Incidental Mutation 'R2289:Mcrip1'
ID 244225
Institutional Source Beutler Lab
Gene Symbol Mcrip1
Ensembl Gene ENSMUSG00000061111
Gene Name MAPK regulated corepressor interacting protein 1
Synonyms Fam195b, BC003940
MMRRC Submission 040288-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R2289 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 120433714-120440553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120435530 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 35 (E35G)
Ref Sequence ENSEMBL: ENSMUSP00000034913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034913]
AlphaFold Q3UGS4
Predicted Effect probably damaging
Transcript: ENSMUST00000034913
AA Change: E35G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034913
Gene: ENSMUSG00000061111
AA Change: E35G

DomainStartEndE-ValueType
Pfam:FAM195 4 94 3.3e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135515
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp12a G A 14: 56,610,719 (GRCm39) V288I possibly damaging Het
Cntn6 C T 6: 104,545,989 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cplx3 T A 9: 57,520,941 (GRCm39) E220V possibly damaging Het
Cracdl T C 1: 37,651,342 (GRCm39) K1175R possibly damaging Het
Dcaf10 T A 4: 45,359,816 (GRCm39) W244R probably damaging Het
Dixdc1 A G 9: 50,595,172 (GRCm39) probably null Het
Dlg4 T A 11: 69,917,752 (GRCm39) Y12N probably damaging Het
Fsd1l T A 4: 53,696,931 (GRCm39) Y442N possibly damaging Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Hcrt C A 11: 100,652,745 (GRCm39) A90S probably damaging Het
Itga6 T A 2: 71,648,873 (GRCm39) V119D probably damaging Het
Klrh1 T C 6: 129,745,140 (GRCm39) N152S probably null Het
Lmtk2 T A 5: 144,112,924 (GRCm39) S1215T possibly damaging Het
Loxl2 G A 14: 69,930,524 (GRCm39) E763K probably benign Het
Nle1 T A 11: 82,793,879 (GRCm39) I386F probably benign Het
Nqo1 T C 8: 108,119,630 (GRCm39) I8V probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Pax8 T C 2: 24,330,752 (GRCm39) D227G probably benign Het
Phf14 T C 6: 12,047,845 (GRCm39) C885R probably damaging Het
Rhobtb3 A C 13: 76,059,046 (GRCm39) C251G probably damaging Het
Samd13 C T 3: 146,368,446 (GRCm39) A49T probably damaging Het
Snrpa1 T A 7: 65,713,586 (GRCm39) V101E probably benign Het
Styx A G 14: 45,592,404 (GRCm39) E20G possibly damaging Het
Thoc1 T C 18: 9,984,488 (GRCm39) Y325H probably damaging Het
Tmem163 T A 1: 127,423,477 (GRCm39) T262S possibly damaging Het
Tsr1 T G 11: 74,790,111 (GRCm39) L102R probably damaging Het
Vash1 G C 12: 86,726,952 (GRCm39) R64P probably damaging Het
Vps13b A C 15: 35,572,251 (GRCm39) D956A probably damaging Het
Vrk1 G A 12: 106,024,120 (GRCm39) G199S probably damaging Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Zfp870 A T 17: 33,102,334 (GRCm39) S333T probably benign Het
Zranb1 T C 7: 132,551,768 (GRCm39) Y140H probably damaging Het
Zscan4b A G 7: 10,635,789 (GRCm39) probably null Het
Other mutations in Mcrip1
AlleleSourceChrCoordTypePredicted EffectPPH Score
devonian UTSW 11 120,435,505 (GRCm39) critical splice donor site probably null
R0184:Mcrip1 UTSW 11 120,435,710 (GRCm39) start codon destroyed probably null 0.00
R2304:Mcrip1 UTSW 11 120,435,519 (GRCm39) missense probably damaging 1.00
R7185:Mcrip1 UTSW 11 120,435,505 (GRCm39) critical splice donor site probably null
R8811:Mcrip1 UTSW 11 120,435,605 (GRCm39) missense probably damaging 1.00
R9142:Mcrip1 UTSW 11 120,435,542 (GRCm39) missense probably damaging 1.00
R9237:Mcrip1 UTSW 11 120,435,542 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAAGACCATCTCCCAGATCCTG -3'
(R):5'- ATCCCAGCAATGACCAGGTG -3'

Sequencing Primer
(F):5'- TGCGTTGTCACCCCAATG -3'
(R):5'- CCAGGTGGGTCTCAGGTGAATG -3'
Posted On 2014-10-30