Incidental Mutation 'R2291:Kif19a'
ID 244373
Institutional Source Beutler Lab
Gene Symbol Kif19a
Ensembl Gene ENSMUSG00000010021
Gene Name kinesin family member 19A
Synonyms N-8 kinesin
MMRRC Submission 040290-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R2291 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 114656227-114681565 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 114681019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 247 (T247A)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000206] [ENSMUST00000084368] [ENSMUST00000138804]
AlphaFold Q99PT9
Predicted Effect probably benign
Transcript: ENSMUST00000000206
SMART Domains Protein: ENSMUSP00000000206
Gene: ENSMUSG00000000202

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 49 59 N/A INTRINSIC
BTB 63 162 2.01e-11 SMART
BACK 169 269 8.58e-19 SMART
Blast:BACK 425 460 1e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000084368
AA Change: T976A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000081398
Gene: ENSMUSG00000010021
AA Change: T976A

DomainStartEndE-ValueType
KISc 9 354 4.53e-150 SMART
coiled coil region 361 388 N/A INTRINSIC
coiled coil region 431 449 N/A INTRINSIC
coiled coil region 506 551 N/A INTRINSIC
low complexity region 628 641 N/A INTRINSIC
low complexity region 750 766 N/A INTRINSIC
low complexity region 807 815 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126555
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131782
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134165
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137326
Predicted Effect probably damaging
Transcript: ENSMUST00000138340
AA Change: T247A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000122743
Gene: ENSMUSG00000010021
AA Change: T247A

DomainStartEndE-ValueType
low complexity region 22 38 N/A INTRINSIC
low complexity region 79 87 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137965
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141481
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146853
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156053
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141386
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156192
Predicted Effect probably benign
Transcript: ENSMUST00000138804
SMART Domains Protein: ENSMUSP00000115663
Gene: ENSMUSG00000010021

DomainStartEndE-ValueType
KISc 9 312 2.99e-118 SMART
coiled coil region 319 346 N/A INTRINSIC
coiled coil region 389 407 N/A INTRINSIC
coiled coil region 464 509 N/A INTRINSIC
low complexity region 586 599 N/A INTRINSIC
low complexity region 683 692 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display partial postnatal lethality, hydroencephaly, female infertility, oviduct obstruction, increased motile cilium length and impaired motile cilium movement. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A T 3: 124,207,450 (GRCm39) I247N probably damaging Het
Afdn A G 17: 14,109,153 (GRCm39) K1559E probably damaging Het
Ankhd1 C T 18: 36,777,386 (GRCm39) T1523I probably benign Het
Apc T A 18: 34,445,544 (GRCm39) N795K probably benign Het
Arhgap26 G T 18: 39,490,751 (GRCm39) probably benign Het
Atm C T 9: 53,402,209 (GRCm39) probably null Het
Atp1a4 T C 1: 172,072,473 (GRCm39) N394D probably damaging Het
Brinp3 T A 1: 146,776,812 (GRCm39) S420T possibly damaging Het
Cacna1d G T 14: 29,764,299 (GRCm39) R2078S probably damaging Het
Cacna1e T C 1: 154,279,429 (GRCm39) D1720G probably damaging Het
Camk2a T A 18: 61,097,031 (GRCm39) V38E probably damaging Het
Camk4 G A 18: 33,240,996 (GRCm39) probably null Het
Ccr7 G A 11: 99,036,161 (GRCm39) R254C probably damaging Het
Celf5 C T 10: 81,302,881 (GRCm39) G267D probably damaging Het
Cfap65 G A 1: 74,965,634 (GRCm39) P459S probably damaging Het
Chd1l T C 3: 97,498,599 (GRCm39) K267E probably damaging Het
Chl1 T A 6: 103,692,354 (GRCm39) Y331N probably damaging Het
Cltc G A 11: 86,624,448 (GRCm39) T158I probably benign Het
Col16a1 T A 4: 129,960,833 (GRCm39) D430E unknown Het
Cspg4 T C 9: 56,800,027 (GRCm39) V1597A probably damaging Het
Cstf2t T A 19: 31,062,264 (GRCm39) L600H probably benign Het
Cyp27b1 T C 10: 126,884,163 (GRCm39) V5A possibly damaging Het
Depdc5 C A 5: 33,136,746 (GRCm39) Q1339K probably damaging Het
Diaph3 G T 14: 87,203,882 (GRCm39) P592Q probably damaging Het
Dync2i1 A T 12: 116,193,191 (GRCm39) probably null Het
Epha8 T C 4: 136,660,658 (GRCm39) M687V probably damaging Het
Fhod1 T A 8: 106,063,596 (GRCm39) probably benign Het
Gls2 C A 10: 128,043,479 (GRCm39) S73* probably null Het
Gm3604 T A 13: 62,519,657 (GRCm39) M33L probably damaging Het
Gpr39 A G 1: 125,605,278 (GRCm39) T69A probably benign Het
Hal T C 10: 93,339,398 (GRCm39) F496L probably damaging Het
Hipk1 T C 3: 103,668,926 (GRCm39) E490G probably damaging Het
Ints7 T G 1: 191,338,315 (GRCm39) probably null Het
Itpr3 A G 17: 27,332,553 (GRCm39) E1799G possibly damaging Het
Kif11 T A 19: 37,395,451 (GRCm39) M570K probably benign Het
Kif18b G T 11: 102,799,096 (GRCm39) Q702K probably damaging Het
Lama3 A G 18: 12,658,136 (GRCm39) E360G probably damaging Het
Loxl3 G T 6: 83,014,469 (GRCm39) A126S probably benign Het
Mc5r C T 18: 68,472,435 (GRCm39) R265W probably damaging Het
Mpl A G 4: 118,306,197 (GRCm39) V340A probably benign Het
Mrpl13 G T 15: 55,411,615 (GRCm39) H56Q probably damaging Het
Msr1 T C 8: 40,077,263 (GRCm39) T116A probably benign Het
N4bp3 T C 11: 51,536,930 (GRCm39) K48E probably damaging Het
Naaladl1 A G 19: 6,156,225 (GRCm39) T104A probably benign Het
Neu1 C T 17: 35,151,742 (GRCm39) R179W probably damaging Het
Or10d5 T C 9: 39,861,630 (GRCm39) T146A probably benign Het
Or8k21 A T 2: 86,145,524 (GRCm39) Y35* probably null Het
Osbp G T 19: 11,951,198 (GRCm39) E248* probably null Het
Otx1 T A 11: 21,946,634 (GRCm39) probably benign Het
Parp4 A T 14: 56,851,274 (GRCm39) Q759L probably damaging Het
Pax6 A C 2: 105,516,228 (GRCm39) S169R probably benign Het
Pigg T G 5: 108,480,783 (GRCm39) I389M probably damaging Het
Pla2g4a C A 1: 149,776,940 (GRCm39) V59F probably damaging Het
Plcb4 A T 2: 135,781,903 (GRCm39) Q241H probably benign Het
Plpp6 A G 19: 28,941,720 (GRCm39) D107G probably damaging Het
Ppp6r2 T A 15: 89,159,690 (GRCm39) L459Q probably damaging Het
Prss55 A T 14: 64,313,171 (GRCm39) W238R probably damaging Het
Rgl1 C T 1: 152,412,032 (GRCm39) E446K probably damaging Het
Ric3 C T 7: 108,638,090 (GRCm39) G221D probably damaging Het
Rnf167 T C 11: 70,540,129 (GRCm39) F83S probably damaging Het
Ryr1 C T 7: 28,798,202 (GRCm39) V947M probably damaging Het
Scn1a A G 2: 66,119,312 (GRCm39) L1397P probably benign Het
Sh3bp1 T A 15: 78,802,519 (GRCm39) V251E possibly damaging Het
Slc25a10 A T 11: 120,387,900 (GRCm39) I198L probably benign Het
Smoc2 A T 17: 14,589,233 (GRCm39) N234I possibly damaging Het
Spdl1 T A 11: 34,710,136 (GRCm39) K382* probably null Het
Ssrp1 G A 2: 84,872,660 (GRCm39) probably null Het
Tril G T 6: 53,795,012 (GRCm39) R737S probably damaging Het
Triqk T A 4: 12,974,817 (GRCm39) probably null Het
Ttc19 T C 11: 62,174,519 (GRCm39) Y128H probably damaging Het
Vmn1r15 T C 6: 57,235,677 (GRCm39) S182P possibly damaging Het
Vmn1r226 A G 17: 20,908,475 (GRCm39) I236V probably damaging Het
Vmn2r120 A C 17: 57,816,479 (GRCm39) N625K probably damaging Het
Vmn2r78 T C 7: 86,569,362 (GRCm39) I85T probably damaging Het
Whamm C T 7: 81,241,519 (GRCm39) R277* probably null Het
Wnt7a C T 6: 91,371,468 (GRCm39) V165I probably benign Het
Zbtb40 A T 4: 136,712,328 (GRCm39) Y1127N possibly damaging Het
Zfyve1 A T 12: 83,594,705 (GRCm39) H762Q probably damaging Het
Other mutations in Kif19a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Kif19a APN 11 114,670,411 (GRCm39) missense probably damaging 1.00
IGL00743:Kif19a APN 11 114,675,599 (GRCm39) missense probably damaging 1.00
IGL00763:Kif19a APN 11 114,657,994 (GRCm39) missense probably benign 0.00
IGL01327:Kif19a APN 11 114,672,625 (GRCm39) splice site probably benign
IGL02422:Kif19a APN 11 114,680,187 (GRCm39) missense probably damaging 1.00
IGL02481:Kif19a APN 11 114,679,979 (GRCm39) missense probably benign 0.28
IGL02496:Kif19a APN 11 114,670,470 (GRCm39) missense probably damaging 0.99
IGL02735:Kif19a APN 11 114,676,393 (GRCm39) missense probably damaging 1.00
IGL02830:Kif19a APN 11 114,672,034 (GRCm39) missense probably damaging 1.00
IGL02902:Kif19a APN 11 114,676,396 (GRCm39) missense possibly damaging 0.46
IGL03372:Kif19a APN 11 114,670,044 (GRCm39) missense probably damaging 0.99
PIT4520001:Kif19a UTSW 11 114,672,034 (GRCm39) missense probably damaging 1.00
R0212:Kif19a UTSW 11 114,675,736 (GRCm39) missense possibly damaging 0.48
R0383:Kif19a UTSW 11 114,656,340 (GRCm39) start codon destroyed possibly damaging 0.63
R0850:Kif19a UTSW 11 114,671,613 (GRCm39) missense probably damaging 0.99
R1343:Kif19a UTSW 11 114,676,653 (GRCm39) missense probably benign 0.08
R1422:Kif19a UTSW 11 114,676,635 (GRCm39) missense probably benign 0.01
R1547:Kif19a UTSW 11 114,677,398 (GRCm39) missense probably benign 0.41
R1591:Kif19a UTSW 11 114,680,057 (GRCm39) missense probably benign
R2148:Kif19a UTSW 11 114,671,594 (GRCm39) missense probably damaging 1.00
R3814:Kif19a UTSW 11 114,672,745 (GRCm39) missense probably damaging 1.00
R3944:Kif19a UTSW 11 114,677,561 (GRCm39) missense probably benign 0.34
R4631:Kif19a UTSW 11 114,675,673 (GRCm39) missense possibly damaging 0.95
R4866:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R4867:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R5022:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R5071:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R5072:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R5073:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R5074:Kif19a UTSW 11 114,658,053 (GRCm39) missense probably benign 0.00
R5091:Kif19a UTSW 11 114,673,923 (GRCm39) missense probably damaging 1.00
R5640:Kif19a UTSW 11 114,670,041 (GRCm39) missense probably benign 0.25
R5646:Kif19a UTSW 11 114,670,480 (GRCm39) missense probably damaging 1.00
R5786:Kif19a UTSW 11 114,670,049 (GRCm39) nonsense probably null
R5890:Kif19a UTSW 11 114,680,264 (GRCm39) missense possibly damaging 0.92
R6344:Kif19a UTSW 11 114,672,777 (GRCm39) critical splice donor site probably null
R6522:Kif19a UTSW 11 114,676,605 (GRCm39) missense probably damaging 1.00
R6570:Kif19a UTSW 11 114,675,731 (GRCm39) missense possibly damaging 0.63
R6879:Kif19a UTSW 11 114,672,159 (GRCm39) missense probably benign 0.03
R7028:Kif19a UTSW 11 114,672,034 (GRCm39) missense probably damaging 1.00
R7274:Kif19a UTSW 11 114,656,281 (GRCm39) start gained probably benign
R7492:Kif19a UTSW 11 114,681,065 (GRCm39) missense probably benign 0.36
R7782:Kif19a UTSW 11 114,672,748 (GRCm39) missense probably damaging 1.00
R8473:Kif19a UTSW 11 114,678,377 (GRCm39) missense probably damaging 1.00
R8712:Kif19a UTSW 11 114,675,599 (GRCm39) missense probably damaging 1.00
R9332:Kif19a UTSW 11 114,680,033 (GRCm39) missense possibly damaging 0.49
R9596:Kif19a UTSW 11 114,676,752 (GRCm39) missense probably benign 0.31
Z1176:Kif19a UTSW 11 114,680,655 (GRCm39) missense probably benign 0.12
Z1176:Kif19a UTSW 11 114,677,416 (GRCm39) missense probably damaging 1.00
Z1177:Kif19a UTSW 11 114,675,730 (GRCm39) missense probably benign 0.33
Z1177:Kif19a UTSW 11 114,672,141 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- TCAAGGAGCAGTACTGGGTG -3'
(R):5'- TGCAGATAACTCTACCGTTTCC -3'

Sequencing Primer
(F):5'- ACTGGGTGGGGTTTGCAAAC -3'
(R):5'- AGCCCAGTCCGCTAAACTCTTG -3'
Posted On 2014-10-30