Mutagenetix > Incidental Mutation

Incidental Mutation 'R2261:Taar3'

243806

Institutional Source

Beutler Lab

Gene Symbol

Taar3

Ensembl Gene

ENSMUSG00000069708

Gene Name

trace amine-associated receptor 3

Synonyms

MMRRC Submission

040261-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.125) question?

Stock #

R2261 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23825456-23826487 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23826053 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 200 (I200V)

Ref Sequence

ENSEMBL: ENSMUSP00000036817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045152]

AlphaFold

Q5QD16

Predicted Effect

probably benign
Transcript: ENSMUST00000045152
AA Change: I200V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000036817
Gene: ENSMUSG00000069708
AA Change: I200V

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	320	1.8e-13	PFAM
Pfam:7tm_1	48	309	1.4e-53	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.2%
20x: 94.7%

Validation Efficiency

98% (60/61)

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,242,288 (GRCm39)	M1384L	probably benign	Het
Ahdc1	A	G	4: 132,790,474 (GRCm39)	T572A	unknown	Het
Arhgap31	T	A	16: 38,429,639 (GRCm39)	Q412L	probably damaging	Het
Arsi	T	C	18: 61,049,737 (GRCm39)	Y207H	probably damaging	Het
Bco1	T	C	8: 117,859,764 (GRCm39)	L489S	probably damaging	Het
Cacna1g	T	A	11: 94,347,961 (GRCm39)	H709L	probably benign	Het
Cacna1h	T	C	17: 25,652,139 (GRCm39)	T2A	possibly damaging	Het
Casz1	G	T	4: 149,013,556 (GRCm39)	R40L	probably damaging	Het
Cdh23	A	G	10: 60,152,907 (GRCm39)	V2372A	probably damaging	Het
Cdk17	T	A	10: 93,047,820 (GRCm39)	S56T	possibly damaging	Het
Ces2h	T	A	8: 105,743,191 (GRCm39)	M142K	probably damaging	Het
Cfap69	C	A	5: 5,646,018 (GRCm39)	V561F	probably damaging	Het
Col1a2	G	A	6: 4,518,822 (GRCm39)		probably benign	Het
Dnah11	T	A	12: 117,843,760 (GRCm39)	M4362L	probably benign	Het
Dnah11	T	C	12: 117,930,374 (GRCm39)	T3324A	probably damaging	Het
Dnajc3	A	G	14: 119,198,232 (GRCm39)	Q118R	probably damaging	Het
Dok4	A	T	8: 95,593,140 (GRCm39)	C182S	probably damaging	Het
Fam184a	A	G	10: 53,523,666 (GRCm39)		probably null	Het
Fanca	A	G	8: 124,016,098 (GRCm39)		probably null	Het
Flt3	G	A	5: 147,284,873 (GRCm39)	P748L	probably benign	Het
Gbp2b	G	A	3: 142,312,496 (GRCm39)	S293N	probably benign	Het
Gbp8	T	C	5: 105,163,999 (GRCm39)	Q433R	possibly damaging	Het
Gm12874	G	A	4: 122,487,533 (GRCm39)		noncoding transcript	Het
Golgb1	T	A	16: 36,713,722 (GRCm39)	F234L	probably damaging	Het
Gpr65	A	T	12: 98,241,494 (GRCm39)	N49I	probably damaging	Het
Grip1	G	A	10: 119,821,489 (GRCm39)	V385M	probably benign	Het
Ltbp3	G	A	19: 5,804,050 (GRCm39)	R854Q	probably benign	Het
Mast4	A	G	13: 102,934,715 (GRCm39)		probably benign	Het
Mia3	A	G	1: 183,115,647 (GRCm39)	Y295H	probably benign	Het
Morc3	T	A	16: 93,650,109 (GRCm39)		probably benign	Het
Muc6	G	A	7: 141,218,313 (GRCm39)	S2120F	possibly damaging	Het
Nell1	C	T	7: 50,210,569 (GRCm39)	T494I	possibly damaging	Het
Npy2r	A	G	3: 82,448,346 (GRCm39)	V30A	possibly damaging	Het
Nsd2	A	T	5: 34,042,871 (GRCm39)	Q1045L	probably damaging	Het
Or51t4	T	C	7: 102,598,464 (GRCm39)	F254S	probably damaging	Het
Or5d40	T	A	2: 88,015,965 (GRCm39)	I248N	probably damaging	Het
Otub1	T	A	19: 7,176,861 (GRCm39)		probably null	Het
Pcdh1	A	T	18: 38,331,710 (GRCm39)	L431H	probably benign	Het
Pdgfra	T	C	5: 75,346,184 (GRCm39)	V778A	probably benign	Het
Plekhm2	C	T	4: 141,370,043 (GRCm39)	E29K	probably damaging	Het
Ralgapa2	T	C	2: 146,184,603 (GRCm39)	N1468S	probably damaging	Het
Rnf111	T	C	9: 70,383,673 (GRCm39)	S87G	probably benign	Het
Ryr3	C	G	2: 112,506,218 (GRCm39)	R3443P	probably damaging	Het
Saxo1	C	T	4: 86,397,212 (GRCm39)	D109N	probably damaging	Het
Slc19a3	A	T	1: 83,000,678 (GRCm39)	F113Y	probably damaging	Het
Slc20a1	A	G	2: 129,048,394 (GRCm39)	R260G	possibly damaging	Het
Slk	T	C	19: 47,625,791 (GRCm39)	I1090T	probably damaging	Het
Spr-ps1	G	T	6: 85,132,945 (GRCm39)		noncoding transcript	Het
Ssh1	T	C	5: 114,080,764 (GRCm39)	S867G	possibly damaging	Het
St18	T	A	1: 6,915,796 (GRCm39)	C814S	probably damaging	Het
Stmn2	T	C	3: 8,606,955 (GRCm39)	F25S	probably damaging	Het
Tmem184c	A	G	8: 78,323,672 (GRCm39)	Y397H	probably damaging	Het
Tmem184c	T	C	8: 78,323,804 (GRCm39)	T353A	probably damaging	Het
Tuba1c	A	G	15: 98,935,757 (GRCm39)	H406R	probably damaging	Het
Ubr4	T	C	4: 139,140,773 (GRCm39)	S1231P	probably damaging	Het
Ubr5	A	T	15: 37,988,528 (GRCm39)	D2143E	probably damaging	Het
Vmn2r6	T	C	3: 64,464,090 (GRCm39)	N248S	probably benign	Het
Vmn2r63	G	T	7: 42,578,031 (GRCm39)	T169N	probably benign	Het
Zfp37	A	T	4: 62,109,873 (GRCm39)	L397Q	probably damaging	Het
Zmym2	G	A	14: 57,165,719 (GRCm39)	E681K	probably damaging	Het

Other mutations in Taar3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Taar3	APN	10	23,826,330 (GRCm39)	missense	probably damaging	1.00
IGL01777:Taar3	APN	10	23,825,903 (GRCm39)	missense	probably benign	0.39
IGL01940:Taar3	APN	10	23,825,855 (GRCm39)	missense	probably damaging	1.00
IGL02120:Taar3	APN	10	23,826,065 (GRCm39)	missense	probably benign	0.33
PIT4445001:Taar3	UTSW	10	23,825,586 (GRCm39)	missense	possibly damaging	0.85
R0582:Taar3	UTSW	10	23,825,715 (GRCm39)	missense	probably damaging	1.00
R1925:Taar3	UTSW	10	23,826,483 (GRCm39)	missense	probably benign	0.22
R4088:Taar3	UTSW	10	23,825,757 (GRCm39)	missense	possibly damaging	0.46
R4504:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4505:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4507:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4925:Taar3	UTSW	10	23,826,441 (GRCm39)	missense	probably damaging	0.99
R6221:Taar3	UTSW	10	23,825,970 (GRCm39)	missense	possibly damaging	0.92
R6451:Taar3	UTSW	10	23,825,705 (GRCm39)	missense	possibly damaging	0.96
R7290:Taar3	UTSW	10	23,826,298 (GRCm39)	nonsense	probably null
R7414:Taar3	UTSW	10	23,825,715 (GRCm39)	missense	probably damaging	1.00
R8432:Taar3	UTSW	10	23,826,053 (GRCm39)	missense	probably benign	0.11
X0057:Taar3	UTSW	10	23,825,544 (GRCm39)	missense	probably benign	0.13

Predicted Primers

PCR Primer
(F):5'- CGCGATCGACCGGTTTTATG -3'
(R):5'- CAGGGTCTTAGCTGCTTTCC -3'

Sequencing Primer
(F):5'- GCAGTGTGTGACCCTTTGCAC -3'
(R):5'- TCCTGTCCTTTTTCTTAGACAGG -3'

Posted On

2014-10-16