|Institutional Source||Beutler Lab|
|Gene Name||5 hydroxytryptamine (serotonin) receptor 4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2215 (G1)|
|Chromosomal Location||62324204-62467802 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 62413716 bp|
|Amino Acid Change||Cysteine to Stop codon at position 113 (C113*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027560 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027560]|
|Predicted Effect||probably null
AA Change: C113*
AA Change: C113*
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (68/68)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice exhibit attenuated feeding behavior following stress and novelty and show a hypersensitivity to seizures. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Htr4||
(F):5'- GGGAAAACTGAGTCTCGTGG -3'
(R):5'- TGCCCTGGTGAAAGAATCGC -3'
(F):5'- GAAAACTGAGTCTCGTGGATTATG -3'
(R):5'- AAGAATCGCTGACCTTCTGG -3'