Incidental Mutation 'R2245:Csnk1d'
ID 240638
Institutional Source Beutler Lab
Gene Symbol Csnk1d
Ensembl Gene ENSMUSG00000025162
Gene Name casein kinase 1, delta
Synonyms 1200006A05Rik
MMRRC Submission 040245-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2245 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 120849816-120882156 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 120863229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 237 (I237T)
Ref Sequence ENSEMBL: ENSMUSP00000070721 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018274] [ENSMUST00000070575]
AlphaFold Q9DC28
Predicted Effect probably damaging
Transcript: ENSMUST00000018274
AA Change: I237T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000018274
Gene: ENSMUSG00000025162
AA Change: I237T

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 9 273 3.7e-18 PFAM
Pfam:Pkinase 9 277 1.8e-28 PFAM
low complexity region 299 314 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000070575
AA Change: I237T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000070721
Gene: ENSMUSG00000025162
AA Change: I237T

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 9 273 1.6e-18 PFAM
Pfam:Pkinase 9 280 2.8e-41 PFAM
low complexity region 299 314 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139267
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141071
Predicted Effect probably benign
Transcript: ENSMUST00000146837
SMART Domains Protein: ENSMUSP00000115055
Gene: ENSMUSG00000025162

DomainStartEndE-ValueType
Pfam:Pkinase 2 55 6.6e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000154483
SMART Domains Protein: ENSMUSP00000117472
Gene: ENSMUSG00000025162

DomainStartEndE-ValueType
low complexity region 12 25 N/A INTRINSIC
Pfam:Pkinase_Tyr 27 210 2.5e-12 PFAM
Pfam:Pkinase 28 218 3.4e-21 PFAM
Meta Mutation Damage Score 0.2858 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (31/31)
MGI Phenotype FUNCTION: This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice die 1.5 to 5 days after birth and fetal weight is significantly smaller than controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 A G 7: 82,099,308 (GRCm39) Q154R probably damaging Het
Alpk2 A G 18: 65,438,234 (GRCm39) L1520P probably benign Het
Brd1 A G 15: 88,574,063 (GRCm39) probably null Het
Ccdc158 A G 5: 92,757,811 (GRCm39) probably benign Het
Cep350 C A 1: 155,754,766 (GRCm39) V1950F probably benign Het
Ddah2 T C 17: 35,280,561 (GRCm39) L234P probably damaging Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Ephb1 A C 9: 101,873,973 (GRCm39) probably benign Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Muc6 G A 7: 141,218,313 (GRCm39) S2120F possibly damaging Het
Myadml2 A T 11: 120,538,656 (GRCm39) F60I probably damaging Het
Myo15a T C 11: 60,399,925 (GRCm39) V2893A probably damaging Het
Ntn1 A G 11: 68,276,120 (GRCm39) V276A probably benign Het
Or11h6 T A 14: 50,880,062 (GRCm39) I102N probably damaging Het
Or4c111 A T 2: 88,843,493 (GRCm39) I305K probably benign Het
Or7a39 A G 10: 78,715,765 (GRCm39) Y253C probably damaging Het
Otof T C 5: 30,527,551 (GRCm39) Y1962C probably damaging Het
Pcf11 T C 7: 92,315,080 (GRCm39) probably benign Het
Polr2a A G 11: 69,626,009 (GRCm39) S1676P unknown Het
Prpf40b A G 15: 99,203,047 (GRCm39) probably benign Het
Ptprh T C 7: 4,576,345 (GRCm39) D305G probably benign Het
Rdh16f2 A G 10: 127,712,145 (GRCm39) K201E probably damaging Het
Slc19a3 T C 1: 82,991,691 (GRCm39) Y439C possibly damaging Het
Son G T 16: 91,444,848 (GRCm39) probably null Het
Specc1 T C 11: 62,022,713 (GRCm39) L710P probably damaging Het
Tex15 A G 8: 34,061,524 (GRCm39) D592G possibly damaging Het
Tmem237 A T 1: 59,147,863 (GRCm39) D209E probably damaging Het
Vmn2r106 T C 17: 20,488,423 (GRCm39) T659A probably benign Het
Vmn2r71 T A 7: 85,273,388 (GRCm39) I734N probably damaging Het
Wdr7 A T 18: 64,057,980 (GRCm39) I1270F possibly damaging Het
Other mutations in Csnk1d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01689:Csnk1d APN 11 120,862,393 (GRCm39) missense probably benign 0.06
IGL01905:Csnk1d APN 11 120,864,789 (GRCm39) missense probably damaging 1.00
IGL02476:Csnk1d APN 11 120,863,338 (GRCm39) missense probably damaging 1.00
R1971:Csnk1d UTSW 11 120,863,274 (GRCm39) missense possibly damaging 0.95
R4472:Csnk1d UTSW 11 120,855,800 (GRCm39) unclassified probably benign
R4767:Csnk1d UTSW 11 120,859,954 (GRCm39) missense probably benign
R4809:Csnk1d UTSW 11 120,854,668 (GRCm39) unclassified probably benign
R4870:Csnk1d UTSW 11 120,874,014 (GRCm39) intron probably benign
R6522:Csnk1d UTSW 11 120,862,449 (GRCm39) missense probably damaging 1.00
R6657:Csnk1d UTSW 11 120,855,820 (GRCm39) missense possibly damaging 0.75
RF009:Csnk1d UTSW 11 120,862,453 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- GTCTCTCCTGGGCAAAAGTG -3'
(R):5'- AGACACATATGCCATCCCTG -3'

Sequencing Primer
(F):5'- GCCATCTTCATATGTAAGTACCCAC -3'
(R):5'- ACATATGCCATCCCTGACATAGTTTC -3'
Posted On 2014-10-15