Incidental Mutation 'R2288:Adgrf4'
ID 244192
Institutional Source Beutler Lab
Gene Symbol Adgrf4
Ensembl Gene ENSMUSG00000023918
Gene Name adhesion G protein-coupled receptor F4
Synonyms 4632435A09Rik, Gpr115
MMRRC Submission 040287-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2288 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 42967782-43003175 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42978402 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 314 (T314A)
Ref Sequence ENSEMBL: ENSMUSP00000133261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024711] [ENSMUST00000167993] [ENSMUST00000170723]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000024711
AA Change: T314A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000024711
Gene: ENSMUSG00000023918
AA Change: T314A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 5.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000167993
AA Change: T314A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000132890
Gene: ENSMUSG00000023918
AA Change: T314A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 5.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170723
AA Change: T314A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133261
Gene: ENSMUSG00000023918
AA Change: T314A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 9.2e-36 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ces2a T C 8: 105,464,069 (GRCm39) S234P probably damaging Het
Cfh A T 1: 140,026,639 (GRCm39) N571K possibly damaging Het
Clasp1 A G 1: 118,506,608 (GRCm39) I940V probably benign Het
Dapk1 T C 13: 60,909,563 (GRCm39) L1392S probably damaging Het
Fbxw19 T A 9: 109,322,636 (GRCm39) L111F probably damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Nek10 G T 14: 14,853,956 (GRCm38) E381* probably null Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or5m3b T A 2: 85,872,377 (GRCm39) C239* probably null Het
Peg3 T C 7: 6,712,114 (GRCm39) E1036G probably damaging Het
Pgap4 A T 4: 49,586,445 (GRCm39) L241Q probably damaging Het
Psma3 T G 12: 71,041,145 (GRCm39) D173E possibly damaging Het
Ptpn14 T C 1: 189,597,695 (GRCm39) L1135P probably damaging Het
Sfxn1 A G 13: 54,247,976 (GRCm39) I234V probably benign Het
Tcf20 A G 15: 82,735,886 (GRCm39) V1855A probably benign Het
Tctn3 A T 19: 40,594,157 (GRCm39) C419S probably damaging Het
Tlr3 T A 8: 45,850,705 (GRCm39) I207F probably damaging Het
Ubr1 T A 2: 120,739,963 (GRCm39) R992S probably damaging Het
V1ra8 T C 6: 90,180,024 (GRCm39) S76P probably damaging Het
Vnn3 A G 10: 23,740,354 (GRCm39) D219G probably benign Het
Zfp536 T A 7: 37,179,773 (GRCm39) D944V probably damaging Het
Zfp683 CGGG CCGGGGG 4: 133,783,381 (GRCm39) probably benign Het
Other mutations in Adgrf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00425:Adgrf4 APN 17 42,977,547 (GRCm39) missense probably damaging 1.00
IGL00474:Adgrf4 APN 17 42,986,650 (GRCm39) missense probably damaging 0.97
IGL00913:Adgrf4 APN 17 42,977,793 (GRCm39) missense possibly damaging 0.81
IGL02134:Adgrf4 APN 17 42,980,581 (GRCm39) missense probably damaging 1.00
IGL02225:Adgrf4 APN 17 42,974,269 (GRCm39) critical splice donor site probably null
IGL02423:Adgrf4 APN 17 42,983,467 (GRCm39) missense probably benign 0.06
IGL02945:Adgrf4 APN 17 42,978,257 (GRCm39) missense probably benign
R0329:Adgrf4 UTSW 17 42,978,204 (GRCm39) missense probably damaging 1.00
R0330:Adgrf4 UTSW 17 42,978,204 (GRCm39) missense probably damaging 1.00
R1595:Adgrf4 UTSW 17 42,978,764 (GRCm39) missense probably benign 0.09
R1739:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1762:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1783:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1785:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2038:Adgrf4 UTSW 17 42,978,754 (GRCm39) missense probably damaging 1.00
R2069:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2140:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2142:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2230:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2232:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R3107:Adgrf4 UTSW 17 42,977,758 (GRCm39) nonsense probably null
R3732:Adgrf4 UTSW 17 42,983,472 (GRCm39) missense probably damaging 1.00
R4003:Adgrf4 UTSW 17 42,980,650 (GRCm39) missense probably damaging 1.00
R4158:Adgrf4 UTSW 17 42,978,568 (GRCm39) missense probably benign
R4160:Adgrf4 UTSW 17 42,978,568 (GRCm39) missense probably benign
R4163:Adgrf4 UTSW 17 42,978,477 (GRCm39) missense probably benign
R4865:Adgrf4 UTSW 17 42,978,156 (GRCm39) missense probably damaging 1.00
R4940:Adgrf4 UTSW 17 42,977,420 (GRCm39) missense possibly damaging 0.90
R5411:Adgrf4 UTSW 17 42,978,104 (GRCm39) missense probably damaging 1.00
R5512:Adgrf4 UTSW 17 42,978,176 (GRCm39) missense probably benign 0.03
R6421:Adgrf4 UTSW 17 42,983,392 (GRCm39) missense probably damaging 1.00
R7089:Adgrf4 UTSW 17 42,977,424 (GRCm39) missense possibly damaging 0.95
R7261:Adgrf4 UTSW 17 42,978,326 (GRCm39) missense probably benign 0.01
R7359:Adgrf4 UTSW 17 42,978,003 (GRCm39) missense possibly damaging 0.78
R7502:Adgrf4 UTSW 17 42,980,548 (GRCm39) missense possibly damaging 0.53
R7522:Adgrf4 UTSW 17 42,980,675 (GRCm39) missense probably benign 0.04
R7555:Adgrf4 UTSW 17 42,983,494 (GRCm39) missense probably benign 0.16
R7567:Adgrf4 UTSW 17 42,978,333 (GRCm39) missense probably benign
R7743:Adgrf4 UTSW 17 42,983,453 (GRCm39) nonsense probably null
R8002:Adgrf4 UTSW 17 42,978,683 (GRCm39) missense probably benign 0.05
R8210:Adgrf4 UTSW 17 42,978,441 (GRCm39) missense probably damaging 1.00
R8344:Adgrf4 UTSW 17 42,977,799 (GRCm39) missense probably benign 0.00
R8429:Adgrf4 UTSW 17 42,978,340 (GRCm39) missense probably benign
R9131:Adgrf4 UTSW 17 42,978,258 (GRCm39) missense probably benign 0.00
R9159:Adgrf4 UTSW 17 42,973,293 (GRCm39) missense probably benign
R9214:Adgrf4 UTSW 17 42,978,704 (GRCm39) missense possibly damaging 0.89
R9226:Adgrf4 UTSW 17 42,980,606 (GRCm39) missense probably damaging 1.00
R9237:Adgrf4 UTSW 17 42,980,782 (GRCm39) missense probably benign
R9546:Adgrf4 UTSW 17 42,978,283 (GRCm39) nonsense probably null
X0027:Adgrf4 UTSW 17 42,978,419 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CCGGCATTTCACTGTGCTATTG -3'
(R):5'- AAGGCTCTCGTATCTCTCACAG -3'

Sequencing Primer
(F):5'- ATGTCTGACATCACTGTACATGGGC -3'
(R):5'- GTTCCTCAGAGCACAGCCTCAG -3'
Posted On 2014-10-30