Incidental Mutation 'R0184:Cyp2b9'
ID 23962
Institutional Source Beutler Lab
Gene Symbol Cyp2b9
Ensembl Gene ENSMUSG00000040660
Gene Name cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms phenobarbitol inducible, type a, Cyp2b
MMRRC Submission 038449-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R0184 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 7
Chromosomal Location 25872836-25910086 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 25886432 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 152 (C152*)
Ref Sequence ENSEMBL: ENSMUSP00000080846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082214]
AlphaFold P12790
Predicted Effect probably null
Transcript: ENSMUST00000082214
AA Change: C152*
SMART Domains Protein: ENSMUSP00000080846
Gene: ENSMUSG00000040660
AA Change: C152*

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:p450 31 488 1.7e-146 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.6%
  • 20x: 93.9%
Validation Efficiency 66% (50/76)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C A 3: 124,212,899 (GRCm39) V131F probably damaging Het
Adam28 T C 14: 68,874,822 (GRCm39) D285G probably benign Het
Akr1c13 A G 13: 4,244,055 (GRCm39) E36G probably damaging Het
Antxr2 A G 5: 98,127,889 (GRCm39) L214S probably damaging Het
Arhgap26 T A 18: 38,750,726 (GRCm39) D46E unknown Het
Armc9 T C 1: 86,126,092 (GRCm39) L61P probably damaging Het
Bicc1 C A 10: 70,915,045 (GRCm39) R73L probably benign Het
Calm2 T C 17: 87,743,269 (GRCm39) N43S probably benign Het
Cct7 A G 6: 85,438,536 (GRCm39) D105G probably null Het
Cdk18 T C 1: 132,046,276 (GRCm39) N215D probably benign Het
Cep126 T C 9: 8,103,396 (GRCm39) T205A probably benign Het
Cfap57 A T 4: 118,456,209 (GRCm39) I495N probably damaging Het
Dab2ip G A 2: 35,608,803 (GRCm39) R579H probably damaging Het
Dnah8 T C 17: 30,902,657 (GRCm39) V905A probably benign Het
Eif4h C A 5: 134,654,229 (GRCm39) D134Y possibly damaging Het
Espl1 T A 15: 102,207,651 (GRCm39) S372T probably benign Het
Fat2 T A 11: 55,187,114 (GRCm39) H1244L probably damaging Het
Fbxo11 T A 17: 88,316,101 (GRCm39) N443I probably benign Het
Git2 G A 5: 114,877,098 (GRCm39) T128M possibly damaging Het
Gm10985 T A 3: 53,752,679 (GRCm39) Y21N probably damaging Het
Gm12790 A T 4: 101,824,811 (GRCm39) Y152* probably null Het
Heatr5a T C 12: 51,956,752 (GRCm39) D1115G probably benign Het
Hipk2 T C 6: 38,695,866 (GRCm39) N726S possibly damaging Het
Hrg T C 16: 22,772,521 (GRCm39) probably null Het
Iars1 T G 13: 49,875,688 (GRCm39) S792A probably benign Het
Igf1r A G 7: 67,875,941 (GRCm39) N1301S possibly damaging Het
Il22 A T 10: 118,041,511 (GRCm39) I75F probably damaging Het
Ilkap T C 1: 91,304,027 (GRCm39) probably benign Het
Ints13 A T 6: 146,456,542 (GRCm39) Y435N probably benign Het
Ints8 A C 4: 11,218,637 (GRCm39) S797A probably benign Het
Itgad T A 7: 127,788,403 (GRCm39) D405E probably benign Het
Itgam A T 7: 127,685,230 (GRCm39) I448F probably damaging Het
Klk1 C T 7: 43,878,173 (GRCm39) T41I possibly damaging Het
Mcrip1 T C 11: 120,435,710 (GRCm39) M1V probably null Het
Mdga1 A G 17: 30,071,416 (GRCm39) Y128H probably damaging Het
Mtor G T 4: 148,549,428 (GRCm39) R604L probably benign Het
Or52p1 T C 7: 104,267,447 (GRCm39) V187A probably damaging Het
Or5d41 A T 2: 88,055,124 (GRCm39) L84* probably null Het
Pcdhb7 T A 18: 37,476,443 (GRCm39) D526E probably benign Het
Pip4k2a T C 2: 18,893,939 (GRCm39) D139G probably damaging Het
Pkp3 A C 7: 140,668,280 (GRCm39) N536T probably benign Het
Pla2g4c T A 7: 13,090,145 (GRCm39) S524T probably benign Het
Pno1 T C 11: 17,161,127 (GRCm39) E69G probably benign Het
Pold1 C T 7: 44,191,139 (GRCm39) V231M probably benign Het
Poli A G 18: 70,655,802 (GRCm39) S248P probably damaging Het
Ppox C T 1: 171,107,126 (GRCm39) S138N probably damaging Het
Psg20 T C 7: 18,419,901 (GRCm39) E6G probably null Het
Rbmx C T X: 56,436,926 (GRCm39) probably null Het
Rln1 T A 19: 29,309,336 (GRCm39) K148* probably null Het
Rnf213 C T 11: 119,305,347 (GRCm39) T526I probably damaging Het
Rps6kc1 A T 1: 190,531,290 (GRCm39) V904E probably null Het
Sf3b2 T A 19: 5,333,700 (GRCm39) I633F probably damaging Het
Sfswap T A 5: 129,584,253 (GRCm39) I189N probably damaging Het
Smarca2 T A 19: 26,669,649 (GRCm39) Y973* probably null Het
Spink5 G A 18: 44,136,265 (GRCm39) D559N probably benign Het
Spty2d1 C T 7: 46,647,322 (GRCm39) V536I possibly damaging Het
Tbx3 T C 5: 119,813,627 (GRCm39) I221T probably damaging Het
Tcf20 T A 15: 82,736,501 (GRCm39) D1650V probably damaging Het
Thsd7b A G 1: 129,358,701 (GRCm39) K45R probably benign Het
Tirap A G 9: 35,100,490 (GRCm39) S65P probably benign Het
Trim25 C T 11: 88,890,466 (GRCm39) P51L probably damaging Het
Trim61 T C 8: 65,467,069 (GRCm39) N64S probably benign Het
Twf1 T A 15: 94,478,948 (GRCm39) probably null Het
Ubr4 A C 4: 139,172,573 (GRCm39) T1692P probably damaging Het
Usp3 A G 9: 66,469,863 (GRCm39) M86T probably damaging Het
Utrn T C 10: 12,543,362 (GRCm39) D1762G probably benign Het
V1rd19 T A 7: 23,702,632 (GRCm39) F33I probably benign Het
Vmn2r52 T C 7: 9,893,265 (GRCm39) S625G probably damaging Het
Vmn2r90 G A 17: 17,947,139 (GRCm39) W472* probably null Het
Vrk2 C A 11: 26,500,046 (GRCm39) A56S probably damaging Het
Yeats2 C T 16: 20,022,435 (GRCm39) P620S possibly damaging Het
Zbtb21 C T 16: 97,751,713 (GRCm39) D171N probably damaging Het
Zeb1 A T 18: 5,766,808 (GRCm39) I440F probably damaging Het
Zfp292 A G 4: 34,819,563 (GRCm39) I253T probably damaging Het
Other mutations in Cyp2b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Cyp2b9 APN 7 25,897,930 (GRCm39) missense probably damaging 0.99
IGL01133:Cyp2b9 APN 7 25,909,660 (GRCm39) missense probably damaging 1.00
IGL01331:Cyp2b9 APN 7 25,887,140 (GRCm39) missense probably damaging 0.99
IGL02281:Cyp2b9 APN 7 25,900,529 (GRCm39) missense probably damaging 0.99
IGL02502:Cyp2b9 APN 7 25,887,239 (GRCm39) critical splice donor site probably null
IGL02713:Cyp2b9 APN 7 25,872,945 (GRCm39) missense probably benign 0.12
IGL03032:Cyp2b9 APN 7 25,898,025 (GRCm39) splice site probably benign
IGL03307:Cyp2b9 APN 7 25,898,476 (GRCm39) missense probably benign 0.00
R0010:Cyp2b9 UTSW 7 25,886,178 (GRCm39) splice site probably benign
R0025:Cyp2b9 UTSW 7 25,900,238 (GRCm39) missense probably benign 0.09
R0040:Cyp2b9 UTSW 7 25,872,899 (GRCm39) missense possibly damaging 0.68
R0370:Cyp2b9 UTSW 7 25,909,531 (GRCm39) missense probably damaging 1.00
R1595:Cyp2b9 UTSW 7 25,900,332 (GRCm39) missense possibly damaging 0.72
R1751:Cyp2b9 UTSW 7 25,886,100 (GRCm39) missense probably benign 0.05
R1835:Cyp2b9 UTSW 7 25,900,208 (GRCm39) missense probably benign
R1879:Cyp2b9 UTSW 7 25,897,994 (GRCm39) missense probably damaging 0.99
R2256:Cyp2b9 UTSW 7 25,873,030 (GRCm39) critical splice donor site probably null
R2257:Cyp2b9 UTSW 7 25,873,030 (GRCm39) critical splice donor site probably null
R2418:Cyp2b9 UTSW 7 25,886,132 (GRCm39) missense probably benign 0.00
R3420:Cyp2b9 UTSW 7 25,909,528 (GRCm39) missense probably damaging 1.00
R4088:Cyp2b9 UTSW 7 25,872,881 (GRCm39) missense probably damaging 0.99
R4412:Cyp2b9 UTSW 7 25,897,868 (GRCm39) missense probably damaging 1.00
R4495:Cyp2b9 UTSW 7 25,900,180 (GRCm39) missense probably benign 0.00
R4615:Cyp2b9 UTSW 7 25,900,550 (GRCm39) missense probably damaging 1.00
R5375:Cyp2b9 UTSW 7 25,887,167 (GRCm39) missense probably damaging 1.00
R5426:Cyp2b9 UTSW 7 25,887,080 (GRCm39) missense probably benign
R5862:Cyp2b9 UTSW 7 25,887,232 (GRCm39) missense probably benign 0.01
R6237:Cyp2b9 UTSW 7 25,872,999 (GRCm39) missense probably benign 0.02
R6445:Cyp2b9 UTSW 7 25,886,412 (GRCm39) missense probably benign 0.13
R6992:Cyp2b9 UTSW 7 25,900,564 (GRCm39) missense probably benign 0.00
R7515:Cyp2b9 UTSW 7 25,898,596 (GRCm39) missense probably damaging 1.00
R7654:Cyp2b9 UTSW 7 25,886,367 (GRCm39) missense possibly damaging 0.72
R7816:Cyp2b9 UTSW 7 25,900,517 (GRCm39) missense probably benign 0.01
R7850:Cyp2b9 UTSW 7 25,886,111 (GRCm39) nonsense probably null
R8734:Cyp2b9 UTSW 7 25,898,035 (GRCm39) intron probably benign
R8790:Cyp2b9 UTSW 7 25,898,167 (GRCm39) intron probably benign
R8839:Cyp2b9 UTSW 7 25,900,185 (GRCm39) missense probably damaging 0.96
R9209:Cyp2b9 UTSW 7 25,873,004 (GRCm39) missense possibly damaging 0.52
R9723:Cyp2b9 UTSW 7 25,909,596 (GRCm39) nonsense probably null
R9787:Cyp2b9 UTSW 7 25,900,259 (GRCm39) missense probably benign 0.04
Z1177:Cyp2b9 UTSW 7 25,900,588 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- TGAGACCCAAGCTCTGAGGAATGAC -3'
(R):5'- CACTCCCAATGGCAGGAAAGGATG -3'

Sequencing Primer
(F):5'- GCTCTGAGGAATGACTGAGG -3'
(R):5'- AGAAAGGTTCAGGGATTTCCTGTG -3'
Posted On 2013-04-16