Mutagenetix > Incidental Mutation

Incidental Mutation 'R2291:Vmn1r15'

244343

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r15

Ensembl Gene

ENSMUSG00000115199

Gene Name

vomeronasal 1 receptor 15

Synonyms

V1rc6

MMRRC Submission

040290-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.201) question?

Stock #

R2291 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57257952-57259972 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57258692 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 182 (S182P)

Ref Sequence

ENSEMBL: ENSMUSP00000154252 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000228297]

AlphaFold

Q14C10

Predicted Effect

possibly damaging
Transcript: ENSMUST00000071304
AA Change: S182P

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: S182P

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	4.5e-56	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228297
AA Change: S182P

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	T	3: 124,413,801 (GRCm38)	I247N	probably damaging	Het
Afdn	A	G	17: 13,888,891 (GRCm38)	K1559E	probably damaging	Het
Ankhd1	C	T	18: 36,644,333 (GRCm38)	T1523I	probably benign	Het
Apc	T	A	18: 34,312,491 (GRCm38)	N795K	probably benign	Het
Arhgap26	G	T	18: 39,357,698 (GRCm38)		probably benign	Het
Atm	C	T	9: 53,490,909 (GRCm38)		probably null	Het
Atp1a4	T	C	1: 172,244,906 (GRCm38)	N394D	probably damaging	Het
Brinp3	T	A	1: 146,901,074 (GRCm38)	S420T	possibly damaging	Het
Cacna1d	G	T	14: 30,042,342 (GRCm38)	R2078S	probably damaging	Het
Cacna1e	T	C	1: 154,403,683 (GRCm38)	D1720G	probably damaging	Het
Camk2a	T	A	18: 60,963,959 (GRCm38)	V38E	probably damaging	Het
Camk4	G	A	18: 33,107,943 (GRCm38)		probably null	Het
Ccr7	G	A	11: 99,145,335 (GRCm38)	R254C	probably damaging	Het
Celf5	C	T	10: 81,467,047 (GRCm38)	G267D	probably damaging	Het
Cfap65	G	A	1: 74,926,475 (GRCm38)	P459S	probably damaging	Het
Chd1l	T	C	3: 97,591,283 (GRCm38)	K267E	probably damaging	Het
Chl1	T	A	6: 103,715,393 (GRCm38)	Y331N	probably damaging	Het
Cltc	G	A	11: 86,733,622 (GRCm38)	T158I	probably benign	Het
Col16a1	T	A	4: 130,067,040 (GRCm38)	D430E	unknown	Het
Cspg4	T	C	9: 56,892,743 (GRCm38)	V1597A	probably damaging	Het
Cstf2t	T	A	19: 31,084,864 (GRCm38)	L600H	probably benign	Het
Cyp27b1	T	C	10: 127,048,294 (GRCm38)	V5A	possibly damaging	Het
Depdc5	C	A	5: 32,979,402 (GRCm38)	Q1339K	probably damaging	Het
Diaph3	G	T	14: 86,966,446 (GRCm38)	P592Q	probably damaging	Het
Epha8	T	C	4: 136,933,347 (GRCm38)	M687V	probably damaging	Het
Fhod1	T	A	8: 105,336,964 (GRCm38)		probably benign	Het
Gls2	C	A	10: 128,207,610 (GRCm38)	S73*	probably null	Het
Gm3604	T	A	13: 62,371,843 (GRCm38)	M33L	probably damaging	Het
Gpr39	A	G	1: 125,677,541 (GRCm38)	T69A	probably benign	Het
Hal	T	C	10: 93,503,536 (GRCm38)	F496L	probably damaging	Het
Hipk1	T	C	3: 103,761,610 (GRCm38)	E490G	probably damaging	Het
Ints7	T	G	1: 191,606,203 (GRCm38)		probably null	Het
Itpr3	A	G	17: 27,113,579 (GRCm38)	E1799G	possibly damaging	Het
Kif11	T	A	19: 37,407,003 (GRCm38)	M570K	probably benign	Het
Kif18b	G	T	11: 102,908,270 (GRCm38)	Q702K	probably damaging	Het
Kif19a	A	G	11: 114,790,193 (GRCm38)	T247A	probably damaging	Het
Lama3	A	G	18: 12,525,079 (GRCm38)	E360G	probably damaging	Het
Loxl3	G	T	6: 83,037,488 (GRCm38)	A126S	probably benign	Het
Mc5r	C	T	18: 68,339,364 (GRCm38)	R265W	probably damaging	Het
Mpl	A	G	4: 118,449,000 (GRCm38)	V340A	probably benign	Het
Mrpl13	G	T	15: 55,548,219 (GRCm38)	H56Q	probably damaging	Het
Msr1	T	C	8: 39,624,222 (GRCm38)	T116A	probably benign	Het
N4bp3	T	C	11: 51,646,103 (GRCm38)	K48E	probably damaging	Het
Naaladl1	A	G	19: 6,106,195 (GRCm38)	T104A	probably benign	Het
Neu1	C	T	17: 34,932,766 (GRCm38)	R179W	probably damaging	Het
Olfr1053	A	T	2: 86,315,180 (GRCm38)	Y35*	probably null	Het
Olfr975	T	C	9: 39,950,334 (GRCm38)	T146A	probably benign	Het
Osbp	G	T	19: 11,973,834 (GRCm38)	E248*	probably null	Het
Otx1	T	A	11: 21,996,634 (GRCm38)		probably benign	Het
Parp4	A	T	14: 56,613,817 (GRCm38)	Q759L	probably damaging	Het
Pax6	A	C	2: 105,685,883 (GRCm38)	S169R	probably benign	Het
Pigg	T	G	5: 108,332,917 (GRCm38)	I389M	probably damaging	Het
Pla2g4a	C	A	1: 149,901,189 (GRCm38)	V59F	probably damaging	Het
Plcb4	A	T	2: 135,939,983 (GRCm38)	Q241H	probably benign	Het
Plpp6	A	G	19: 28,964,320 (GRCm38)	D107G	probably damaging	Het
Ppp6r2	T	A	15: 89,275,487 (GRCm38)	L459Q	probably damaging	Het
Prss55	A	T	14: 64,075,722 (GRCm38)	W238R	probably damaging	Het
Rgl1	C	T	1: 152,536,281 (GRCm38)	E446K	probably damaging	Het
Ric3	C	T	7: 109,038,883 (GRCm38)	G221D	probably damaging	Het
Rnf167	T	C	11: 70,649,303 (GRCm38)	F83S	probably damaging	Het
Ryr1	C	T	7: 29,098,777 (GRCm38)	V947M	probably damaging	Het
Scn1a	A	G	2: 66,288,968 (GRCm38)	L1397P	probably benign	Het
Sh3bp1	T	A	15: 78,918,319 (GRCm38)	V251E	possibly damaging	Het
Slc25a10	A	T	11: 120,497,074 (GRCm38)	I198L	probably benign	Het
Smoc2	A	T	17: 14,368,971 (GRCm38)	N234I	possibly damaging	Het
Spdl1	T	A	11: 34,819,309 (GRCm38)	K382*	probably null	Het
Ssrp1	G	A	2: 85,042,316 (GRCm38)		probably null	Het
Tril	G	T	6: 53,818,027 (GRCm38)	R737S	probably damaging	Het
Triqk	T	A	4: 12,974,817 (GRCm38)		probably null	Het
Ttc19	T	C	11: 62,283,693 (GRCm38)	Y128H	probably damaging	Het
Vmn1r226	A	G	17: 20,688,213 (GRCm38)	I236V	probably damaging	Het
Vmn2r120	A	C	17: 57,509,479 (GRCm38)	N625K	probably damaging	Het
Vmn2r78	T	C	7: 86,920,154 (GRCm38)	I85T	probably damaging	Het
Wdr60	A	T	12: 116,229,571 (GRCm38)		probably null	Het
Whamm	C	T	7: 81,591,771 (GRCm38)	R277*	probably null	Het
Wnt7a	C	T	6: 91,394,486 (GRCm38)	V165I	probably benign	Het
Zbtb40	A	T	4: 136,985,017 (GRCm38)	Y1127N	possibly damaging	Het
Zfyve1	A	T	12: 83,547,931 (GRCm38)	H762Q	probably damaging	Het

Other mutations in Vmn1r15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01645:Vmn1r15	APN	6	57,258,562 (GRCm38)	nonsense	probably null
IGL02326:Vmn1r15	APN	6	57,258,270 (GRCm38)	missense	probably benign	0.02
IGL02431:Vmn1r15	APN	6	57,258,903 (GRCm38)	missense	possibly damaging	0.94
IGL02936:Vmn1r15	APN	6	57,258,818 (GRCm38)	nonsense	probably null
IGL02990:Vmn1r15	APN	6	57,258,608 (GRCm38)	missense	probably benign	0.14
IGL03177:Vmn1r15	APN	6	57,258,473 (GRCm38)	missense	probably benign	0.27
IGL03382:Vmn1r15	APN	6	57,258,570 (GRCm38)	missense	probably benign	0.04
R0531:Vmn1r15	UTSW	6	57,258,251 (GRCm38)	missense	probably benign	0.10
R1858:Vmn1r15	UTSW	6	57,258,631 (GRCm38)	missense	probably benign	0.13
R2010:Vmn1r15	UTSW	6	57,258,284 (GRCm38)	missense	probably benign	0.02
R2055:Vmn1r15	UTSW	6	57,258,744 (GRCm38)	missense	possibly damaging	0.90
R3697:Vmn1r15	UTSW	6	57,258,336 (GRCm38)	missense	possibly damaging	0.63
R5161:Vmn1r15	UTSW	6	57,258,512 (GRCm38)	missense	probably benign	0.00
R5884:Vmn1r15	UTSW	6	57,259,008 (GRCm38)	missense	probably damaging	0.99
R7287:Vmn1r15	UTSW	6	57,258,216 (GRCm38)	missense	possibly damaging	0.63
R7376:Vmn1r15	UTSW	6	57,258,357 (GRCm38)	missense	probably benign	0.11
R7773:Vmn1r15	UTSW	6	57,258,659 (GRCm38)	missense	probably benign	0.05
R7980:Vmn1r15	UTSW	6	57,258,414 (GRCm38)	missense	probably damaging	1.00
R8309:Vmn1r15	UTSW	6	57,258,650 (GRCm38)	missense	probably benign	0.01
R8753:Vmn1r15	UTSW	6	57,258,910 (GRCm38)	missense	probably benign	0.01
R8765:Vmn1r15	UTSW	6	57,258,600 (GRCm38)	missense	probably benign	0.01
R8812:Vmn1r15	UTSW	6	57,258,138 (GRCm38)	start gained	probably benign

Predicted Primers

PCR Primer
(F):5'- CCAGGCTGTCACAATCAGTC -3'
(R):5'- ATGATGAAATCCACCCAGTACATG -3'

Sequencing Primer
(F):5'- AATCAGTCCCAGTACCTCTATGCTG -3'
(R):5'- TGAAATCCACCCAGTACATGACTAC -3'

Posted On

2014-10-30