Incidental Mutation 'R0165:Armh4'
ID 24126
Institutional Source Beutler Lab
Gene Symbol Armh4
Ensembl Gene ENSMUSG00000036242
Gene Name armadillo-like helical domain containing 4
Synonyms 3632451O06Rik
MMRRC Submission 038441-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0165 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 14
Chromosomal Location 49919017-50020843 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50011243 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 155 (S155P)
Ref Sequence ENSEMBL: ENSMUSP00000113609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036972] [ENSMUST00000118129]
AlphaFold Q8BT18
Predicted Effect probably benign
Transcript: ENSMUST00000036972
AA Change: S155P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000036220
Gene: ENSMUSG00000036242
AA Change: S155P

DomainStartEndE-ValueType
Pfam:DUF4696 48 609 3.8e-224 PFAM
transmembrane domain 714 736 N/A INTRINSIC
low complexity region 741 753 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000118129
AA Change: S155P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000113609
Gene: ENSMUSG00000036242
AA Change: S155P

DomainStartEndE-ValueType
coiled coil region 603 644 N/A INTRINSIC
transmembrane domain 714 736 N/A INTRINSIC
low complexity region 741 754 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.5%
  • 10x: 96.2%
  • 20x: 91.4%
Validation Efficiency 96% (81/84)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,213,924 (GRCm39) I717T possibly damaging Het
6430571L13Rik A G 9: 107,223,383 (GRCm39) probably benign Het
Abca15 T A 7: 119,950,126 (GRCm39) probably benign Het
Abca6 A G 11: 110,110,430 (GRCm39) V573A possibly damaging Het
Adgrl2 A G 3: 148,558,499 (GRCm39) probably benign Het
Agap3 A G 5: 24,684,743 (GRCm39) T544A probably damaging Het
Ahrr G A 13: 74,431,143 (GRCm39) probably benign Het
Akr1c20 T C 13: 4,573,295 (GRCm39) T7A probably benign Het
Ankrd26 A G 6: 118,517,445 (GRCm39) S459P probably benign Het
Ascc3 T A 10: 50,718,223 (GRCm39) probably null Het
Brd1 T C 15: 88,613,980 (GRCm39) N305S probably damaging Het
Catip T A 1: 74,407,628 (GRCm39) L320Q possibly damaging Het
Cplane1 G A 15: 8,245,866 (GRCm39) V1413M probably damaging Het
Cttnbp2 G A 6: 18,435,409 (GRCm39) Q150* probably null Het
Cyp2d22 T G 15: 82,257,481 (GRCm39) N228T probably benign Het
Dapk1 T C 13: 60,909,407 (GRCm39) V1340A probably benign Het
Dcaf4 G A 12: 83,582,762 (GRCm39) probably benign Het
Ddhd1 G A 14: 45,833,049 (GRCm39) T849M probably damaging Het
Dnah6 A G 6: 72,998,306 (GRCm39) S3987P probably benign Het
Dst C A 1: 34,193,727 (GRCm39) probably benign Het
Epha2 T C 4: 141,049,203 (GRCm39) probably null Het
Ern2 T C 7: 121,779,002 (GRCm39) T281A probably benign Het
Extl1 A G 4: 134,085,014 (GRCm39) F652S probably damaging Het
Gckr A G 5: 31,484,292 (GRCm39) S541G possibly damaging Het
Gdap1l1 A G 2: 163,293,419 (GRCm39) probably null Het
Gm7535 T C 17: 18,131,437 (GRCm39) probably benign Het
Gmps T A 3: 63,901,375 (GRCm39) I398N probably damaging Het
Igf2r A G 17: 12,917,414 (GRCm39) V1556A probably benign Het
Il3ra T A 14: 14,350,967 (GRCm38) N283K probably benign Het
Ist1 A G 8: 110,401,998 (GRCm39) probably benign Het
Lama3 A T 18: 12,657,867 (GRCm39) I1934F probably damaging Het
Lars1 A T 18: 42,335,762 (GRCm39) M1118K possibly damaging Het
Lpin2 C T 17: 71,553,514 (GRCm39) S846L probably damaging Het
Lrrc4b C A 7: 44,111,739 (GRCm39) T537K probably damaging Het
Ltn1 G A 16: 87,202,407 (GRCm39) probably benign Het
Meiob A G 17: 25,054,135 (GRCm39) T401A probably benign Het
Mettl21e G A 1: 44,250,283 (GRCm39) T41M probably damaging Het
Miga1 C T 3: 151,996,480 (GRCm39) E323K probably damaging Het
Ndufs1 A T 1: 63,198,907 (GRCm39) probably null Het
Or5p62 T C 7: 107,771,882 (GRCm39) D23G probably benign Het
Otog G A 7: 45,953,655 (GRCm39) V2638M probably damaging Het
Parp6 T C 9: 59,540,208 (GRCm39) Y274H probably damaging Het
Prom2 A T 2: 127,381,434 (GRCm39) probably benign Het
Prune2 T A 19: 17,099,974 (GRCm39) M1826K probably benign Het
Qki T A 17: 10,457,892 (GRCm39) D159V probably damaging Het
Rab12 A T 17: 66,807,312 (GRCm39) I139N probably damaging Het
Rab25 T A 3: 88,455,362 (GRCm39) E7D probably benign Het
Rala A T 13: 18,063,174 (GRCm39) V139E probably benign Het
Ralgapa2 A G 2: 146,230,407 (GRCm39) probably benign Het
Rbl2 T A 8: 91,800,804 (GRCm39) Y89N probably damaging Het
Rho A T 6: 115,909,188 (GRCm39) I75F probably damaging Het
Slc38a4 C A 15: 96,906,830 (GRCm39) A303S probably benign Het
Slc6a15 A G 10: 103,245,670 (GRCm39) D551G probably null Het
Smyd3 T C 1: 178,871,437 (GRCm39) N314S probably benign Het
Speer4f1 T A 5: 17,684,512 (GRCm39) L180* probably null Het
Stat6 T C 10: 127,493,096 (GRCm39) V576A probably damaging Het
Strn T C 17: 78,984,803 (GRCm39) D127G possibly damaging Het
Syne1 T C 10: 4,983,096 (GRCm39) R8610G probably benign Het
Tbc1d7 A C 13: 43,306,678 (GRCm39) probably null Het
Tcf3 C T 10: 80,248,831 (GRCm39) R548Q probably damaging Het
Tlr9 C A 9: 106,103,286 (GRCm39) A859D probably benign Het
Tmem106c T A 15: 97,866,020 (GRCm39) probably benign Het
Tmprss11c A T 5: 86,379,786 (GRCm39) probably benign Het
Tnfsf18 A G 1: 161,322,300 (GRCm39) R7G probably benign Het
Tnrc6b T A 15: 80,742,871 (GRCm39) probably null Het
Trpm7 A T 2: 126,639,433 (GRCm39) F1684I probably damaging Het
Ttbk1 C A 17: 46,789,864 (GRCm39) R133L possibly damaging Het
Ttn A G 2: 76,551,686 (GRCm39) S22962P probably damaging Het
Ube2q1 T A 3: 89,683,460 (GRCm39) L135Q probably damaging Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vwce T C 19: 10,637,337 (GRCm39) probably benign Het
Wdhd1 A G 14: 47,504,525 (GRCm39) S350P probably benign Het
Zbtb21 A G 16: 97,752,604 (GRCm39) S560P probably damaging Het
Other mutations in Armh4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00470:Armh4 APN 14 50,010,460 (GRCm39) missense probably damaging 1.00
IGL00981:Armh4 APN 14 50,010,447 (GRCm39) missense probably damaging 1.00
IGL01447:Armh4 APN 14 50,005,923 (GRCm39) missense probably damaging 0.99
IGL01645:Armh4 APN 14 50,011,011 (GRCm39) missense probably damaging 1.00
IGL02135:Armh4 APN 14 50,011,386 (GRCm39) missense probably damaging 0.99
IGL02154:Armh4 APN 14 50,010,399 (GRCm39) missense possibly damaging 0.58
IGL02163:Armh4 APN 14 50,011,614 (GRCm39) missense possibly damaging 0.61
IGL03234:Armh4 APN 14 50,005,973 (GRCm39) missense probably damaging 1.00
P0014:Armh4 UTSW 14 49,989,116 (GRCm39) missense probably damaging 1.00
R0240:Armh4 UTSW 14 50,005,859 (GRCm39) splice site probably benign
R0553:Armh4 UTSW 14 49,920,143 (GRCm39) missense probably damaging 0.99
R0616:Armh4 UTSW 14 50,011,113 (GRCm39) missense possibly damaging 0.74
R0635:Armh4 UTSW 14 50,010,600 (GRCm39) missense probably benign 0.00
R1423:Armh4 UTSW 14 49,988,896 (GRCm39) missense probably damaging 1.00
R1547:Armh4 UTSW 14 50,010,953 (GRCm39) missense probably benign 0.01
R1642:Armh4 UTSW 14 50,005,867 (GRCm39) splice site probably null
R1657:Armh4 UTSW 14 50,011,017 (GRCm39) missense probably damaging 0.99
R1717:Armh4 UTSW 14 49,989,121 (GRCm39) missense probably damaging 0.99
R1875:Armh4 UTSW 14 49,919,815 (GRCm39) missense probably damaging 1.00
R1900:Armh4 UTSW 14 50,008,040 (GRCm39) missense probably damaging 1.00
R1916:Armh4 UTSW 14 50,005,932 (GRCm39) missense probably damaging 1.00
R1945:Armh4 UTSW 14 50,005,940 (GRCm39) missense probably damaging 1.00
R2102:Armh4 UTSW 14 50,011,459 (GRCm39) missense probably damaging 0.98
R2147:Armh4 UTSW 14 49,989,028 (GRCm39) missense probably benign 0.31
R2149:Armh4 UTSW 14 49,989,028 (GRCm39) missense probably benign 0.31
R3921:Armh4 UTSW 14 50,011,659 (GRCm39) missense probably benign 0.13
R4063:Armh4 UTSW 14 50,011,444 (GRCm39) missense probably benign 0.02
R4373:Armh4 UTSW 14 50,007,893 (GRCm39) missense probably damaging 1.00
R4374:Armh4 UTSW 14 50,007,893 (GRCm39) missense probably damaging 1.00
R4377:Armh4 UTSW 14 50,007,893 (GRCm39) missense probably damaging 1.00
R4589:Armh4 UTSW 14 50,011,039 (GRCm39) missense probably damaging 1.00
R4940:Armh4 UTSW 14 50,010,939 (GRCm39) missense probably benign 0.15
R4986:Armh4 UTSW 14 49,989,111 (GRCm39) missense probably damaging 0.97
R5047:Armh4 UTSW 14 50,007,895 (GRCm39) missense probably damaging 1.00
R5104:Armh4 UTSW 14 50,010,929 (GRCm39) missense possibly damaging 0.77
R5682:Armh4 UTSW 14 49,989,043 (GRCm39) missense probably damaging 1.00
R6357:Armh4 UTSW 14 50,010,769 (GRCm39) missense probably benign 0.10
R6478:Armh4 UTSW 14 50,010,789 (GRCm39) missense possibly damaging 0.61
R6673:Armh4 UTSW 14 50,008,049 (GRCm39) missense probably benign 0.00
R7035:Armh4 UTSW 14 50,010,507 (GRCm39) missense possibly damaging 0.77
R7054:Armh4 UTSW 14 50,011,155 (GRCm39) missense probably damaging 1.00
R7458:Armh4 UTSW 14 49,920,196 (GRCm39) missense probably damaging 1.00
R7536:Armh4 UTSW 14 50,011,703 (GRCm39) splice site probably null
R7944:Armh4 UTSW 14 50,010,670 (GRCm39) missense probably benign 0.25
R7945:Armh4 UTSW 14 50,010,670 (GRCm39) missense probably benign 0.25
R8049:Armh4 UTSW 14 50,010,993 (GRCm39) missense probably damaging 0.97
R8066:Armh4 UTSW 14 50,005,980 (GRCm39) missense possibly damaging 0.83
R8519:Armh4 UTSW 14 50,010,693 (GRCm39) missense probably damaging 1.00
R8765:Armh4 UTSW 14 49,920,100 (GRCm39) missense probably damaging 1.00
R8766:Armh4 UTSW 14 50,011,497 (GRCm39) missense probably damaging 1.00
R8833:Armh4 UTSW 14 50,011,318 (GRCm39) missense probably benign 0.17
R8936:Armh4 UTSW 14 50,008,024 (GRCm39) missense probably damaging 0.98
R9007:Armh4 UTSW 14 50,011,695 (GRCm39) missense probably damaging 0.99
R9122:Armh4 UTSW 14 50,011,459 (GRCm39) missense possibly damaging 0.64
R9406:Armh4 UTSW 14 50,010,945 (GRCm39) missense possibly damaging 0.93
R9741:Armh4 UTSW 14 50,008,081 (GRCm39) missense probably benign 0.06
X0026:Armh4 UTSW 14 49,920,193 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACACTCACTGTGACCTTAGCATCC -3'
(R):5'- TGCAGCAGATGTCCTCTGAAGCTC -3'

Sequencing Primer
(F):5'- ACCAAATACTTGGTGGTAGTGCTC -3'
(R):5'- AGATGTCCTCTGAAGCTCCAATG -3'
Posted On 2013-04-16