Incidental Mutation 'R2271:Adam22'
ID 242460
Institutional Source Beutler Lab
Gene Symbol Adam22
Ensembl Gene ENSMUSG00000040537
Gene Name a disintegrin and metallopeptidase domain 22
Synonyms MDC2, 2900022I03Rik
MMRRC Submission 040271-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2271 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 8122352-8418160 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 8171108 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 614 (E614G)
Ref Sequence ENSEMBL: ENSMUSP00000111044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046838] [ENSMUST00000050166] [ENSMUST00000088744] [ENSMUST00000088761] [ENSMUST00000115386] [ENSMUST00000115388] [ENSMUST00000123168] [ENSMUST00000144241] [ENSMUST00000130315] [ENSMUST00000136808] [ENSMUST00000153889] [ENSMUST00000136524] [ENSMUST00000139048] [ENSMUST00000139841] [ENSMUST00000153427] [ENSMUST00000154935] [ENSMUST00000126384] [ENSMUST00000197700] [ENSMUST00000199853]
AlphaFold Q9R1V6
Predicted Effect probably benign
Transcript: ENSMUST00000046838
AA Change: E614G

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000049120
Gene: ENSMUSG00000040537
AA Change: E614G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 7e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 9.3e-9 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 789 808 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000050166
AA Change: E614G

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000055000
Gene: ENSMUSG00000040537
AA Change: E614G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 7.6e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.1e-8 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3.4e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 824 839 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088744
AA Change: E614G

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000086122
Gene: ENSMUSG00000040537
AA Change: E614G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 41 186 4.2e-29 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.2e-8 PFAM
Pfam:Reprolysin 237 436 2.9e-65 PFAM
Pfam:Reprolysin_3 261 378 9.2e-13 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 736 758 N/A INTRINSIC
low complexity region 785 800 N/A INTRINSIC
low complexity region 883 898 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088761
AA Change: E614G

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000086139
Gene: ENSMUSG00000040537
AA Change: E614G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 8.1e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.2e-8 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3.6e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 789 808 N/A INTRINSIC
low complexity region 860 875 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115386
AA Change: E614G

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000111044
Gene: ENSMUSG00000040537
AA Change: E614G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 3.4e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 5.1e-9 PFAM
Pfam:Reprolysin 237 436 5e-59 PFAM
Pfam:Reprolysin_3 261 379 1.6e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 850 870 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115388
AA Change: E614G

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000111046
Gene: ENSMUSG00000040537
AA Change: E614G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Pep_M12B_propep 44 186 8e-27 PFAM
low complexity region 214 230 N/A INTRINSIC
Pfam:Reprolysin_5 235 405 1.1e-8 PFAM
Pfam:Reprolysin 237 436 1.1e-58 PFAM
Pfam:Reprolysin_3 261 379 3.5e-12 PFAM
DISIN 451 527 3.38e-31 SMART
ACR 528 669 3.05e-58 SMART
EGF 676 710 1.28e1 SMART
transmembrane domain 735 757 N/A INTRINSIC
low complexity region 852 872 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000123168
SMART Domains Protein: ENSMUSP00000122758
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 123 143 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000144241
SMART Domains Protein: ENSMUSP00000138353
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 75 94 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130315
SMART Domains Protein: ENSMUSP00000121156
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 150 170 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000136808
SMART Domains Protein: ENSMUSP00000122426
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 83 98 N/A INTRINSIC
low complexity region 207 227 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153889
SMART Domains Protein: ENSMUSP00000123196
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 81 100 N/A INTRINSIC
low complexity region 152 167 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000136524
SMART Domains Protein: ENSMUSP00000116422
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 152 172 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139048
SMART Domains Protein: ENSMUSP00000116736
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 81 100 N/A INTRINSIC
low complexity region 186 206 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139841
SMART Domains Protein: ENSMUSP00000115775
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 144 164 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153427
SMART Domains Protein: ENSMUSP00000120995
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 75 94 N/A INTRINSIC
low complexity region 209 229 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000154935
SMART Domains Protein: ENSMUSP00000119409
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 83 98 N/A INTRINSIC
low complexity region 225 245 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124121
SMART Domains Protein: ENSMUSP00000122652
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
Blast:ACR 2 52 5e-28 BLAST
EGF 59 93 1.28e1 SMART
transmembrane domain 118 140 N/A INTRINSIC
low complexity region 207 222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000126384
SMART Domains Protein: ENSMUSP00000118571
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 83 98 N/A INTRINSIC
low complexity region 181 196 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000197700
SMART Domains Protein: ENSMUSP00000142580
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
low complexity region 129 145 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000199853
SMART Domains Protein: ENSMUSP00000143097
Gene: ENSMUSG00000040537

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik T A 10: 28,857,575 (GRCm39) Q194L probably damaging Het
Acsf2 T A 11: 94,449,699 (GRCm39) K574* probably null Het
Ap4e1 T C 2: 126,889,083 (GRCm39) probably null Het
Arid3c T A 4: 41,724,744 (GRCm39) I364F probably damaging Het
Bcan T A 3: 87,900,401 (GRCm39) S611C probably damaging Het
Birc6 T C 17: 74,909,966 (GRCm39) V1453A probably benign Het
Carnmt1 T C 19: 18,680,734 (GRCm39) L336P probably damaging Het
Ccdc146 C A 5: 21,604,719 (GRCm39) D40Y probably benign Het
Ccdc83 C T 7: 89,873,285 (GRCm39) V357I probably damaging Het
Cdh22 A T 2: 164,985,767 (GRCm39) probably null Het
Cdk5rap2 A C 4: 70,184,915 (GRCm39) S1178R probably benign Het
Cdkl3 T C 11: 51,923,322 (GRCm39) V45A probably benign Het
Chd7 A G 4: 8,785,532 (GRCm39) D612G probably damaging Het
Chst11 T C 10: 83,027,004 (GRCm39) Y144H probably damaging Het
Cops6 A T 5: 138,159,403 (GRCm39) N10I probably benign Het
Cyfip1 G T 7: 55,549,705 (GRCm39) R624L probably null Het
Cyp27a1 A G 1: 74,775,846 (GRCm39) N344D probably damaging Het
Des T G 1: 75,340,137 (GRCm39) M348R probably damaging Het
Dis3l T A 9: 64,238,165 (GRCm39) D109V probably damaging Het
Disp3 C T 4: 148,356,059 (GRCm39) R267Q possibly damaging Het
Dnah3 T A 7: 119,574,352 (GRCm39) I2136F probably benign Het
Dnah9 T C 11: 66,003,188 (GRCm39) D872G probably benign Het
Dnajb14 G A 3: 137,591,141 (GRCm39) G31S probably benign Het
Dop1a T G 9: 86,376,471 (GRCm39) V235G probably damaging Het
Efcab6 T A 15: 83,831,200 (GRCm39) R571S probably benign Het
Emsy T G 7: 98,275,830 (GRCm39) K352N probably damaging Het
Erbb4 T C 1: 68,238,047 (GRCm39) N814S probably damaging Het
Fgfbp1 T A 5: 44,136,672 (GRCm39) M207L probably benign Het
Filip1 T C 9: 79,727,212 (GRCm39) E469G probably damaging Het
Garem2 T G 5: 30,321,972 (GRCm39) L777R probably damaging Het
Garin5b T A 7: 4,761,186 (GRCm39) T509S probably benign Het
Hkdc1 T C 10: 62,253,677 (GRCm39) T35A probably benign Het
Hps6 C T 19: 45,994,121 (GRCm39) A686V possibly damaging Het
Irs1 T C 1: 82,266,180 (GRCm39) S679G probably benign Het
Ism1 T A 2: 139,599,293 (GRCm39) I415N probably damaging Het
Kdm1b TCATTGTCC TCATTGTCCATTGTCC 13: 47,217,564 (GRCm39) probably null Het
Kpna1 G A 16: 35,851,591 (GRCm39) A392T probably damaging Het
Lipa T A 19: 34,488,290 (GRCm39) R119* probably null Het
Lrrc37 T C 11: 103,505,033 (GRCm39) T2312A possibly damaging Het
Mocs1 A T 17: 49,756,137 (GRCm39) K198M probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Msh5 A G 17: 35,263,366 (GRCm39) I154T probably benign Het
Muc6 T A 7: 141,217,423 (GRCm39) T2417S possibly damaging Het
Ncbp2 T C 16: 31,775,769 (GRCm39) Y138H probably damaging Het
Ndufv1 C A 19: 4,058,347 (GRCm39) R359L probably benign Het
Neu3 G C 7: 99,462,650 (GRCm39) R358G probably benign Het
Ntrk3 A C 7: 78,166,471 (GRCm39) probably null Het
Or1n1 G A 2: 36,749,637 (GRCm39) S241F probably damaging Het
Or8b12i T A 9: 20,082,705 (GRCm39) H54L possibly damaging Het
Or8j3 A G 2: 86,028,161 (GRCm39) F312L probably benign Het
Pik3c2b T C 1: 133,031,166 (GRCm39) S1491P probably benign Het
Plb1 G T 5: 32,450,586 (GRCm39) D376Y probably damaging Het
Plch1 T A 3: 63,651,956 (GRCm39) K378N probably damaging Het
Plekhm1 C T 11: 103,277,948 (GRCm39) E383K probably benign Het
Plxnb1 T C 9: 108,931,776 (GRCm39) probably null Het
Prkdc A G 16: 15,472,681 (GRCm39) probably null Het
Prpf8 T A 11: 75,386,189 (GRCm39) V946E probably damaging Het
Psma5-ps A G 10: 85,149,595 (GRCm39) noncoding transcript Het
Ptprh C A 7: 4,606,132 (GRCm39) probably benign Het
Rngtt T A 4: 33,500,302 (GRCm39) C565* probably null Het
Sacs A G 14: 61,442,109 (GRCm39) H1385R probably benign Het
Sec24a A G 11: 51,607,277 (GRCm39) S656P possibly damaging Het
Serpinb13 A T 1: 106,926,756 (GRCm39) I251L possibly damaging Het
Shc1 G A 3: 89,330,849 (GRCm39) G91S probably damaging Het
Sin3b T A 8: 73,460,047 (GRCm39) N211K probably benign Het
Slc22a2 A T 17: 12,805,692 (GRCm39) M148L probably benign Het
Slc3a1 G A 17: 85,371,220 (GRCm39) V591I probably benign Het
Slc47a2 A T 11: 61,219,352 (GRCm39) probably null Het
Spag17 C T 3: 100,014,113 (GRCm39) P2129S probably damaging Het
Specc1l C T 10: 75,081,438 (GRCm39) S278F probably damaging Het
Sphkap T A 1: 83,234,942 (GRCm39) D1628V probably damaging Het
Themis3 C T 17: 66,862,699 (GRCm39) V420I possibly damaging Het
Ttc39d A G 17: 80,524,675 (GRCm39) K445E probably damaging Het
U2surp T C 9: 95,373,473 (GRCm39) E232G possibly damaging Het
Usp25 T A 16: 76,873,317 (GRCm39) F458L probably damaging Het
Usp7 T C 16: 8,516,333 (GRCm39) S649G probably benign Het
Vmn1r10 A G 6: 57,091,088 (GRCm39) T227A probably damaging Het
Zcchc12 C T X: 35,462,118 (GRCm39) T345M possibly damaging Het
Zfp444 T C 7: 6,192,554 (GRCm39) C191R probably damaging Het
Zfp729b A T 13: 67,740,352 (GRCm39) C648S probably damaging Het
Zfp799 A G 17: 33,040,777 (GRCm39) Y58H probably damaging Het
Zfp938 C T 10: 82,061,381 (GRCm39) G413D probably damaging Het
Other mutations in Adam22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01325:Adam22 APN 5 8,177,333 (GRCm39) missense probably benign 0.44
IGL01368:Adam22 APN 5 8,177,411 (GRCm39) missense probably damaging 1.00
IGL01406:Adam22 APN 5 8,180,212 (GRCm39) nonsense probably null
IGL01463:Adam22 APN 5 8,142,790 (GRCm39) missense probably damaging 1.00
IGL01691:Adam22 APN 5 8,142,742 (GRCm39) missense probably damaging 1.00
IGL01798:Adam22 APN 5 8,282,604 (GRCm39) splice site probably null
IGL01975:Adam22 APN 5 8,217,396 (GRCm39) missense probably damaging 1.00
IGL02076:Adam22 APN 5 8,186,900 (GRCm39) missense probably damaging 1.00
IGL02170:Adam22 APN 5 8,184,845 (GRCm39) missense probably benign
IGL02189:Adam22 APN 5 8,380,029 (GRCm39) missense possibly damaging 0.91
IGL02859:Adam22 APN 5 8,217,375 (GRCm39) missense probably damaging 1.00
IGL03189:Adam22 APN 5 8,161,897 (GRCm39) nonsense probably null
IGL03326:Adam22 APN 5 8,177,421 (GRCm39) missense probably damaging 1.00
IGL03329:Adam22 APN 5 8,199,210 (GRCm39) missense possibly damaging 0.48
IGL03354:Adam22 APN 5 8,208,890 (GRCm39) missense possibly damaging 0.82
IGL03394:Adam22 APN 5 8,217,379 (GRCm39) missense probably benign 0.00
IGL03047:Adam22 UTSW 5 8,132,220 (GRCm39) missense probably damaging 1.00
R0445:Adam22 UTSW 5 8,230,591 (GRCm39) intron probably benign
R0486:Adam22 UTSW 5 8,380,048 (GRCm39) missense probably damaging 1.00
R0669:Adam22 UTSW 5 8,193,036 (GRCm39) splice site probably benign
R0866:Adam22 UTSW 5 8,132,156 (GRCm39) missense probably damaging 0.98
R1510:Adam22 UTSW 5 8,202,408 (GRCm39) missense probably benign 0.06
R1562:Adam22 UTSW 5 8,145,007 (GRCm39) missense probably damaging 1.00
R1640:Adam22 UTSW 5 8,195,689 (GRCm39) missense probably damaging 1.00
R1903:Adam22 UTSW 5 8,184,525 (GRCm39) missense probably damaging 1.00
R1939:Adam22 UTSW 5 8,380,015 (GRCm39) missense probably damaging 1.00
R1998:Adam22 UTSW 5 8,379,995 (GRCm39) missense probably damaging 1.00
R2012:Adam22 UTSW 5 8,167,634 (GRCm39) missense probably damaging 1.00
R2214:Adam22 UTSW 5 8,186,805 (GRCm39) critical splice donor site probably null
R2270:Adam22 UTSW 5 8,171,108 (GRCm39) missense probably damaging 0.98
R2286:Adam22 UTSW 5 8,195,616 (GRCm39) missense probably damaging 1.00
R2304:Adam22 UTSW 5 8,142,366 (GRCm39) missense probably damaging 1.00
R2406:Adam22 UTSW 5 8,230,064 (GRCm39) intron probably benign
R2656:Adam22 UTSW 5 8,167,696 (GRCm39) missense probably damaging 1.00
R3106:Adam22 UTSW 5 8,167,583 (GRCm39) splice site probably null
R3870:Adam22 UTSW 5 8,182,418 (GRCm39) missense probably damaging 1.00
R3923:Adam22 UTSW 5 8,180,514 (GRCm39) missense possibly damaging 0.68
R4092:Adam22 UTSW 5 8,145,004 (GRCm39) missense probably damaging 1.00
R4180:Adam22 UTSW 5 8,199,218 (GRCm39) missense probably damaging 1.00
R4247:Adam22 UTSW 5 8,195,626 (GRCm39) missense probably benign
R4486:Adam22 UTSW 5 8,230,227 (GRCm39) intron probably benign
R4629:Adam22 UTSW 5 8,282,663 (GRCm39) missense possibly damaging 0.95
R4744:Adam22 UTSW 5 8,128,699 (GRCm39) missense probably damaging 0.98
R4839:Adam22 UTSW 5 8,186,813 (GRCm39) missense probably damaging 1.00
R5007:Adam22 UTSW 5 8,217,393 (GRCm39) missense probably damaging 1.00
R5030:Adam22 UTSW 5 8,229,645 (GRCm39) intron probably benign
R5061:Adam22 UTSW 5 8,230,238 (GRCm39) intron probably benign
R5312:Adam22 UTSW 5 8,140,182 (GRCm39) missense probably damaging 1.00
R5353:Adam22 UTSW 5 8,140,182 (GRCm39) missense probably damaging 1.00
R5354:Adam22 UTSW 5 8,140,182 (GRCm39) missense probably damaging 1.00
R5356:Adam22 UTSW 5 8,140,182 (GRCm39) missense probably damaging 1.00
R5423:Adam22 UTSW 5 8,140,182 (GRCm39) missense probably damaging 1.00
R5424:Adam22 UTSW 5 8,140,182 (GRCm39) missense probably damaging 1.00
R5719:Adam22 UTSW 5 8,417,217 (GRCm39) missense probably benign
R5763:Adam22 UTSW 5 8,184,544 (GRCm39) missense probably damaging 1.00
R5768:Adam22 UTSW 5 8,177,426 (GRCm39) missense probably benign 0.35
R5776:Adam22 UTSW 5 8,177,361 (GRCm39) missense probably benign 0.26
R5839:Adam22 UTSW 5 8,186,861 (GRCm39) missense probably damaging 0.99
R6314:Adam22 UTSW 5 8,177,365 (GRCm39) nonsense probably null
R6520:Adam22 UTSW 5 8,166,635 (GRCm39) missense probably damaging 0.98
R6798:Adam22 UTSW 5 8,210,784 (GRCm39) missense probably damaging 1.00
R6924:Adam22 UTSW 5 8,417,322 (GRCm39) missense possibly damaging 0.78
R6938:Adam22 UTSW 5 8,196,499 (GRCm39) missense probably benign 0.01
R7317:Adam22 UTSW 5 8,140,202 (GRCm39) missense probably benign
R7402:Adam22 UTSW 5 8,145,049 (GRCm39) missense possibly damaging 0.95
R7431:Adam22 UTSW 5 8,142,818 (GRCm39) missense probably damaging 1.00
R7527:Adam22 UTSW 5 8,132,239 (GRCm39) missense possibly damaging 0.66
R7571:Adam22 UTSW 5 8,132,160 (GRCm39) nonsense probably null
R7627:Adam22 UTSW 5 8,417,933 (GRCm39) missense probably benign
R7678:Adam22 UTSW 5 8,137,750 (GRCm39) splice site probably null
R7714:Adam22 UTSW 5 8,167,587 (GRCm39) critical splice donor site probably null
R7806:Adam22 UTSW 5 8,142,825 (GRCm39) missense probably damaging 1.00
R7834:Adam22 UTSW 5 8,180,535 (GRCm39) missense probably damaging 1.00
R7837:Adam22 UTSW 5 8,199,284 (GRCm39) critical splice acceptor site probably null
R7979:Adam22 UTSW 5 8,186,804 (GRCm39) critical splice donor site probably null
R8123:Adam22 UTSW 5 8,142,833 (GRCm39) critical splice acceptor site probably null
R8511:Adam22 UTSW 5 8,184,558 (GRCm39) missense probably damaging 0.98
R8722:Adam22 UTSW 5 8,166,554 (GRCm39) missense probably benign
R8730:Adam22 UTSW 5 8,208,830 (GRCm39) missense probably benign 0.00
R8956:Adam22 UTSW 5 8,142,343 (GRCm39) missense probably damaging 1.00
R9015:Adam22 UTSW 5 8,136,688 (GRCm39) intron probably benign
R9068:Adam22 UTSW 5 8,177,343 (GRCm39) missense probably benign 0.01
R9198:Adam22 UTSW 5 8,167,583 (GRCm39) splice site probably null
R9441:Adam22 UTSW 5 8,161,974 (GRCm39) missense possibly damaging 0.70
R9480:Adam22 UTSW 5 8,193,077 (GRCm39) missense probably benign 0.01
X0067:Adam22 UTSW 5 8,177,329 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GCTGAACATAATTCCAGCAGC -3'
(R):5'- AGATGTTAATCTTGAGACCTGGAG -3'

Sequencing Primer
(F):5'- AATCCCCATGTATCACTCTTAACTAC -3'
(R):5'- TGCTTAGCATACACATGAGTAATGTC -3'
Posted On 2014-10-16