Incidental Mutation 'R2229:Wnk4'
| ID |
239621 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wnk4
|
| Ensembl Gene |
ENSMUSG00000035112 |
| Gene Name |
WNK lysine deficient protein kinase 4 |
| Synonyms |
2010002J11Rik, Prkwnk4 |
| MMRRC Submission |
040230-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.257)
|
| Stock # |
R2229 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
101260567-101277409 bp(+) (GRCm38) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to A
at 101275641 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000017332]
[ENSMUST00000103107]
[ENSMUST00000103108]
[ENSMUST00000139487]
[ENSMUST00000147741]
[ENSMUST00000168089]
[ENSMUST00000170056]
|
| AlphaFold |
Q80UE6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000017332
|
| SMART Domains |
Protein: ENSMUSP00000017332
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
106 |
1.8e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103107
|
| SMART Domains |
Protein: ENSMUSP00000099396
Gene: ENSMUSG00000078653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Cyclin_N
|
111 |
180 |
1.8e-6 |
PFAM |
|
low complexity region
|
212 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
319 |
330 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000103108
AA Change: N971K
|
| SMART Domains |
Protein: ENSMUSP00000099397
Gene: ENSMUSG00000035112
AA Change: N971K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
427 |
4.7e-42 |
PFAM |
|
Pfam:Pkinase
|
171 |
429 |
9e-55 |
PFAM |
|
Pfam:OSR1_C
|
450 |
486 |
3e-18 |
PFAM |
|
low complexity region
|
503 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
627 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
660 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
877 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
915 |
N/A |
INTRINSIC |
|
low complexity region
|
921 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1093 |
1112 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128735
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139487
|
| SMART Domains |
Protein: ENSMUSP00000129666
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
242 |
4e-8 |
PFAM |
|
Pfam:Pkinase
|
171 |
252 |
1.9e-10 |
PFAM |
|
low complexity region
|
269 |
283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147741
|
| SMART Domains |
Protein: ENSMUSP00000131298
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
171 |
394 |
9.3e-50 |
PFAM |
|
Pfam:Pkinase_Tyr
|
171 |
399 |
3.7e-38 |
PFAM |
|
low complexity region
|
401 |
413 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168089
|
| SMART Domains |
Protein: ENSMUSP00000130367
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
74 |
2.7e-35 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170056
|
| SMART Domains |
Protein: ENSMUSP00000132123
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:OSR1_C
|
13 |
49 |
8.6e-20 |
PFAM |
|
low complexity region
|
66 |
76 |
N/A |
INTRINSIC |
|
low complexity region
|
79 |
93 |
N/A |
INTRINSIC |
|
low complexity region
|
107 |
123 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170372
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
99% (78/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam24 |
A |
T |
8: 40,680,365 (GRCm38) |
I291L |
probably benign |
Het |
| Adcy8 |
C |
A |
15: 64,822,207 (GRCm38) |
R407L |
possibly damaging |
Het |
| Adgb |
A |
T |
10: 10,436,051 (GRCm38) |
V212E |
probably damaging |
Het |
| Adgrg7 |
C |
T |
16: 56,752,403 (GRCm38) |
S350N |
probably benign |
Het |
| Agbl1 |
A |
G |
7: 76,433,378 (GRCm38) |
T448A |
probably benign |
Het |
| Aldh1l1 |
C |
G |
6: 90,583,186 (GRCm38) |
T605R |
probably damaging |
Het |
| Arfip1 |
A |
T |
3: 84,547,973 (GRCm38) |
N18K |
probably damaging |
Het |
| Atp6v1b2 |
C |
A |
8: 69,102,759 (GRCm38) |
|
probably null |
Het |
| Banp |
G |
A |
8: 121,978,685 (GRCm38) |
S98N |
probably damaging |
Het |
| Btnl9 |
T |
C |
11: 49,169,118 (GRCm38) |
D601G |
probably damaging |
Het |
| C9 |
T |
C |
15: 6,445,420 (GRCm38) |
I20T |
possibly damaging |
Het |
| Cacna1b |
A |
G |
2: 24,685,804 (GRCm38) |
V744A |
probably damaging |
Het |
| Catsper3 |
A |
G |
13: 55,808,054 (GRCm38) |
E311G |
probably damaging |
Het |
| Ccdc180 |
G |
T |
4: 45,948,856 (GRCm38) |
|
probably null |
Het |
| Cdc5l |
A |
G |
17: 45,407,846 (GRCm38) |
Y615H |
probably benign |
Het |
| Crybg2 |
TGGAGGAGGAGGAGGAGGAG |
TGGAGGAGGAGGAGGAG |
4: 134,074,526 (GRCm38) |
|
probably benign |
Het |
| Eml4 |
C |
T |
17: 83,451,056 (GRCm38) |
P502S |
probably benign |
Het |
| Fsip1 |
T |
C |
2: 118,222,444 (GRCm38) |
E367G |
probably benign |
Het |
| Gja3 |
T |
C |
14: 57,036,714 (GRCm38) |
D67G |
probably damaging |
Het |
| Gm4894 |
T |
C |
9: 49,274,190 (GRCm38) |
|
probably benign |
Het |
| Gm7853 |
A |
G |
14: 36,089,527 (GRCm38) |
|
noncoding transcript |
Het |
| Gmps |
T |
G |
3: 64,014,263 (GRCm38) |
Y562* |
probably null |
Het |
| Golga2 |
C |
A |
2: 32,306,465 (GRCm38) |
P976T |
probably benign |
Het |
| Gpr182 |
T |
A |
10: 127,750,141 (GRCm38) |
I314F |
possibly damaging |
Het |
| Gprc6a |
A |
G |
10: 51,626,795 (GRCm38) |
V324A |
possibly damaging |
Het |
| Gykl1 |
A |
G |
18: 52,695,267 (GRCm38) |
T516A |
probably benign |
Het |
| Hist2h2ab |
T |
C |
3: 96,220,106 (GRCm38) |
L64P |
possibly damaging |
Het |
| Ifit1bl2 |
G |
T |
19: 34,619,230 (GRCm38) |
L329M |
possibly damaging |
Het |
| Igsf9b |
T |
C |
9: 27,333,496 (GRCm38) |
S920P |
probably damaging |
Het |
| Kif3c |
T |
A |
12: 3,366,671 (GRCm38) |
S231T |
probably benign |
Het |
| Kpna7 |
A |
T |
5: 144,989,697 (GRCm38) |
Y482N |
probably damaging |
Het |
| Lmnb2 |
T |
C |
10: 80,904,392 (GRCm38) |
|
probably benign |
Het |
| Lrrc69 |
T |
C |
4: 14,773,694 (GRCm38) |
S121G |
probably benign |
Het |
| Mppe1 |
A |
G |
18: 67,228,011 (GRCm38) |
|
probably null |
Het |
| Muc5b |
T |
A |
7: 141,861,644 (GRCm38) |
C2776S |
possibly damaging |
Het |
| Myh8 |
T |
G |
11: 67,308,348 (GRCm38) |
N1893K |
probably damaging |
Het |
| Myo7a |
T |
C |
7: 98,054,910 (GRCm38) |
T1932A |
probably benign |
Het |
| Nbn |
A |
G |
4: 15,970,904 (GRCm38) |
T296A |
probably benign |
Het |
| Nckap1l |
T |
C |
15: 103,455,934 (GRCm38) |
|
probably null |
Het |
| Nek5 |
A |
T |
8: 22,113,632 (GRCm38) |
N151K |
possibly damaging |
Het |
| Nup93 |
C |
T |
8: 94,304,191 (GRCm38) |
T305I |
probably benign |
Het |
| Oca2 |
T |
A |
7: 56,357,155 (GRCm38) |
H663Q |
probably benign |
Het |
| Optn |
T |
A |
2: 5,024,117 (GRCm38) |
H525L |
probably damaging |
Het |
| Pdzph1 |
A |
G |
17: 58,932,412 (GRCm38) |
|
probably benign |
Het |
| Pikfyve |
A |
G |
1: 65,267,855 (GRCm38) |
K1801E |
probably damaging |
Het |
| Pkd2l2 |
G |
A |
18: 34,430,329 (GRCm38) |
V478M |
probably damaging |
Het |
| Pmepa1 |
G |
A |
2: 173,228,133 (GRCm38) |
R210W |
probably damaging |
Het |
| Ppp1r3c |
C |
A |
19: 36,733,698 (GRCm38) |
R224L |
probably benign |
Het |
| Prpf19 |
A |
G |
19: 10,897,598 (GRCm38) |
T39A |
probably benign |
Het |
| Pwwp2b |
T |
C |
7: 139,255,188 (GRCm38) |
C182R |
probably damaging |
Het |
| Rcan3 |
T |
C |
4: 135,425,377 (GRCm38) |
D11G |
probably benign |
Het |
| Rgsl1 |
C |
A |
1: 153,822,358 (GRCm38) |
W482L |
possibly damaging |
Het |
| Sfxn4 |
C |
T |
19: 60,851,020 (GRCm38) |
G200E |
probably damaging |
Het |
| Slc4a8 |
T |
C |
15: 100,809,299 (GRCm38) |
I848T |
probably damaging |
Het |
| Slc7a13 |
T |
C |
4: 19,839,399 (GRCm38) |
V334A |
probably benign |
Het |
| Smarcc2 |
A |
G |
10: 128,488,341 (GRCm38) |
|
probably benign |
Het |
| Spata18 |
A |
T |
5: 73,666,901 (GRCm38) |
I156L |
possibly damaging |
Het |
| Spats2 |
T |
C |
15: 99,174,453 (GRCm38) |
|
probably null |
Het |
| Tas2r104 |
G |
A |
6: 131,685,132 (GRCm38) |
H205Y |
probably damaging |
Het |
| Tcof1 |
A |
G |
18: 60,832,177 (GRCm38) |
|
probably benign |
Het |
| Tex15 |
C |
A |
8: 33,571,237 (GRCm38) |
H232N |
probably benign |
Het |
| Tg |
A |
T |
15: 66,674,011 (GRCm38) |
Q194L |
probably damaging |
Het |
| Tnfrsf22 |
C |
T |
7: 143,644,776 (GRCm38) |
|
probably null |
Het |
| Trim25 |
T |
A |
11: 89,016,621 (GRCm38) |
V602E |
probably damaging |
Het |
| Ttll9 |
A |
G |
2: 152,983,063 (GRCm38) |
E54G |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,729,324 (GRCm38) |
T29578A |
probably damaging |
Het |
| Tubgcp5 |
A |
G |
7: 55,830,881 (GRCm38) |
Q960R |
probably damaging |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm38) |
P46S |
probably benign |
Het |
| Usp13 |
A |
G |
3: 32,917,551 (GRCm38) |
I727V |
probably benign |
Het |
| Vmn2r67 |
T |
A |
7: 85,152,042 (GRCm38) |
I229F |
probably benign |
Het |
| Vmn2r92 |
A |
C |
17: 18,167,392 (GRCm38) |
I220L |
probably benign |
Het |
| Wwp1 |
A |
T |
4: 19,641,745 (GRCm38) |
Y437N |
probably damaging |
Het |
| Zdhhc5 |
A |
G |
2: 84,690,213 (GRCm38) |
I540T |
probably damaging |
Het |
| Zfp729b |
T |
C |
13: 67,595,265 (GRCm38) |
I60M |
probably damaging |
Het |
|
| Other mutations in Wnk4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00231:Wnk4
|
APN |
11 |
101,268,748 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
IGL00535:Wnk4
|
APN |
11 |
101,264,349 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01401:Wnk4
|
APN |
11 |
101,276,683 (GRCm38) |
splice site |
probably benign |
|
|
IGL01931:Wnk4
|
APN |
11 |
101,268,484 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL01977:Wnk4
|
APN |
11 |
101,265,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02165:Wnk4
|
APN |
11 |
101,275,291 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02197:Wnk4
|
APN |
11 |
101,263,957 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02457:Wnk4
|
APN |
11 |
101,269,563 (GRCm38) |
splice site |
probably benign |
|
|
IGL02963:Wnk4
|
APN |
11 |
101,276,213 (GRCm38) |
unclassified |
probably benign |
|
|
ashamed
|
UTSW |
11 |
101,265,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
blushing
|
UTSW |
11 |
101,265,377 (GRCm38) |
missense |
probably damaging |
0.96 |
|
Caught_dead
|
UTSW |
11 |
101,264,330 (GRCm38) |
missense |
probably damaging |
1.00 |
|
lowered
|
UTSW |
11 |
101,268,492 (GRCm38) |
critical splice donor site |
probably null |
|
|
mortification
|
UTSW |
11 |
101,263,894 (GRCm38) |
makesense |
probably null |
|
|
shame
|
UTSW |
11 |
101,262,856 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0066:Wnk4
|
UTSW |
11 |
101,265,435 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0317:Wnk4
|
UTSW |
11 |
101,268,804 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0628:Wnk4
|
UTSW |
11 |
101,275,023 (GRCm38) |
missense |
probably benign |
0.10 |
|
R0630:Wnk4
|
UTSW |
11 |
101,265,386 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0710:Wnk4
|
UTSW |
11 |
101,274,106 (GRCm38) |
missense |
probably benign |
0.22 |
|
R1290:Wnk4
|
UTSW |
11 |
101,276,340 (GRCm38) |
unclassified |
probably benign |
|
|
R1482:Wnk4
|
UTSW |
11 |
101,269,636 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1775:Wnk4
|
UTSW |
11 |
101,276,340 (GRCm38) |
unclassified |
probably benign |
|
|
R2005:Wnk4
|
UTSW |
11 |
101,263,890 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2258:Wnk4
|
UTSW |
11 |
101,275,035 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2323:Wnk4
|
UTSW |
11 |
101,268,481 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3081:Wnk4
|
UTSW |
11 |
101,276,891 (GRCm38) |
splice site |
probably benign |
|
|
R3763:Wnk4
|
UTSW |
11 |
101,269,288 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4196:Wnk4
|
UTSW |
11 |
101,269,631 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4447:Wnk4
|
UTSW |
11 |
101,268,451 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4614:Wnk4
|
UTSW |
11 |
101,274,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4751:Wnk4
|
UTSW |
11 |
101,276,362 (GRCm38) |
unclassified |
probably benign |
|
|
R4948:Wnk4
|
UTSW |
11 |
101,268,281 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5067:Wnk4
|
UTSW |
11 |
101,262,856 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5073:Wnk4
|
UTSW |
11 |
101,261,188 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5107:Wnk4
|
UTSW |
11 |
101,275,538 (GRCm38) |
unclassified |
probably benign |
|
|
R5181:Wnk4
|
UTSW |
11 |
101,265,377 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5205:Wnk4
|
UTSW |
11 |
101,265,138 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R5252:Wnk4
|
UTSW |
11 |
101,268,748 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R5273:Wnk4
|
UTSW |
11 |
101,263,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5293:Wnk4
|
UTSW |
11 |
101,275,197 (GRCm38) |
unclassified |
probably benign |
|
|
R5609:Wnk4
|
UTSW |
11 |
101,275,636 (GRCm38) |
unclassified |
probably benign |
|
|
R5915:Wnk4
|
UTSW |
11 |
101,263,894 (GRCm38) |
makesense |
probably null |
|
|
R5931:Wnk4
|
UTSW |
11 |
101,261,221 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6126:Wnk4
|
UTSW |
11 |
101,276,348 (GRCm38) |
unclassified |
probably benign |
|
|
R6164:Wnk4
|
UTSW |
11 |
101,275,068 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R6191:Wnk4
|
UTSW |
11 |
101,264,330 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6267:Wnk4
|
UTSW |
11 |
101,273,998 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6274:Wnk4
|
UTSW |
11 |
101,265,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6296:Wnk4
|
UTSW |
11 |
101,273,998 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7132:Wnk4
|
UTSW |
11 |
101,261,200 (GRCm38) |
missense |
probably benign |
0.22 |
|
R7251:Wnk4
|
UTSW |
11 |
101,265,153 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R7352:Wnk4
|
UTSW |
11 |
101,264,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7404:Wnk4
|
UTSW |
11 |
101,268,492 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7624:Wnk4
|
UTSW |
11 |
101,264,354 (GRCm38) |
nonsense |
probably null |
|
|
R7634:Wnk4
|
UTSW |
11 |
101,262,895 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7780:Wnk4
|
UTSW |
11 |
101,269,577 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8006:Wnk4
|
UTSW |
11 |
101,268,356 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8046:Wnk4
|
UTSW |
11 |
101,274,092 (GRCm38) |
missense |
probably benign |
0.20 |
|
R8143:Wnk4
|
UTSW |
11 |
101,262,799 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8458:Wnk4
|
UTSW |
11 |
101,275,321 (GRCm38) |
nonsense |
probably null |
|
|
R8735:Wnk4
|
UTSW |
11 |
101,276,266 (GRCm38) |
missense |
unknown |
|
|
R9025:Wnk4
|
UTSW |
11 |
101,262,815 (GRCm38) |
nonsense |
probably null |
|
|
R9206:Wnk4
|
UTSW |
11 |
101,274,056 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9295:Wnk4
|
UTSW |
11 |
101,269,252 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9610:Wnk4
|
UTSW |
11 |
101,268,424 (GRCm38) |
nonsense |
probably null |
|
|
R9611:Wnk4
|
UTSW |
11 |
101,268,424 (GRCm38) |
nonsense |
probably null |
|
|
R9674:Wnk4
|
UTSW |
11 |
101,276,048 (GRCm38) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTCCTCTGCCTAGCCTG -3'
(R):5'- GTCACTTGGAAACGGCCAAC -3'
Sequencing Primer
(F):5'- GCCTAGCCTGCCCCTTTC -3'
(R):5'- TTGGAAACGGCCAACAAGCTG -3'
|
| Posted On |
2014-10-15 |
Incidental Mutation