Incidental Mutation 'R2308:Zfp352'
ID 244671
Institutional Source Beutler Lab
Gene Symbol Zfp352
Ensembl Gene ENSMUSG00000070902
Gene Name zinc finger protein 352
Synonyms 2czf48
MMRRC Submission 040307-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2308 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 90218820-90225702 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 90225243 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 540 (K540R)
Ref Sequence ENSEMBL: ENSMUSP00000102746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080541] [ENSMUST00000107129]
AlphaFold A2AML7
Predicted Effect probably benign
Transcript: ENSMUST00000080541
AA Change: K540R

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000079383
Gene: ENSMUSG00000070902
AA Change: K540R

DomainStartEndE-ValueType
ZnF_C2H2 459 483 3.34e-2 SMART
ZnF_C2H2 489 513 8.22e-2 SMART
ZnF_C2H2 519 542 1.76e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107129
AA Change: K540R

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000102746
Gene: ENSMUSG00000070902
AA Change: K540R

DomainStartEndE-ValueType
ZnF_C2H2 459 483 3.34e-2 SMART
ZnF_C2H2 489 513 8.22e-2 SMART
ZnF_C2H2 519 542 1.76e-1 SMART
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 93.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Depdc1b G A 13: 108,373,841 (GRCm38) V296I possibly damaging Het
Dot1l T C 10: 80,789,069 (GRCm38) S907P probably damaging Het
Epha7 G A 4: 28,821,503 (GRCm38) E223K possibly damaging Het
Ercc6 T C 14: 32,566,409 (GRCm38) I846T possibly damaging Het
Exoc4 A G 6: 33,918,568 (GRCm38) Y840C probably damaging Het
Gramd1a T C 7: 31,139,790 (GRCm38) D231G probably damaging Het
Mark2 A C 19: 7,281,934 (GRCm38) S90A probably damaging Het
Mbd1 A G 18: 74,276,477 (GRCm38) Q432R probably benign Het
Mcm2 G A 6: 88,893,008 (GRCm38) R60C probably damaging Het
Met T C 6: 17,491,742 (GRCm38) S168P probably benign Het
Nup210 T C 6: 91,040,868 (GRCm38) I304V probably benign Het
Olfr1197 T A 2: 88,729,084 (GRCm38) I172F probably damaging Het
Olfr356 T A 2: 36,937,300 (GRCm38) Y60* probably null Het
Ppfia4 A G 1: 134,332,397 (GRCm38) S43P possibly damaging Het
Rbbp8 A T 18: 11,696,776 (GRCm38) K132I possibly damaging Het
Rpap1 G A 2: 119,783,766 (GRCm38) P50L probably benign Het
Slc41a3 T A 6: 90,612,120 (GRCm38) I71K possibly damaging Het
Spaca7 A T 8: 12,598,959 (GRCm38) N127I probably benign Het
Stkld1 A T 2: 26,952,714 (GRCm38) D566V probably damaging Het
Tbxas1 A G 6: 39,027,661 (GRCm38) M281V probably benign Het
Txnl1 T C 18: 63,671,620 (GRCm38) T268A probably benign Het
Unc80 A T 1: 66,648,997 (GRCm38) I2385F possibly damaging Het
Vmn2r118 A G 17: 55,624,650 (GRCm38) I8T probably benign Het
Vmn2r80 T C 10: 79,171,621 (GRCm38) F477S probably damaging Het
Ythdc2 A G 18: 44,847,748 (GRCm38) E470G possibly damaging Het
Other mutations in Zfp352
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01963:Zfp352 APN 4 90,224,154 (GRCm38) missense possibly damaging 0.95
IGL02252:Zfp352 APN 4 90,224,130 (GRCm38) missense probably benign 0.02
IGL03156:Zfp352 APN 4 90,224,087 (GRCm38) missense possibly damaging 0.57
IGL03167:Zfp352 APN 4 90,224,702 (GRCm38) missense probably damaging 0.99
IGL03190:Zfp352 APN 4 90,223,757 (GRCm38) missense possibly damaging 0.94
IGL03335:Zfp352 APN 4 90,224,346 (GRCm38) missense probably damaging 0.99
R0051:Zfp352 UTSW 4 90,224,285 (GRCm38) missense probably damaging 0.99
R0403:Zfp352 UTSW 4 90,225,009 (GRCm38) missense possibly damaging 0.60
R0550:Zfp352 UTSW 4 90,224,690 (GRCm38) missense probably damaging 0.99
R0671:Zfp352 UTSW 4 90,223,919 (GRCm38) missense probably benign
R1034:Zfp352 UTSW 4 90,224,156 (GRCm38) missense possibly damaging 0.94
R1754:Zfp352 UTSW 4 90,223,809 (GRCm38) missense probably benign 0.23
R2016:Zfp352 UTSW 4 90,225,171 (GRCm38) missense probably benign 0.42
R2064:Zfp352 UTSW 4 90,225,120 (GRCm38) missense probably benign 0.08
R3552:Zfp352 UTSW 4 90,225,102 (GRCm38) missense probably benign 0.33
R3794:Zfp352 UTSW 4 90,225,149 (GRCm38) missense probably damaging 1.00
R3795:Zfp352 UTSW 4 90,225,149 (GRCm38) missense probably damaging 1.00
R4135:Zfp352 UTSW 4 90,225,024 (GRCm38) missense probably damaging 0.96
R4356:Zfp352 UTSW 4 90,223,834 (GRCm38) missense possibly damaging 0.91
R4409:Zfp352 UTSW 4 90,225,164 (GRCm38) missense probably benign 0.00
R4590:Zfp352 UTSW 4 90,224,535 (GRCm38) missense probably damaging 0.98
R4614:Zfp352 UTSW 4 90,225,081 (GRCm38) missense probably benign 0.00
R4617:Zfp352 UTSW 4 90,225,081 (GRCm38) missense probably benign 0.00
R4618:Zfp352 UTSW 4 90,225,081 (GRCm38) missense probably benign 0.00
R4741:Zfp352 UTSW 4 90,224,940 (GRCm38) missense possibly damaging 0.94
R4931:Zfp352 UTSW 4 90,224,304 (GRCm38) missense probably damaging 0.98
R4959:Zfp352 UTSW 4 90,224,139 (GRCm38) missense probably benign 0.01
R4973:Zfp352 UTSW 4 90,224,139 (GRCm38) missense probably benign 0.01
R5167:Zfp352 UTSW 4 90,224,216 (GRCm38) missense possibly damaging 0.94
R5260:Zfp352 UTSW 4 90,224,460 (GRCm38) missense probably damaging 0.99
R5524:Zfp352 UTSW 4 90,225,104 (GRCm38) missense possibly damaging 0.95
R5942:Zfp352 UTSW 4 90,225,070 (GRCm38) missense probably damaging 0.98
R6802:Zfp352 UTSW 4 90,225,200 (GRCm38) missense probably benign 0.33
R6819:Zfp352 UTSW 4 90,224,699 (GRCm38) missense probably benign
R7072:Zfp352 UTSW 4 90,224,424 (GRCm38) missense probably benign 0.00
R7099:Zfp352 UTSW 4 90,224,880 (GRCm38) missense probably benign 0.00
R7569:Zfp352 UTSW 4 90,223,659 (GRCm38) missense possibly damaging 0.77
R7645:Zfp352 UTSW 4 90,224,777 (GRCm38) missense probably benign 0.13
R7705:Zfp352 UTSW 4 90,225,275 (GRCm38) missense possibly damaging 0.94
R8424:Zfp352 UTSW 4 90,224,243 (GRCm38) missense possibly damaging 0.87
R9180:Zfp352 UTSW 4 90,224,881 (GRCm38) missense probably benign 0.38
R9378:Zfp352 UTSW 4 90,224,338 (GRCm38) missense probably benign 0.13
R9509:Zfp352 UTSW 4 90,224,706 (GRCm38) missense probably damaging 0.99
R9623:Zfp352 UTSW 4 90,224,891 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTGTCACAGAAGGACCCTAGTC -3'
(R):5'- GCTCTGCACATTCTGGACAG -3'

Sequencing Primer
(F):5'- GACCCTAGTCCTTTGAAGCTC -3'
(R):5'- TCTGCACATTCTGGACAGATCAGG -3'
Posted On 2014-10-30