Incidental Mutation 'R2241:Gpr149'
ID 240653
Institutional Source Beutler Lab
Gene Symbol Gpr149
Ensembl Gene ENSMUSG00000043441
Gene Name G protein-coupled receptor 149
Synonyms PGR10, 9630018L10Rik, R35, Ieda
MMRRC Submission 040241-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R2241 (G1)
Quality Score 220
Status Not validated
Chromosome 3
Chromosomal Location 62436851-62512861 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 62511474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 175 (V175A)
Ref Sequence ENSEMBL: ENSMUSP00000060893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058535]
AlphaFold Q3UVY1
Predicted Effect probably benign
Transcript: ENSMUST00000058535
AA Change: V175A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000060893
Gene: ENSMUSG00000043441
AA Change: V175A

DomainStartEndE-ValueType
Pfam:7tm_1 52 363 7.2e-7 PFAM
coiled coil region 694 730 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149007
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 G T 15: 64,571,230 (GRCm39) L1138I possibly damaging Het
Aftph T C 11: 20,676,328 (GRCm39) D427G possibly damaging Het
Cep350 C T 1: 155,834,302 (GRCm39) probably null Het
Clca4b A T 3: 144,616,987 (GRCm39) S888T probably benign Het
Cyb5b A G 8: 107,897,045 (GRCm39) D105G probably benign Het
Ddx20 A C 3: 105,590,521 (GRCm39) Y258* probably null Het
Farp2 C T 1: 93,507,625 (GRCm39) T441I probably benign Het
Fzd6 G T 15: 38,894,931 (GRCm39) A366S probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Itga4 T A 2: 79,131,357 (GRCm39) I575N probably damaging Het
Kcnj14 C T 7: 45,469,325 (GRCm39) R60H probably benign Het
Lrch3 A G 16: 32,816,211 (GRCm39) T151A probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mterf2 T C 10: 84,956,180 (GRCm39) N148S possibly damaging Het
Nae1 A C 8: 105,246,420 (GRCm39) D268E probably benign Het
Or5p5 T C 7: 107,414,040 (GRCm39) V83A possibly damaging Het
Or6c211 G A 10: 129,505,764 (GRCm39) T208I probably damaging Het
Or8b48 A G 9: 38,493,101 (GRCm39) H176R probably damaging Het
Pcnx4 T C 12: 72,620,928 (GRCm39) L916P probably damaging Het
Prune2 T A 19: 17,100,456 (GRCm39) Y1987N probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Ryr3 A G 2: 112,631,737 (GRCm39) L2096P probably damaging Het
Serpina3m G A 12: 104,355,708 (GRCm39) S125N probably benign Het
Tep1 G C 14: 51,091,667 (GRCm39) R625G probably benign Het
Vmn2r102 T C 17: 19,897,003 (GRCm39) Y117H probably benign Het
Wdfy4 A T 14: 32,795,468 (GRCm39) N2091K possibly damaging Het
Yme1l1 C T 2: 23,086,912 (GRCm39) R673* probably null Het
Other mutations in Gpr149
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Gpr149 APN 3 62,438,094 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr149 APN 3 62,511,718 (GRCm39) missense probably damaging 1.00
IGL01399:Gpr149 APN 3 62,511,852 (GRCm39) missense probably damaging 1.00
IGL01954:Gpr149 APN 3 62,438,348 (GRCm39) missense probably benign 0.36
IGL02115:Gpr149 APN 3 62,502,336 (GRCm39) missense probably benign 0.02
IGL02218:Gpr149 APN 3 62,437,952 (GRCm39) utr 3 prime probably benign
IGL02592:Gpr149 APN 3 62,511,231 (GRCm39) missense possibly damaging 0.75
IGL03393:Gpr149 APN 3 62,511,366 (GRCm39) missense probably benign 0.15
R0578:Gpr149 UTSW 3 62,510,110 (GRCm39) missense possibly damaging 0.81
R1173:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1174:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1175:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1432:Gpr149 UTSW 3 62,438,439 (GRCm39) missense probably damaging 1.00
R1484:Gpr149 UTSW 3 62,502,592 (GRCm39) missense probably benign 0.00
R1972:Gpr149 UTSW 3 62,438,216 (GRCm39) missense probably benign 0.39
R1973:Gpr149 UTSW 3 62,438,216 (GRCm39) missense probably benign 0.39
R2180:Gpr149 UTSW 3 62,511,489 (GRCm39) missense probably damaging 1.00
R3118:Gpr149 UTSW 3 62,502,443 (GRCm39) missense probably benign 0.00
R3547:Gpr149 UTSW 3 62,502,549 (GRCm39) missense probably benign 0.01
R3548:Gpr149 UTSW 3 62,502,549 (GRCm39) missense probably benign 0.01
R4206:Gpr149 UTSW 3 62,511,924 (GRCm39) missense possibly damaging 0.92
R4332:Gpr149 UTSW 3 62,511,794 (GRCm39) missense possibly damaging 0.93
R4531:Gpr149 UTSW 3 62,510,099 (GRCm39) missense probably benign 0.00
R4557:Gpr149 UTSW 3 62,511,918 (GRCm39) missense probably benign 0.02
R4557:Gpr149 UTSW 3 62,438,291 (GRCm39) missense probably damaging 1.00
R4593:Gpr149 UTSW 3 62,510,151 (GRCm39) intron probably benign
R5397:Gpr149 UTSW 3 62,438,226 (GRCm39) missense probably damaging 1.00
R6592:Gpr149 UTSW 3 62,437,961 (GRCm39) missense probably benign 0.02
R6642:Gpr149 UTSW 3 62,437,995 (GRCm39) missense probably damaging 1.00
R6845:Gpr149 UTSW 3 62,511,942 (GRCm39) missense possibly damaging 0.58
R7303:Gpr149 UTSW 3 62,502,491 (GRCm39) missense possibly damaging 0.59
R7659:Gpr149 UTSW 3 62,511,256 (GRCm39) missense probably benign 0.01
R7682:Gpr149 UTSW 3 62,438,160 (GRCm39) missense probably damaging 1.00
R7803:Gpr149 UTSW 3 62,438,136 (GRCm39) missense probably damaging 1.00
R7904:Gpr149 UTSW 3 62,502,356 (GRCm39) missense probably benign 0.00
R7943:Gpr149 UTSW 3 62,438,132 (GRCm39) missense probably damaging 1.00
R8844:Gpr149 UTSW 3 62,502,572 (GRCm39) missense probably benign 0.05
R8919:Gpr149 UTSW 3 62,438,478 (GRCm39) missense probably damaging 1.00
R9043:Gpr149 UTSW 3 62,511,360 (GRCm39) missense probably damaging 1.00
R9209:Gpr149 UTSW 3 62,511,093 (GRCm39) missense probably benign 0.40
Z1177:Gpr149 UTSW 3 62,511,380 (GRCm39) frame shift probably null
Z1190:Gpr149 UTSW 3 62,511,972 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GCCACGAGAAATTTCCTGGTAG -3'
(R):5'- AGGGCTACTTCCAGTCTCTG -3'

Sequencing Primer
(F):5'- CACGAGAAATTTCCTGGTAGTTGGC -3'
(R):5'- GCCCTACTGTATATGTGCCAGG -3'
Posted On 2014-10-15