A |
5: 124,112,780 (GRCm38) |
|
probably null |
Het |
| Oit3 |
T |
C |
10: 59,428,070 (GRCm38) |
D414G |
probably damaging |
Het |
| Or6c5c |
A |
T |
10: 129,462,940 (GRCm38) |
K88M |
probably damaging |
Het |
| Or6c6c |
A |
G |
10: 129,705,451 (GRCm38) |
H191R |
probably benign |
Het |
| Or8k32 |
T |
C |
2: 86,538,513 (GRCm38) |
Y132C |
probably damaging |
Het |
| Or9q2 |
T |
A |
19: 13,795,369 (GRCm38) |
M81L |
probably benign |
Het |
| Pals1 |
A |
T |
12: 78,797,248 (GRCm38) |
K75N |
possibly damaging |
Het |
| Pcbp4 |
C |
A |
9: 106,460,734 (GRCm38) |
H74Q |
probably benign |
Het |
| Pip5k1b |
A |
T |
19: 24,378,850 (GRCm38) |
D241E |
probably damaging |
Het |
| Plcb2 |
T |
C |
2: 118,723,534 (GRCm38) |
D102G |
probably benign |
Het |
| Plekha5 |
G |
A |
6: 140,525,861 (GRCm38) |
E4K |
possibly damaging |
Het |
| Ppargc1a |
A |
C |
5: 51,474,259 (GRCm38) |
S343A |
possibly damaging |
Het |
| Ppwd1 |
G |
A |
13: 104,207,142 (GRCm38) |
S585L |
probably benign |
Het |
| Rarg |
T |
C |
15: 102,239,524 (GRCm38) |
N284S |
probably benign |
Het |
| Rnpepl1 |
C |
T |
1: 92,916,380 (GRCm38) |
L278F |
probably damaging |
Het |
| Rp1 |
A |
C |
1: 4,348,139 (GRCm38) |
S917A |
probably damaging |
Het |
| Rsf1 |
ATGGCG |
ATGGCGAGGGTGGCG |
7: 97,579,904 (GRCm38) |
|
probably benign |
Het |
| Rsph3b |
T |
C |
17: 6,941,740 (GRCm38) |
S189G |
probably benign |
Het |
| Sec31b |
A |
T |
19: 44,523,150 (GRCm38) |
L604Q |
probably damaging |
Het |
| Sema6b |
T |
A |
17: 56,124,741 (GRCm38) |
I641F |
probably benign |
Het |
| Slc35f5 |
A |
T |
1: 125,579,264 (GRCm38) |
I309F |
possibly damaging |
Het |
| Smarca4 |
A |
G |
9: 21,686,029 (GRCm38) |
E1360G |
probably damaging |
Het |
| Spata31d1c |
T |
C |
13: 65,035,939 (GRCm38) |
S432P |
probably benign |
Het |
| Spsb3 |
T |
C |
17: 24,890,937 (GRCm38) |
|
probably null |
Het |
| Sptbn4 |
T |
C |
7: 27,367,609 (GRCm38) |
D1960G |
probably damaging |
Het |
| Srgap1 |
A |
G |
10: 121,853,740 (GRCm38) |
V345A |
possibly damaging |
Het |
| Tiam2 |
C |
A |
17: 3,414,918 (GRCm38) |
C307* |
probably null |
Het |
| Trim43b |
T |
A |
9: 89,085,249 (GRCm38) |
T444S |
possibly damaging |
Het |
| Trmt13 |
A |
G |
3: 116,594,754 (GRCm38) |
I11T |
probably benign |
Het |
| Ylpm1 |
A |
T |
12: 85,044,378 (GRCm38) |
R1073* |
probably null |
Het |
| Zfp524 |
T |
C |
7: 5,017,919 (GRCm38) |
S149P |
probably damaging |
Het |
| Zfp777 |
T |
C |
6: 48,043,885 (GRCm38) |
I312V |
possibly damaging |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,855,700 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,849,581 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,914,644 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,849,637 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,880,002 (GRCm38) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,880,306 (GRCm38) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,860,039 (GRCm38) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,879,951 (GRCm38) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,880,900 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,855,588 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,892,091 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,861,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,914,721 (GRCm38) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,849,628 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,880,689 (GRCm38) |
missense |
probably benign |
0.41 |
|
R0304:Arhgap21
|
UTSW |
2 |
20,859,801 (GRCm38) |
splice site |
probably benign |
|
|
R0363:Arhgap21
|
UTSW |
2 |
20,881,133 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,863,117 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,914,799 (GRCm38) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,855,387 (GRCm38) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,849,934 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,881,765 (GRCm38) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,880,840 (GRCm38) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,881,848 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,861,099 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,861,204 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,861,204 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,849,520 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,863,226 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,863,226 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,863,226 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,880,051 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,854,998 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,850,291 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,859,906 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,892,104 (GRCm38) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,887,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,887,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,887,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,887,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,887,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,967,335 (GRCm38) |
missense |
probably benign |
|
|
R4686:Arhgap21
|
UTSW |
2 |
20,863,222 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4817:Arhgap21
|
UTSW |
2 |
20,850,156 (GRCm38) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,865,319 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,881,187 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,880,468 (GRCm38) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,850,061 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,858,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4994:Arhgap21
|
UTSW |
2 |
20,849,890 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,880,037 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,848,834 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,849,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,849,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,881,086 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,880,686 (GRCm38) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,863,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,849,041 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,881,376 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R6014:Arhgap21
|
UTSW |
2 |
20,881,805 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,880,732 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,880,296 (GRCm38) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,848,848 (GRCm38) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,881,305 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,880,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,850,331 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7011:Arhgap21
|
UTSW |
2 |
20,848,878 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,865,387 (GRCm38) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,849,972 (GRCm38) |
nonsense |
probably null |
|
|
R7261:Arhgap21
|
UTSW |
2 |
20,880,366 (GRCm38) |
missense |
probably benign |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,855,610 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,912,291 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,850,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,849,479 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,863,172 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,880,713 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,849,196 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,863,156 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,880,405 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,871,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,871,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,849,410 (GRCm38) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,860,425 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,881,305 (GRCm38) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,854,180 (GRCm38) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,967,333 (GRCm38) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,881,214 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,854,172 (GRCm38) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,881,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,855,658 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,855,658 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,849,250 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,881,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,880,653 (GRCm38) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,865,342 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,881,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,881,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,892,142 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,849,215 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,881,472 (GRCm38) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAGGCCTGCTCATTTACACC -3'
(R):5'- TTCTCAAGATGCATACCTGAAAGGC -3'
Sequencing Primer
(F):5'- AGGCCTGCTCATTTACACCATACC -3'
(R):5'- TACCTGAAAGGCAATGAAGCTTAC -3'
|
| Posted On |
2014-10-15 |
Incidental Mutation