Mutagenetix > Incidental Mutation

Incidental Mutation 'R2216:Dmxl1'

241190

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

040218-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R2216 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

49832670-49965473 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 49893923 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 2033 (V2033I)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041772
AA Change: V2033I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: V2033I

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000180611
AA Change: V2033I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: V2033I

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181907

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.0%
20x: 94.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aipl1	G	T	11: 72,031,446 (GRCm38)	P146T	probably damaging	Het
Arnt2	T	A	7: 84,275,351 (GRCm38)	T423S	probably damaging	Het
Bend5	A	G	4: 111,448,590 (GRCm38)	N277S	probably null	Het
Cd22	G	T	7: 30,867,046 (GRCm38)	T816N	probably damaging	Het
Cep126	G	A	9: 8,120,678 (GRCm38)	R115C	probably damaging	Het
Cep85	T	C	4: 134,131,430 (GRCm38)	H710R	possibly damaging	Het
Cmya5	A	T	13: 93,093,495 (GRCm38)	L1695H	probably damaging	Het
Col24a1	T	C	3: 145,314,981 (GRCm38)	V371A	probably benign	Het
Csmd1	T	A	8: 17,027,339 (GRCm38)		probably null	Het
Cyp1a1	T	A	9: 57,702,069 (GRCm38)		probably null	Het
Dennd1c	C	T	17: 57,074,492 (GRCm38)		probably null	Het
Dtna	A	G	18: 23,569,565 (GRCm38)	H51R	probably damaging	Het
Dysf	G	A	6: 84,207,245 (GRCm38)		probably null	Het
Gcn1	T	A	5: 115,593,661 (GRCm38)	V945E	probably benign	Het
Gpbar1	C	G	1: 74,278,894 (GRCm38)	L99V	probably damaging	Het
Hdac9	A	T	12: 34,429,517 (GRCm38)	D212E	probably damaging	Het
Itga1	A	T	13: 114,997,029 (GRCm38)	D448E	probably benign	Het
Itga2b	T	A	11: 102,467,866 (GRCm38)	N75I	probably benign	Het
Klra7	T	C	6: 130,228,586 (GRCm38)	E117G	probably benign	Het
Kmt2b	G	A	7: 30,574,065 (GRCm38)	R2349C	probably benign	Het
Masp1	T	C	16: 23,492,055 (GRCm38)	N209S	probably benign	Het
Mybpc2	C	T	7: 44,512,500 (GRCm38)		probably null	Het
Myh15	C	G	16: 49,165,838 (GRCm38)	S1557*	probably null	Het
Myo3a	A	C	2: 22,577,771 (GRCm38)	T346P	probably benign	Het
Nim1k	A	G	13: 119,714,215 (GRCm38)	Y152H	probably damaging	Het
Nrp2	C	T	1: 62,762,918 (GRCm38)	R507*	probably null	Het
Or13n4	T	A	7: 106,823,998 (GRCm38)	H176L	probably damaging	Het
Or5e1	C	T	7: 108,755,612 (GRCm38)	T252M	probably damaging	Het
Parp14	T	C	16: 35,857,205 (GRCm38)	I798V	probably benign	Het
Pcnx2	C	T	8: 125,888,077 (GRCm38)	A212T	probably benign	Het
Pkhd1l1	A	T	15: 44,573,895 (GRCm38)	H3522L	probably damaging	Het
Pram1	C	T	17: 33,641,284 (GRCm38)	A275V	probably benign	Het
Pramel18	T	A	4: 101,910,060 (GRCm38)	W169R	probably damaging	Het
Prkag1	A	T	15: 98,815,946 (GRCm38)	M1K	probably null	Het
Prss52	T	C	14: 64,113,593 (GRCm38)	S276P	probably damaging	Het
Ranbp17	A	T	11: 33,481,125 (GRCm38)	V284D	probably damaging	Het
Reln	T	C	5: 22,048,005 (GRCm38)	D648G	probably benign	Het
Rnf112	A	G	11: 61,452,279 (GRCm38)	L190P	probably damaging	Het
Scn5a	G	T	9: 119,485,612 (GRCm38)	P2010Q	probably benign	Het
Scn5a	T	C	9: 119,513,085 (GRCm38)	Y1138C	probably benign	Het
Slc4a9	A	G	18: 36,530,745 (GRCm38)	H274R	probably benign	Het
Slc5a6	T	G	5: 31,039,335 (GRCm38)	E391D	possibly damaging	Het
Speer2	T	C	16: 69,858,842 (GRCm38)	Q32R	possibly damaging	Het
Tars1	A	G	15: 11,389,708 (GRCm38)	V372A	probably benign	Het
Thsd7a	A	T	6: 12,337,268 (GRCm38)	L1250Q	possibly damaging	Het
Tnnt3	A	G	7: 142,512,564 (GRCm38)	Y222C	probably benign	Het
Trim40	T	C	17: 36,888,983 (GRCm38)	I68V	probably benign	Het
Trp53tg5	T	C	2: 164,471,306 (GRCm38)	I150V	probably benign	Het
Ube2u	T	C	4: 100,532,168 (GRCm38)	V109A	probably benign	Het
Usp54	A	T	14: 20,561,840 (GRCm38)	D969E	probably benign	Het
Vil1	G	T	1: 74,425,679 (GRCm38)	R495L	probably benign	Het
Wfs1	T	A	5: 36,967,220 (GRCm38)	K700*	probably null	Het
Zcchc8	A	G	5: 123,707,403 (GRCm38)	L298P	probably damaging	Het
Zfp946	A	T	17: 22,454,716 (GRCm38)	Q150H	possibly damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,851,467 (GRCm38)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	49,939,553 (GRCm38)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	49,917,668 (GRCm38)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	49,912,725 (GRCm38)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	49,912,751 (GRCm38)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,857,334 (GRCm38)	missense	probably benign
IGL01475:Dmxl1	APN	18	49,871,714 (GRCm38)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	49,920,938 (GRCm38)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	49,962,205 (GRCm38)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,863,025 (GRCm38)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,864,868 (GRCm38)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	49,878,382 (GRCm38)	nonsense	probably null
IGL01933:Dmxl1	APN	18	49,877,785 (GRCm38)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	49,890,654 (GRCm38)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	49,894,178 (GRCm38)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	49,961,163 (GRCm38)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	49,877,674 (GRCm38)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,840,499 (GRCm38)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,864,895 (GRCm38)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	49,878,180 (GRCm38)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	49,920,893 (GRCm38)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,864,818 (GRCm38)	missense	probably benign
capture	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
carnivora	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
digestion	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
drowning	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
hibiscus	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
impound	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
pitcher	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	49,931,963 (GRCm38)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	49,888,897 (GRCm38)	splice site	probably benign
R0027:Dmxl1	UTSW	18	49,957,295 (GRCm38)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	49,955,803 (GRCm38)	splice site	probably benign
R0349:Dmxl1	UTSW	18	49,879,282 (GRCm38)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	49,879,362 (GRCm38)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	49,891,467 (GRCm38)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,857,430 (GRCm38)	splice site	probably benign
R0542:Dmxl1	UTSW	18	49,893,694 (GRCm38)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	49,935,307 (GRCm38)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,851,423 (GRCm38)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	49,893,402 (GRCm38)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	49,893,611 (GRCm38)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	49,893,225 (GRCm38)	missense	probably benign
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	49,888,853 (GRCm38)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,857,249 (GRCm38)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,852,367 (GRCm38)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,859,286 (GRCm38)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	49,890,767 (GRCm38)	nonsense	probably null
R1646:Dmxl1	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	49,934,637 (GRCm38)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	49,902,988 (GRCm38)	missense	probably benign
R1732:Dmxl1	UTSW	18	49,893,444 (GRCm38)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	49,955,914 (GRCm38)	splice site	probably null
R1911:Dmxl1	UTSW	18	49,878,163 (GRCm38)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	49,889,558 (GRCm38)	nonsense	probably null
R2116:Dmxl1	UTSW	18	49,878,817 (GRCm38)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	49,917,631 (GRCm38)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	49,894,094 (GRCm38)	missense	probably benign	0.12
R2255:Dmxl1	UTSW	18	49,846,639 (GRCm38)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	49,919,976 (GRCm38)	splice site	probably null
R2343:Dmxl1	UTSW	18	49,890,678 (GRCm38)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	49,880,791 (GRCm38)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,863,962 (GRCm38)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,851,431 (GRCm38)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	49,961,197 (GRCm38)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	49,878,017 (GRCm38)	nonsense	probably null
R4406:Dmxl1	UTSW	18	49,889,553 (GRCm38)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,848,761 (GRCm38)	missense	probably benign
R4454:Dmxl1	UTSW	18	49,893,332 (GRCm38)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	49,961,216 (GRCm38)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	49,962,181 (GRCm38)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	49,878,631 (GRCm38)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	49,878,021 (GRCm38)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,862,992 (GRCm38)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,851,476 (GRCm38)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	49,957,281 (GRCm38)	intron	probably benign
R4885:Dmxl1	UTSW	18	49,878,795 (GRCm38)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	49,895,127 (GRCm38)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	49,870,923 (GRCm38)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	49,893,584 (GRCm38)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	49,951,235 (GRCm38)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,863,119 (GRCm38)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	49,867,899 (GRCm38)	splice site	probably null
R5484:Dmxl1	UTSW	18	49,889,464 (GRCm38)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,864,478 (GRCm38)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	49,891,626 (GRCm38)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	49,894,257 (GRCm38)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	49,931,941 (GRCm38)	nonsense	probably null
R5706:Dmxl1	UTSW	18	49,957,395 (GRCm38)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R5876:Dmxl1	UTSW	18	49,870,984 (GRCm38)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,857,386 (GRCm38)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	49,912,766 (GRCm38)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	49,893,335 (GRCm38)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,863,015 (GRCm38)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	49,902,367 (GRCm38)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	49,871,732 (GRCm38)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,852,300 (GRCm38)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,864,578 (GRCm38)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,859,179 (GRCm38)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	49,878,246 (GRCm38)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	49,880,780 (GRCm38)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	49,893,974 (GRCm38)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,852,288 (GRCm38)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,864,835 (GRCm38)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	49,935,305 (GRCm38)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,843,784 (GRCm38)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	49,920,902 (GRCm38)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,863,057 (GRCm38)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,851,495 (GRCm38)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	49,955,853 (GRCm38)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,864,614 (GRCm38)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	49,878,612 (GRCm38)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	49,893,957 (GRCm38)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	49,902,794 (GRCm38)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,859,270 (GRCm38)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	49,893,552 (GRCm38)	missense	probably benign
R7688:Dmxl1	UTSW	18	49,955,871 (GRCm38)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,846,618 (GRCm38)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	49,893,461 (GRCm38)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	49,878,315 (GRCm38)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	49,920,977 (GRCm38)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,840,490 (GRCm38)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	49,961,147 (GRCm38)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	49,893,407 (GRCm38)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	49,878,433 (GRCm38)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	49,888,830 (GRCm38)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,843,811 (GRCm38)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	49,898,714 (GRCm38)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	49,878,342 (GRCm38)	missense	probably benign
R8402:Dmxl1	UTSW	18	49,878,326 (GRCm38)	nonsense	probably null
R8402:Dmxl1	UTSW	18	49,878,327 (GRCm38)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,865,116 (GRCm38)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	49,871,692 (GRCm38)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	49,955,870 (GRCm38)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	49,957,339 (GRCm38)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,893,674 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,864,508 (GRCm38)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	49,922,612 (GRCm38)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	49,893,852 (GRCm38)	missense
R9011:Dmxl1	UTSW	18	49,864,173 (GRCm38)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	49,878,925 (GRCm38)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
R9254:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,843,852 (GRCm38)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	49,958,410 (GRCm38)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	49,877,721 (GRCm38)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	49,893,710 (GRCm38)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	49,878,204 (GRCm38)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,865,161 (GRCm38)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	49,880,758 (GRCm38)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	49,893,394 (GRCm38)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,864,368 (GRCm38)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	49,919,899 (GRCm38)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	49,920,965 (GRCm38)	missense	probably benign
Z1188:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TTGATTGGAGCCAACCGAGTG -3'
(R):5'- CAGATTCATCTGCACTCTGGC -3'

Sequencing Primer
(F):5'- CCAACCGAGTGTGGTATTTCAAG -3'
(R):5'- CATCTGCACTCTGGCTAAATGTGG -3'

Posted On

2014-10-15