Incidental Mutation 'R2282:Or8c16'
ID 243184
Institutional Source Beutler Lab
Gene Symbol Or8c16
Ensembl Gene ENSMUSG00000070311
Gene Name olfactory receptor family 8 subfamily C member 16
Synonyms Olfr894, MOR170-5, GA_x6K02T2PVTD-31898993-31899934
MMRRC Submission 040281-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2282 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38130114-38131062 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38130124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 2 (M2V)
Ref Sequence ENSEMBL: ENSMUSP00000091389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093866] [ENSMUST00000212992]
AlphaFold Q9EQB2
Predicted Effect probably benign
Transcript: ENSMUST00000093866
AA Change: M2V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000091389
Gene: ENSMUSG00000070311
AA Change: M2V

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 8.8e-47 PFAM
Pfam:7tm_1 44 293 1.1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212992
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk2 A G 18: 65,440,697 (GRCm39) L232P probably benign Het
Ap5b1 A T 19: 5,619,665 (GRCm39) T362S possibly damaging Het
Ash2l A G 8: 26,325,070 (GRCm39) M163T probably damaging Het
Atp13a5 T C 16: 29,056,073 (GRCm39) Y1029C probably damaging Het
Baz1a G T 12: 54,963,597 (GRCm39) S829* probably null Het
Cd1d2 A G 3: 86,894,558 (GRCm39) K109E probably benign Het
Col4a3 T C 1: 82,686,359 (GRCm39) F1309L unknown Het
Dnah5 A T 15: 28,327,448 (GRCm39) E2055V probably damaging Het
Eif1ad8 A T 12: 87,564,087 (GRCm39) I141F unknown Het
Epha5 A T 5: 84,298,269 (GRCm39) I542N probably damaging Het
Hectd1 A T 12: 51,815,791 (GRCm39) V1432D possibly damaging Het
Klf12 C T 14: 100,137,581 (GRCm39) E322K probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Or1j11 G A 2: 36,312,012 (GRCm39) V201I probably benign Het
Or2y1c T G 11: 49,361,470 (GRCm39) M164R probably damaging Het
Or4k5 A G 14: 50,385,776 (GRCm39) V185A probably benign Het
Pde6b A G 5: 108,571,452 (GRCm39) probably null Het
Pdzd2 C T 15: 12,373,934 (GRCm39) G2067D possibly damaging Het
Rfx2 T C 17: 57,110,722 (GRCm39) Y88C probably damaging Het
S100a1 A G 3: 90,418,599 (GRCm39) F72L probably damaging Het
Smg5 A G 3: 88,252,705 (GRCm39) M164V probably benign Het
Snx5 T A 2: 144,095,595 (GRCm39) E355D probably benign Het
Tmbim6 T C 15: 99,302,407 (GRCm39) F93S probably damaging Het
Trp53bp1 G A 2: 121,100,754 (GRCm39) Q77* probably null Het
Ttn A G 2: 76,629,882 (GRCm39) V14216A possibly damaging Het
Vmn2r68 C T 7: 84,870,859 (GRCm39) C808Y possibly damaging Het
Wnt10b A G 15: 98,672,102 (GRCm39) F205S probably damaging Het
Other mutations in Or8c16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Or8c16 APN 9 38,131,039 (GRCm39) missense probably benign 0.18
IGL01772:Or8c16 APN 9 38,130,905 (GRCm39) missense probably damaging 0.97
IGL02253:Or8c16 APN 9 38,131,031 (GRCm39) missense probably benign 0.01
IGL02279:Or8c16 APN 9 38,130,389 (GRCm39) missense probably benign 0.00
IGL03031:Or8c16 APN 9 38,130,361 (GRCm39) missense probably damaging 0.99
IGL03163:Or8c16 APN 9 38,130,710 (GRCm39) missense probably benign 0.00
R0417:Or8c16 UTSW 9 38,130,751 (GRCm39) missense probably benign 0.01
R0458:Or8c16 UTSW 9 38,130,344 (GRCm39) missense probably damaging 0.97
R1498:Or8c16 UTSW 9 38,130,676 (GRCm39) missense probably damaging 1.00
R1765:Or8c16 UTSW 9 38,130,548 (GRCm39) missense probably benign 0.01
R2020:Or8c16 UTSW 9 38,130,728 (GRCm39) missense possibly damaging 0.47
R3928:Or8c16 UTSW 9 38,130,131 (GRCm39) start codon destroyed probably null 0.63
R4716:Or8c16 UTSW 9 38,130,714 (GRCm39) missense probably damaging 0.99
R4911:Or8c16 UTSW 9 38,130,392 (GRCm39) missense probably damaging 0.99
R5148:Or8c16 UTSW 9 38,130,317 (GRCm39) missense probably benign 0.01
R7677:Or8c16 UTSW 9 38,130,324 (GRCm39) missense probably damaging 1.00
R7971:Or8c16 UTSW 9 38,130,843 (GRCm39) missense probably benign 0.00
R8219:Or8c16 UTSW 9 38,130,668 (GRCm39) missense probably damaging 0.98
R8754:Or8c16 UTSW 9 38,130,865 (GRCm39) missense possibly damaging 0.56
R9248:Or8c16 UTSW 9 38,130,706 (GRCm39) missense probably benign 0.04
R9256:Or8c16 UTSW 9 38,130,498 (GRCm39) nonsense probably null
R9352:Or8c16 UTSW 9 38,130,683 (GRCm39) missense probably damaging 1.00
R9593:Or8c16 UTSW 9 38,130,868 (GRCm39) missense probably benign 0.20
X0050:Or8c16 UTSW 9 38,130,446 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTAGACAGCTAAACAAATCATGGG -3'
(R):5'- AGGAGATGGTGTTCTTCTCTACAAC -3'

Sequencing Primer
(F):5'- CAGCTAAACAAATCATGGGTAGGG -3'
(R):5'- CAGCATTTTTGGGGTAAAGACC -3'
Posted On 2014-10-16