Incidental Mutation 'R2233:Sun3'
ID 240196
Institutional Source Beutler Lab
Gene Symbol Sun3
Ensembl Gene ENSMUSG00000040985
Gene Name Sad1 and UNC84 domain containing 3
Synonyms Sunc1, D630047F21Rik
MMRRC Submission 040234-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R2233 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 8966054-8998991 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 8973371 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 109 (K109*)
Ref Sequence ENSEMBL: ENSMUSP00000099973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043377] [ENSMUST00000102909]
AlphaFold Q5SS91
Predicted Effect probably null
Transcript: ENSMUST00000043377
AA Change: K169*
SMART Domains Protein: ENSMUSP00000045199
Gene: ENSMUSG00000040985
AA Change: K169*

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:Sad1_UNC 182 316 3.4e-48 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000102909
AA Change: K109*
SMART Domains Protein: ENSMUSP00000099973
Gene: ENSMUSG00000040985
AA Change: K109*

DomainStartEndE-ValueType
Pfam:Sad1_UNC 122 256 3.2e-48 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam23 A G 1: 63,584,671 (GRCm39) I360V probably benign Het
Adarb1 A G 10: 77,153,183 (GRCm39) V322A probably damaging Het
Atad2b T G 12: 5,056,745 (GRCm39) F867C probably damaging Het
Ccdc24 T C 4: 117,727,113 (GRCm39) K79R possibly damaging Het
Cfap44 A G 16: 44,271,888 (GRCm39) I1214V probably benign Het
Chrm4 A G 2: 91,758,875 (GRCm39) S428G probably benign Het
Chrnb1 A T 11: 69,686,428 (GRCm39) I64N probably damaging Het
Crh A T 3: 19,748,096 (GRCm39) M182K probably damaging Het
Dazap1 A G 10: 80,113,433 (GRCm39) K110E possibly damaging Het
Dhx16 T C 17: 36,198,778 (GRCm39) C737R probably damaging Het
Dst A G 1: 34,313,343 (GRCm39) E6384G probably damaging Het
Dync1i2 C T 2: 71,079,764 (GRCm39) Q419* probably null Het
E2f4 T A 8: 106,025,283 (GRCm39) V121E probably damaging Het
Enah G A 1: 181,749,537 (GRCm39) P415L probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Fezf1 T C 6: 23,246,002 (GRCm39) T388A probably damaging Het
Gimap6 T A 6: 48,681,418 (GRCm39) H72L possibly damaging Het
Gm11149 A G 9: 49,473,446 (GRCm39) probably benign Het
Gm12695 C T 4: 96,612,266 (GRCm39) R499Q probably damaging Het
Grhl1 A G 12: 24,658,510 (GRCm39) D385G probably damaging Het
Hyou1 C T 9: 44,300,388 (GRCm39) T855M probably benign Het
Igf1r T A 7: 67,861,828 (GRCm39) N1129K probably damaging Het
Iglon5 T C 7: 43,130,062 (GRCm39) E34G probably damaging Het
Kcnab1 T A 3: 65,226,888 (GRCm39) V189D probably damaging Het
Kifap3 T A 1: 163,683,634 (GRCm39) D438E probably benign Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lrrc41 G A 4: 115,953,582 (GRCm39) R756Q possibly damaging Het
Lrrc49 A T 9: 60,505,440 (GRCm39) F538L possibly damaging Het
Nphp3 G A 9: 103,914,575 (GRCm39) R1052H probably benign Het
Nynrin G A 14: 56,109,524 (GRCm39) V1544I possibly damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or6z5 T C 7: 6,477,441 (GRCm39) S111P possibly damaging Het
Or9m1 G A 2: 87,733,819 (GRCm39) S67F probably damaging Het
Osbpl6 T C 2: 76,417,113 (GRCm39) F577L probably damaging Het
Otc A G X: 10,169,606 (GRCm39) Q216R probably benign Het
Ppp1r12a A G 10: 108,034,780 (GRCm39) I108M possibly damaging Het
Prl7a1 C A 13: 27,826,402 (GRCm39) probably null Het
Prss16 T C 13: 22,193,579 (GRCm39) D72G possibly damaging Het
Qrsl1 T C 10: 43,772,092 (GRCm39) K33E probably benign Het
Rabepk A T 2: 34,685,246 (GRCm39) I58N possibly damaging Het
Ralgapa1 A T 12: 55,763,856 (GRCm39) H1403Q probably benign Het
Rhobtb3 C A 13: 76,020,484 (GRCm39) C606F possibly damaging Het
Rnf216 G A 5: 143,076,681 (GRCm39) H68Y probably benign Het
Scap T C 9: 110,210,661 (GRCm39) C998R probably damaging Het
Scgb1b27 T C 7: 33,721,249 (GRCm39) Y46H probably damaging Het
Sel1l2 T C 2: 140,086,085 (GRCm39) Y502C probably damaging Het
Sf3a2 G T 10: 80,638,663 (GRCm39) A95S probably benign Het
Sis A T 3: 72,820,527 (GRCm39) F1412L probably benign Het
Slc25a29 A T 12: 108,801,587 (GRCm39) C9S possibly damaging Het
Snap91 T C 9: 86,680,624 (GRCm39) T427A probably benign Het
St3gal6 A G 16: 58,293,897 (GRCm39) F211L probably damaging Het
Stab1 G A 14: 30,883,837 (GRCm39) S240F probably benign Het
Syne1 T C 10: 4,991,484 (GRCm39) N8410S probably benign Het
Tbx18 G T 9: 87,606,403 (GRCm39) S247R probably damaging Het
Tenm3 T C 8: 48,729,204 (GRCm39) I1601V probably benign Het
Tmem135 T C 7: 88,803,282 (GRCm39) N297S probably damaging Het
Tnk1 C T 11: 69,746,017 (GRCm39) probably null Het
Txnl4b A G 8: 110,295,551 (GRCm39) probably benign Het
Uck1 T C 2: 32,148,315 (GRCm39) D167G probably damaging Het
Vmn2r124 A T 17: 18,269,927 (GRCm39) H61L possibly damaging Het
Xylt2 C T 11: 94,560,822 (GRCm39) V239M possibly damaging Het
Zmpste24 T C 4: 120,955,162 (GRCm39) D12G probably benign Het
Zscan25 A G 5: 145,220,502 (GRCm39) Y99C probably damaging Het
Other mutations in Sun3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01290:Sun3 APN 11 8,973,341 (GRCm39) missense possibly damaging 0.91
IGL01473:Sun3 APN 11 8,979,394 (GRCm39) missense probably benign 0.00
IGL01578:Sun3 APN 11 8,979,436 (GRCm39) missense probably damaging 0.98
IGL03340:Sun3 APN 11 8,973,285 (GRCm39) splice site probably benign
R1944:Sun3 UTSW 11 8,988,296 (GRCm39) missense probably benign 0.00
R1945:Sun3 UTSW 11 8,988,296 (GRCm39) missense probably benign 0.00
R4356:Sun3 UTSW 11 8,966,328 (GRCm39) missense probably damaging 1.00
R4784:Sun3 UTSW 11 8,988,266 (GRCm39) missense probably benign 0.00
R4785:Sun3 UTSW 11 8,988,266 (GRCm39) missense probably benign 0.00
R4975:Sun3 UTSW 11 8,988,311 (GRCm39) nonsense probably null
R5022:Sun3 UTSW 11 8,988,314 (GRCm39) missense probably damaging 0.96
R5134:Sun3 UTSW 11 8,988,287 (GRCm39) missense probably benign 0.04
R5163:Sun3 UTSW 11 8,973,295 (GRCm39) missense possibly damaging 0.89
R5358:Sun3 UTSW 11 8,981,496 (GRCm39) missense possibly damaging 0.90
R5668:Sun3 UTSW 11 8,981,433 (GRCm39) critical splice donor site probably null
R6621:Sun3 UTSW 11 8,966,242 (GRCm39) missense probably damaging 1.00
R7442:Sun3 UTSW 11 8,981,445 (GRCm39) missense possibly damaging 0.75
R8022:Sun3 UTSW 11 8,973,376 (GRCm39) missense probably damaging 1.00
R8134:Sun3 UTSW 11 8,979,346 (GRCm39) missense probably benign 0.00
R9130:Sun3 UTSW 11 8,968,170 (GRCm39) missense probably benign 0.13
R9454:Sun3 UTSW 11 8,988,281 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGATGTTCTTGCTTCCATGTTAAAC -3'
(R):5'- AGCCCTGGCCTAACTGAATC -3'

Sequencing Primer
(F):5'- GAGTACACTGTAGCTGTCTTCAGAC -3'
(R):5'- TGGCCTAACTGAATCCCAATGG -3'
Posted On 2014-10-15