Mutagenetix > Incidental Mutation

Incidental Mutation 'R2211:Olfr804'

239392

Institutional Source

Beutler Lab

Gene Symbol

Olfr804

Ensembl Gene

ENSMUSG00000095401

Gene Name

olfactory receptor 804

Synonyms

MOR110-7, GA_x6K02T2PULF-11383575-11384519

MMRRC Submission

040213-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

R2211 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

129703210-129710018 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 129705451 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 191 (H191R)

Ref Sequence

ENSEMBL: ENSMUSP00000150132 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077312] [ENSMUST00000213331]

AlphaFold

Q7TRH7

Predicted Effect

probably benign
Transcript: ENSMUST00000077312
AA Change: H191R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000076540
Gene: ENSMUSG00000095401
AA Change: H191R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	6e-48	PFAM
Pfam:7tm_1	39	288	3.3e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213331
AA Change: H191R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216747

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430078G23Rik	T	C	8: 3,387,680	S268P	possibly damaging	Het
Adam18	A	G	8: 24,628,155	S34P	probably damaging	Het
Adam23	T	A	1: 63,573,129		probably benign	Het
Adcy10	A	T	1: 165,518,212	I277F	probably damaging	Het
Arfgef3	A	T	10: 18,592,245	S1736T	possibly damaging	Het
Arhgap21	A	T	2: 20,881,640	M242K	possibly damaging	Het
Astn1	A	G	1: 158,657,306	R4G	probably benign	Het
AU041133	G	A	10: 82,150,921	C135Y	probably damaging	Het
Cdc42bpb	A	G	12: 111,301,854	V53A	probably benign	Het
Cdh23	T	C	10: 60,466,004	D428G	possibly damaging	Het
Cebpa	T	C	7: 35,120,466	S350P	probably damaging	Het
Cftr	A	G	6: 18,214,280	M152V	probably null	Het
Cpa4	A	G	6: 30,583,650	N255S	possibly damaging	Het
Ddx51	T	A	5: 110,655,768	D343E	probably damaging	Het
Dnah7a	T	C	1: 53,479,773	I2942V	probably benign	Het
Dnajc1	G	T	2: 18,392,475	A9E	probably damaging	Het
Dpysl5	G	A	5: 30,791,597	D399N	probably damaging	Het
Edem3	A	G	1: 151,804,702	D526G	possibly damaging	Het
Emc10	G	A	7: 44,493,192	R109W	probably damaging	Het
Etaa1	G	A	11: 17,952,686	Q84*	probably null	Het
Fabp3	C	T	4: 130,312,387	T57I	probably benign	Het
Fam149a	G	A	8: 45,341,009	T674I	probably damaging	Het
Fam98a	A	G	17: 75,538,945		probably null	Het
Fat4	A	G	3: 38,891,527	N1523S	possibly damaging	Het
Fbxw10	A	G	11: 62,867,535	T529A	probably damaging	Het
Gzf1	C	T	2: 148,684,950	A447V	probably damaging	Het
Hap1	G	A	11: 100,354,724	T138M	probably benign	Het
Hic1	T	A	11: 75,169,384	R46W	possibly damaging	Het
Id4	T	A	13: 48,261,802	L102Q	probably damaging	Het
Il3ra	T	C	14: 14,355,029	C271R	probably benign	Het
Ints4	T	C	7: 97,509,750	I443T	possibly damaging	Het
Lmln	A	G	16: 33,109,778	E535G	probably benign	Het
Lrrtm4	A	G	6: 80,022,640	H345R	probably benign	Het
Ltbp3	T	C	19: 5,753,962	I834T	possibly damaging	Het
Mnd1	C	A	3: 84,134,109	C62F	probably benign	Het
Mpp5	A	T	12: 78,797,248	K75N	possibly damaging	Het
Ms4a18	C	A	19: 10,997,305	V341L	probably benign	Het
Nbr1	T	C	11: 101,567,264		probably null	Het
Nf1	T	C	11: 79,444,064	M914T	probably benign	Het
Notch3	T	A	17: 32,147,978	H861L	probably benign	Het
Nupl1	A	G	14: 60,232,640	F341L	probably damaging	Het
Ogfod2	C	A	5: 124,112,780		probably null	Het
Oit3	T	C	10: 59,428,070	D414G	probably damaging	Het
Olfr1079	T	C	2: 86,538,513	Y132C	probably damaging	Het
Olfr1497	T	A	19: 13,795,369	M81L	probably benign	Het
Olfr787	A	T	10: 129,462,940	K88M	probably damaging	Het
Pcbp4	C	A	9: 106,460,734	H74Q	probably benign	Het
Pip5k1b	A	T	19: 24,378,850	D241E	probably damaging	Het
Plcb2	T	C	2: 118,723,534	D102G	probably benign	Het
Plekha5	G	A	6: 140,525,861	E4K	possibly damaging	Het
Ppargc1a	A	C	5: 51,474,259	S343A	possibly damaging	Het
Ppwd1	G	A	13: 104,207,142	S585L	probably benign	Het
Rarg	T	C	15: 102,239,524	N284S	probably benign	Het
Rnpepl1	C	T	1: 92,916,380	L278F	probably damaging	Het
Rp1	A	C	1: 4,348,139	S917A	probably damaging	Het
Rsf1	ATGGCG	ATGGCGAGGGTGGCG	7: 97,579,904		probably benign	Het
Rsph3b	T	C	17: 6,941,740	S189G	probably benign	Het
Sec31b	A	T	19: 44,523,150	L604Q	probably damaging	Het
Sema6b	T	A	17: 56,124,741	I641F	probably benign	Het
Slc35f5	A	T	1: 125,579,264	I309F	possibly damaging	Het
Smarca4	A	G	9: 21,686,029	E1360G	probably damaging	Het
Spata31d1c	T	C	13: 65,035,939	S432P	probably benign	Het
Spsb3	T	C	17: 24,890,937		probably null	Het
Sptbn4	T	C	7: 27,367,609	D1960G	probably damaging	Het
Srgap1	A	G	10: 121,853,740	V345A	possibly damaging	Het
Tiam2	C	A	17: 3,414,918	C307*	probably null	Het
Trim43b	T	A	9: 89,085,249	T444S	possibly damaging	Het
Trmt13	A	G	3: 116,594,754	I11T	probably benign	Het
Ylpm1	A	T	12: 85,044,378	R1073*	probably null	Het
Zfp524	T	C	7: 5,017,919	S149P	probably damaging	Het
Zfp777	T	C	6: 48,043,885	I312V	possibly damaging	Het

Other mutations in Olfr804

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01613:Olfr804	APN	10	129705623	missense	probably benign	0.01
IGL02041:Olfr804	APN	10	129705235	missense	probably damaging	1.00
IGL02245:Olfr804	APN	10	129705739	missense	probably damaging	1.00
IGL02341:Olfr804	APN	10	129705489	missense	probably damaging	0.99
IGL02433:Olfr804	APN	10	129705576	missense	probably benign	0.01
authen	UTSW	10	129705799	missense	probably benign	0.00
R0111:Olfr804	UTSW	10	129705277	missense	probably damaging	1.00
R0309:Olfr804	UTSW	10	129705139	missense	probably benign	0.38
R0326:Olfr804	UTSW	10	129705769	missense	possibly damaging	0.69
R0374:Olfr804	UTSW	10	129705647	missense	probably benign	0.00
R1573:Olfr804	UTSW	10	129705618	missense	probably damaging	1.00
R1663:Olfr804	UTSW	10	129705291	missense	probably benign	0.44
R1778:Olfr804	UTSW	10	129705705	missense	probably benign	0.01
R1789:Olfr804	UTSW	10	129705607	missense	possibly damaging	0.82
R1906:Olfr804	UTSW	10	129705496	missense	probably benign	0.00
R2108:Olfr804	UTSW	10	129705621	missense	probably benign
R2432:Olfr804	UTSW	10	129704925	missense	possibly damaging	0.91
R2902:Olfr804	UTSW	10	129705451	missense	probably benign
R4114:Olfr804	UTSW	10	129705799	missense	probably benign	0.00
R5149:Olfr804	UTSW	10	129705508	missense	probably benign	0.00
R5153:Olfr804	UTSW	10	129705157	missense	probably benign	0.05
R5846:Olfr804	UTSW	10	129704887	missense	probably damaging	0.99
R6553:Olfr804	UTSW	10	129705063	missense	probably benign	0.07
R7676:Olfr804	UTSW	10	129705286	missense	possibly damaging	0.63
R8161:Olfr804	UTSW	10	129704884	missense	possibly damaging	0.94
R9266:Olfr804	UTSW	10	129705678	missense	probably benign	0.17
R9318:Olfr804	UTSW	10	129705414	missense	probably benign	0.00
R9334:Olfr804	UTSW	10	129705814	missense	probably benign	0.00
R9746:Olfr804	UTSW	10	129705339	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- CTATCATCATGAACAGCAAAGTGTG -3'
(R):5'- ACTCTCTCCCTTGCAGATGG -3'

Sequencing Primer
(F):5'- AGTGTGCCACCAACTCGTC -3'
(R):5'- CTCCCTTGCAGATGGTTTAATATAC -3'

Posted On

2014-10-15