Incidental Mutation 'R2267:Mrc2'
| ID |
242155 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc2
|
| Ensembl Gene |
ENSMUSG00000020695 |
| Gene Name |
mannose receptor, C type 2 |
| Synonyms |
Endo180, uPARAP, novel lectin |
| MMRRC Submission |
040267-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2267 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
105183469-105241965 bp(+) (GRCm39) |
| Type of Mutation |
splice site (5 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 105239257 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021038]
[ENSMUST00000100335]
|
| AlphaFold |
Q64449 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021038
|
| SMART Domains |
Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100335
|
| SMART Domains |
Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
CLECT
|
971 |
1107 |
3.91e-36 |
SMART |
|
CLECT
|
1124 |
1243 |
1.04e-17 |
SMART |
|
CLECT
|
1259 |
1392 |
9.08e-23 |
SMART |
|
transmembrane domain
|
1412 |
1434 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
98% (108/110) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadac |
T |
A |
3: 59,944,737 (GRCm39) |
D136E |
probably damaging |
Het |
| Abca16 |
A |
G |
7: 120,030,383 (GRCm39) |
D165G |
probably benign |
Het |
| Abca8b |
G |
A |
11: 109,845,974 (GRCm39) |
T820M |
probably benign |
Het |
| Acot2 |
C |
T |
12: 84,037,334 (GRCm39) |
A216V |
probably damaging |
Het |
| Agap2 |
T |
A |
10: 126,918,297 (GRCm39) |
|
probably benign |
Het |
| Ak7 |
T |
C |
12: 105,713,473 (GRCm39) |
V419A |
probably benign |
Het |
| Apmap |
A |
G |
2: 150,430,821 (GRCm39) |
|
probably null |
Het |
| Apob |
T |
C |
12: 8,065,475 (GRCm39) |
F4115S |
possibly damaging |
Het |
| Cachd1 |
T |
A |
4: 100,806,266 (GRCm39) |
|
probably benign |
Het |
| Ccdc39 |
T |
A |
3: 33,869,633 (GRCm39) |
E731D |
probably damaging |
Het |
| Ces2a |
A |
T |
8: 105,466,822 (GRCm39) |
I65F |
probably benign |
Het |
| Commd8 |
A |
G |
5: 72,322,765 (GRCm39) |
W51R |
probably damaging |
Het |
| D2hgdh |
C |
T |
1: 93,763,157 (GRCm39) |
A314V |
probably damaging |
Het |
| Dcun1d4 |
T |
A |
5: 73,638,618 (GRCm39) |
|
probably benign |
Het |
| Dgke |
T |
A |
11: 88,943,295 (GRCm39) |
E231D |
probably benign |
Het |
| Dhrs9 |
A |
G |
2: 69,223,197 (GRCm39) |
|
probably benign |
Het |
| Dhx30 |
C |
T |
9: 109,916,102 (GRCm39) |
G662R |
probably damaging |
Het |
| Dipk2b |
A |
G |
X: 18,289,926 (GRCm39) |
S179P |
possibly damaging |
Het |
| Dnah7b |
T |
A |
1: 46,273,075 (GRCm39) |
M2401K |
probably damaging |
Het |
| Dnmt3a |
T |
A |
12: 3,947,551 (GRCm39) |
|
probably null |
Het |
| Dst |
C |
T |
1: 34,334,547 (GRCm39) |
T4874I |
probably damaging |
Het |
| Eef2kmt |
G |
A |
16: 5,073,804 (GRCm39) |
|
probably benign |
Het |
| Ess2 |
T |
C |
16: 17,727,859 (GRCm39) |
T107A |
probably damaging |
Het |
| Etfa |
A |
T |
9: 55,394,015 (GRCm39) |
L212Q |
probably damaging |
Het |
| Exosc5 |
T |
C |
7: 25,363,809 (GRCm39) |
L107P |
possibly damaging |
Het |
| Fam117b |
T |
C |
1: 59,952,789 (GRCm39) |
L156P |
probably damaging |
Het |
| Fam186b |
T |
G |
15: 99,183,524 (GRCm39) |
D40A |
probably damaging |
Het |
| Fga |
T |
C |
3: 82,940,257 (GRCm39) |
L637P |
probably damaging |
Het |
| Foxn4 |
T |
C |
5: 114,393,662 (GRCm39) |
T486A |
probably damaging |
Het |
| Gcc1 |
A |
G |
6: 28,418,498 (GRCm39) |
S612P |
probably benign |
Het |
| Gjd3 |
C |
T |
11: 98,873,227 (GRCm39) |
V206M |
probably damaging |
Het |
| Gpam |
A |
T |
19: 55,061,142 (GRCm39) |
|
probably null |
Het |
| Gpc6 |
A |
T |
14: 118,125,932 (GRCm39) |
|
probably null |
Het |
| Gphb5 |
C |
G |
12: 75,459,720 (GRCm39) |
V92L |
probably benign |
Het |
| Grid2ip |
C |
T |
5: 143,371,847 (GRCm39) |
P690L |
probably benign |
Het |
| Gsdmc |
T |
C |
15: 63,648,647 (GRCm39) |
E429G |
probably benign |
Het |
| H2bc9 |
T |
C |
13: 23,727,162 (GRCm39) |
K121E |
possibly damaging |
Het |
| Heatr5a |
T |
C |
12: 51,940,528 (GRCm39) |
D1444G |
possibly damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,474,761 (GRCm39) |
S4709G |
probably benign |
Het |
| Hr |
A |
T |
14: 70,795,547 (GRCm39) |
D393V |
probably benign |
Het |
| Ido2 |
T |
C |
8: 25,025,268 (GRCm39) |
Y253C |
probably damaging |
Het |
| Itgal |
A |
G |
7: 126,905,873 (GRCm39) |
I352V |
possibly damaging |
Het |
| Itih4 |
A |
G |
14: 30,614,385 (GRCm39) |
D445G |
probably damaging |
Het |
| Kcnh8 |
GAGACCAACGAGCAGCTGATGCTTCAGA |
GAGA |
17: 53,032,934 (GRCm39) |
74 |
probably benign |
Het |
| Kcnt2 |
G |
A |
1: 140,501,421 (GRCm39) |
|
probably null |
Het |
| Klk1b21 |
T |
C |
7: 43,753,863 (GRCm39) |
I49T |
possibly damaging |
Het |
| Klrb1 |
A |
T |
6: 128,699,937 (GRCm39) |
S25T |
probably damaging |
Het |
| L3mbtl3 |
C |
T |
10: 26,207,755 (GRCm39) |
W321* |
probably null |
Het |
| Lama2 |
T |
A |
10: 26,868,932 (GRCm39) |
I2838F |
probably damaging |
Het |
| Lrrtm1 |
C |
A |
6: 77,220,996 (GRCm39) |
A151E |
probably damaging |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Magi3 |
G |
A |
3: 103,928,382 (GRCm39) |
|
probably benign |
Het |
| Mamdc2 |
A |
T |
19: 23,281,267 (GRCm39) |
|
probably benign |
Het |
| Mcc |
T |
C |
18: 44,652,608 (GRCm39) |
D272G |
probably damaging |
Het |
| Mgst3 |
T |
A |
1: 167,201,368 (GRCm39) |
T106S |
probably benign |
Het |
| Mink1 |
G |
A |
11: 70,492,550 (GRCm39) |
|
probably null |
Het |
| Mlh3 |
G |
T |
12: 85,307,585 (GRCm39) |
H1181N |
possibly damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,121,449 (GRCm39) |
K773R |
probably benign |
Het |
| Mro |
T |
C |
18: 74,006,368 (GRCm39) |
I104T |
probably benign |
Het |
| Mtbp |
G |
A |
15: 55,432,556 (GRCm39) |
|
probably null |
Het |
| Mtss2 |
A |
G |
8: 111,455,362 (GRCm39) |
K92E |
possibly damaging |
Het |
| Mybphl |
A |
G |
3: 108,272,317 (GRCm39) |
E2G |
probably damaging |
Het |
| Nbeal1 |
T |
A |
1: 60,370,037 (GRCm39) |
|
probably benign |
Het |
| Neurod2 |
C |
A |
11: 98,218,582 (GRCm39) |
C194F |
probably damaging |
Het |
| Nr4a2 |
T |
A |
2: 57,002,018 (GRCm39) |
D145V |
possibly damaging |
Het |
| Ntmt1 |
C |
A |
2: 30,710,472 (GRCm39) |
N58K |
probably benign |
Het |
| Nup205 |
T |
C |
6: 35,218,284 (GRCm39) |
S1819P |
possibly damaging |
Het |
| Obsl1 |
T |
C |
1: 75,482,342 (GRCm39) |
H176R |
probably damaging |
Het |
| Or51f1d |
G |
A |
7: 102,701,344 (GRCm39) |
V280I |
probably benign |
Het |
| Or7g21 |
A |
T |
9: 19,032,737 (GRCm39) |
H162L |
probably benign |
Het |
| Or8d2b |
A |
G |
9: 38,789,359 (GRCm39) |
T296A |
probably benign |
Het |
| P2ry13 |
T |
C |
3: 59,117,449 (GRCm39) |
M110V |
probably damaging |
Het |
| P2ry14 |
T |
C |
3: 59,022,992 (GRCm39) |
N165S |
probably damaging |
Het |
| Phka1 |
A |
G |
X: 101,584,716 (GRCm39) |
|
probably benign |
Het |
| Plxnd1 |
A |
G |
6: 115,939,704 (GRCm39) |
V1425A |
probably benign |
Het |
| Ppp2ca |
G |
A |
11: 52,008,913 (GRCm39) |
G138R |
probably damaging |
Het |
| Ptpn12 |
A |
T |
5: 21,203,409 (GRCm39) |
N456K |
probably damaging |
Het |
| Scarb1 |
A |
T |
5: 125,364,439 (GRCm39) |
S97T |
possibly damaging |
Het |
| Scyl1 |
C |
T |
19: 5,811,749 (GRCm39) |
D440N |
possibly damaging |
Het |
| Sema5a |
C |
A |
15: 32,575,065 (GRCm39) |
T391K |
probably benign |
Het |
| Sipa1l3 |
T |
A |
7: 29,099,027 (GRCm39) |
N414I |
probably damaging |
Het |
| Skint6 |
T |
C |
4: 112,700,019 (GRCm39) |
|
probably null |
Het |
| Slc35a3 |
T |
C |
3: 116,467,285 (GRCm39) |
K325E |
possibly damaging |
Het |
| Spag17 |
C |
A |
3: 99,969,182 (GRCm39) |
|
probably null |
Het |
| Spib |
T |
A |
7: 44,178,348 (GRCm39) |
M141L |
probably benign |
Het |
| Srebf1 |
A |
G |
11: 60,097,973 (GRCm39) |
S44P |
probably damaging |
Het |
| Styk1 |
T |
C |
6: 131,289,539 (GRCm39) |
E25G |
probably benign |
Het |
| Taar8b |
T |
C |
10: 23,967,270 (GRCm39) |
N308S |
probably damaging |
Het |
| Taf15 |
T |
G |
11: 83,388,088 (GRCm39) |
S200R |
probably damaging |
Het |
| Tanc1 |
G |
A |
2: 59,667,563 (GRCm39) |
|
probably null |
Het |
| Tas2r134 |
A |
G |
2: 51,518,249 (GRCm39) |
T243A |
probably benign |
Het |
| Tatdn1 |
A |
T |
15: 58,777,601 (GRCm39) |
M218K |
probably damaging |
Het |
| Tbc1d14 |
A |
G |
5: 36,700,561 (GRCm39) |
L269P |
possibly damaging |
Het |
| Tbx1 |
T |
C |
16: 18,400,744 (GRCm39) |
|
probably null |
Het |
| Tgfbr3l |
A |
G |
8: 4,300,506 (GRCm39) |
E228G |
probably benign |
Het |
| Tmem233 |
G |
C |
5: 116,189,517 (GRCm39) |
|
probably benign |
Het |
| Tmprss11d |
A |
G |
5: 86,521,208 (GRCm39) |
Y2H |
probably benign |
Het |
| Trps1 |
G |
A |
15: 50,685,794 (GRCm39) |
R544C |
probably damaging |
Het |
| Ttc22 |
T |
C |
4: 106,496,282 (GRCm39) |
V444A |
possibly damaging |
Het |
| Ttc28 |
A |
G |
5: 111,373,869 (GRCm39) |
T1071A |
possibly damaging |
Het |
| Tymp |
A |
T |
15: 89,258,011 (GRCm39) |
V378D |
probably damaging |
Het |
| Ube2j1 |
T |
A |
4: 33,049,943 (GRCm39) |
F257I |
possibly damaging |
Het |
| Vmn2r18 |
T |
C |
5: 151,510,127 (GRCm39) |
E82G |
probably damaging |
Het |
| Wwp1 |
T |
C |
4: 19,638,618 (GRCm39) |
D575G |
probably damaging |
Het |
|
| Other mutations in Mrc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01105:Mrc2
|
APN |
11 |
105,219,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01374:Mrc2
|
APN |
11 |
105,238,469 (GRCm39) |
nonsense |
probably null |
|
|
IGL01751:Mrc2
|
APN |
11 |
105,216,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01780:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Mrc2
|
APN |
11 |
105,227,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02357:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Mrc2
|
APN |
11 |
105,227,533 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02863:Mrc2
|
APN |
11 |
105,224,446 (GRCm39) |
splice site |
probably benign |
|
|
IGL02940:Mrc2
|
APN |
11 |
105,231,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Mrc2
|
UTSW |
11 |
105,216,397 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0254:Mrc2
|
UTSW |
11 |
105,238,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Mrc2
|
UTSW |
11 |
105,238,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1102:Mrc2
|
UTSW |
11 |
105,231,647 (GRCm39) |
missense |
probably benign |
|
|
R1233:Mrc2
|
UTSW |
11 |
105,239,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R1458:Mrc2
|
UTSW |
11 |
105,228,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1500:Mrc2
|
UTSW |
11 |
105,238,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1573:Mrc2
|
UTSW |
11 |
105,227,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Mrc2
|
UTSW |
11 |
105,229,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1842:Mrc2
|
UTSW |
11 |
105,228,546 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2156:Mrc2
|
UTSW |
11 |
105,238,682 (GRCm39) |
splice site |
probably null |
|
|
R2165:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2265:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2266:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2269:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2270:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2271:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2272:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2296:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2298:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2300:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2326:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2518:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2519:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2520:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2895:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3029:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3030:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3079:Mrc2
|
UTSW |
11 |
105,227,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3149:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3150:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3420:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3422:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3441:Mrc2
|
UTSW |
11 |
105,238,542 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3726:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3731:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3800:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3820:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3821:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3837:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3838:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3849:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3850:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Mrc2
|
UTSW |
11 |
105,238,058 (GRCm39) |
splice site |
probably benign |
|
|
R3932:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3933:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3971:Mrc2
|
UTSW |
11 |
105,218,857 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4105:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4107:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4113:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4274:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4399:Mrc2
|
UTSW |
11 |
105,227,484 (GRCm39) |
nonsense |
probably null |
|
|
R4477:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4478:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4493:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4494:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4495:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4547:Mrc2
|
UTSW |
11 |
105,227,467 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4600:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4601:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4602:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4603:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4610:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4611:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4637:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4672:Mrc2
|
UTSW |
11 |
105,233,923 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4674:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4675:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4693:Mrc2
|
UTSW |
11 |
105,234,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4706:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4707:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4791:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4792:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4888:Mrc2
|
UTSW |
11 |
105,232,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5523:Mrc2
|
UTSW |
11 |
105,234,408 (GRCm39) |
missense |
probably benign |
|
|
R5600:Mrc2
|
UTSW |
11 |
105,224,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Mrc2
|
UTSW |
11 |
105,227,040 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Mrc2
|
UTSW |
11 |
105,227,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5706:Mrc2
|
UTSW |
11 |
105,223,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5775:Mrc2
|
UTSW |
11 |
105,228,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Mrc2
|
UTSW |
11 |
105,237,615 (GRCm39) |
missense |
probably benign |
|
|
R6146:Mrc2
|
UTSW |
11 |
105,216,470 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6225:Mrc2
|
UTSW |
11 |
105,237,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6437:Mrc2
|
UTSW |
11 |
105,240,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Mrc2
|
UTSW |
11 |
105,240,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Mrc2
|
UTSW |
11 |
105,233,906 (GRCm39) |
splice site |
probably null |
|
|
R6680:Mrc2
|
UTSW |
11 |
105,216,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6868:Mrc2
|
UTSW |
11 |
105,219,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Mrc2
|
UTSW |
11 |
105,239,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7038:Mrc2
|
UTSW |
11 |
105,223,062 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7303:Mrc2
|
UTSW |
11 |
105,216,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7320:Mrc2
|
UTSW |
11 |
105,220,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7422:Mrc2
|
UTSW |
11 |
105,183,609 (GRCm39) |
start gained |
probably benign |
|
|
R7537:Mrc2
|
UTSW |
11 |
105,183,623 (GRCm39) |
missense |
probably benign |
|
|
R7640:Mrc2
|
UTSW |
11 |
105,223,121 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7709:Mrc2
|
UTSW |
11 |
105,237,285 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7885:Mrc2
|
UTSW |
11 |
105,223,092 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7976:Mrc2
|
UTSW |
11 |
105,238,829 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8042:Mrc2
|
UTSW |
11 |
105,239,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8096:Mrc2
|
UTSW |
11 |
105,234,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8519:Mrc2
|
UTSW |
11 |
105,238,132 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8771:Mrc2
|
UTSW |
11 |
105,240,596 (GRCm39) |
missense |
probably benign |
|
|
R8787:Mrc2
|
UTSW |
11 |
105,238,465 (GRCm39) |
missense |
probably benign |
|
|
R8925:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8927:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8991:Mrc2
|
UTSW |
11 |
105,229,740 (GRCm39) |
missense |
probably benign |
|
|
R9017:Mrc2
|
UTSW |
11 |
105,216,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9096:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9097:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Mrc2
|
UTSW |
11 |
105,220,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9471:Mrc2
|
UTSW |
11 |
105,234,559 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9531:Mrc2
|
UTSW |
11 |
105,240,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
T0970:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0004:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0062:Mrc2
|
UTSW |
11 |
105,238,301 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,238,186 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,232,202 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTGCACTTGAGCTGCCAG -3'
(R):5'- TGTGGAAGGAACCCATTGG -3'
Sequencing Primer
(F):5'- GGTCTATCACCATAAGGAGAATCTGC -3'
(R):5'- CCATTGGGAAGGTGTGGGAATG -3'
|
| Posted On |
2014-10-16 |
Incidental Mutation