Incidental Mutation 'R0164:Dhx58'
ID24360
Institutional Source Beutler Lab
Gene Symbol Dhx58
Ensembl Gene ENSMUSG00000017830
Gene NameDEXH (Asp-Glu-X-His) box polypeptide 58
SynonymsD11Lgp2e, B430001I08Rik, LPG2
MMRRC Submission 038440-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.180) question?
Stock #R0164 (G1)
Quality Score225
Status Not validated
Chromosome11
Chromosomal Location100694884-100704271 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 100695324 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 624 (I624V)
Ref Sequence ENSEMBL: ENSMUSP00000017974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017974] [ENSMUST00000153494]
Predicted Effect probably benign
Transcript: ENSMUST00000017974
AA Change: I624V

PolyPhen 2 Score 0.421 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000017974
Gene: ENSMUSG00000017830
AA Change: I624V

DomainStartEndE-ValueType
DEXDc 2 207 2.86e-22 SMART
HELICc 387 475 3.85e-14 SMART
Blast:HELICc 497 543 4e-12 BLAST
Pfam:RIG-I_C-RD 552 667 1.5e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137154
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140543
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149869
Predicted Effect probably benign
Transcript: ENSMUST00000153494
SMART Domains Protein: ENSMUSP00000115268
Gene: ENSMUSG00000014198

DomainStartEndE-ValueType
Pfam:zf-met 42 67 6.4e-8 PFAM
low complexity region 79 102 N/A INTRINSIC
Meta Mutation Damage Score 0.0779 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 69% (18/26)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to EMCV infection and decreased susceptibility to VSV infection. Mice homozygous for a different knock-out allele exhibit increased susceptibility to WNV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,295,159 probably benign Het
4930522L14Rik T C 5: 109,736,847 K382E probably damaging Het
Adck1 A G 12: 88,455,510 E297G probably damaging Het
Aldh3a2 C T 11: 61,248,888 V473I probably benign Het
Arfgef3 A T 10: 18,647,915 I369K possibly damaging Het
Atp1b3 T C 9: 96,338,709 I178V possibly damaging Het
Axdnd1 T C 1: 156,378,386 E520G possibly damaging Het
BB019430 A T 10: 58,704,271 noncoding transcript Het
Btbd1 T A 7: 81,801,003 Q343L probably benign Het
Catsper1 A G 19: 5,339,475 T473A possibly damaging Het
Chmp6 G A 11: 119,915,523 probably null Het
D130040H23Rik T C 8: 69,302,543 V200A possibly damaging Het
D830013O20Rik C T 12: 73,364,331 noncoding transcript Het
Dcaf1 T A 9: 106,844,145 S379T possibly damaging Het
Disp3 T C 4: 148,254,251 E821G probably damaging Het
Dlc1 T A 8: 36,599,440 E464V probably damaging Het
Dnah10 G A 5: 124,783,834 V2151I probably damaging Het
Dnah8 G A 17: 30,748,665 G2617D probably benign Het
Dnah9 C A 11: 65,918,804 E872* probably null Het
Dock9 T C 14: 121,597,665 Y99C probably damaging Het
Dpy19l3 T A 7: 35,716,646 I310F probably damaging Het
Fggy A T 4: 95,837,654 I137F probably damaging Het
Gm14012 C T 2: 128,238,016 noncoding transcript Het
Gm14421 A T 2: 177,056,722 noncoding transcript Het
Gm5689 T A 18: 42,173,543 D58E probably damaging Het
Grin2a A G 16: 9,994,821 probably null Het
Incenp A G 19: 9,894,879 S72P probably benign Het
Klc3 T A 7: 19,394,926 N469Y possibly damaging Het
Lrrc42 A G 4: 107,247,505 S88P probably benign Het
Lrrc49 G A 9: 60,680,600 T93I probably benign Het
Mlycd A T 8: 119,407,641 Q294L probably damaging Het
Mrpl22 T A 11: 58,171,821 I19N probably benign Het
Msh3 T A 13: 92,349,209 K202N probably damaging Het
Mucl2 C T 15: 103,899,179 probably null Het
Ncam1 C T 9: 49,568,409 D90N probably damaging Het
Nckap5 A T 1: 126,024,407 D1405E possibly damaging Het
Ncoa2 A G 1: 13,186,731 probably null Het
Nlrp1b A T 11: 71,164,099 W844R probably damaging Het
Nmnat1 G T 4: 149,469,150 N168K possibly damaging Het
Olfr1446 A G 19: 12,890,445 L44P probably damaging Het
Ost4 T C 5: 30,907,459 H26R probably damaging Het
Otog G A 7: 46,304,231 V2638M probably damaging Het
Otogl A T 10: 107,874,530 I566N probably damaging Het
Pcyt1a T C 16: 32,470,186 S282P probably damaging Het
Prkcg G A 7: 3,329,119 E581K probably damaging Het
Ralgps2 A G 1: 156,887,089 probably null Het
Scmh1 T C 4: 120,529,865 probably benign Het
Sgo2b T C 8: 63,938,383 H150R possibly damaging Het
Sh2b3 T G 5: 121,829,037 T5P probably damaging Het
Tdp2 A G 13: 24,838,239 M214V probably damaging Het
Tmem204 A G 17: 25,058,350 I187T probably damaging Het
Tmem208 T G 8: 105,334,694 D117E probably benign Het
Tnks1bp1 C T 2: 85,059,221 P631S possibly damaging Het
Tomm70a T C 16: 57,147,821 V517A probably damaging Het
Ttc7 T C 17: 87,379,895 V801A probably damaging Het
Txndc5 A T 13: 38,507,953 C146S probably damaging Het
Ube4b G T 4: 149,360,324 T493K probably damaging Het
Ufl1 A T 4: 25,256,008 Y504N probably benign Het
Ulk3 T A 9: 57,590,686 I90N probably damaging Het
Unc13c T C 9: 73,694,892 I1357M probably benign Het
Vmn1r28 G A 6: 58,265,717 A182T probably benign Het
Vmn2r91 A C 17: 18,106,137 N228T probably benign Het
Wisp1 T C 15: 66,919,210 L287P probably damaging Het
Zbtb6 G T 2: 37,429,588 Y109* probably null Het
Zfp640 C A 13: 66,670,974 noncoding transcript Het
Zfp640 G T 13: 66,670,998 noncoding transcript Het
Zfp980 A G 4: 145,701,997 D432G probably benign Het
Other mutations in Dhx58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Dhx58 APN 11 100703926 missense probably damaging 0.97
IGL02476:Dhx58 APN 11 100702264 missense probably benign 0.00
R0103:Dhx58 UTSW 11 100695270 missense probably damaging 1.00
R0103:Dhx58 UTSW 11 100695270 missense probably damaging 1.00
R0137:Dhx58 UTSW 11 100696997 missense probably damaging 0.99
R0164:Dhx58 UTSW 11 100695324 missense probably benign 0.42
R0369:Dhx58 UTSW 11 100701548 critical splice donor site probably null
R0390:Dhx58 UTSW 11 100699264 missense probably damaging 1.00
R0606:Dhx58 UTSW 11 100702251 missense probably benign 0.00
R1710:Dhx58 UTSW 11 100703574 missense probably benign 0.20
R1816:Dhx58 UTSW 11 100703152 missense probably damaging 0.98
R1993:Dhx58 UTSW 11 100703490 splice site probably null
R2281:Dhx58 UTSW 11 100698154 critical splice donor site probably null
R3176:Dhx58 UTSW 11 100696979 missense probably damaging 1.00
R3276:Dhx58 UTSW 11 100696979 missense probably damaging 1.00
R4651:Dhx58 UTSW 11 100701359 missense probably damaging 1.00
R4652:Dhx58 UTSW 11 100701359 missense probably damaging 1.00
R4716:Dhx58 UTSW 11 100696971 splice site probably null
R5030:Dhx58 UTSW 11 100696137 missense probably damaging 1.00
R5082:Dhx58 UTSW 11 100696976 missense probably benign 0.29
R5098:Dhx58 UTSW 11 100695173 missense probably benign
R5394:Dhx58 UTSW 11 100698208 missense probably benign 0.00
R5397:Dhx58 UTSW 11 100703920 missense probably damaging 1.00
R5787:Dhx58 UTSW 11 100701319 missense possibly damaging 0.91
R5975:Dhx58 UTSW 11 100702209 missense probably damaging 0.98
R6310:Dhx58 UTSW 11 100699367 missense probably benign 0.01
R6935:Dhx58 UTSW 11 100698406 splice site probably null
R7311:Dhx58 UTSW 11 100698171 missense probably benign
R7908:Dhx58 UTSW 11 100695304 missense probably damaging 0.99
R7989:Dhx58 UTSW 11 100695304 missense probably damaging 0.99
Predicted Primers
Posted On2013-04-16