Incidental Mutation 'R2229:Tnfrsf22'
ID239604
Institutional Source Beutler Lab
Gene Symbol Tnfrsf22
Ensembl Gene ENSMUSG00000010751
Gene Nametumor necrosis factor receptor superfamily, member 22
SynonymsTnfrh2, mDcTrailr2, 2810028K06Rik, SOBa, C130035G06Rik
MMRRC Submission 040230-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #R2229 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location143634806-143649661 bp(-) (GRCm38)
Type of Mutationsplice site (5 bp from exon)
DNA Base Change (assembly) C to T at 143644776 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075588] [ENSMUST00000084396] [ENSMUST00000146692]
Predicted Effect probably null
Transcript: ENSMUST00000075588
SMART Domains Protein: ENSMUSP00000075018
Gene: ENSMUSG00000010751

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
transmembrane domain 177 196 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000084396
SMART Domains Protein: ENSMUSP00000081432
Gene: ENSMUSG00000010751

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
low complexity region 166 177 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000146692
SMART Domains Protein: ENSMUSP00000119297
Gene: ENSMUSG00000010751

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
low complexity region 166 177 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207189
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 99% (78/79)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam24 A T 8: 40,680,365 I291L probably benign Het
Adcy8 C A 15: 64,822,207 R407L possibly damaging Het
Adgb A T 10: 10,436,051 V212E probably damaging Het
Adgrg7 C T 16: 56,752,403 S350N probably benign Het
Agbl1 A G 7: 76,433,378 T448A probably benign Het
Aldh1l1 C G 6: 90,583,186 T605R probably damaging Het
Arfip1 A T 3: 84,547,973 N18K probably damaging Het
Atp6v1b2 C A 8: 69,102,759 probably null Het
Banp G A 8: 121,978,685 S98N probably damaging Het
Btnl9 T C 11: 49,169,118 D601G probably damaging Het
C9 T C 15: 6,445,420 I20T possibly damaging Het
Cacna1b A G 2: 24,685,804 V744A probably damaging Het
Catsper3 A G 13: 55,808,054 E311G probably damaging Het
Ccdc180 G T 4: 45,948,856 probably null Het
Cdc5l A G 17: 45,407,846 Y615H probably benign Het
Crybg2 TGGAGGAGGAGGAGGAGGAG TGGAGGAGGAGGAGGAG 4: 134,074,526 probably benign Het
Eml4 C T 17: 83,451,056 P502S probably benign Het
Fsip1 T C 2: 118,222,444 E367G probably benign Het
Gja3 T C 14: 57,036,714 D67G probably damaging Het
Gm4894 T C 9: 49,274,190 probably benign Het
Gm7853 A G 14: 36,089,527 noncoding transcript Het
Gmps T G 3: 64,014,263 Y562* probably null Het
Golga2 C A 2: 32,306,465 P976T probably benign Het
Gpr182 T A 10: 127,750,141 I314F possibly damaging Het
Gprc6a A G 10: 51,626,795 V324A possibly damaging Het
Gykl1 A G 18: 52,695,267 T516A probably benign Het
Hist2h2ab T C 3: 96,220,106 L64P possibly damaging Het
Ifit1bl2 G T 19: 34,619,230 L329M possibly damaging Het
Igsf9b T C 9: 27,333,496 S920P probably damaging Het
Kif3c T A 12: 3,366,671 S231T probably benign Het
Kpna7 A T 5: 144,989,697 Y482N probably damaging Het
Lmnb2 T C 10: 80,904,392 probably benign Het
Lrrc69 T C 4: 14,773,694 S121G probably benign Het
Mppe1 A G 18: 67,228,011 probably null Het
Muc5b T A 7: 141,861,644 C2776S possibly damaging Het
Myh8 T G 11: 67,308,348 N1893K probably damaging Het
Myo7a T C 7: 98,054,910 T1932A probably benign Het
Nbn A G 4: 15,970,904 T296A probably benign Het
Nckap1l T C 15: 103,455,934 probably null Het
Nek5 A T 8: 22,113,632 N151K possibly damaging Het
Nup93 C T 8: 94,304,191 T305I probably benign Het
Oca2 T A 7: 56,357,155 H663Q probably benign Het
Optn T A 2: 5,024,117 H525L probably damaging Het
Pdzph1 A G 17: 58,932,412 probably benign Het
Pikfyve A G 1: 65,267,855 K1801E probably damaging Het
Pkd2l2 G A 18: 34,430,329 V478M probably damaging Het
Pmepa1 G A 2: 173,228,133 R210W probably damaging Het
Ppp1r3c C A 19: 36,733,698 R224L probably benign Het
Prpf19 A G 19: 10,897,598 T39A probably benign Het
Pwwp2b T C 7: 139,255,188 C182R probably damaging Het
Rcan3 T C 4: 135,425,377 D11G probably benign Het
Rgsl1 C A 1: 153,822,358 W482L possibly damaging Het
Sfxn4 C T 19: 60,851,020 G200E probably damaging Het
Slc4a8 T C 15: 100,809,299 I848T probably damaging Het
Slc7a13 T C 4: 19,839,399 V334A probably benign Het
Smarcc2 A G 10: 128,488,341 probably benign Het
Spata18 A T 5: 73,666,901 I156L possibly damaging Het
Spats2 T C 15: 99,174,453 probably null Het
Tas2r104 G A 6: 131,685,132 H205Y probably damaging Het
Tcof1 A G 18: 60,832,177 probably benign Het
Tex15 C A 8: 33,571,237 H232N probably benign Het
Tg A T 15: 66,674,011 Q194L probably damaging Het
Trim25 T A 11: 89,016,621 V602E probably damaging Het
Ttll9 A G 2: 152,983,063 E54G probably damaging Het
Ttn T C 2: 76,729,324 T29578A probably damaging Het
Tubgcp5 A G 7: 55,830,881 Q960R probably damaging Het
Ugcg C T 4: 59,207,798 P46S probably benign Het
Usp13 A G 3: 32,917,551 I727V probably benign Het
Vmn2r67 T A 7: 85,152,042 I229F probably benign Het
Vmn2r92 A C 17: 18,167,392 I220L probably benign Het
Wnk4 T A 11: 101,275,641 probably benign Het
Wwp1 A T 4: 19,641,745 Y437N probably damaging Het
Zdhhc5 A G 2: 84,690,213 I540T probably damaging Het
Zfp729b T C 13: 67,595,265 I60M probably damaging Het
Other mutations in Tnfrsf22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Tnfrsf22 APN 7 143643374 missense probably damaging 1.00
IGL01959:Tnfrsf22 APN 7 143643275 critical splice donor site probably null
IGL02395:Tnfrsf22 APN 7 143643316 missense probably damaging 1.00
IGL02608:Tnfrsf22 APN 7 143644796 nonsense probably null
IGL03054:Tnfrsf22 UTSW 7 143640795 missense probably damaging 1.00
R1987:Tnfrsf22 UTSW 7 143638389 unclassified probably benign
R2228:Tnfrsf22 UTSW 7 143644776 splice site probably null
R4562:Tnfrsf22 UTSW 7 143649576 missense unknown
R4829:Tnfrsf22 UTSW 7 143643330 missense possibly damaging 0.91
R6486:Tnfrsf22 UTSW 7 143640756 missense possibly damaging 0.93
R6903:Tnfrsf22 UTSW 7 143639904 unclassified probably benign
R7146:Tnfrsf22 UTSW 7 143640819 missense probably damaging 1.00
R7406:Tnfrsf22 UTSW 7 143640827 missense probably damaging 1.00
R8108:Tnfrsf22 UTSW 7 143638373 missense unknown
Predicted Primers PCR Primer
(F):5'- AGGGGTGACATTCTGTGTACC -3'
(R):5'- TCTACAGCATAGCATCAGCC -3'

Sequencing Primer
(F):5'- CTTGGTTAGGAAGCATCTCCTAGAG -3'
(R):5'- TAGCATCAGATAGTCCCCGCTG -3'
Posted On2014-10-15