Incidental Mutation 'R2232:Tet3'
ID 240101
Institutional Source Beutler Lab
Gene Symbol Tet3
Ensembl Gene ENSMUSG00000034832
Gene Name tet methylcytosine dioxygenase 3
Synonyms B430006D22Rik, D230004J03Rik
MMRRC Submission 040233-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.640) question?
Stock # R2232 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 83339355-83434190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 83346453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1328 (D1328G)
Ref Sequence ENSEMBL: ENSMUSP00000139630 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089622] [ENSMUST00000186548]
AlphaFold Q8BG87
Predicted Effect probably damaging
Transcript: ENSMUST00000089622
AA Change: D1193G

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000087049
Gene: ENSMUSG00000034832
AA Change: D1193G

DomainStartEndE-ValueType
low complexity region 27 38 N/A INTRINSIC
low complexity region 66 77 N/A INTRINSIC
low complexity region 115 126 N/A INTRINSIC
internal_repeat_1 160 277 4.9e-5 PROSPERO
low complexity region 279 297 N/A INTRINSIC
low complexity region 359 371 N/A INTRINSIC
low complexity region 418 456 N/A INTRINSIC
Tet_JBP 858 1570 N/A SMART
coiled coil region 1579 1603 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000186548
AA Change: D1328G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139630
Gene: ENSMUSG00000034832
AA Change: D1328G

DomainStartEndE-ValueType
Pfam:zf-CXXC 49 89 8e-6 PFAM
low complexity region 162 173 N/A INTRINSIC
low complexity region 201 212 N/A INTRINSIC
low complexity region 250 261 N/A INTRINSIC
internal_repeat_1 295 412 5.5e-5 PROSPERO
low complexity region 414 432 N/A INTRINSIC
low complexity region 494 506 N/A INTRINSIC
low complexity region 553 591 N/A INTRINSIC
Tet_JBP 993 1705 N/A SMART
coiled coil region 1714 1738 N/A INTRINSIC
Meta Mutation Damage Score 0.1291 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
PHENOTYPE: Mice inheriting a null allele from a germ cell conditional null mother display impaired reprogramming of the paternal genome resulting in reduced embryo viability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1a A C 5: 121,657,795 (GRCm39) D499E possibly damaging Het
Adamtsl2 G A 2: 26,993,190 (GRCm39) G740E probably damaging Het
Adgrf4 C T 17: 42,977,789 (GRCm39) R518Q possibly damaging Het
Akap9 G A 5: 4,096,603 (GRCm39) V2493I probably damaging Het
Ankra2 T C 13: 98,407,646 (GRCm39) F199L probably damaging Het
Ankrd63 A G 2: 118,533,846 (GRCm39) probably benign Het
Asns A G 6: 7,689,316 (GRCm39) I62T possibly damaging Het
Celf3 T A 3: 94,387,566 (GRCm39) probably null Het
Cyp4f37 A G 17: 32,853,244 (GRCm39) T403A probably benign Het
Dennd2b T C 7: 109,156,414 (GRCm39) D112G probably benign Het
Dgkd T A 1: 87,857,464 (GRCm39) S725R probably benign Het
Dnah5 G A 15: 28,408,563 (GRCm39) probably null Het
Entrep2 G A 7: 64,408,970 (GRCm39) H475Y probably damaging Het
Ergic3 A G 2: 155,859,736 (GRCm39) T346A probably damaging Het
Fam227a T A 15: 79,499,582 (GRCm39) Y591F possibly damaging Het
Gal3st1 T C 11: 3,948,282 (GRCm39) I163T probably benign Het
Ghrhr T C 6: 55,362,444 (GRCm39) F347S probably damaging Het
Htr2a A T 14: 74,882,469 (GRCm39) I152F probably damaging Het
Il17re T C 6: 113,441,761 (GRCm39) C219R probably damaging Het
Kansl2 A G 15: 98,422,359 (GRCm39) L403S probably damaging Het
Kif21a G A 15: 90,869,565 (GRCm39) Q429* probably null Het
L1cam T A X: 72,904,947 (GRCm39) N503I possibly damaging Het
Lrrk2 A G 15: 91,648,919 (GRCm39) K1638E probably benign Het
Mcpt9 A T 14: 56,265,445 (GRCm39) C85S probably benign Het
Mindy3 C A 2: 12,408,856 (GRCm39) R73M probably benign Het
Mrgprb3 T C 7: 48,292,770 (GRCm39) I260M probably benign Het
Nes T A 3: 87,886,238 (GRCm39) I1499N possibly damaging Het
Ninl A G 2: 150,791,970 (GRCm39) V851A probably benign Het
Oaz3 T C 3: 94,341,846 (GRCm39) T130A probably benign Het
Or10j7 A G 1: 173,011,182 (GRCm39) I273T probably benign Het
Or4c3d A T 2: 89,882,569 (GRCm39) F33Y probably benign Het
Pacs2 G A 12: 113,026,987 (GRCm39) D605N probably damaging Het
Pcare A G 17: 72,056,279 (GRCm39) S1133P probably benign Het
Pdk3 G T X: 92,857,604 (GRCm39) N59K probably damaging Het
Pigq T C 17: 26,151,183 (GRCm39) H322R probably benign Het
Ppp3r1 G A 11: 17,143,115 (GRCm39) G68R probably damaging Het
Proz A G 8: 13,113,356 (GRCm39) Y59C probably damaging Het
Prpf39 C T 12: 65,090,786 (GRCm39) R32* probably null Het
Prr5 T C 15: 84,586,981 (GRCm39) S244P probably benign Het
Pth2r G T 1: 65,375,928 (GRCm39) W62L probably damaging Het
Scin T A 12: 40,118,930 (GRCm39) K622I probably damaging Het
Serpinb6a T C 13: 34,109,303 (GRCm39) K143R probably damaging Het
Ska1 G T 18: 74,330,137 (GRCm39) probably null Het
Slc30a8 G T 15: 52,169,960 (GRCm39) R62S probably benign Het
Slc8a3 A C 12: 81,361,994 (GRCm39) I275S probably damaging Het
Sp2 C T 11: 96,846,762 (GRCm39) C527Y probably damaging Het
Spmap2l A G 5: 77,207,252 (GRCm39) I337V possibly damaging Het
Sspo A G 6: 48,425,606 (GRCm39) I76V probably damaging Het
Sult1c2 G T 17: 54,138,848 (GRCm39) T243K probably benign Het
Svil T A 18: 5,046,640 (GRCm39) M1K probably null Het
Tnfsf14 T C 17: 57,500,876 (GRCm39) D65G probably benign Het
Trmt9b T A 8: 36,979,707 (GRCm39) C437S probably damaging Het
Ttc3 T C 16: 94,260,831 (GRCm39) S1439P probably benign Het
Ttn A T 2: 76,774,497 (GRCm39) F2136L probably damaging Het
Usb1 T G 8: 96,070,674 (GRCm39) L200R probably damaging Het
Usp20 A G 2: 30,908,750 (GRCm39) N777S probably benign Het
Zfp92 G T X: 72,466,358 (GRCm39) L450F possibly damaging Het
Other mutations in Tet3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00929:Tet3 APN 6 83,345,637 (GRCm39) missense probably benign 0.06
IGL01396:Tet3 APN 6 83,346,620 (GRCm39) nonsense probably null
IGL02344:Tet3 APN 6 83,380,815 (GRCm39) missense probably benign 0.04
IGL02987:Tet3 APN 6 83,345,074 (GRCm39) missense probably damaging 0.99
IGL03126:Tet3 APN 6 83,353,769 (GRCm39) missense probably damaging 1.00
IGL03155:Tet3 APN 6 83,345,365 (GRCm39) missense probably damaging 1.00
IGL03286:Tet3 APN 6 83,352,760 (GRCm39) missense probably damaging 1.00
Reedy UTSW 6 83,345,066 (GRCm39) nonsense probably null
P0033:Tet3 UTSW 6 83,345,494 (GRCm39) missense probably damaging 1.00
R0131:Tet3 UTSW 6 83,345,770 (GRCm39) missense probably damaging 1.00
R0295:Tet3 UTSW 6 83,346,121 (GRCm39) missense probably benign 0.14
R0504:Tet3 UTSW 6 83,350,776 (GRCm39) missense probably damaging 1.00
R0524:Tet3 UTSW 6 83,356,924 (GRCm39) missense probably damaging 1.00
R1061:Tet3 UTSW 6 83,350,305 (GRCm39) missense probably damaging 0.99
R1160:Tet3 UTSW 6 83,381,434 (GRCm39) missense probably benign 0.00
R1550:Tet3 UTSW 6 83,363,010 (GRCm39) missense probably damaging 0.97
R1640:Tet3 UTSW 6 83,346,297 (GRCm39) missense probably benign 0.44
R1658:Tet3 UTSW 6 83,346,039 (GRCm39) missense probably benign 0.44
R1746:Tet3 UTSW 6 83,345,050 (GRCm39) missense probably damaging 1.00
R1761:Tet3 UTSW 6 83,380,641 (GRCm39) missense probably damaging 0.99
R1832:Tet3 UTSW 6 83,380,627 (GRCm39) missense probably benign
R1835:Tet3 UTSW 6 83,381,145 (GRCm39) missense possibly damaging 0.95
R1932:Tet3 UTSW 6 83,381,361 (GRCm39) missense possibly damaging 0.94
R2014:Tet3 UTSW 6 83,363,057 (GRCm39) missense probably damaging 1.00
R2230:Tet3 UTSW 6 83,346,453 (GRCm39) missense probably damaging 1.00
R2922:Tet3 UTSW 6 83,345,494 (GRCm39) missense probably damaging 1.00
R3429:Tet3 UTSW 6 83,380,401 (GRCm39) missense probably damaging 1.00
R3430:Tet3 UTSW 6 83,380,401 (GRCm39) missense probably damaging 1.00
R4291:Tet3 UTSW 6 83,350,181 (GRCm39) missense probably damaging 1.00
R4349:Tet3 UTSW 6 83,380,257 (GRCm39) missense probably benign
R4809:Tet3 UTSW 6 83,379,928 (GRCm39) missense probably benign
R4846:Tet3 UTSW 6 83,353,865 (GRCm39) nonsense probably null
R5039:Tet3 UTSW 6 83,352,878 (GRCm39) missense probably damaging 1.00
R5233:Tet3 UTSW 6 83,363,045 (GRCm39) missense probably damaging 1.00
R5363:Tet3 UTSW 6 83,353,746 (GRCm39) critical splice donor site probably null
R5880:Tet3 UTSW 6 83,347,532 (GRCm39) missense probably damaging 1.00
R6270:Tet3 UTSW 6 83,352,773 (GRCm39) missense possibly damaging 0.86
R6277:Tet3 UTSW 6 83,345,066 (GRCm39) nonsense probably null
R6564:Tet3 UTSW 6 83,363,052 (GRCm39) missense possibly damaging 0.92
R6622:Tet3 UTSW 6 83,380,426 (GRCm39) missense probably benign 0.00
R7089:Tet3 UTSW 6 83,432,006 (GRCm39) missense possibly damaging 0.46
R7244:Tet3 UTSW 6 83,347,603 (GRCm39) missense probably damaging 1.00
R7251:Tet3 UTSW 6 83,381,038 (GRCm39) missense probably benign
R7361:Tet3 UTSW 6 83,345,076 (GRCm39) missense probably benign 0.15
R7436:Tet3 UTSW 6 83,345,211 (GRCm39) small insertion probably benign
R7438:Tet3 UTSW 6 83,345,211 (GRCm39) small insertion probably benign
R7544:Tet3 UTSW 6 83,381,623 (GRCm39) missense probably damaging 1.00
R7552:Tet3 UTSW 6 83,345,289 (GRCm39) missense probably damaging 1.00
R7942:Tet3 UTSW 6 83,353,956 (GRCm39) missense probably damaging 1.00
R8010:Tet3 UTSW 6 83,380,228 (GRCm39) missense unknown
R8063:Tet3 UTSW 6 83,379,723 (GRCm39) missense probably damaging 1.00
R8307:Tet3 UTSW 6 83,356,909 (GRCm39) missense probably damaging 1.00
R9016:Tet3 UTSW 6 83,345,253 (GRCm39) missense probably damaging 1.00
R9020:Tet3 UTSW 6 83,381,418 (GRCm39) missense probably damaging 1.00
R9377:Tet3 UTSW 6 83,380,596 (GRCm39) missense possibly damaging 0.95
R9476:Tet3 UTSW 6 83,381,808 (GRCm39) critical splice acceptor site probably null
R9476:Tet3 UTSW 6 83,380,935 (GRCm39) missense possibly damaging 0.91
R9510:Tet3 UTSW 6 83,381,808 (GRCm39) critical splice acceptor site probably null
R9510:Tet3 UTSW 6 83,380,935 (GRCm39) missense possibly damaging 0.91
R9582:Tet3 UTSW 6 83,381,226 (GRCm39) missense probably damaging 0.99
R9671:Tet3 UTSW 6 83,381,136 (GRCm39) missense possibly damaging 0.89
R9801:Tet3 UTSW 6 83,346,436 (GRCm39) missense possibly damaging 0.94
X0004:Tet3 UTSW 6 83,380,405 (GRCm39) missense probably benign 0.17
Z1176:Tet3 UTSW 6 83,436,003 (GRCm39) missense unknown
Z1176:Tet3 UTSW 6 83,381,332 (GRCm39) missense probably damaging 1.00
Z1176:Tet3 UTSW 6 83,347,680 (GRCm39) missense probably damaging 1.00
Z1177:Tet3 UTSW 6 83,381,276 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- TTGTAGCAACTGGAACTCTGAGC -3'
(R):5'- ACCATTCGCGCTATGCACAG -3'

Sequencing Primer
(F):5'- CAACTGGAACTCTGAGCAAAGG -3'
(R):5'- TATGCACAGCCTGGCCTG -3'
Posted On 2014-10-15