Incidental Mutation 'R2255:Kif1b'
| ID |
241935 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif1b
|
| Ensembl Gene |
ENSMUSG00000063077 |
| Gene Name |
kinesin family member 1B |
| Synonyms |
Kif1b beta, KIF1Bp130, A530096N05Rik, D4Mil1e, Kif1b alpha, N-3 kinesin, KIF1Bp204 |
| MMRRC Submission |
040255-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2255 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
149176319-149307693 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 149274997 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 94
(F94L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030806
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030806]
[ENSMUST00000055647]
[ENSMUST00000060537]
|
| AlphaFold |
Q60575 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030806
AA Change: F94L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000030806
Gene: ENSMUSG00000063077
AA Change: F94L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
660 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
889 |
902 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055647
AA Change: F94L
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000061472
Gene: ENSMUSG00000063077
AA Change: F94L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
685 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
799 |
846 |
9.7e-13 |
PFAM |
|
internal_repeat_1
|
901 |
933 |
7.01e-7 |
PROSPERO |
|
low complexity region
|
1165 |
1179 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1220 |
1368 |
1.1e-46 |
PFAM |
|
low complexity region
|
1444 |
1461 |
N/A |
INTRINSIC |
|
low complexity region
|
1479 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1591 |
N/A |
INTRINSIC |
|
PH
|
1656 |
1755 |
1.02e-14 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000060537
AA Change: F94L
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000056754
Gene: ENSMUSG00000063077
AA Change: F94L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
362 |
7.61e-175 |
SMART |
|
low complexity region
|
390 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
432 |
450 |
N/A |
INTRINSIC |
|
FHA
|
555 |
612 |
1.61e-4 |
SMART |
|
coiled coil region
|
672 |
731 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
845 |
892 |
7.1e-15 |
PFAM |
|
internal_repeat_1
|
947 |
979 |
4.76e-7 |
PROSPERO |
|
low complexity region
|
1211 |
1225 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1266 |
1413 |
1.1e-40 |
PFAM |
|
low complexity region
|
1490 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1525 |
1553 |
N/A |
INTRINSIC |
|
low complexity region
|
1619 |
1637 |
N/A |
INTRINSIC |
|
PH
|
1702 |
1801 |
1.02e-14 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150230
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.2%
- 20x: 94.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc10 |
G |
A |
17: 46,305,635 (GRCm38) |
T1210I |
probably benign |
Het |
| Agbl1 |
T |
C |
7: 76,422,184 (GRCm38) |
F581S |
probably damaging |
Het |
| Ambra1 |
A |
T |
2: 91,917,461 (GRCm38) |
N1061Y |
probably damaging |
Het |
| Aoc1l1 |
G |
A |
6: 48,975,957 (GRCm38) |
R272H |
possibly damaging |
Het |
| Arl6ip5 |
T |
C |
6: 97,232,400 (GRCm38) |
L132S |
probably damaging |
Het |
| Atp10b |
G |
A |
11: 43,234,380 (GRCm38) |
V1058I |
probably damaging |
Het |
| B3gnt4 |
A |
C |
5: 123,511,279 (GRCm38) |
I236L |
probably damaging |
Het |
| Bmper |
T |
A |
9: 23,381,463 (GRCm38) |
I356N |
possibly damaging |
Het |
| Bpifa6 |
T |
A |
2: 153,990,895 (GRCm38) |
I310N |
probably damaging |
Het |
| Btnl9 |
A |
T |
11: 49,169,316 (GRCm38) |
L535* |
probably null |
Het |
| Capn3 |
A |
G |
2: 120,501,251 (GRCm38) |
E614G |
probably benign |
Het |
| Catip |
T |
C |
1: 74,369,000 (GRCm38) |
|
probably benign |
Het |
| Ccdc180 |
T |
A |
4: 45,921,996 (GRCm38) |
S1023R |
probably damaging |
Het |
| Ces2g |
G |
A |
8: 104,967,414 (GRCm38) |
E461K |
probably damaging |
Het |
| Chad |
C |
A |
11: 94,565,697 (GRCm38) |
H200Q |
possibly damaging |
Het |
| Crbn |
C |
T |
6: 106,795,198 (GRCm38) |
|
probably null |
Het |
| Crip3 |
G |
C |
17: 46,429,372 (GRCm38) |
E33Q |
probably damaging |
Het |
| D130043K22Rik |
A |
T |
13: 24,856,911 (GRCm38) |
R105S |
probably damaging |
Het |
| Dmxl1 |
C |
T |
18: 49,846,639 (GRCm38) |
H114Y |
probably benign |
Het |
| Dpp3 |
T |
C |
19: 4,918,319 (GRCm38) |
N242D |
probably benign |
Het |
| Dtx3l |
T |
C |
16: 35,936,579 (GRCm38) |
N78S |
probably benign |
Het |
| Dync2h1 |
A |
G |
9: 6,955,905 (GRCm38) |
|
probably null |
Het |
| Esrp1 |
A |
G |
4: 11,365,211 (GRCm38) |
V260A |
probably damaging |
Het |
| Etfdh |
A |
G |
3: 79,604,042 (GRCm38) |
V544A |
probably benign |
Het |
| Ezhip |
T |
G |
X: 6,082,700 (GRCm38) |
E87A |
probably benign |
Het |
| Fcgr1 |
G |
T |
3: 96,285,917 (GRCm38) |
H255N |
possibly damaging |
Het |
| Fcrl2 |
G |
T |
3: 87,257,348 (GRCm38) |
Y290* |
probably null |
Het |
| Frem2 |
A |
G |
3: 53,652,514 (GRCm38) |
V1524A |
probably damaging |
Het |
| Gabbr1 |
T |
C |
17: 37,071,866 (GRCm38) |
I817T |
probably damaging |
Het |
| Gapdhs |
G |
C |
7: 30,729,908 (GRCm38) |
|
probably null |
Het |
| Gm57858 |
A |
G |
3: 36,019,950 (GRCm38) |
V350A |
probably benign |
Het |
| Gopc |
A |
T |
10: 52,349,085 (GRCm38) |
I356K |
probably damaging |
Het |
| Gpi1 |
T |
C |
7: 34,202,877 (GRCm38) |
N471S |
probably damaging |
Het |
| Gpr171 |
A |
G |
3: 59,098,207 (GRCm38) |
V49A |
probably benign |
Het |
| Greb1l |
T |
A |
18: 10,554,857 (GRCm38) |
N1634K |
probably damaging |
Het |
| Gria1 |
G |
A |
11: 57,185,949 (GRCm38) |
R57H |
probably damaging |
Het |
| Herpud1 |
A |
G |
8: 94,394,613 (GRCm38) |
E344G |
probably benign |
Het |
| Hhip |
A |
G |
8: 80,045,181 (GRCm38) |
F167L |
probably damaging |
Het |
| Hp1bp3 |
T |
A |
4: 138,225,898 (GRCm38) |
D84E |
probably damaging |
Het |
| Ier3 |
A |
G |
17: 35,822,261 (GRCm38) |
Y145C |
probably damaging |
Het |
| Ifi47 |
A |
T |
11: 49,096,647 (GRCm38) |
I414L |
probably benign |
Het |
| Ifnl2 |
C |
T |
7: 28,510,213 (GRCm38) |
A50T |
possibly damaging |
Het |
| Jade1 |
A |
G |
3: 41,591,750 (GRCm38) |
Y70C |
probably damaging |
Het |
| Krt33a |
A |
T |
11: 100,014,178 (GRCm38) |
D167E |
possibly damaging |
Het |
| Map1a |
A |
G |
2: 121,303,791 (GRCm38) |
D1458G |
possibly damaging |
Het |
| Mrgpra4 |
A |
G |
7: 47,981,775 (GRCm38) |
L26S |
possibly damaging |
Het |
| Mtmr2 |
T |
C |
9: 13,796,057 (GRCm38) |
Y230H |
possibly damaging |
Het |
| Nae1 |
T |
A |
8: 104,530,068 (GRCm38) |
D69V |
probably damaging |
Het |
| Nbr1 |
T |
A |
11: 101,572,817 (GRCm38) |
V625E |
possibly damaging |
Het |
| Nek1 |
T |
C |
8: 61,089,773 (GRCm38) |
L702P |
probably damaging |
Het |
| Ntf3 |
T |
C |
6: 126,101,726 (GRCm38) |
*272W |
probably null |
Het |
| Ofcc1 |
A |
C |
13: 40,094,705 (GRCm38) |
L651R |
probably damaging |
Het |
| Olfm3 |
A |
T |
3: 115,122,193 (GRCm38) |
|
probably null |
Het |
| Pcdhb19 |
C |
T |
18: 37,497,944 (GRCm38) |
A264V |
probably benign |
Het |
| Pear1 |
C |
A |
3: 87,752,186 (GRCm38) |
W780C |
probably damaging |
Het |
| Pkhd1 |
T |
A |
1: 20,565,639 (GRCm38) |
H489L |
probably benign |
Het |
| Pros1 |
T |
A |
16: 62,903,572 (GRCm38) |
C228S |
possibly damaging |
Het |
| Rbm10 |
G |
A |
X: 20,635,739 (GRCm38) |
R9H |
unknown |
Het |
| Rwdd1 |
T |
C |
10: 34,002,470 (GRCm38) |
E123G |
probably damaging |
Het |
| Slc22a2 |
G |
T |
17: 12,599,175 (GRCm38) |
V213F |
probably damaging |
Het |
| Slc34a1 |
T |
C |
13: 23,821,008 (GRCm38) |
I412T |
probably benign |
Het |
| Smarca2 |
A |
T |
19: 26,771,038 (GRCm38) |
I98L |
probably benign |
Het |
| Spag6l |
T |
C |
16: 16,777,339 (GRCm38) |
E394G |
probably damaging |
Het |
| Spdef |
T |
C |
17: 27,720,295 (GRCm38) |
T26A |
probably benign |
Het |
| Stk17b |
T |
C |
1: 53,776,572 (GRCm38) |
I23V |
probably benign |
Het |
| Sult2a7 |
A |
G |
7: 14,491,893 (GRCm38) |
I56T |
probably damaging |
Het |
| Tango6 |
T |
A |
8: 106,689,294 (GRCm38) |
|
probably null |
Het |
| Tex46 |
T |
C |
4: 136,610,533 (GRCm38) |
L12P |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,811,243 (GRCm38) |
L5176Q |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,768,340 (GRCm38) |
M19410L |
possibly damaging |
Het |
| Unc5cl |
T |
A |
17: 48,459,946 (GRCm38) |
I116N |
possibly damaging |
Het |
| Unc80 |
A |
T |
1: 66,618,258 (GRCm38) |
I1630F |
possibly damaging |
Het |
| Upb1 |
G |
A |
10: 75,436,217 (GRCm38) |
R288H |
probably damaging |
Het |
| Wdr62 |
T |
G |
7: 30,267,903 (GRCm38) |
I309L |
probably damaging |
Het |
| Whrn |
C |
T |
4: 63,418,148 (GRCm38) |
V295M |
possibly damaging |
Het |
| Wrn |
G |
A |
8: 33,329,202 (GRCm38) |
P241S |
probably benign |
Het |
| Zer1 |
G |
A |
2: 30,108,274 (GRCm38) |
L342F |
probably damaging |
Het |
| Zfp687 |
A |
T |
3: 95,010,437 (GRCm38) |
C675S |
probably damaging |
Het |
| Zfp954 |
A |
G |
7: 7,115,322 (GRCm38) |
Y408H |
possibly damaging |
Het |
|
| Other mutations in Kif1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Kif1b
|
APN |
4 |
149,220,602 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01943:Kif1b
|
APN |
4 |
149,214,905 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02240:Kif1b
|
APN |
4 |
149,246,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02414:Kif1b
|
APN |
4 |
149,199,314 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02490:Kif1b
|
APN |
4 |
149,204,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02501:Kif1b
|
APN |
4 |
149,214,976 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02833:Kif1b
|
APN |
4 |
149,246,364 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02852:Kif1b
|
APN |
4 |
149,291,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02900:Kif1b
|
APN |
4 |
149,180,809 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL03287:Kif1b
|
APN |
4 |
149,214,981 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL03412:Kif1b
|
APN |
4 |
149,274,939 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4305001:Kif1b
|
UTSW |
4 |
149,220,792 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R0005:Kif1b
|
UTSW |
4 |
149,181,927 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0044:Kif1b
|
UTSW |
4 |
149,263,601 (GRCm38) |
splice site |
probably benign |
|
|
R0044:Kif1b
|
UTSW |
4 |
149,263,601 (GRCm38) |
splice site |
probably benign |
|
|
R0129:Kif1b
|
UTSW |
4 |
149,261,201 (GRCm38) |
missense |
probably benign |
|
|
R0180:Kif1b
|
UTSW |
4 |
149,213,659 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0288:Kif1b
|
UTSW |
4 |
149,199,338 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0360:Kif1b
|
UTSW |
4 |
149,262,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0383:Kif1b
|
UTSW |
4 |
149,202,512 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0398:Kif1b
|
UTSW |
4 |
149,204,231 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R0403:Kif1b
|
UTSW |
4 |
149,181,967 (GRCm38) |
nonsense |
probably null |
|
|
R0445:Kif1b
|
UTSW |
4 |
149,188,009 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1466:Kif1b
|
UTSW |
4 |
149,223,252 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1466:Kif1b
|
UTSW |
4 |
149,223,252 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1681:Kif1b
|
UTSW |
4 |
149,195,501 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R1728:Kif1b
|
UTSW |
4 |
149,187,722 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1840:Kif1b
|
UTSW |
4 |
149,188,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1874:Kif1b
|
UTSW |
4 |
149,187,632 (GRCm38) |
missense |
probably benign |
|
|
R1915:Kif1b
|
UTSW |
4 |
149,267,216 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2106:Kif1b
|
UTSW |
4 |
149,187,640 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2124:Kif1b
|
UTSW |
4 |
149,222,296 (GRCm38) |
missense |
probably benign |
0.08 |
|
R2126:Kif1b
|
UTSW |
4 |
149,187,640 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2127:Kif1b
|
UTSW |
4 |
149,187,640 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2128:Kif1b
|
UTSW |
4 |
149,187,640 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2129:Kif1b
|
UTSW |
4 |
149,187,640 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2146:Kif1b
|
UTSW |
4 |
149,184,309 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2392:Kif1b
|
UTSW |
4 |
149,220,620 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R2883:Kif1b
|
UTSW |
4 |
149,237,648 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R2981:Kif1b
|
UTSW |
4 |
149,220,541 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3038:Kif1b
|
UTSW |
4 |
149,213,333 (GRCm38) |
missense |
probably benign |
0.02 |
|
R3616:Kif1b
|
UTSW |
4 |
149,262,283 (GRCm38) |
splice site |
probably benign |
|
|
R3935:Kif1b
|
UTSW |
4 |
149,237,160 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4347:Kif1b
|
UTSW |
4 |
149,247,234 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4423:Kif1b
|
UTSW |
4 |
149,214,105 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4637:Kif1b
|
UTSW |
4 |
149,199,311 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4745:Kif1b
|
UTSW |
4 |
149,237,882 (GRCm38) |
nonsense |
probably null |
|
|
R4807:Kif1b
|
UTSW |
4 |
149,247,921 (GRCm38) |
intron |
probably benign |
|
|
R5618:Kif1b
|
UTSW |
4 |
149,269,889 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5644:Kif1b
|
UTSW |
4 |
149,238,482 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5683:Kif1b
|
UTSW |
4 |
149,222,261 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5696:Kif1b
|
UTSW |
4 |
149,273,849 (GRCm38) |
splice site |
probably null |
|
|
R6022:Kif1b
|
UTSW |
4 |
149,198,532 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6048:Kif1b
|
UTSW |
4 |
149,263,629 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6137:Kif1b
|
UTSW |
4 |
149,238,426 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R6139:Kif1b
|
UTSW |
4 |
149,237,532 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6171:Kif1b
|
UTSW |
4 |
149,258,048 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6250:Kif1b
|
UTSW |
4 |
149,213,643 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6423:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6424:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6425:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6443:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6460:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6462:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6463:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6469:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6470:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6471:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6472:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6504:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6536:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6537:Kif1b
|
UTSW |
4 |
149,192,596 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6668:Kif1b
|
UTSW |
4 |
149,213,407 (GRCm38) |
missense |
probably benign |
0.09 |
|
R6698:Kif1b
|
UTSW |
4 |
149,274,956 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7065:Kif1b
|
UTSW |
4 |
149,202,525 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7222:Kif1b
|
UTSW |
4 |
149,225,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7342:Kif1b
|
UTSW |
4 |
149,214,090 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7720:Kif1b
|
UTSW |
4 |
149,182,355 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7744:Kif1b
|
UTSW |
4 |
149,237,075 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R7797:Kif1b
|
UTSW |
4 |
149,237,387 (GRCm38) |
missense |
probably benign |
|
|
R7829:Kif1b
|
UTSW |
4 |
149,220,990 (GRCm38) |
splice site |
probably null |
|
|
R7869:Kif1b
|
UTSW |
4 |
149,184,376 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7878:Kif1b
|
UTSW |
4 |
149,214,997 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7980:Kif1b
|
UTSW |
4 |
149,269,921 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8047:Kif1b
|
UTSW |
4 |
149,214,922 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8237:Kif1b
|
UTSW |
4 |
149,191,185 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8243:Kif1b
|
UTSW |
4 |
149,204,267 (GRCm38) |
missense |
probably benign |
|
|
R8252:Kif1b
|
UTSW |
4 |
149,273,805 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8342:Kif1b
|
UTSW |
4 |
149,222,348 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8460:Kif1b
|
UTSW |
4 |
149,187,620 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R8462:Kif1b
|
UTSW |
4 |
149,182,340 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8496:Kif1b
|
UTSW |
4 |
149,192,611 (GRCm38) |
nonsense |
probably null |
|
|
R8687:Kif1b
|
UTSW |
4 |
149,261,163 (GRCm38) |
nonsense |
probably null |
|
|
R8694:Kif1b
|
UTSW |
4 |
149,220,567 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8842:Kif1b
|
UTSW |
4 |
149,253,739 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8883:Kif1b
|
UTSW |
4 |
149,276,885 (GRCm38) |
missense |
probably benign |
|
|
R8971:Kif1b
|
UTSW |
4 |
149,247,816 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8994:Kif1b
|
UTSW |
4 |
149,195,482 (GRCm38) |
missense |
|
|
|
R9002:Kif1b
|
UTSW |
4 |
149,191,255 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9227:Kif1b
|
UTSW |
4 |
149,237,900 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9231:Kif1b
|
UTSW |
4 |
149,191,195 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9450:Kif1b
|
UTSW |
4 |
149,238,010 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9478:Kif1b
|
UTSW |
4 |
149,261,159 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9571:Kif1b
|
UTSW |
4 |
149,220,641 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9644:Kif1b
|
UTSW |
4 |
149,291,379 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF008:Kif1b
|
UTSW |
4 |
149,251,738 (GRCm38) |
splice site |
probably null |
|
|
X0009:Kif1b
|
UTSW |
4 |
149,247,264 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0062:Kif1b
|
UTSW |
4 |
149,275,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Kif1b
|
UTSW |
4 |
149,266,298 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTTAGACCAACACTCTCCTGAG -3'
(R):5'- AGAGTCGTGGAGCTCTAACC -3'
Sequencing Primer
(F):5'- ACCTTAGGGCCTTGCATATCAGAG -3'
(R):5'- AGAGTCGTGGAGCTCTAACCTCTAC -3'
|
| Posted On |
2014-10-16 |
Incidental Mutation