Incidental Mutation 'R2249:Olfr1161'
ID 240759
Institutional Source Beutler Lab
Gene Symbol Olfr1161
Ensembl Gene ENSMUSG00000045150
Gene Name olfactory receptor 1161
Synonyms MOR174-2, GA_x6K02T2Q125-49516664-49517629
MMRRC Submission 040249-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R2249 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88022774-88028252 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88025363 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 214 (I214F)
Ref Sequence ENSEMBL: ENSMUSP00000150220 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054845] [ENSMUST00000214438] [ENSMUST00000217006]
AlphaFold Q7TR29
Predicted Effect probably damaging
Transcript: ENSMUST00000054845
AA Change: I214F

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000060977
Gene: ENSMUSG00000045150
AA Change: I214F

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 8.8e-52 PFAM
Pfam:7tm_1 42 291 9e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214438
AA Change: I214F

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000217006
AA Change: I214F

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930444G20Rik T C 10: 22,067,116 I322V possibly damaging Het
5330417C22Rik A T 3: 108,471,410 Y409* probably null Het
Acvr1b G A 15: 101,203,094 R379Q probably null Het
Adam23 C T 1: 63,535,176 Q276* probably null Het
Apob A T 12: 8,007,499 S1961C probably damaging Het
Atxn7l1 C T 12: 33,358,840 P334S probably damaging Het
Ccnb1 T C 13: 100,781,319 M258V possibly damaging Het
Cd34 A C 1: 194,947,952 T65P possibly damaging Het
Cog6 A G 3: 53,000,479 probably null Het
Cp T C 3: 19,987,570 M953T probably damaging Het
Cwc27 C T 13: 104,631,622 R455Q unknown Het
Dhx57 A T 17: 80,281,234 D63E probably damaging Het
Flt4 T A 11: 49,645,959 M1252K possibly damaging Het
Gfral C T 9: 76,193,349 C269Y probably damaging Het
Itih4 C T 14: 30,899,394 Q788* probably null Het
Kif18b A G 11: 102,912,388 S499P probably benign Het
Map1a G C 2: 121,300,287 R528P probably damaging Het
Map3k5 T C 10: 20,127,697 F1152L probably damaging Het
Marveld2 T C 13: 100,612,091 D160G probably benign Het
Mug1 A T 6: 121,870,510 M616L probably benign Het
Ndst4 A T 3: 125,438,174 I131F probably benign Het
Neto1 G T 18: 86,461,274 A196S probably benign Het
Notum A G 11: 120,654,411 F441L probably benign Het
Nsmce4a A G 7: 130,539,039 I239T probably benign Het
Olfr1090 A G 2: 86,754,054 M228T probably damaging Het
Olfr578 A T 7: 102,984,440 N241K possibly damaging Het
Olfr619 T A 7: 103,603,736 D27E probably benign Het
Olfr750 T A 14: 51,070,413 K327* probably null Het
Olfr986 A T 9: 40,187,684 T190S possibly damaging Het
Pde4dip A T 3: 97,793,525 V221D probably damaging Het
Pkp1 T C 1: 135,880,807 Y474C probably damaging Het
Ptk6 A C 2: 181,196,380 H363Q probably benign Het
Rb1cc1 T C 1: 6,272,724 W187R probably damaging Het
Rbfox3 A T 11: 118,503,738 F132L probably damaging Het
Rcl1 A T 19: 29,121,868 I188F possibly damaging Het
Scfd1 T A 12: 51,415,516 S385T possibly damaging Het
Sema6d A G 2: 124,659,588 E483G possibly damaging Het
Sipa1l1 T C 12: 82,342,116 V372A probably benign Het
Slc17a6 G A 7: 51,667,906 G429D probably damaging Het
Slc22a5 A G 11: 53,883,706 V151A possibly damaging Het
Soga1 A T 2: 157,040,093 C680S probably benign Het
Spidr T C 16: 16,118,923 D106G probably damaging Het
Tekt3 A T 11: 63,083,952 T366S probably benign Het
Trpm3 T C 19: 22,733,034 M281T probably benign Het
Ttn A G 2: 76,952,141 V917A probably damaging Het
Tubgcp4 A T 2: 121,183,629 D221V possibly damaging Het
Ubr4 C T 4: 139,448,921 R3153W probably damaging Het
Vmn1r89 A C 7: 13,220,260 T308P possibly damaging Het
Vmn2r59 A G 7: 42,058,902 I27T probably benign Het
Vps13c T G 9: 67,988,053 probably null Het
Zfp142 A G 1: 74,567,032 V1793A probably damaging Het
Zfp472 T A 17: 32,978,135 C395S possibly damaging Het
Other mutations in Olfr1161
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Olfr1161 APN 2 88025003 missense probably benign 0.23
IGL01564:Olfr1161 APN 2 88025304 missense probably benign 0.00
IGL01588:Olfr1161 APN 2 88025073 missense probably benign
R0268:Olfr1161 UTSW 2 88025468 missense probably damaging 0.99
R1587:Olfr1161 UTSW 2 88025133 missense probably damaging 1.00
R1995:Olfr1161 UTSW 2 88025672 missense probably benign 0.06
R3813:Olfr1161 UTSW 2 88024761 missense probably damaging 1.00
R4473:Olfr1161 UTSW 2 88025120 missense probably damaging 1.00
R4772:Olfr1161 UTSW 2 88024863 missense probably damaging 0.99
R4787:Olfr1161 UTSW 2 88024860 missense possibly damaging 0.79
R4870:Olfr1161 UTSW 2 88025460 missense probably damaging 1.00
R5260:Olfr1161 UTSW 2 88025474 missense probably benign 0.02
R5896:Olfr1161 UTSW 2 88025121 missense probably damaging 0.98
R6262:Olfr1161 UTSW 2 88025394 missense probably benign 0.00
R7330:Olfr1161 UTSW 2 88024921 missense possibly damaging 0.59
R8702:Olfr1161 UTSW 2 88025495 missense possibly damaging 0.69
R9100:Olfr1161 UTSW 2 88024986 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGCATCAGTCTAGTGGTGG -3'
(R):5'- CACTTTGAATGTGAGCTGGGAG -3'

Sequencing Primer
(F):5'- CATATGCATGGGGACTCATATGTTCC -3'
(R):5'- AGTTCTTTGAGTTGGGTACAGAGTAG -3'
Posted On 2014-10-15