Incidental Mutation 'R2245:Or11h6'
ID 240640
Institutional Source Beutler Lab
Gene Symbol Or11h6
Ensembl Gene ENSMUSG00000050028
Gene Name olfactory receptor family 11 subfamily H member 6
Synonyms GA_x6K02T2PMLR-6361495-6362481, Olfr745, MOR106-11
MMRRC Submission 040245-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R2245 (G1)
Quality Score 188
Status Validated
Chromosome 14
Chromosomal Location 50879652-50880826 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50880062 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 102 (I102N)
Ref Sequence ENSEMBL: ENSMUSP00000153971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062534] [ENSMUST00000213127] [ENSMUST00000218546]
AlphaFold Q7TRL9
Predicted Effect probably damaging
Transcript: ENSMUST00000062534
AA Change: I108N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050184
Gene: ENSMUSG00000050028
AA Change: I108N

DomainStartEndE-ValueType
transmembrane domain 5 27 N/A INTRINSIC
Pfam:7tm_4 44 324 6.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 51 191 6.6e-6 PFAM
Pfam:7tm_1 57 306 1e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206749
Predicted Effect probably damaging
Transcript: ENSMUST00000213127
AA Change: I102N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216105
Predicted Effect probably benign
Transcript: ENSMUST00000218546
Meta Mutation Damage Score 0.8986 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (31/31)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 A G 7: 82,099,308 (GRCm39) Q154R probably damaging Het
Alpk2 A G 18: 65,438,234 (GRCm39) L1520P probably benign Het
Brd1 A G 15: 88,574,063 (GRCm39) probably null Het
Ccdc158 A G 5: 92,757,811 (GRCm39) probably benign Het
Cep350 C A 1: 155,754,766 (GRCm39) V1950F probably benign Het
Csnk1d A G 11: 120,863,229 (GRCm39) I237T probably damaging Het
Ddah2 T C 17: 35,280,561 (GRCm39) L234P probably damaging Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Ephb1 A C 9: 101,873,973 (GRCm39) probably benign Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Muc6 G A 7: 141,218,313 (GRCm39) S2120F possibly damaging Het
Myadml2 A T 11: 120,538,656 (GRCm39) F60I probably damaging Het
Myo15a T C 11: 60,399,925 (GRCm39) V2893A probably damaging Het
Ntn1 A G 11: 68,276,120 (GRCm39) V276A probably benign Het
Or4c111 A T 2: 88,843,493 (GRCm39) I305K probably benign Het
Or7a39 A G 10: 78,715,765 (GRCm39) Y253C probably damaging Het
Otof T C 5: 30,527,551 (GRCm39) Y1962C probably damaging Het
Pcf11 T C 7: 92,315,080 (GRCm39) probably benign Het
Polr2a A G 11: 69,626,009 (GRCm39) S1676P unknown Het
Prpf40b A G 15: 99,203,047 (GRCm39) probably benign Het
Ptprh T C 7: 4,576,345 (GRCm39) D305G probably benign Het
Rdh16f2 A G 10: 127,712,145 (GRCm39) K201E probably damaging Het
Slc19a3 T C 1: 82,991,691 (GRCm39) Y439C possibly damaging Het
Son G T 16: 91,444,848 (GRCm39) probably null Het
Specc1 T C 11: 62,022,713 (GRCm39) L710P probably damaging Het
Tex15 A G 8: 34,061,524 (GRCm39) D592G possibly damaging Het
Tmem237 A T 1: 59,147,863 (GRCm39) D209E probably damaging Het
Vmn2r106 T C 17: 20,488,423 (GRCm39) T659A probably benign Het
Vmn2r71 T A 7: 85,273,388 (GRCm39) I734N probably damaging Het
Wdr7 A T 18: 64,057,980 (GRCm39) I1270F possibly damaging Het
Other mutations in Or11h6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Or11h6 APN 14 50,880,625 (GRCm39) missense probably benign 0.02
IGL02316:Or11h6 APN 14 50,879,744 (GRCm39) missense probably benign 0.25
IGL02377:Or11h6 APN 14 50,879,975 (GRCm39) splice site probably null
IGL02471:Or11h6 APN 14 50,880,214 (GRCm39) missense probably benign 0.43
IGL02486:Or11h6 APN 14 50,880,089 (GRCm39) missense probably damaging 1.00
IGL02517:Or11h6 APN 14 50,880,658 (GRCm39) missense probably benign 0.01
R0453:Or11h6 UTSW 14 50,880,461 (GRCm39) missense possibly damaging 0.90
R0727:Or11h6 UTSW 14 50,880,460 (GRCm39) missense probably damaging 0.98
R0746:Or11h6 UTSW 14 50,880,232 (GRCm39) splice site probably null
R1638:Or11h6 UTSW 14 50,880,565 (GRCm39) missense possibly damaging 0.93
R1688:Or11h6 UTSW 14 50,880,705 (GRCm39) missense probably benign 0.04
R1991:Or11h6 UTSW 14 50,880,323 (GRCm39) missense possibly damaging 0.90
R3758:Or11h6 UTSW 14 50,880,493 (GRCm39) missense possibly damaging 0.96
R4084:Or11h6 UTSW 14 50,880,305 (GRCm39) missense probably damaging 0.98
R5033:Or11h6 UTSW 14 50,880,619 (GRCm39) missense probably damaging 1.00
R5211:Or11h6 UTSW 14 50,880,710 (GRCm39) missense possibly damaging 0.78
R5302:Or11h6 UTSW 14 50,879,776 (GRCm39) splice site probably null
R5645:Or11h6 UTSW 14 50,880,524 (GRCm39) missense probably benign 0.00
R5731:Or11h6 UTSW 14 50,880,248 (GRCm39) missense probably damaging 1.00
R6917:Or11h6 UTSW 14 50,880,680 (GRCm39) missense possibly damaging 0.67
R7408:Or11h6 UTSW 14 50,879,852 (GRCm39) missense probably benign 0.16
R7716:Or11h6 UTSW 14 50,879,815 (GRCm39) missense probably benign 0.17
R7728:Or11h6 UTSW 14 50,879,849 (GRCm39) missense probably benign 0.00
R8208:Or11h6 UTSW 14 50,880,088 (GRCm39) missense probably benign 0.28
R8447:Or11h6 UTSW 14 50,880,008 (GRCm39) missense probably benign 0.00
R8726:Or11h6 UTSW 14 50,880,703 (GRCm39) missense probably benign 0.00
R8748:Or11h6 UTSW 14 50,880,211 (GRCm39) missense probably benign 0.19
R9279:Or11h6 UTSW 14 50,880,493 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- CCTGGGTTTCAGTAATCAGGGG -3'
(R):5'- CTGGATAGCAGAGGAATCCACTC -3'

Sequencing Primer
(F):5'- CAGGGGGAGATGCAAAGTTTCTTC -3'
(R):5'- TCACCCAGCAGATACAAATCAGGATG -3'
Posted On 2014-10-15