|Institutional Source||Beutler Lab|
|Gene Name||cysteine rich transmembrane BMP regulator 1 (chordin like)|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R2273 (G1)|
|Chromosomal Location||78200248-78376592 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 78355179 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000108117 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000112498]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
PHENOTYPE: Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Crim1||
(F):5'- CACATCCCATAATGAGAGCGTGC -3'
(R):5'- TTCACGCATCCATCTTGGGG -3'
(F):5'- TGCCTAGCTACTGCAGGAATG -3'
(R):5'- CATCTTGGGGGCACAGCTTTC -3'