Incidental Mutation 'R2307:Orc3'
ID 244620
Institutional Source Beutler Lab
Gene Symbol Orc3
Ensembl Gene ENSMUSG00000040044
Gene Name origin recognition complex, subunit 3
Synonyms Orc3l
MMRRC Submission 040306-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2307 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 34570796-34614944 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 34586503 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 382 (V382M)
Ref Sequence ENSEMBL: ENSMUSP00000103777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048706] [ENSMUST00000108142]
AlphaFold Q9JK30
Predicted Effect probably damaging
Transcript: ENSMUST00000048706
AA Change: V382M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000048319
Gene: ENSMUSG00000040044
AA Change: V382M

DomainStartEndE-ValueType
Pfam:ORC3_N 25 350 3e-130 PFAM
low complexity region 653 664 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108142
AA Change: V382M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103777
Gene: ENSMUSG00000040044
AA Change: V382M

DomainStartEndE-ValueType
Pfam:ORC3_N 24 350 7.7e-136 PFAM
low complexity region 652 663 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132918
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156987
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in the neural cells exhibit reduced neuronal precursor proliferation and reduced radial glial cell. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot5 T C 12: 84,122,375 (GRCm39) F320L possibly damaging Het
Alox12e T C 11: 70,212,087 (GRCm39) K170R probably damaging Het
Ano2 T C 6: 125,969,849 (GRCm39) S722P probably benign Het
Cep192 A G 18: 67,946,970 (GRCm39) Y215C probably benign Het
Ces2g A G 8: 105,695,044 (GRCm39) N555S probably benign Het
Cfap58 C T 19: 47,950,925 (GRCm39) Q429* probably null Het
Clcnkb A G 4: 141,139,640 (GRCm39) S121P probably damaging Het
Cltb T A 13: 54,746,564 (GRCm39) E67D probably damaging Het
Ddhd1 A T 14: 45,846,447 (GRCm39) L581Q probably damaging Het
Dnajc3 T C 14: 119,190,633 (GRCm39) probably null Het
Fgf14 T A 14: 124,221,234 (GRCm39) N190I probably damaging Het
Galnt17 T G 5: 130,929,460 (GRCm39) Y449S probably damaging Het
Grin3a C T 4: 49,793,033 (GRCm39) probably null Het
Gxylt2 A G 6: 100,764,173 (GRCm39) N286S probably damaging Het
H2-K2 A G 17: 34,216,113 (GRCm39) V120A probably benign Het
Inpp5f T C 7: 128,296,034 (GRCm39) V168A probably damaging Het
Kif1a G T 1: 93,006,491 (GRCm39) H59N probably damaging Het
Krt24 T C 11: 99,175,456 (GRCm39) Q193R possibly damaging Het
Krtap5-4 C A 7: 141,857,351 (GRCm39) S7* probably null Het
Ltn1 A G 16: 87,229,312 (GRCm39) probably null Het
Mcm2 G A 6: 88,869,990 (GRCm39) R60C probably damaging Het
Mep1b A T 18: 21,221,632 (GRCm39) D194V probably damaging Het
Mettl25b A T 3: 87,834,162 (GRCm39) M171K possibly damaging Het
Pclo T A 5: 14,728,665 (GRCm39) probably benign Het
Pcolce T C 5: 137,607,356 (GRCm39) H45R probably damaging Het
Prf1 T C 10: 61,138,942 (GRCm39) V300A possibly damaging Het
Prorp T C 12: 55,351,101 (GRCm39) F137L probably damaging Het
Prss53 T C 7: 127,490,037 (GRCm39) I18V probably benign Het
Rnase2b A G 14: 51,400,188 (GRCm39) T90A probably benign Het
Rpap1 G A 2: 119,614,247 (GRCm39) P50L probably benign Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sec16b G A 1: 157,363,062 (GRCm39) V298I probably damaging Het
Smarcd3 C T 5: 24,800,746 (GRCm39) R156Q probably damaging Het
St6galnac2 C T 11: 116,572,731 (GRCm39) A242T probably damaging Het
Syce1l T C 8: 114,369,937 (GRCm39) probably null Het
Tcam1 T C 11: 106,174,940 (GRCm39) C132R probably damaging Het
Trpa1 T C 1: 14,982,605 (GRCm39) I84V probably benign Het
Ttn G A 2: 76,717,342 (GRCm39) R455* probably null Het
Ubl5 T A 9: 20,557,876 (GRCm39) probably benign Het
Ubr2 T A 17: 47,277,141 (GRCm39) K779* probably null Het
Ugt1a10 A G 1: 87,983,669 (GRCm39) I156V probably benign Het
Unc13b A G 4: 43,239,854 (GRCm39) T3513A probably damaging Het
Vmn1r20 C T 6: 57,409,121 (GRCm39) T149I probably benign Het
Zfp804a T A 2: 82,087,201 (GRCm39) D343E probably benign Het
Other mutations in Orc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01636:Orc3 APN 4 34,595,096 (GRCm39) missense probably damaging 1.00
IGL03293:Orc3 APN 4 34,595,210 (GRCm39) missense probably damaging 0.96
IGL02991:Orc3 UTSW 4 34,593,083 (GRCm39) missense probably damaging 1.00
R0157:Orc3 UTSW 4 34,607,130 (GRCm39) critical splice donor site probably null
R0708:Orc3 UTSW 4 34,597,368 (GRCm39) missense probably damaging 1.00
R1331:Orc3 UTSW 4 34,599,748 (GRCm39) missense probably benign 0.01
R1481:Orc3 UTSW 4 34,607,228 (GRCm39) missense possibly damaging 0.50
R1755:Orc3 UTSW 4 34,575,114 (GRCm39) missense possibly damaging 0.67
R1886:Orc3 UTSW 4 34,584,829 (GRCm39) missense probably damaging 1.00
R2008:Orc3 UTSW 4 34,611,049 (GRCm39) splice site probably null
R2054:Orc3 UTSW 4 34,584,846 (GRCm39) missense probably damaging 0.97
R3001:Orc3 UTSW 4 34,571,790 (GRCm39) missense probably benign 0.10
R3002:Orc3 UTSW 4 34,571,790 (GRCm39) missense probably benign 0.10
R3153:Orc3 UTSW 4 34,575,124 (GRCm39) missense probably damaging 0.99
R4044:Orc3 UTSW 4 34,587,055 (GRCm39) nonsense probably null
R4814:Orc3 UTSW 4 34,572,450 (GRCm39) splice site probably benign
R4825:Orc3 UTSW 4 34,571,774 (GRCm39) missense possibly damaging 0.95
R4939:Orc3 UTSW 4 34,593,126 (GRCm39) nonsense probably null
R6314:Orc3 UTSW 4 34,579,797 (GRCm39) missense possibly damaging 0.85
R6867:Orc3 UTSW 4 34,605,539 (GRCm39) missense probably damaging 1.00
R7227:Orc3 UTSW 4 34,572,542 (GRCm39) missense probably benign 0.00
R7417:Orc3 UTSW 4 34,595,136 (GRCm39) missense probably damaging 1.00
R7655:Orc3 UTSW 4 34,587,032 (GRCm39) nonsense probably null
R7656:Orc3 UTSW 4 34,587,032 (GRCm39) nonsense probably null
R7707:Orc3 UTSW 4 34,598,691 (GRCm39) nonsense probably null
R7856:Orc3 UTSW 4 34,585,647 (GRCm39) missense probably benign
R7967:Orc3 UTSW 4 34,598,645 (GRCm39) missense probably damaging 0.98
R8058:Orc3 UTSW 4 34,595,223 (GRCm39) nonsense probably null
R8443:Orc3 UTSW 4 34,593,173 (GRCm39) missense probably damaging 1.00
R8670:Orc3 UTSW 4 34,572,529 (GRCm39) missense probably damaging 1.00
R8738:Orc3 UTSW 4 34,599,778 (GRCm39) missense possibly damaging 0.91
R8827:Orc3 UTSW 4 34,605,569 (GRCm39) missense probably benign 0.01
R9303:Orc3 UTSW 4 34,607,181 (GRCm39) nonsense probably null
R9305:Orc3 UTSW 4 34,607,181 (GRCm39) nonsense probably null
R9684:Orc3 UTSW 4 34,607,135 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATGTTGGTTACATGGAGGAGTACC -3'
(R):5'- CTCGGGTATATAGCCTTAATGACTTC -3'

Sequencing Primer
(F):5'- GTTACATGGAGGAGTACCCCATC -3'
(R):5'- GAAACCAGTCTAGCTAGCAA -3'
Posted On 2014-10-30