Mutagenetix > Incidental Mutation

Incidental Mutation 'R2267:Hmcn1'

242086

Institutional Source

Beutler Lab

Gene Symbol

Hmcn1

Ensembl Gene

ENSMUSG00000066842

Gene Name

hemicentin 1

Synonyms

LOC240793, EG545370

MMRRC Submission

040267-MU

Accession Numbers

Ncbi RefSeq: NM_001024720.3; MGI:2685047

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2267 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

150562524-150993435 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 150599010 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 4709 (S4709G)

Ref Sequence

ENSEMBL: ENSMUSP00000121500 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074783] [ENSMUST00000137197]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000074783
AA Change: S4709G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000074340
Gene: ENSMUSG00000066842
AA Change: S4709G

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
VWA	39	213	3e-1	SMART
IG_like	445	506	1.13e0	SMART
IGc2	532	598	2.32e-8	SMART
IGc2	624	688	1.24e-8	SMART
IGc2	714	779	7.52e-8	SMART
IGc2	805	874	2.19e-9	SMART
IGc2	902	967	5.15e-15	SMART
IGc2	993	1058	1.28e-10	SMART
IGc2	1092	1157	1.69e-10	SMART
IGc2	1183	1247	1.09e-13	SMART
IGc2	1278	1344	6.49e-12	SMART
IGc2	1372	1437	5.2e-11	SMART
IGc2	1465	1531	1.34e-13	SMART
IGc2	1559	1624	6.25e-14	SMART
IGc2	1653	1718	4.06e-13	SMART
IGc2	1746	1811	4.12e-14	SMART
IGc2	1838	1904	5.92e-15	SMART
IGc2	1932	1997	7.69e-14	SMART
IGc2	2023	2089	3.3e-13	SMART
IGc2	2115	2180	5e-13	SMART
IGc2	2208	2275	1.32e-12	SMART
IGc2	2304	2369	2.91e-14	SMART
IGc2	2398	2463	4e-12	SMART
IGc2	2491	2556	1.94e-19	SMART
IGc2	2587	2652	2.54e-14	SMART
IGc2	2686	2751	7.57e-13	SMART
IGc2	2789	2854	4.88e-16	SMART
IGc2	2884	2949	2.7e-9	SMART
IGc2	2976	3041	1.47e-10	SMART
IGc2	3071	3136	2.24e-15	SMART
IGc2	3163	3230	8.83e-14	SMART
IGc2	3258	3325	9.76e-16	SMART
IGc2	3354	3419	1.54e-13	SMART
IGc2	3447	3512	4.35e-13	SMART
IGc2	3540	3605	2e-12	SMART
IGc2	3633	3698	7.69e-14	SMART
IGc2	3724	3789	1.92e-14	SMART
IGc2	3815	3882	2.58e-6	SMART
IGc2	3908	3973	6.4e-11	SMART
IGc2	3999	4064	2.78e-11	SMART
IGc2	4090	4154	1.74e-12	SMART
low complexity region	4155	4160	N/A	INTRINSIC
IGc2	4180	4245	3.35e-14	SMART
IGc2	4271	4334	8.12e-13	SMART
IGc2	4361	4425	1.79e-14	SMART
IGc2	4451	4515	1.06e-11	SMART
TSP1	4531	4583	4.72e-15	SMART
TSP1	4588	4640	2.39e-16	SMART
TSP1	4645	4697	1.67e-15	SMART
TSP1	4702	4754	2.2e-15	SMART
TSP1	4759	4811	2.77e-12	SMART
TSP1	4816	4868	2.67e-14	SMART
Pfam:G2F	4869	5051	1.5e-57	PFAM
EGF_CA	5106	5145	4.38e-11	SMART
EGF_CA	5146	5190	4.49e-8	SMART
EGF_CA	5191	5228	2.38e-12	SMART
EGF_CA	5229	5270	6.8e-8	SMART
EGF_CA	5271	5313	3.51e-10	SMART
EGF_CA	5314	5354	4.32e-10	SMART
low complexity region	5384	5400	N/A	INTRINSIC
low complexity region	5401	5412	N/A	INTRINSIC
EGF_CA	5431	5470	2.78e-13	SMART
EGF	5474	5516	1.44e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000137197
AA Change: S4709G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000121500
Gene: ENSMUSG00000066842
AA Change: S4709G

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
VWA	39	213	3e-1	SMART
IG_like	445	506	1.13e0	SMART
IGc2	532	598	2.32e-8	SMART
IGc2	624	688	1.24e-8	SMART
IGc2	714	779	7.52e-8	SMART
IGc2	805	874	2.19e-9	SMART
IGc2	902	967	5.15e-15	SMART
IGc2	993	1058	1.28e-10	SMART
IGc2	1092	1157	1.69e-10	SMART
IGc2	1183	1247	1.09e-13	SMART
IGc2	1278	1344	6.49e-12	SMART
IGc2	1372	1437	5.2e-11	SMART
IGc2	1465	1531	1.34e-13	SMART
IGc2	1559	1624	6.25e-14	SMART
IGc2	1653	1718	4.06e-13	SMART
IGc2	1746	1811	4.12e-14	SMART
IGc2	1838	1904	5.92e-15	SMART
IGc2	1932	1997	7.69e-14	SMART
IGc2	2023	2089	3.3e-13	SMART
IGc2	2115	2180	5e-13	SMART
IGc2	2208	2275	1.32e-12	SMART
IGc2	2304	2369	2.91e-14	SMART
IGc2	2398	2463	4e-12	SMART
IGc2	2491	2556	1.94e-19	SMART
IGc2	2587	2652	2.54e-14	SMART
IGc2	2686	2751	7.57e-13	SMART
IGc2	2789	2854	4.88e-16	SMART
IGc2	2884	2949	2.7e-9	SMART
IGc2	2976	3041	1.47e-10	SMART
IGc2	3071	3136	2.24e-15	SMART
IGc2	3163	3230	8.83e-14	SMART
IGc2	3258	3325	9.76e-16	SMART
IGc2	3354	3419	1.54e-13	SMART
IGc2	3447	3512	4.35e-13	SMART
IGc2	3540	3605	2e-12	SMART
IGc2	3633	3698	7.69e-14	SMART
IGc2	3724	3789	1.92e-14	SMART
IGc2	3815	3882	2.58e-6	SMART
IGc2	3908	3973	6.4e-11	SMART
IGc2	3999	4064	2.78e-11	SMART
IGc2	4090	4154	1.74e-12	SMART
low complexity region	4155	4160	N/A	INTRINSIC
IGc2	4180	4245	3.35e-14	SMART
IGc2	4271	4334	8.12e-13	SMART
IGc2	4361	4425	1.79e-14	SMART
IGc2	4451	4515	1.06e-11	SMART
TSP1	4531	4583	4.72e-15	SMART
TSP1	4588	4640	2.39e-16	SMART
TSP1	4645	4697	1.67e-15	SMART
TSP1	4702	4754	2.2e-15	SMART
TSP1	4759	4811	2.77e-12	SMART
TSP1	4816	4868	2.67e-14	SMART
PDB:1GL4\|A	4869	5082	3e-6	PDB
SCOP:d1gl4a1	4869	5082	3e-79	SMART
EGF_CA	5106	5145	4.38e-11	SMART
EGF_CA	5146	5190	4.49e-8	SMART
EGF_CA	5191	5228	2.38e-12	SMART
EGF_CA	5229	5270	6.8e-8	SMART
EGF_CA	5271	5313	3.51e-10	SMART
EGF_CA	5314	5353	2.78e-13	SMART
EGF	5357	5399	1.44e1	SMART

Meta Mutation Damage Score

0.1154

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.1%

Validation Efficiency

98% (108/110)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578C19Rik	A	G	X: 18,423,687 (GRCm38)	S179P	possibly damaging	Het
Aadac	T	A	3: 60,037,316 (GRCm38)	D136E	probably damaging	Het
Abca16	A	G	7: 120,431,160 (GRCm38)	D165G	probably benign	Het
Abca8b	G	A	11: 109,955,148 (GRCm38)	T820M	probably benign	Het
Acot2	C	T	12: 83,990,560 (GRCm38)	A216V	probably damaging	Het
Agap2	T	A	10: 127,082,428 (GRCm38)		probably benign	Het
Ak7	T	C	12: 105,747,214 (GRCm38)	V419A	probably benign	Het
Apmap	A	G	2: 150,588,901 (GRCm38)		probably null	Het
Apob	T	C	12: 8,015,475 (GRCm38)	F4115S	possibly damaging	Het
Cachd1	T	A	4: 100,949,069 (GRCm38)		probably benign	Het
Ccdc39	T	A	3: 33,815,484 (GRCm38)	E731D	probably damaging	Het
Ces2a	A	T	8: 104,740,190 (GRCm38)	I65F	probably benign	Het
Commd8	A	G	5: 72,165,422 (GRCm38)	W51R	probably damaging	Het
D2hgdh	C	T	1: 93,835,435 (GRCm38)	A314V	probably damaging	Het
Dcun1d4	T	A	5: 73,481,275 (GRCm38)		probably benign	Het
Dgcr14	T	C	16: 17,909,995 (GRCm38)	T107A	probably damaging	Het
Dgke	T	A	11: 89,052,469 (GRCm38)	E231D	probably benign	Het
Dhrs9	A	G	2: 69,392,853 (GRCm38)		probably benign	Het
Dhx30	C	T	9: 110,087,034 (GRCm38)	G662R	probably damaging	Het
Dnah7b	T	A	1: 46,233,915 (GRCm38)	M2401K	probably damaging	Het
Dnmt3a	T	A	12: 3,897,551 (GRCm38)		probably null	Het
Dst	C	T	1: 34,295,466 (GRCm38)	T4874I	probably damaging	Het
Eef2kmt	G	A	16: 5,255,940 (GRCm38)		probably benign	Het
Etfa	A	T	9: 55,486,731 (GRCm38)	L212Q	probably damaging	Het
Exosc5	T	C	7: 25,664,384 (GRCm38)	L107P	possibly damaging	Het
Fam117b	T	C	1: 59,913,630 (GRCm38)	L156P	probably damaging	Het
Fam186b	T	G	15: 99,285,643 (GRCm38)	D40A	probably damaging	Het
Fga	T	C	3: 83,032,950 (GRCm38)	L637P	probably damaging	Het
Foxn4	T	C	5: 114,255,601 (GRCm38)	T486A	probably damaging	Het
Gcc1	A	G	6: 28,418,499 (GRCm38)	S612P	probably benign	Het
Gjd3	C	T	11: 98,982,401 (GRCm38)	V206M	probably damaging	Het
Gpam	A	T	19: 55,072,710 (GRCm38)		probably null	Het
Gpc6	A	T	14: 117,888,520 (GRCm38)		probably null	Het
Gphb5	C	G	12: 75,412,946 (GRCm38)	V92L	probably benign	Het
Grid2ip	C	T	5: 143,386,092 (GRCm38)	P690L	probably benign	Het
Gsdmc	T	C	15: 63,776,798 (GRCm38)	E429G	probably benign	Het
Heatr5a	T	C	12: 51,893,745 (GRCm38)	D1444G	possibly damaging	Het
Hist1h2bh	T	C	13: 23,542,992 (GRCm38)	K121E	possibly damaging	Het
Hr	A	T	14: 70,558,107 (GRCm38)	D393V	probably benign	Het
Ido2	T	C	8: 24,535,252 (GRCm38)	Y253C	probably damaging	Het
Itgal	A	G	7: 127,306,701 (GRCm38)	I352V	possibly damaging	Het
Itih4	A	G	14: 30,892,428 (GRCm38)	D445G	probably damaging	Het
Kcnh8	GAGACCAACGAGCAGCTGATGCTTCAGA	GAGA	17: 52,725,906 (GRCm38)	74	probably benign	Het
Kcnt2	G	A	1: 140,573,683 (GRCm38)		probably null	Het
Klk1b21	T	C	7: 44,104,439 (GRCm38)	I49T	possibly damaging	Het
Klrb1	A	T	6: 128,722,974 (GRCm38)	S25T	probably damaging	Het
L3mbtl3	C	T	10: 26,331,857 (GRCm38)	W321*	probably null	Het
Lama2	T	A	10: 26,992,936 (GRCm38)	I2838F	probably damaging	Het
Lrrtm1	C	A	6: 77,244,013 (GRCm38)	A151E	probably damaging	Het
Lsmem1	GTACATACATACATACATACATACATACA	GTACATACATACATACATACATACATACATACA	12: 40,185,261 (GRCm38)		probably null	Het
Magi3	G	A	3: 104,021,066 (GRCm38)		probably benign	Het
Mamdc2	A	T	19: 23,303,903 (GRCm38)		probably benign	Het
Mcc	T	C	18: 44,519,541 (GRCm38)	D272G	probably damaging	Het
Mgst3	T	A	1: 167,373,799 (GRCm38)	T106S	probably benign	Het
Mink1	G	A	11: 70,601,724 (GRCm38)		probably null	Het
Mlh3	G	T	12: 85,260,811 (GRCm38)	H1181N	possibly damaging	Het
Mmrn2	A	G	14: 34,399,492 (GRCm38)	K773R	probably benign	Het
Mrc2	G	A	11: 105,348,431 (GRCm38)		probably null	Het
Mro	T	C	18: 73,873,297 (GRCm38)	I104T	probably benign	Het
Mtbp	G	A	15: 55,569,160 (GRCm38)		probably null	Het
Mtss1l	A	G	8: 110,728,730 (GRCm38)	K92E	possibly damaging	Het
Mybphl	A	G	3: 108,365,001 (GRCm38)	E2G	probably damaging	Het
Nbeal1	T	A	1: 60,330,878 (GRCm38)		probably benign	Het
Neurod2	C	A	11: 98,327,756 (GRCm38)	C194F	probably damaging	Het
Nr4a2	T	A	2: 57,112,006 (GRCm38)	D145V	possibly damaging	Het
Ntmt1	C	A	2: 30,820,460 (GRCm38)	N58K	probably benign	Het
Nup205	T	C	6: 35,241,349 (GRCm38)	S1819P	possibly damaging	Het
Obsl1	T	C	1: 75,505,698 (GRCm38)	H176R	probably damaging	Het
Olfr583	G	A	7: 103,052,137 (GRCm38)	V280I	probably benign	Het
Olfr836	A	T	9: 19,121,441 (GRCm38)	H162L	probably benign	Het
Olfr926	A	G	9: 38,878,063 (GRCm38)	T296A	probably benign	Het
P2ry13	T	C	3: 59,210,028 (GRCm38)	M110V	probably damaging	Het
P2ry14	T	C	3: 59,115,571 (GRCm38)	N165S	probably damaging	Het
Phka1	A	G	X: 102,541,110 (GRCm38)		probably benign	Het
Plxnd1	A	G	6: 115,962,743 (GRCm38)	V1425A	probably benign	Het
Ppp2ca	G	A	11: 52,118,086 (GRCm38)	G138R	probably damaging	Het
Ptpn12	A	T	5: 20,998,411 (GRCm38)	N456K	probably damaging	Het
Scarb1	A	T	5: 125,287,375 (GRCm38)	S97T	possibly damaging	Het
Scyl1	C	T	19: 5,761,721 (GRCm38)	D440N	possibly damaging	Het
Sema5a	C	A	15: 32,574,919 (GRCm38)	T391K	probably benign	Het
Sipa1l3	T	A	7: 29,399,602 (GRCm38)	N414I	probably damaging	Het
Skint6	T	C	4: 112,842,822 (GRCm38)		probably null	Het
Slc35a3	T	C	3: 116,673,636 (GRCm38)	K325E	possibly damaging	Het
Spag17	C	A	3: 100,061,866 (GRCm38)		probably null	Het
Spib	T	A	7: 44,528,924 (GRCm38)	M141L	probably benign	Het
Srebf1	A	G	11: 60,207,147 (GRCm38)	S44P	probably damaging	Het
Styk1	T	C	6: 131,312,576 (GRCm38)	E25G	probably benign	Het
Taar8b	T	C	10: 24,091,372 (GRCm38)	N308S	probably damaging	Het
Taf15	T	G	11: 83,497,262 (GRCm38)	S200R	probably damaging	Het
Tanc1	G	A	2: 59,837,219 (GRCm38)		probably null	Het
Tas2r134	A	G	2: 51,628,237 (GRCm38)	T243A	probably benign	Het
Tatdn1	A	T	15: 58,905,752 (GRCm38)	M218K	probably damaging	Het
Tbc1d14	A	G	5: 36,543,217 (GRCm38)	L269P	possibly damaging	Het
Tbx1	T	C	16: 18,581,994 (GRCm38)		probably null	Het
Tgfbr3l	A	G	8: 4,250,506 (GRCm38)	E228G	probably benign	Het
Tmem233	G	C	5: 116,051,458 (GRCm38)		probably benign	Het
Tmprss11d	A	G	5: 86,373,349 (GRCm38)	Y2H	probably benign	Het
Trps1	G	A	15: 50,822,398 (GRCm38)	R544C	probably damaging	Het
Ttc22	T	C	4: 106,639,085 (GRCm38)	V444A	possibly damaging	Het
Ttc28	A	G	5: 111,226,003 (GRCm38)	T1071A	possibly damaging	Het
Tymp	A	T	15: 89,373,808 (GRCm38)	V378D	probably damaging	Het
Ube2j1	T	A	4: 33,049,943 (GRCm38)	F257I	possibly damaging	Het
Vmn2r18	T	C	5: 151,586,662 (GRCm38)	E82G	probably damaging	Het
Wwp1	T	C	4: 19,638,618 (GRCm38)	D575G	probably damaging	Het

Other mutations in Hmcn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00417:Hmcn1	APN	1	150,677,278 (GRCm38)	missense	probably benign
IGL00571:Hmcn1	APN	1	150,638,999 (GRCm38)	missense	probably benign	0.05
IGL00726:Hmcn1	APN	1	150,806,366 (GRCm38)	critical splice donor site	probably null
IGL00802:Hmcn1	APN	1	150,664,936 (GRCm38)	missense	probably benign	0.19
IGL00824:Hmcn1	APN	1	150,656,734 (GRCm38)	missense	probably damaging	1.00
IGL00834:Hmcn1	APN	1	150,630,340 (GRCm38)	missense	probably benign	0.00
IGL00843:Hmcn1	APN	1	150,610,713 (GRCm38)	missense	possibly damaging	0.95
IGL00845:Hmcn1	APN	1	150,605,006 (GRCm38)	missense	probably damaging	0.98
IGL00851:Hmcn1	APN	1	150,582,301 (GRCm38)	missense	probably benign	0.02
IGL00909:Hmcn1	APN	1	150,638,869 (GRCm38)	missense	probably benign	0.12
IGL01074:Hmcn1	APN	1	150,627,033 (GRCm38)	missense	possibly damaging	0.82
IGL01112:Hmcn1	APN	1	150,632,552 (GRCm38)	splice site	probably benign
IGL01304:Hmcn1	APN	1	150,622,924 (GRCm38)	missense	probably damaging	0.99
IGL01307:Hmcn1	APN	1	150,745,001 (GRCm38)	missense	possibly damaging	0.84
IGL01318:Hmcn1	APN	1	150,719,240 (GRCm38)	missense	probably damaging	1.00
IGL01403:Hmcn1	APN	1	150,593,097 (GRCm38)	missense	probably damaging	1.00
IGL01417:Hmcn1	APN	1	150,859,239 (GRCm38)	missense	probably damaging	1.00
IGL01503:Hmcn1	APN	1	150,605,072 (GRCm38)	missense	probably benign	0.38
IGL01509:Hmcn1	APN	1	150,609,631 (GRCm38)	missense	probably damaging	1.00
IGL01550:Hmcn1	APN	1	150,598,397 (GRCm38)	missense	probably damaging	1.00
IGL01601:Hmcn1	APN	1	150,627,413 (GRCm38)	missense	probably benign	0.01
IGL01617:Hmcn1	APN	1	150,672,032 (GRCm38)	missense	probably benign	0.05
IGL01636:Hmcn1	APN	1	150,580,233 (GRCm38)	missense	probably damaging	1.00
IGL01662:Hmcn1	APN	1	150,737,299 (GRCm38)	missense	possibly damaging	0.46
IGL01693:Hmcn1	APN	1	150,583,280 (GRCm38)	missense	probably damaging	1.00
IGL01723:Hmcn1	APN	1	150,744,960 (GRCm38)	missense	probably benign	0.01
IGL01776:Hmcn1	APN	1	150,672,038 (GRCm38)	missense	possibly damaging	0.70
IGL01783:Hmcn1	APN	1	150,615,300 (GRCm38)	missense	possibly damaging	0.60
IGL01789:Hmcn1	APN	1	150,690,601 (GRCm38)	missense	probably damaging	1.00
IGL01900:Hmcn1	APN	1	150,742,260 (GRCm38)	splice site	probably benign
IGL01906:Hmcn1	APN	1	150,667,887 (GRCm38)	missense	probably benign	0.01
IGL01947:Hmcn1	APN	1	150,732,892 (GRCm38)	missense	possibly damaging	0.93
IGL01958:Hmcn1	APN	1	150,603,871 (GRCm38)	missense	probably benign	0.01
IGL02002:Hmcn1	APN	1	150,615,298 (GRCm38)	missense	probably damaging	1.00
IGL02058:Hmcn1	APN	1	150,704,181 (GRCm38)	missense	probably benign	0.02
IGL02115:Hmcn1	APN	1	150,630,728 (GRCm38)	missense	probably damaging	1.00
IGL02127:Hmcn1	APN	1	150,722,607 (GRCm38)	missense	probably benign
IGL02155:Hmcn1	APN	1	150,563,598 (GRCm38)	missense	probably damaging	1.00
IGL02222:Hmcn1	APN	1	150,806,401 (GRCm38)	missense	probably benign	0.05
IGL02293:Hmcn1	APN	1	150,664,915 (GRCm38)	missense	probably damaging	0.97
IGL02398:Hmcn1	APN	1	150,802,897 (GRCm38)	missense	possibly damaging	0.78
IGL02420:Hmcn1	APN	1	150,722,424 (GRCm38)	missense	probably damaging	1.00
IGL02553:Hmcn1	APN	1	150,993,023 (GRCm38)	missense	probably benign	0.12
IGL02561:Hmcn1	APN	1	150,809,726 (GRCm38)	missense	probably benign	0.32
IGL02569:Hmcn1	APN	1	150,697,493 (GRCm38)	missense	probably benign	0.01
IGL02607:Hmcn1	APN	1	150,744,995 (GRCm38)	missense	possibly damaging	0.88
IGL02676:Hmcn1	APN	1	150,619,009 (GRCm38)	missense	probably benign	0.01
IGL02725:Hmcn1	APN	1	150,604,903 (GRCm38)	missense	possibly damaging	0.92
IGL02726:Hmcn1	APN	1	150,656,694 (GRCm38)	nonsense	probably null
IGL02735:Hmcn1	APN	1	150,646,832 (GRCm38)	missense	probably benign	0.02
IGL02737:Hmcn1	APN	1	150,563,828 (GRCm38)	missense	probably damaging	1.00
IGL02892:Hmcn1	APN	1	150,675,974 (GRCm38)	critical splice donor site	probably null
IGL02927:Hmcn1	APN	1	150,577,278 (GRCm38)	missense	probably damaging	1.00
IGL02931:Hmcn1	APN	1	150,657,207 (GRCm38)	missense	probably benign	0.37
IGL02936:Hmcn1	APN	1	150,697,522 (GRCm38)	missense	probably damaging	0.98
IGL02985:Hmcn1	APN	1	150,671,917 (GRCm38)	missense	probably damaging	1.00
IGL03027:Hmcn1	APN	1	150,808,539 (GRCm38)	missense	probably benign
IGL03195:Hmcn1	APN	1	150,802,909 (GRCm38)	missense	probably benign	0.06
IGL03217:Hmcn1	APN	1	150,743,667 (GRCm38)	missense	possibly damaging	0.58
IGL03232:Hmcn1	APN	1	150,770,352 (GRCm38)	splice site	probably benign
IGL03268:Hmcn1	APN	1	150,772,510 (GRCm38)	missense	probably damaging	1.00
IGL03271:Hmcn1	APN	1	150,598,424 (GRCm38)	missense	possibly damaging	0.92
IGL03304:Hmcn1	APN	1	150,630,231 (GRCm38)	missense	probably damaging	0.97
IGL03329:Hmcn1	APN	1	150,732,910 (GRCm38)	missense	probably damaging	1.00
IGL03339:Hmcn1	APN	1	150,701,969 (GRCm38)	missense	probably benign	0.04
IGL03368:Hmcn1	APN	1	150,663,872 (GRCm38)	missense	probably damaging	1.00
Backbone	UTSW	1	150,622,994 (GRCm38)	missense	probably benign	0.09
Cambrian	UTSW	1	150,732,846 (GRCm38)	missense	probably damaging	1.00
chordate	UTSW	1	150,587,015 (GRCm38)	missense	probably benign	0.00
Justamere	UTSW	1	150,588,257 (GRCm38)	missense	probably damaging	1.00
Lancelet	UTSW	1	150,675,540 (GRCm38)	missense	probably benign	0.00
notochord	UTSW	1	150,770,293 (GRCm38)	missense	probably benign	0.00
wippoorwill	UTSW	1	150,732,946 (GRCm38)	missense	probably damaging	1.00
BB004:Hmcn1	UTSW	1	150,609,775 (GRCm38)	missense	probably damaging	1.00
BB014:Hmcn1	UTSW	1	150,609,775 (GRCm38)	missense	probably damaging	1.00
IGL02991:Hmcn1	UTSW	1	150,738,658 (GRCm38)	missense	possibly damaging	0.56
P0017:Hmcn1	UTSW	1	150,720,689 (GRCm38)	missense	possibly damaging	0.49
PIT1430001:Hmcn1	UTSW	1	150,808,737 (GRCm38)	missense	probably benign	0.00
PIT4514001:Hmcn1	UTSW	1	150,669,487 (GRCm38)	missense	possibly damaging	0.93
R0006:Hmcn1	UTSW	1	150,808,676 (GRCm38)	missense	probably damaging	0.99
R0018:Hmcn1	UTSW	1	150,652,551 (GRCm38)	missense	probably benign	0.16
R0052:Hmcn1	UTSW	1	150,677,406 (GRCm38)	missense	probably damaging	1.00
R0107:Hmcn1	UTSW	1	150,587,015 (GRCm38)	missense	probably benign	0.00
R0115:Hmcn1	UTSW	1	150,808,647 (GRCm38)	missense	possibly damaging	0.88
R0149:Hmcn1	UTSW	1	150,677,324 (GRCm38)	missense	probably benign	0.00
R0152:Hmcn1	UTSW	1	150,663,879 (GRCm38)	missense	probably benign	0.01
R0381:Hmcn1	UTSW	1	150,603,811 (GRCm38)	missense	probably damaging	1.00
R0398:Hmcn1	UTSW	1	150,798,814 (GRCm38)	missense	possibly damaging	0.83
R0414:Hmcn1	UTSW	1	150,715,822 (GRCm38)	missense	possibly damaging	0.72
R0494:Hmcn1	UTSW	1	150,732,792 (GRCm38)	splice site	probably benign
R0503:Hmcn1	UTSW	1	150,859,252 (GRCm38)	missense	probably damaging	1.00
R0504:Hmcn1	UTSW	1	150,876,419 (GRCm38)	splice site	probably benign
R0506:Hmcn1	UTSW	1	150,742,341 (GRCm38)	missense	possibly damaging	0.69
R0554:Hmcn1	UTSW	1	150,719,117 (GRCm38)	missense	probably benign	0.34
R0576:Hmcn1	UTSW	1	150,650,017 (GRCm38)	nonsense	probably null
R0599:Hmcn1	UTSW	1	150,609,801 (GRCm38)	missense	possibly damaging	0.91
R0605:Hmcn1	UTSW	1	150,657,376 (GRCm38)	critical splice donor site	probably null
R0607:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R0620:Hmcn1	UTSW	1	150,594,016 (GRCm38)	missense	probably benign	0.04
R0626:Hmcn1	UTSW	1	150,798,719 (GRCm38)	splice site	probably null
R0699:Hmcn1	UTSW	1	150,819,410 (GRCm38)	missense	probably damaging	1.00
R0765:Hmcn1	UTSW	1	150,808,787 (GRCm38)	missense	probably damaging	1.00
R0782:Hmcn1	UTSW	1	150,753,665 (GRCm38)	missense	possibly damaging	0.82
R0783:Hmcn1	UTSW	1	150,650,073 (GRCm38)	missense	probably damaging	1.00
R0841:Hmcn1	UTSW	1	150,679,607 (GRCm38)	splice site	probably null
R0975:Hmcn1	UTSW	1	150,577,377 (GRCm38)	missense	probably benign	0.00
R1070:Hmcn1	UTSW	1	150,689,590 (GRCm38)	missense	probably damaging	0.98
R1118:Hmcn1	UTSW	1	150,618,928 (GRCm38)	missense	possibly damaging	0.56
R1119:Hmcn1	UTSW	1	150,618,928 (GRCm38)	missense	possibly damaging	0.56
R1145:Hmcn1	UTSW	1	150,679,607 (GRCm38)	splice site	probably null
R1145:Hmcn1	UTSW	1	150,679,607 (GRCm38)	splice site	probably null
R1233:Hmcn1	UTSW	1	150,749,026 (GRCm38)	missense	probably benign
R1234:Hmcn1	UTSW	1	150,753,654 (GRCm38)	nonsense	probably null
R1291:Hmcn1	UTSW	1	150,748,191 (GRCm38)	missense	probably damaging	1.00
R1334:Hmcn1	UTSW	1	150,586,468 (GRCm38)	missense	possibly damaging	0.73
R1372:Hmcn1	UTSW	1	150,680,715 (GRCm38)	missense	probably benign	0.22
R1424:Hmcn1	UTSW	1	150,646,794 (GRCm38)	missense	probably benign	0.00
R1450:Hmcn1	UTSW	1	150,652,506 (GRCm38)	splice site	probably benign
R1458:Hmcn1	UTSW	1	150,609,700 (GRCm38)	missense	probably damaging	1.00
R1467:Hmcn1	UTSW	1	150,689,590 (GRCm38)	missense	probably damaging	0.98
R1467:Hmcn1	UTSW	1	150,689,590 (GRCm38)	missense	probably damaging	0.98
R1473:Hmcn1	UTSW	1	150,772,552 (GRCm38)	missense	probably benign	0.03
R1517:Hmcn1	UTSW	1	150,669,421 (GRCm38)	missense	probably damaging	1.00
R1527:Hmcn1	UTSW	1	150,773,803 (GRCm38)	missense	probably benign	0.00
R1557:Hmcn1	UTSW	1	150,734,532 (GRCm38)	missense	possibly damaging	0.86
R1576:Hmcn1	UTSW	1	150,657,241 (GRCm38)	missense	possibly damaging	0.77
R1617:Hmcn1	UTSW	1	150,745,027 (GRCm38)	missense	probably damaging	0.98
R1635:Hmcn1	UTSW	1	150,669,558 (GRCm38)	missense	probably benign	0.00
R1655:Hmcn1	UTSW	1	150,630,333 (GRCm38)	missense	probably benign	0.03
R1698:Hmcn1	UTSW	1	150,565,369 (GRCm38)	nonsense	probably null
R1710:Hmcn1	UTSW	1	150,675,984 (GRCm38)	missense	probably damaging	1.00
R1717:Hmcn1	UTSW	1	150,859,186 (GRCm38)	missense	probably damaging	1.00
R1753:Hmcn1	UTSW	1	150,586,468 (GRCm38)	missense	possibly damaging	0.73
R1756:Hmcn1	UTSW	1	150,599,030 (GRCm38)	missense	probably damaging	1.00
R1772:Hmcn1	UTSW	1	150,563,568 (GRCm38)	missense	probably damaging	0.99
R1793:Hmcn1	UTSW	1	150,749,083 (GRCm38)	missense	probably benign	0.01
R1794:Hmcn1	UTSW	1	150,627,152 (GRCm38)	missense	probably damaging	0.98
R1794:Hmcn1	UTSW	1	150,598,285 (GRCm38)	missense	probably benign	0.00
R1856:Hmcn1	UTSW	1	150,721,664 (GRCm38)	missense	probably benign	0.02
R1859:Hmcn1	UTSW	1	150,657,193 (GRCm38)	missense	probably damaging	1.00
R1862:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R1865:Hmcn1	UTSW	1	150,603,812 (GRCm38)	missense	probably damaging	1.00
R1874:Hmcn1	UTSW	1	150,720,695 (GRCm38)	missense	probably damaging	1.00
R1880:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R1881:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R1886:Hmcn1	UTSW	1	150,577,295 (GRCm38)	missense	probably benign	0.02
R1888:Hmcn1	UTSW	1	150,819,500 (GRCm38)	missense	possibly damaging	0.82
R1888:Hmcn1	UTSW	1	150,819,500 (GRCm38)	missense	possibly damaging	0.82
R1899:Hmcn1	UTSW	1	150,657,451 (GRCm38)	missense	probably damaging	1.00
R1905:Hmcn1	UTSW	1	150,992,855 (GRCm38)	missense	probably damaging	1.00
R1912:Hmcn1	UTSW	1	150,604,882 (GRCm38)	missense	probably benign	0.28
R1959:Hmcn1	UTSW	1	150,649,676 (GRCm38)	missense	probably benign	0.00
R1960:Hmcn1	UTSW	1	150,677,376 (GRCm38)	missense	possibly damaging	0.72
R1960:Hmcn1	UTSW	1	150,675,991 (GRCm38)	missense	probably benign	0.00
R2001:Hmcn1	UTSW	1	150,738,613 (GRCm38)	missense	possibly damaging	0.81
R2011:Hmcn1	UTSW	1	150,677,334 (GRCm38)	missense	probably benign	0.01
R2075:Hmcn1	UTSW	1	150,577,323 (GRCm38)	missense	possibly damaging	0.86
R2136:Hmcn1	UTSW	1	150,633,659 (GRCm38)	missense	probably damaging	1.00
R2192:Hmcn1	UTSW	1	150,715,815 (GRCm38)	missense	probably damaging	0.97
R2268:Hmcn1	UTSW	1	150,624,598 (GRCm38)	splice site	probably benign
R2303:Hmcn1	UTSW	1	150,704,226 (GRCm38)	missense	probably damaging	1.00
R2330:Hmcn1	UTSW	1	150,652,678 (GRCm38)	splice site	probably benign
R2338:Hmcn1	UTSW	1	150,622,934 (GRCm38)	missense	possibly damaging	0.89
R2380:Hmcn1	UTSW	1	150,565,384 (GRCm38)	missense	probably benign	0.01
R2405:Hmcn1	UTSW	1	150,860,341 (GRCm38)	missense	probably damaging	1.00
R2443:Hmcn1	UTSW	1	150,599,032 (GRCm38)	missense	probably benign	0.01
R2496:Hmcn1	UTSW	1	150,615,221 (GRCm38)	missense	probably benign	0.01
R2504:Hmcn1	UTSW	1	150,686,867 (GRCm38)	nonsense	probably null
R2519:Hmcn1	UTSW	1	150,773,820 (GRCm38)	nonsense	probably null
R2520:Hmcn1	UTSW	1	150,743,647 (GRCm38)	missense	possibly damaging	0.72
R2679:Hmcn1	UTSW	1	150,652,575 (GRCm38)	missense	possibly damaging	0.67
R2831:Hmcn1	UTSW	1	150,630,652 (GRCm38)	critical splice donor site	probably null
R2847:Hmcn1	UTSW	1	150,563,599 (GRCm38)	nonsense	probably null
R2849:Hmcn1	UTSW	1	150,563,599 (GRCm38)	nonsense	probably null
R2869:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2869:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2871:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2871:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2872:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2872:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2873:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2897:Hmcn1	UTSW	1	150,802,873 (GRCm38)	missense	probably damaging	1.00
R2905:Hmcn1	UTSW	1	150,749,035 (GRCm38)	missense	probably damaging	1.00
R3498:Hmcn1	UTSW	1	150,605,102 (GRCm38)	missense	probably damaging	0.98
R3499:Hmcn1	UTSW	1	150,605,102 (GRCm38)	missense	probably damaging	0.98
R3724:Hmcn1	UTSW	1	150,689,518 (GRCm38)	missense	possibly damaging	0.82
R3765:Hmcn1	UTSW	1	150,745,025 (GRCm38)	missense	possibly damaging	0.72
R3778:Hmcn1	UTSW	1	150,802,824 (GRCm38)	missense	possibly damaging	0.95
R3790:Hmcn1	UTSW	1	150,622,994 (GRCm38)	missense	probably benign	0.09
R3796:Hmcn1	UTSW	1	150,586,418 (GRCm38)	missense	probably damaging	1.00
R3811:Hmcn1	UTSW	1	150,649,577 (GRCm38)	critical splice donor site	probably null
R3825:Hmcn1	UTSW	1	150,586,965 (GRCm38)	missense	probably benign	0.28
R3890:Hmcn1	UTSW	1	150,635,195 (GRCm38)	missense	probably damaging	1.00
R3891:Hmcn1	UTSW	1	150,635,195 (GRCm38)	missense	probably damaging	1.00
R3892:Hmcn1	UTSW	1	150,635,195 (GRCm38)	missense	probably damaging	1.00
R3918:Hmcn1	UTSW	1	150,690,610 (GRCm38)	missense	probably benign	0.00
R3964:Hmcn1	UTSW	1	150,573,569 (GRCm38)	missense	probably benign	0.00
R4005:Hmcn1	UTSW	1	150,722,453 (GRCm38)	missense	possibly damaging	0.88
R4026:Hmcn1	UTSW	1	150,722,369 (GRCm38)	missense	probably benign	0.03
R4037:Hmcn1	UTSW	1	150,772,502 (GRCm38)	missense	probably benign	0.00
R4088:Hmcn1	UTSW	1	150,703,216 (GRCm38)	missense	possibly damaging	0.58
R4096:Hmcn1	UTSW	1	150,658,508 (GRCm38)	missense	probably benign	0.20
R4169:Hmcn1	UTSW	1	150,595,999 (GRCm38)	splice site	probably null
R4441:Hmcn1	UTSW	1	150,657,459 (GRCm38)	missense	probably null
R4493:Hmcn1	UTSW	1	150,701,899 (GRCm38)	missense	probably damaging	1.00
R4501:Hmcn1	UTSW	1	150,633,666 (GRCm38)	missense	probably damaging	1.00
R4535:Hmcn1	UTSW	1	150,563,780 (GRCm38)	missense	probably damaging	0.99
R4576:Hmcn1	UTSW	1	150,734,487 (GRCm38)	missense	probably benign
R4601:Hmcn1	UTSW	1	150,738,645 (GRCm38)	missense	probably damaging	0.99
R4627:Hmcn1	UTSW	1	150,595,894 (GRCm38)	missense	probably benign	0.11
R4647:Hmcn1	UTSW	1	150,675,511 (GRCm38)	critical splice donor site	probably null
R4657:Hmcn1	UTSW	1	150,624,550 (GRCm38)	missense	probably damaging	1.00
R4717:Hmcn1	UTSW	1	150,619,065 (GRCm38)	missense	probably benign	0.00
R4721:Hmcn1	UTSW	1	150,772,571 (GRCm38)	splice site	probably null
R4724:Hmcn1	UTSW	1	150,694,833 (GRCm38)	splice site	probably null
R4737:Hmcn1	UTSW	1	150,689,595 (GRCm38)	missense	possibly damaging	0.90
R4744:Hmcn1	UTSW	1	150,577,612 (GRCm38)	missense	probably damaging	1.00
R4795:Hmcn1	UTSW	1	150,753,611 (GRCm38)	missense	probably benign	0.00
R4796:Hmcn1	UTSW	1	150,753,611 (GRCm38)	missense	probably benign	0.00
R4871:Hmcn1	UTSW	1	150,593,085 (GRCm38)	missense	probably benign	0.02
R4895:Hmcn1	UTSW	1	150,677,379 (GRCm38)	missense	probably benign	0.00
R4934:Hmcn1	UTSW	1	150,722,535 (GRCm38)	missense	probably damaging	1.00
R4953:Hmcn1	UTSW	1	150,876,360 (GRCm38)	intron	probably benign
R4968:Hmcn1	UTSW	1	150,657,470 (GRCm38)	missense	possibly damaging	0.67
R4974:Hmcn1	UTSW	1	150,819,449 (GRCm38)	missense	probably benign	0.01
R5024:Hmcn1	UTSW	1	150,680,688 (GRCm38)	missense	possibly damaging	0.65
R5031:Hmcn1	UTSW	1	150,588,257 (GRCm38)	missense	probably damaging	1.00
R5093:Hmcn1	UTSW	1	150,737,256 (GRCm38)	missense	probably benign	0.14
R5096:Hmcn1	UTSW	1	150,610,669 (GRCm38)	missense	probably damaging	1.00
R5185:Hmcn1	UTSW	1	150,656,741 (GRCm38)	missense	probably benign	0.03
R5228:Hmcn1	UTSW	1	150,646,701 (GRCm38)	missense	probably benign	0.00
R5260:Hmcn1	UTSW	1	150,595,861 (GRCm38)	missense	possibly damaging	0.65
R5264:Hmcn1	UTSW	1	150,679,514 (GRCm38)	missense	probably benign	0.01
R5282:Hmcn1	UTSW	1	150,582,296 (GRCm38)	missense	probably damaging	1.00
R5334:Hmcn1	UTSW	1	150,755,372 (GRCm38)	missense	probably damaging	0.99
R5346:Hmcn1	UTSW	1	150,623,244 (GRCm38)	missense	probably damaging	1.00
R5423:Hmcn1	UTSW	1	150,701,972 (GRCm38)	missense	probably damaging	1.00
R5484:Hmcn1	UTSW	1	150,675,540 (GRCm38)	missense	probably benign	0.00
R5491:Hmcn1	UTSW	1	150,609,825 (GRCm38)	splice site	probably null
R5531:Hmcn1	UTSW	1	150,743,788 (GRCm38)	missense	probably damaging	1.00
R5536:Hmcn1	UTSW	1	150,755,291 (GRCm38)	missense	probably benign	0.01
R5547:Hmcn1	UTSW	1	150,737,506 (GRCm38)	missense	possibly damaging	0.64
R5580:Hmcn1	UTSW	1	150,577,539 (GRCm38)	missense	probably benign	0.43
R5626:Hmcn1	UTSW	1	150,656,567 (GRCm38)	missense	probably damaging	1.00
R5657:Hmcn1	UTSW	1	150,658,562 (GRCm38)	missense	probably benign	0.02
R5677:Hmcn1	UTSW	1	150,609,778 (GRCm38)	missense	probably benign	0.00
R5718:Hmcn1	UTSW	1	150,690,600 (GRCm38)	nonsense	probably null
R5718:Hmcn1	UTSW	1	150,609,666 (GRCm38)	missense	probably damaging	1.00
R5723:Hmcn1	UTSW	1	150,694,849 (GRCm38)	missense	possibly damaging	0.95
R5739:Hmcn1	UTSW	1	150,758,474 (GRCm38)	splice site	probably null
R5739:Hmcn1	UTSW	1	150,808,697 (GRCm38)	missense	probably benign	0.45
R5751:Hmcn1	UTSW	1	150,573,554 (GRCm38)	missense	probably damaging	1.00
R5772:Hmcn1	UTSW	1	150,694,878 (GRCm38)	missense	possibly damaging	0.47
R5804:Hmcn1	UTSW	1	150,674,347 (GRCm38)	nonsense	probably null
R5809:Hmcn1	UTSW	1	150,649,607 (GRCm38)	missense	probably damaging	1.00
R5817:Hmcn1	UTSW	1	150,737,524 (GRCm38)	missense	possibly damaging	0.77
R5824:Hmcn1	UTSW	1	150,993,023 (GRCm38)	missense	probably benign	0.12
R5881:Hmcn1	UTSW	1	150,630,327 (GRCm38)	missense	probably damaging	0.99
R5928:Hmcn1	UTSW	1	150,598,897 (GRCm38)	missense	possibly damaging	0.64
R5929:Hmcn1	UTSW	1	150,577,296 (GRCm38)	nonsense	probably null
R5940:Hmcn1	UTSW	1	150,657,222 (GRCm38)	missense	probably benign	0.41
R5973:Hmcn1	UTSW	1	150,563,817 (GRCm38)	missense	probably damaging	1.00
R5997:Hmcn1	UTSW	1	150,704,173 (GRCm38)	missense	possibly damaging	0.74
R6027:Hmcn1	UTSW	1	150,802,895 (GRCm38)	missense	possibly damaging	0.79
R6029:Hmcn1	UTSW	1	150,632,437 (GRCm38)	missense	probably benign	0.13
R6056:Hmcn1	UTSW	1	150,663,909 (GRCm38)	missense	probably damaging	1.00
R6065:Hmcn1	UTSW	1	150,770,330 (GRCm38)	missense	probably benign	0.06
R6083:Hmcn1	UTSW	1	150,755,294 (GRCm38)	missense	probably damaging	1.00
R6083:Hmcn1	UTSW	1	150,755,293 (GRCm38)	missense	probably damaging	1.00
R6108:Hmcn1	UTSW	1	150,631,227 (GRCm38)	missense	possibly damaging	0.95
R6112:Hmcn1	UTSW	1	150,618,936 (GRCm38)	missense	probably damaging	1.00
R6140:Hmcn1	UTSW	1	150,732,846 (GRCm38)	missense	probably damaging	1.00
R6144:Hmcn1	UTSW	1	150,722,424 (GRCm38)	missense	probably damaging	1.00
R6152:Hmcn1	UTSW	1	150,565,425 (GRCm38)	missense	probably damaging	1.00
R6174:Hmcn1	UTSW	1	150,646,784 (GRCm38)	missense	probably benign	0.06
R6185:Hmcn1	UTSW	1	150,615,438 (GRCm38)	splice site	probably null
R6187:Hmcn1	UTSW	1	150,630,728 (GRCm38)	missense	probably damaging	1.00
R6276:Hmcn1	UTSW	1	150,738,681 (GRCm38)	missense	possibly damaging	0.69
R6278:Hmcn1	UTSW	1	150,697,419 (GRCm38)	critical splice donor site	probably null
R6427:Hmcn1	UTSW	1	150,697,476 (GRCm38)	missense	possibly damaging	0.85
R6431:Hmcn1	UTSW	1	150,744,960 (GRCm38)	missense	probably benign	0.01
R6441:Hmcn1	UTSW	1	150,703,216 (GRCm38)	missense	possibly damaging	0.58
R6451:Hmcn1	UTSW	1	150,992,919 (GRCm38)	missense	probably damaging	1.00
R6478:Hmcn1	UTSW	1	150,664,784 (GRCm38)	missense	probably damaging	1.00
R6479:Hmcn1	UTSW	1	150,677,302 (GRCm38)	nonsense	probably null
R6490:Hmcn1	UTSW	1	150,583,278 (GRCm38)	missense	probably benign	0.00
R6525:Hmcn1	UTSW	1	150,697,566 (GRCm38)	missense	probably damaging	1.00
R6571:Hmcn1	UTSW	1	150,615,438 (GRCm38)	splice site	probably null
R6612:Hmcn1	UTSW	1	150,595,118 (GRCm38)	critical splice donor site	probably null
R6616:Hmcn1	UTSW	1	150,723,257 (GRCm38)	critical splice donor site	probably null
R6617:Hmcn1	UTSW	1	150,743,796 (GRCm38)	missense	probably benign	0.01
R6623:Hmcn1	UTSW	1	150,758,306 (GRCm38)	missense	probably benign
R6687:Hmcn1	UTSW	1	150,745,033 (GRCm38)	missense	probably benign	0.30
R6714:Hmcn1	UTSW	1	150,704,175 (GRCm38)	missense	probably damaging	0.97
R6751:Hmcn1	UTSW	1	150,734,518 (GRCm38)	missense	probably damaging	0.98
R6831:Hmcn1	UTSW	1	150,770,293 (GRCm38)	missense	probably benign	0.00
R6971:Hmcn1	UTSW	1	150,993,051 (GRCm38)	start codon destroyed	probably benign	0.00
R7048:Hmcn1	UTSW	1	150,599,653 (GRCm38)	critical splice acceptor site	probably null
R7058:Hmcn1	UTSW	1	150,773,890 (GRCm38)	missense	probably benign	0.43
R7071:Hmcn1	UTSW	1	150,604,102 (GRCm38)	missense	probably damaging	1.00
R7078:Hmcn1	UTSW	1	150,860,367 (GRCm38)	missense	probably damaging	1.00
R7092:Hmcn1	UTSW	1	150,604,246 (GRCm38)	missense	probably damaging	1.00
R7120:Hmcn1	UTSW	1	150,700,541 (GRCm38)	missense	probably damaging	0.98
R7129:Hmcn1	UTSW	1	150,577,210 (GRCm38)	splice site	probably null
R7144:Hmcn1	UTSW	1	150,663,873 (GRCm38)	missense	probably damaging	1.00
R7148:Hmcn1	UTSW	1	150,686,854 (GRCm38)	missense	probably benign	0.00
R7162:Hmcn1	UTSW	1	150,748,993 (GRCm38)	missense	probably benign	0.18
R7172:Hmcn1	UTSW	1	150,753,699 (GRCm38)	missense	possibly damaging	0.92
R7193:Hmcn1	UTSW	1	150,649,580 (GRCm38)	missense	probably null	1.00
R7231:Hmcn1	UTSW	1	150,638,876 (GRCm38)	missense	probably benign	0.00
R7237:Hmcn1	UTSW	1	150,722,643 (GRCm38)	missense	probably damaging	0.98
R7258:Hmcn1	UTSW	1	150,715,823 (GRCm38)	missense	probably benign	0.12
R7286:Hmcn1	UTSW	1	150,582,337 (GRCm38)	missense	probably damaging	0.98
R7289:Hmcn1	UTSW	1	150,683,715 (GRCm38)	missense	possibly damaging	0.52
R7292:Hmcn1	UTSW	1	150,733,129 (GRCm38)	splice site	probably null
R7316:Hmcn1	UTSW	1	150,732,946 (GRCm38)	missense	probably damaging	1.00
R7327:Hmcn1	UTSW	1	150,603,814 (GRCm38)	missense	probably benign	0.01
R7328:Hmcn1	UTSW	1	150,638,866 (GRCm38)	missense	possibly damaging	0.95
R7346:Hmcn1	UTSW	1	150,683,745 (GRCm38)	missense	probably damaging	1.00
R7351:Hmcn1	UTSW	1	150,667,889 (GRCm38)	missense	probably damaging	0.98
R7354:Hmcn1	UTSW	1	150,806,445 (GRCm38)	nonsense	probably null
R7360:Hmcn1	UTSW	1	150,618,846 (GRCm38)	missense	probably damaging	1.00
R7396:Hmcn1	UTSW	1	150,563,631 (GRCm38)	missense	possibly damaging	0.83
R7398:Hmcn1	UTSW	1	150,646,670 (GRCm38)	missense	probably benign	0.00
R7400:Hmcn1	UTSW	1	150,674,430 (GRCm38)	missense	probably damaging	1.00
R7404:Hmcn1	UTSW	1	150,720,759 (GRCm38)	missense	probably benign	0.00
R7424:Hmcn1	UTSW	1	150,630,266 (GRCm38)	nonsense	probably null
R7454:Hmcn1	UTSW	1	150,563,604 (GRCm38)	missense	probably damaging	1.00
R7476:Hmcn1	UTSW	1	150,580,267 (GRCm38)	missense	probably damaging	0.99
R7480:Hmcn1	UTSW	1	150,677,234 (GRCm38)	critical splice donor site	probably null
R7516:Hmcn1	UTSW	1	150,622,967 (GRCm38)	missense	probably benign	0.35
R7526:Hmcn1	UTSW	1	150,656,573 (GRCm38)	missense	probably damaging	1.00
R7531:Hmcn1	UTSW	1	150,686,780 (GRCm38)	missense	probably benign	0.06
R7555:Hmcn1	UTSW	1	150,604,874 (GRCm38)	missense	probably benign	0.40
R7564:Hmcn1	UTSW	1	150,655,835 (GRCm38)	missense	probably benign
R7588:Hmcn1	UTSW	1	150,657,134 (GRCm38)	missense	possibly damaging	0.90
R7719:Hmcn1	UTSW	1	150,565,329 (GRCm38)	missense	possibly damaging	0.95
R7720:Hmcn1	UTSW	1	150,646,709 (GRCm38)	missense	probably benign	0.00
R7722:Hmcn1	UTSW	1	150,667,880 (GRCm38)	missense	probably damaging	0.98
R7761:Hmcn1	UTSW	1	150,722,445 (GRCm38)	missense	possibly damaging	0.70
R7787:Hmcn1	UTSW	1	150,756,592 (GRCm38)	missense	probably damaging	1.00
R7803:Hmcn1	UTSW	1	150,770,279 (GRCm38)	missense	probably benign	0.32
R7862:Hmcn1	UTSW	1	150,806,421 (GRCm38)	missense	probably damaging	0.96
R7876:Hmcn1	UTSW	1	150,744,971 (GRCm38)	missense	probably benign	0.03
R7886:Hmcn1	UTSW	1	150,657,470 (GRCm38)	missense	possibly damaging	0.94
R7891:Hmcn1	UTSW	1	150,593,189 (GRCm38)	missense	probably damaging	1.00
R7892:Hmcn1	UTSW	1	150,664,892 (GRCm38)	missense	probably benign	0.00
R7927:Hmcn1	UTSW	1	150,609,775 (GRCm38)	missense	probably damaging	1.00
R7941:Hmcn1	UTSW	1	150,650,084 (GRCm38)	missense	possibly damaging	0.95
R7960:Hmcn1	UTSW	1	150,655,855 (GRCm38)	missense	probably damaging	1.00
R8001:Hmcn1	UTSW	1	150,664,878 (GRCm38)	nonsense	probably null
R8015:Hmcn1	UTSW	1	150,598,311 (GRCm38)	missense	possibly damaging	0.83
R8070:Hmcn1	UTSW	1	150,649,992 (GRCm38)	nonsense	probably null
R8072:Hmcn1	UTSW	1	150,656,505 (GRCm38)	missense	possibly damaging	0.62
R8113:Hmcn1	UTSW	1	150,749,090 (GRCm38)	missense	possibly damaging	0.50
R8143:Hmcn1	UTSW	1	150,859,206 (GRCm38)	missense	probably benign	0.03
R8145:Hmcn1	UTSW	1	150,753,660 (GRCm38)	missense	probably benign	0.33
R8155:Hmcn1	UTSW	1	150,604,954 (GRCm38)	missense	probably damaging	1.00
R8165:Hmcn1	UTSW	1	150,646,658 (GRCm38)	missense	probably benign	0.09
R8179:Hmcn1	UTSW	1	150,722,514 (GRCm38)	missense	probably benign	0.19
R8193:Hmcn1	UTSW	1	150,577,477 (GRCm38)	nonsense	probably null
R8234:Hmcn1	UTSW	1	150,594,010 (GRCm38)	missense	possibly damaging	0.83
R8249:Hmcn1	UTSW	1	150,819,366 (GRCm38)	missense	probably benign	0.24
R8267:Hmcn1	UTSW	1	150,859,254 (GRCm38)	missense	probably damaging	1.00
R8312:Hmcn1	UTSW	1	150,738,764 (GRCm38)	missense	probably damaging	0.99
R8338:Hmcn1	UTSW	1	150,738,734 (GRCm38)	missense	probably benign	0.35
R8354:Hmcn1	UTSW	1	150,758,391 (GRCm38)	missense	possibly damaging	0.79
R8440:Hmcn1	UTSW	1	150,694,920 (GRCm38)	missense	probably damaging	1.00
R8473:Hmcn1	UTSW	1	150,603,800 (GRCm38)	missense	possibly damaging	0.64
R8497:Hmcn1	UTSW	1	150,580,239 (GRCm38)	missense	probably benign	0.01
R8509:Hmcn1	UTSW	1	150,573,551 (GRCm38)	nonsense	probably null
R8559:Hmcn1	UTSW	1	150,676,038 (GRCm38)	missense	probably benign	0.25
R8701:Hmcn1	UTSW	1	150,755,257 (GRCm38)	missense	probably benign	0.00
R8755:Hmcn1	UTSW	1	150,633,620 (GRCm38)	missense	probably benign	0.19
R8765:Hmcn1	UTSW	1	150,680,662 (GRCm38)	missense	probably damaging	0.98
R8782:Hmcn1	UTSW	1	150,664,885 (GRCm38)	missense	probably benign	0.08
R8794:Hmcn1	UTSW	1	150,715,718 (GRCm38)	missense	probably benign	0.00
R8803:Hmcn1	UTSW	1	150,734,497 (GRCm38)	missense	probably damaging	1.00
R8808:Hmcn1	UTSW	1	150,655,819 (GRCm38)	missense	possibly damaging	0.64
R8853:Hmcn1	UTSW	1	150,671,975 (GRCm38)	missense	probably damaging	1.00
R8877:Hmcn1	UTSW	1	150,638,908 (GRCm38)	missense	probably benign	0.00
R8881:Hmcn1	UTSW	1	150,649,972 (GRCm38)	missense	probably damaging	1.00
R8916:Hmcn1	UTSW	1	150,773,779 (GRCm38)	missense	probably damaging	1.00
R9008:Hmcn1	UTSW	1	150,755,044 (GRCm38)	intron	probably benign
R9030:Hmcn1	UTSW	1	150,817,119 (GRCm38)	missense	probably benign	0.00
R9072:Hmcn1	UTSW	1	150,689,569 (GRCm38)	missense	probably benign	0.04
R9090:Hmcn1	UTSW	1	150,756,558 (GRCm38)	missense	probably damaging	1.00
R9096:Hmcn1	UTSW	1	150,657,118 (GRCm38)	missense	probably benign	0.04
R9102:Hmcn1	UTSW	1	150,697,580 (GRCm38)	missense	probably benign	0.01
R9146:Hmcn1	UTSW	1	150,598,390 (GRCm38)	missense	probably benign	0.02
R9157:Hmcn1	UTSW	1	150,646,592 (GRCm38)	missense	probably benign	0.06
R9169:Hmcn1	UTSW	1	150,630,341 (GRCm38)	missense	probably damaging	0.99
R9182:Hmcn1	UTSW	1	150,612,654 (GRCm38)	missense	probably damaging	1.00
R9182:Hmcn1	UTSW	1	150,624,586 (GRCm38)	nonsense	probably null
R9204:Hmcn1	UTSW	1	150,734,511 (GRCm38)	missense	probably benign	0.40
R9219:Hmcn1	UTSW	1	150,719,093 (GRCm38)	critical splice donor site	probably null
R9267:Hmcn1	UTSW	1	150,597,989 (GRCm38)	missense	probably benign	0.26
R9271:Hmcn1	UTSW	1	150,756,558 (GRCm38)	missense	probably damaging	1.00
R9274:Hmcn1	UTSW	1	150,630,295 (GRCm38)	missense	probably benign	0.01
R9313:Hmcn1	UTSW	1	150,646,592 (GRCm38)	missense	probably benign	0.06
R9414:Hmcn1	UTSW	1	150,669,436 (GRCm38)	missense	probably damaging	1.00
R9456:Hmcn1	UTSW	1	150,630,302 (GRCm38)	nonsense	probably null
R9464:Hmcn1	UTSW	1	150,723,497 (GRCm38)	missense	possibly damaging	0.80
R9474:Hmcn1	UTSW	1	150,630,720 (GRCm38)	missense	probably damaging	1.00
R9476:Hmcn1	UTSW	1	150,586,376 (GRCm38)	missense	probably benign	0.00
R9482:Hmcn1	UTSW	1	150,734,530 (GRCm38)	missense	probably benign	0.06
R9496:Hmcn1	UTSW	1	150,704,220 (GRCm38)	missense	probably benign	0.00
R9501:Hmcn1	UTSW	1	150,595,239 (GRCm38)	missense	possibly damaging	0.67
R9510:Hmcn1	UTSW	1	150,586,376 (GRCm38)	missense	probably benign	0.00
R9529:Hmcn1	UTSW	1	150,669,424 (GRCm38)	missense	probably damaging	1.00
R9566:Hmcn1	UTSW	1	150,622,909 (GRCm38)	missense	probably benign	0.00
R9608:Hmcn1	UTSW	1	150,599,552 (GRCm38)	missense	probably damaging	1.00
R9609:Hmcn1	UTSW	1	150,679,595 (GRCm38)	missense	probably damaging	0.96
R9616:Hmcn1	UTSW	1	150,808,722 (GRCm38)	missense	probably benign	0.16
R9627:Hmcn1	UTSW	1	150,630,303 (GRCm38)	missense	probably damaging	1.00
R9668:Hmcn1	UTSW	1	150,743,741 (GRCm38)	missense	probably benign	0.02
R9686:Hmcn1	UTSW	1	150,737,605 (GRCm38)	missense	probably damaging	0.99
R9717:Hmcn1	UTSW	1	150,609,627 (GRCm38)	missense	probably damaging	1.00
R9727:Hmcn1	UTSW	1	150,798,815 (GRCm38)	missense	probably benign	0.06
R9744:Hmcn1	UTSW	1	150,748,190 (GRCm38)	missense	probably damaging	1.00
R9749:Hmcn1	UTSW	1	150,756,588 (GRCm38)	missense	possibly damaging	0.94
R9761:Hmcn1	UTSW	1	150,992,874 (GRCm38)	missense	probably damaging	0.98
R9783:Hmcn1	UTSW	1	150,722,629 (GRCm38)	missense	probably benign	0.16
R9788:Hmcn1	UTSW	1	150,652,582 (GRCm38)	missense	probably benign	0.00
R9792:Hmcn1	UTSW	1	150,732,938 (GRCm38)	missense	possibly damaging	0.94
R9793:Hmcn1	UTSW	1	150,732,938 (GRCm38)	missense	possibly damaging	0.94
R9795:Hmcn1	UTSW	1	150,732,938 (GRCm38)	missense	possibly damaging	0.94
R9802:Hmcn1	UTSW	1	150,808,640 (GRCm38)	missense	probably benign	0.07
RF003:Hmcn1	UTSW	1	150,624,561 (GRCm38)	missense	probably damaging	1.00
RF005:Hmcn1	UTSW	1	150,635,146 (GRCm38)	nonsense	probably null
X0022:Hmcn1	UTSW	1	150,700,530 (GRCm38)	missense	probably benign	0.04
X0027:Hmcn1	UTSW	1	150,860,376 (GRCm38)	missense	probably damaging	1.00
X0028:Hmcn1	UTSW	1	150,663,901 (GRCm38)	missense	probably damaging	1.00
Z1088:Hmcn1	UTSW	1	150,648,937 (GRCm38)	missense	probably damaging	1.00
Z1176:Hmcn1	UTSW	1	150,663,917 (GRCm38)	missense	probably benign	0.12
Z1176:Hmcn1	UTSW	1	150,655,921 (GRCm38)	missense	possibly damaging	0.65
Z1176:Hmcn1	UTSW	1	150,586,445 (GRCm38)	missense	probably null	0.92

Predicted Primers

PCR Primer
(F):5'- AGCATGGACTCACTGTTGCC -3'
(R):5'- TCACTCGGCCATGGTTTGAC -3'

Sequencing Primer
(F):5'- GTTGCCAACACTCACTTGGAC -3'
(R):5'- CTCTGAATTTGCAGGCAGC -3'

Posted On

2014-10-16