Incidental Mutation 'R2253:Krt9'
ID 241825
Institutional Source Beutler Lab
Gene Symbol Krt9
Ensembl Gene ENSMUSG00000051617
Gene Name keratin 9
Synonyms K9, Krt1-9
MMRRC Submission 040253-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2253 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 100077607-100084072 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 100081685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 281 (N281K)
Ref Sequence ENSEMBL: ENSMUSP00000055255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059707]
AlphaFold Q6RHW0
Predicted Effect possibly damaging
Transcript: ENSMUST00000059707
AA Change: N281K

PolyPhen 2 Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000055255
Gene: ENSMUSG00000051617
AA Change: N281K

DomainStartEndE-ValueType
low complexity region 6 125 N/A INTRINSIC
Filament 130 442 2.96e-124 SMART
low complexity region 462 716 N/A INTRINSIC
low complexity region 721 737 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik G A 14: 59,380,061 (GRCm39) S79F probably damaging Het
Acss3 G A 10: 106,840,609 (GRCm39) A384V probably damaging Het
Aff2 G A X: 68,878,409 (GRCm39) E732K possibly damaging Het
Atp12a A G 14: 56,613,715 (GRCm39) T496A probably benign Het
B3gnt3 A T 8: 72,145,462 (GRCm39) M302K probably damaging Het
Bptf G T 11: 107,002,148 (GRCm39) D321E probably damaging Het
C1ql3 C T 2: 13,015,130 (GRCm39) V177I possibly damaging Het
C2cd5 A T 6: 142,982,042 (GRCm39) Y607* probably null Het
Casp3 G T 8: 47,090,990 (GRCm39) W214L probably damaging Het
Cd248 A G 19: 5,118,154 (GRCm39) M1V probably null Het
Cdh18 A G 15: 23,410,891 (GRCm39) T405A probably benign Het
Cldn24 G T 8: 48,275,363 (GRCm39) R62S probably benign Het
Cnot1 A G 8: 96,489,814 (GRCm39) V463A probably benign Het
Cul2 A T 18: 3,399,876 (GRCm39) L3F probably damaging Het
Ep400 A T 5: 110,866,957 (GRCm39) N1062K unknown Het
Gch1 T C 14: 47,426,798 (GRCm39) probably benign Het
Gzf1 T C 2: 148,525,856 (GRCm39) M109T probably damaging Het
Itch T A 2: 155,054,259 (GRCm39) M701K probably benign Het
Kank4 A T 4: 98,667,463 (GRCm39) I328N probably damaging Het
Lgals12 T A 19: 7,584,130 (GRCm39) probably benign Het
Lrrc37a T C 11: 103,392,293 (GRCm39) Q1044R probably benign Het
Mbtps2 A T X: 156,342,029 (GRCm39) F270L probably benign Het
Nr3c1 G T 18: 39,619,804 (GRCm39) T161K probably benign Het
Or2w3b T C 11: 58,623,821 (GRCm39) T57A probably benign Het
Or4g16 A G 2: 111,136,655 (GRCm39) Y35C probably damaging Het
Or5ak20 A G 2: 85,184,202 (GRCm39) S23P possibly damaging Het
Or5b116 T C 19: 13,422,549 (GRCm39) Y58H probably damaging Het
Pla2g4d T C 2: 120,101,622 (GRCm39) K453E probably damaging Het
Plcb2 T C 2: 118,554,246 (GRCm39) N69S probably benign Het
Prl3d1 T C 13: 27,278,981 (GRCm39) Y59H possibly damaging Het
Rnf133 T C 6: 23,649,174 (GRCm39) M252V probably benign Het
Rnf181 G T 6: 72,338,467 (GRCm39) H14N possibly damaging Het
Sash1 A T 10: 8,605,741 (GRCm39) M883K probably benign Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Slc13a4 A G 6: 35,257,418 (GRCm39) V240A probably benign Het
Slc2a5 T C 4: 150,224,447 (GRCm39) Y315H possibly damaging Het
Slc7a2 T C 8: 41,358,658 (GRCm39) Y334H probably benign Het
Spib A G 7: 44,179,392 (GRCm39) S23P probably benign Het
Tbc1d1 A G 5: 64,442,143 (GRCm39) N721S probably benign Het
Tcf25 A G 8: 124,100,772 (GRCm39) E54G probably benign Het
Tesl2 G A X: 23,824,950 (GRCm39) A75V probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Uba7 A G 9: 107,853,563 (GRCm39) H131R probably benign Het
Vmn2r6 C T 3: 64,467,139 (GRCm39) C120Y probably damaging Het
Zdhhc18 A T 4: 133,360,388 (GRCm39) probably null Het
Zfp970 T A 2: 177,166,614 (GRCm39) probably null Het
Other mutations in Krt9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00725:Krt9 APN 11 100,080,832 (GRCm39) missense probably damaging 1.00
IGL01695:Krt9 APN 11 100,082,263 (GRCm39) critical splice donor site probably null
IGL02383:Krt9 APN 11 100,082,041 (GRCm39) missense probably damaging 1.00
IGL02529:Krt9 APN 11 100,080,792 (GRCm39) missense probably damaging 0.99
IGL02819:Krt9 APN 11 100,082,346 (GRCm39) missense probably damaging 1.00
droplet UTSW 11 100,081,614 (GRCm39) missense probably damaging 1.00
R5944_Krt9_487 UTSW 11 100,079,265 (GRCm39) missense unknown
G1citation:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R1356:Krt9 UTSW 11 100,079,640 (GRCm39) small insertion probably benign
R1397:Krt9 UTSW 11 100,083,464 (GRCm39) missense probably damaging 1.00
R1498:Krt9 UTSW 11 100,079,195 (GRCm39) nonsense probably null
R1772:Krt9 UTSW 11 100,082,131 (GRCm39) missense probably damaging 0.99
R1871:Krt9 UTSW 11 100,081,614 (GRCm39) missense probably damaging 1.00
R1883:Krt9 UTSW 11 100,079,523 (GRCm39) missense unknown
R1985:Krt9 UTSW 11 100,080,817 (GRCm39) missense probably benign 0.02
R2056:Krt9 UTSW 11 100,082,321 (GRCm39) missense probably damaging 1.00
R2305:Krt9 UTSW 11 100,083,942 (GRCm39) missense unknown
R2875:Krt9 UTSW 11 100,080,031 (GRCm39) nonsense probably null
R3813:Krt9 UTSW 11 100,080,503 (GRCm39) missense probably damaging 1.00
R3874:Krt9 UTSW 11 100,081,675 (GRCm39) missense probably damaging 1.00
R4157:Krt9 UTSW 11 100,079,475 (GRCm39) missense unknown
R4762:Krt9 UTSW 11 100,081,675 (GRCm39) missense probably damaging 1.00
R4873:Krt9 UTSW 11 100,080,863 (GRCm39) missense probably benign 0.06
R4875:Krt9 UTSW 11 100,080,863 (GRCm39) missense probably benign 0.06
R4923:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R4973:Krt9 UTSW 11 100,079,538 (GRCm39) missense unknown
R5153:Krt9 UTSW 11 100,082,068 (GRCm39) missense probably damaging 0.99
R5658:Krt9 UTSW 11 100,081,593 (GRCm39) missense probably damaging 0.98
R5696:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R5944:Krt9 UTSW 11 100,079,265 (GRCm39) missense unknown
R6147:Krt9 UTSW 11 100,079,665 (GRCm39) missense unknown
R6403:Krt9 UTSW 11 100,080,485 (GRCm39) missense probably damaging 0.99
R6476:Krt9 UTSW 11 100,081,640 (GRCm39) missense probably damaging 1.00
R6822:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7159:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7174:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7203:Krt9 UTSW 11 100,081,617 (GRCm39) missense probably damaging 1.00
R7805:Krt9 UTSW 11 100,083,522 (GRCm39) missense possibly damaging 0.85
R7817:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7822:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7834:Krt9 UTSW 11 100,083,492 (GRCm39) missense probably benign 0.06
R7947:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7977:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R8943:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9092:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9099:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9203:Krt9 UTSW 11 100,079,734 (GRCm39) missense unknown
R9313:Krt9 UTSW 11 100,079,547 (GRCm39) missense unknown
R9361:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9370:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9438:Krt9 UTSW 11 100,079,824 (GRCm39) missense unknown
R9448:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9455:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9620:Krt9 UTSW 11 100,079,186 (GRCm39) missense unknown
R9676:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9719:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- GTACACAGCATCCATTGGAGG -3'
(R):5'- TCACAGGTGGCATGCAATG -3'

Sequencing Primer
(F):5'- CCTGAAAGGTGGGTTAGAAAACTG -3'
(R):5'- CATTCTGAGAGGACTTGGTG -3'
Posted On 2014-10-16