Incidental Mutation 'R2260:Cdc37l1'
ID 243768
Institutional Source Beutler Lab
Gene Symbol Cdc37l1
Ensembl Gene ENSMUSG00000024780
Gene Name cell division cycle 37-like 1
Synonyms 2700033A15Rik, Harc, Hsp90-associating relative of Cdc37
MMRRC Submission 040260-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2260 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 28967752-29004081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 28984448 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 194 (K194N)
Ref Sequence ENSEMBL: ENSMUSP00000153192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050148] [ENSMUST00000223694] [ENSMUST00000224511] [ENSMUST00000224599] [ENSMUST00000225210] [ENSMUST00000225310]
AlphaFold Q9CZP7
Predicted Effect probably benign
Transcript: ENSMUST00000050148
AA Change: K194N

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000060421
Gene: ENSMUSG00000024780
AA Change: K194N

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
low complexity region 21 40 N/A INTRINSIC
low complexity region 102 115 N/A INTRINSIC
CDC37_M 132 288 7.15e-80 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183196
Predicted Effect probably benign
Transcript: ENSMUST00000223694
Predicted Effect unknown
Transcript: ENSMUST00000224092
AA Change: K37N
Predicted Effect probably benign
Transcript: ENSMUST00000224511
AA Change: K194N

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000224599
AA Change: K194N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000225210
AA Change: K194N

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000225310
AA Change: K194N

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225598
Predicted Effect probably benign
Transcript: ENSMUST00000224830
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A T 5: 114,354,978 (GRCm39) N1252I probably damaging Het
Acot5 A T 12: 84,122,643 (GRCm39) H409L possibly damaging Het
Adgrv1 A T 13: 81,716,493 (GRCm39) V840E probably damaging Het
Adnp2 A T 18: 80,171,664 (GRCm39) M915K probably benign Het
Cd101 G C 3: 100,924,261 (GRCm39) L393V possibly damaging Het
Cd177 A G 7: 24,455,661 (GRCm39) V287A possibly damaging Het
Cep126 T C 9: 8,101,749 (GRCm39) T262A possibly damaging Het
Chit1 A G 1: 134,078,865 (GRCm39) S392G probably benign Het
Col11a2 A G 17: 34,258,651 (GRCm39) H8R probably benign Het
Dusp12 C T 1: 170,708,580 (GRCm39) R120H probably damaging Het
Eln C A 5: 134,758,508 (GRCm39) A126S unknown Het
Entpd2 C T 2: 25,288,099 (GRCm39) P108S probably damaging Het
Fkbp6 C T 5: 135,366,468 (GRCm39) probably null Het
Ftcd T A 10: 76,423,893 (GRCm39) probably null Het
Gdf10 T C 14: 33,654,234 (GRCm39) L247P probably damaging Het
Gigyf1 C A 5: 137,518,594 (GRCm39) A215E possibly damaging Het
Gja4 C A 4: 127,206,623 (GRCm39) D47Y probably damaging Het
Gsn G A 2: 35,180,349 (GRCm39) G130E probably damaging Het
Hrc C A 7: 44,986,105 (GRCm39) R419S possibly damaging Het
Itfg1 C T 8: 86,449,306 (GRCm39) C576Y probably damaging Het
Lama1 G T 17: 68,044,502 (GRCm39) A134S probably damaging Het
Larp4 T G 15: 99,895,277 (GRCm39) F283L possibly damaging Het
Marveld2 A G 13: 100,748,978 (GRCm39) S34P probably benign Het
Mettl18 T A 1: 163,824,394 (GRCm39) D238E probably benign Het
Mfn1 G T 3: 32,617,575 (GRCm39) E74* probably null Het
Mfn2 C A 4: 147,979,063 (GRCm39) E90* probably null Het
Mill2 T A 7: 18,590,413 (GRCm39) D164E probably benign Het
Ncapd3 A G 9: 26,967,368 (GRCm39) D568G probably benign Het
Nt5c1b A T 12: 10,424,965 (GRCm39) R170S probably damaging Het
Or10ak11 T C 4: 118,687,359 (GRCm39) I93V probably damaging Het
Or4c100 G A 2: 88,356,730 (GRCm39) V268I possibly damaging Het
Or5bw2 A T 7: 6,573,022 (GRCm39) I11F probably damaging Het
Or8d1b T C 9: 38,887,296 (GRCm39) V108A probably benign Het
Pald1 G A 10: 61,188,750 (GRCm39) R87W probably damaging Het
Paox T A 7: 139,713,967 (GRCm39) Y242* probably null Het
Pde2a A T 7: 101,133,774 (GRCm39) D85V probably damaging Het
Pitrm1 C T 13: 6,610,161 (GRCm39) T411I probably damaging Het
Pkd1l3 A G 8: 110,350,268 (GRCm39) Q371R probably benign Het
Plaat5 C T 19: 7,590,111 (GRCm39) R46C probably damaging Het
Ptprk A G 10: 28,082,145 (GRCm39) D38G possibly damaging Het
Rag2 G A 2: 101,460,583 (GRCm39) E298K probably benign Het
Rbm12b2 G A 4: 12,095,061 (GRCm39) R640H probably benign Het
Rcsd1 C T 1: 165,486,998 (GRCm39) A72T probably benign Het
Rims2 G T 15: 39,341,962 (GRCm39) E604* probably null Het
Rin2 A G 2: 145,720,824 (GRCm39) D719G probably damaging Het
Sash1 G A 10: 8,662,142 (GRCm39) Q155* probably null Het
Tacr1 A T 6: 82,380,756 (GRCm39) I56F probably damaging Het
Tbc1d4 G A 14: 101,731,847 (GRCm39) T455M probably damaging Het
Tex24 C T 8: 27,834,883 (GRCm39) T137I probably damaging Het
Tmem200a A C 10: 25,869,313 (GRCm39) S319A probably benign Het
Tmem242 G T 17: 5,483,745 (GRCm39) A99E probably damaging Het
Tmem30a C T 9: 79,681,446 (GRCm39) R277H probably benign Het
Tmprss11f G A 5: 86,739,269 (GRCm39) A4V probably benign Het
Triobp T G 15: 78,875,640 (GRCm39) probably null Het
Tshz2 A T 2: 169,728,326 (GRCm39) Q505L probably benign Het
Ttyh1 T C 7: 4,131,183 (GRCm39) V218A probably damaging Het
Vmn2r11 A T 5: 109,201,657 (GRCm39) Y282* probably null Het
Vps13c A G 9: 67,861,142 (GRCm39) N2891S probably benign Het
Xpo5 C T 17: 46,551,822 (GRCm39) Q1050* probably null Het
Other mutations in Cdc37l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02612:Cdc37l1 APN 19 28,993,502 (GRCm39) makesense probably null
R4043:Cdc37l1 UTSW 19 28,968,028 (GRCm39) missense possibly damaging 0.83
R4434:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4437:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4438:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4829:Cdc37l1 UTSW 19 28,967,983 (GRCm39) missense probably benign
R5385:Cdc37l1 UTSW 19 28,989,343 (GRCm39) missense possibly damaging 0.95
R5537:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
R5906:Cdc37l1 UTSW 19 28,989,386 (GRCm39) missense probably benign 0.42
R7385:Cdc37l1 UTSW 19 28,968,071 (GRCm39) critical splice donor site probably null
R7610:Cdc37l1 UTSW 19 28,985,132 (GRCm39) missense possibly damaging 0.90
R9142:Cdc37l1 UTSW 19 28,989,402 (GRCm39) missense possibly damaging 0.86
R9317:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTTGCCCTGTCATGTATC -3'
(R):5'- AGCACACTGGAAGGATGATC -3'

Sequencing Primer
(F):5'- ATCACACTGGTCTGGAACTG -3'
(R):5'- GCGAGTGAGCACAAACCCTG -3'
Posted On 2014-10-16