Incidental Mutation 'R2246:Cwf19l2'
ID 240867
Institutional Source Beutler Lab
Gene Symbol Cwf19l2
Ensembl Gene ENSMUSG00000025898
Gene Name CWF19 like cell cycle control factor 2
Synonyms 3230401L03Rik
MMRRC Submission 040246-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.934) question?
Stock # R2246 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 3403592-3479236 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3430661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 331 (D331G)
Ref Sequence ENSEMBL: ENSMUSP00000027027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027027]
AlphaFold Q8BG79
Predicted Effect probably benign
Transcript: ENSMUST00000027027
AA Change: D331G

PolyPhen 2 Score 0.161 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000027027
Gene: ENSMUSG00000025898
AA Change: D331G

DomainStartEndE-ValueType
low complexity region 64 114 N/A INTRINSIC
coiled coil region 165 196 N/A INTRINSIC
low complexity region 403 418 N/A INTRINSIC
coiled coil region 496 524 N/A INTRINSIC
Pfam:CwfJ_C_1 655 779 1.8e-40 PFAM
Pfam:CwfJ_C_2 788 882 4.6e-34 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212128
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 T G 6: 85,599,949 (GRCm39) S1592A possibly damaging Het
Anapc16 G T 10: 59,832,298 (GRCm39) Y38* probably null Het
Clec7a T A 6: 129,444,532 (GRCm39) H101L probably benign Het
Dcaf1 A G 9: 106,731,376 (GRCm39) T618A possibly damaging Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Fn1 A T 1: 71,667,694 (GRCm39) D766E probably benign Het
Ggta1 T C 2: 35,292,121 (GRCm39) *395W probably null Het
Grik2 C T 10: 49,411,532 (GRCm39) R202H probably damaging Het
Hcls1 G T 16: 36,782,984 (GRCm39) S445I probably damaging Het
Hip1 A C 5: 135,481,698 (GRCm39) S166R probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igsf9 T A 1: 172,319,216 (GRCm39) S236R probably benign Het
Knl1 C T 2: 118,902,708 (GRCm39) P1470S probably damaging Het
Ldb3 A T 14: 34,251,432 (GRCm39) H675Q probably damaging Het
Or10ab4 C T 7: 107,654,989 (GRCm39) R267C probably benign Het
Or10ag57 T A 2: 87,218,195 (GRCm39) S49T probably benign Het
Or6c3b A G 10: 129,527,812 (GRCm39) Y33H probably damaging Het
Palld T C 8: 62,330,169 (GRCm39) D236G probably benign Het
Pank3 A G 11: 35,674,333 (GRCm39) K332R probably benign Het
Phaf1 T A 8: 105,973,132 (GRCm39) D247E possibly damaging Het
Pramel11 A G 4: 143,623,790 (GRCm39) V128A probably benign Het
Prrc2c A G 1: 162,535,360 (GRCm39) probably benign Het
Ror2 C T 13: 53,265,638 (GRCm39) G473S probably damaging Het
Shisal1 T A 15: 84,301,400 (GRCm39) H81L probably damaging Het
Slc15a2 A T 16: 36,582,723 (GRCm39) Y222N probably damaging Het
Slc38a7 A T 8: 96,570,468 (GRCm39) M269K probably damaging Het
Srrd A T 5: 112,487,622 (GRCm39) L159H probably damaging Het
Tap2 C A 17: 34,427,775 (GRCm39) S218Y possibly damaging Het
Tex15 G A 8: 34,072,540 (GRCm39) V2696I possibly damaging Het
Tmem67 G A 4: 12,040,651 (GRCm39) T1030I probably damaging Het
Traf5 T C 1: 191,751,190 (GRCm39) probably null Het
Try4 C T 6: 41,282,406 (GRCm39) T242I possibly damaging Het
Ubqln3 C T 7: 103,791,518 (GRCm39) V191I probably damaging Het
Vmn2r67 T C 7: 84,785,764 (GRCm39) Y747C probably damaging Het
Wipf3 C T 6: 54,466,058 (GRCm39) P439S probably damaging Het
Zbed5 A T 5: 129,931,592 (GRCm39) M514L probably benign Het
Zfp592 A G 7: 80,691,361 (GRCm39) D1180G possibly damaging Het
Zfyve9 A T 4: 108,546,461 (GRCm39) D790E possibly damaging Het
Zkscan16 A G 4: 58,957,329 (GRCm39) K537R probably benign Het
Other mutations in Cwf19l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Cwf19l2 APN 9 3,409,990 (GRCm39) missense probably benign 0.01
IGL00573:Cwf19l2 APN 9 3,450,161 (GRCm39) splice site probably benign
IGL00757:Cwf19l2 APN 9 3,460,054 (GRCm39) missense probably damaging 1.00
IGL00803:Cwf19l2 APN 9 3,430,810 (GRCm39) missense probably benign 0.41
IGL01916:Cwf19l2 APN 9 3,477,869 (GRCm39) missense possibly damaging 0.82
IGL02315:Cwf19l2 APN 9 3,410,030 (GRCm39) missense probably damaging 1.00
IGL02419:Cwf19l2 APN 9 3,418,777 (GRCm39) critical splice donor site probably null
IGL02427:Cwf19l2 APN 9 3,456,817 (GRCm39) missense probably benign 0.00
IGL03026:Cwf19l2 APN 9 3,428,777 (GRCm39) missense probably benign 0.28
IGL03028:Cwf19l2 APN 9 3,430,622 (GRCm39) missense probably benign 0.26
IGL03199:Cwf19l2 APN 9 3,477,830 (GRCm39) missense probably damaging 1.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0532:Cwf19l2 UTSW 9 3,431,057 (GRCm39) missense probably benign 0.38
R0724:Cwf19l2 UTSW 9 3,421,377 (GRCm39) critical splice donor site probably null
R0924:Cwf19l2 UTSW 9 3,441,047 (GRCm39) splice site probably benign
R0947:Cwf19l2 UTSW 9 3,421,286 (GRCm39) missense probably benign 0.16
R1210:Cwf19l2 UTSW 9 3,430,810 (GRCm39) missense probably benign 0.00
R1393:Cwf19l2 UTSW 9 3,456,818 (GRCm39) missense probably benign 0.01
R1541:Cwf19l2 UTSW 9 3,456,760 (GRCm39) missense probably damaging 1.00
R1594:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R1870:Cwf19l2 UTSW 9 3,458,802 (GRCm39) missense possibly damaging 0.56
R1950:Cwf19l2 UTSW 9 3,418,674 (GRCm39) missense probably benign
R1996:Cwf19l2 UTSW 9 3,417,947 (GRCm39) missense probably benign 0.01
R2005:Cwf19l2 UTSW 9 3,430,720 (GRCm39) missense possibly damaging 0.92
R2420:Cwf19l2 UTSW 9 3,411,341 (GRCm39) missense possibly damaging 0.80
R3051:Cwf19l2 UTSW 9 3,410,006 (GRCm39) missense probably benign 0.05
R3738:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R3915:Cwf19l2 UTSW 9 3,456,776 (GRCm39) missense probably damaging 1.00
R4034:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4035:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4323:Cwf19l2 UTSW 9 3,430,452 (GRCm39) missense probably damaging 0.99
R4328:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4329:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4692:Cwf19l2 UTSW 9 3,428,709 (GRCm39) missense probably damaging 1.00
R4775:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R4779:Cwf19l2 UTSW 9 3,410,035 (GRCm39) missense possibly damaging 0.95
R4822:Cwf19l2 UTSW 9 3,458,839 (GRCm39) missense probably damaging 1.00
R4833:Cwf19l2 UTSW 9 3,430,783 (GRCm39) missense probably benign 0.28
R5110:Cwf19l2 UTSW 9 3,450,012 (GRCm39) critical splice acceptor site probably null
R5120:Cwf19l2 UTSW 9 3,418,761 (GRCm39) nonsense probably null
R5164:Cwf19l2 UTSW 9 3,475,511 (GRCm39) missense probably damaging 1.00
R5440:Cwf19l2 UTSW 9 3,475,549 (GRCm39) missense probably damaging 1.00
R5567:Cwf19l2 UTSW 9 3,456,831 (GRCm39) missense probably damaging 1.00
R5594:Cwf19l2 UTSW 9 3,418,773 (GRCm39) missense probably benign 0.42
R5960:Cwf19l2 UTSW 9 3,411,404 (GRCm39) missense probably benign 0.43
R6222:Cwf19l2 UTSW 9 3,454,569 (GRCm39) nonsense probably null
R6259:Cwf19l2 UTSW 9 3,458,879 (GRCm39) missense probably damaging 1.00
R6688:Cwf19l2 UTSW 9 3,450,015 (GRCm39) missense probably benign 0.00
R6983:Cwf19l2 UTSW 9 3,477,817 (GRCm39) missense probably damaging 1.00
R7063:Cwf19l2 UTSW 9 3,430,532 (GRCm39) missense probably benign 0.03
R7506:Cwf19l2 UTSW 9 3,456,775 (GRCm39) missense probably damaging 1.00
R7733:Cwf19l2 UTSW 9 3,450,066 (GRCm39) missense probably benign 0.19
R7846:Cwf19l2 UTSW 9 3,477,889 (GRCm39) missense probably damaging 1.00
R7900:Cwf19l2 UTSW 9 3,460,107 (GRCm39) missense probably damaging 1.00
R8510:Cwf19l2 UTSW 9 3,454,732 (GRCm39) missense possibly damaging 0.89
R8709:Cwf19l2 UTSW 9 3,430,723 (GRCm39) missense probably benign 0.26
R8900:Cwf19l2 UTSW 9 3,447,245 (GRCm39) missense probably benign 0.01
R9031:Cwf19l2 UTSW 9 3,417,942 (GRCm39) missense probably benign 0.00
R9373:Cwf19l2 UTSW 9 3,454,718 (GRCm39) missense probably damaging 0.99
R9701:Cwf19l2 UTSW 9 3,430,454 (GRCm39) missense probably damaging 1.00
T0722:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0003:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0020:Cwf19l2 UTSW 9 3,418,662 (GRCm39) missense probably damaging 1.00
Z1177:Cwf19l2 UTSW 9 3,428,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCATGACACAGTAGCATGAGG -3'
(R):5'- AATGCAAAGAAGCCTGAGCC -3'

Sequencing Primer
(F):5'- AGGAAGACAAGAAACTGAACTTTTC -3'
(R):5'- AGAAGCCTGAGCCACTAATG -3'
Posted On 2014-10-15