Incidental Mutation 'R2323:Zfp558'
ID 244809
Institutional Source Beutler Lab
Gene Symbol Zfp558
Ensembl Gene ENSMUSG00000074500
Gene Name zinc finger protein 558
Synonyms Zfp558-ps, 1700007A21Rik, 4932704I17Rik
MMRRC Submission 040314-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2323 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 18366871-18389564 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 18380573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034647] [ENSMUST00000034647] [ENSMUST00000159596]
AlphaFold E9Q1J0
Predicted Effect noncoding transcript
Transcript: ENSMUST00000034646
Predicted Effect probably null
Transcript: ENSMUST00000034647
SMART Domains Protein: ENSMUSP00000132305
Gene: ENSMUSG00000074500

DomainStartEndE-ValueType
KRAB 43 103 2.52e-29 SMART
ZnF_C2H2 156 178 1.45e-2 SMART
ZnF_C2H2 184 206 2.79e-4 SMART
ZnF_C2H2 212 234 6.52e-5 SMART
ZnF_C2H2 240 262 2.02e-1 SMART
ZnF_C2H2 269 291 5.14e-3 SMART
ZnF_C2H2 297 319 5.21e-4 SMART
ZnF_C2H2 325 347 1.3e-4 SMART
ZnF_C2H2 353 375 2.99e-4 SMART
ZnF_C2H2 381 403 3.39e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000034647
SMART Domains Protein: ENSMUSP00000132305
Gene: ENSMUSG00000074500

DomainStartEndE-ValueType
KRAB 43 103 2.52e-29 SMART
ZnF_C2H2 156 178 1.45e-2 SMART
ZnF_C2H2 184 206 2.79e-4 SMART
ZnF_C2H2 212 234 6.52e-5 SMART
ZnF_C2H2 240 262 2.02e-1 SMART
ZnF_C2H2 269 291 5.14e-3 SMART
ZnF_C2H2 297 319 5.21e-4 SMART
ZnF_C2H2 325 347 1.3e-4 SMART
ZnF_C2H2 353 375 2.99e-4 SMART
ZnF_C2H2 381 403 3.39e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159596
SMART Domains Protein: ENSMUSP00000126946
Gene: ENSMUSG00000074500

DomainStartEndE-ValueType
KRAB 43 100 1.24e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162441
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 G T 2: 25,335,187 (GRCm39) M2008I probably benign Het
Adgrv1 A G 13: 81,743,298 (GRCm39) S68P probably damaging Het
Albfm1 T A 5: 90,732,711 (GRCm39) Y507* probably null Het
Anks3 T C 16: 4,768,634 (GRCm39) probably null Het
Asap2 T C 12: 21,253,969 (GRCm39) I160T probably damaging Het
Asb15 T A 6: 24,556,600 (GRCm39) F32I probably benign Het
Catip A T 1: 74,402,437 (GRCm39) M103L probably benign Het
Cela2a G C 4: 141,553,390 (GRCm39) probably benign Het
Crebrf T C 17: 26,982,581 (GRCm39) probably benign Het
Dnah10 T C 5: 124,819,064 (GRCm39) M450T probably damaging Het
Dst T C 1: 34,267,518 (GRCm39) S5165P possibly damaging Het
Esrp2 T A 8: 106,860,934 (GRCm39) D196V probably benign Het
Hmox2 A T 16: 4,583,720 (GRCm39) K263* probably null Het
Ints10 A G 8: 69,271,997 (GRCm39) H566R probably benign Het
Ints12 G A 3: 132,815,126 (GRCm39) M444I possibly damaging Het
Liph A G 16: 21,802,754 (GRCm39) V105A probably damaging Het
Myo1e T A 9: 70,286,040 (GRCm39) Y941* probably null Het
Myo7b T C 18: 32,104,398 (GRCm39) E1450G probably damaging Het
Myt1 G T 2: 181,448,350 (GRCm39) A594S probably damaging Het
Npas3 T A 12: 54,115,129 (GRCm39) Y666N probably damaging Het
Npsr1 A G 9: 24,211,732 (GRCm39) K240E probably damaging Het
Or52h7 T C 7: 104,213,826 (GRCm39) F133L probably benign Het
Rtkn2 A G 10: 67,837,764 (GRCm39) I102M probably damaging Het
Rundc1 T C 11: 101,316,101 (GRCm39) F58L probably damaging Het
Snrpc T G 17: 28,066,948 (GRCm39) M91R unknown Het
Tgfbr2 T C 9: 115,939,212 (GRCm39) K205R possibly damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tnfrsf21 C A 17: 43,396,420 (GRCm39) S568* probably null Het
Tulp1 C T 17: 28,581,456 (GRCm39) G239D probably damaging Het
Vmn1r234 T C 17: 21,449,965 (GRCm39) I293T probably benign Het
Vmn1r26 T C 6: 57,985,842 (GRCm39) K116E probably damaging Het
Vmn2r98 T A 17: 19,286,081 (GRCm39) I193K probably benign Het
Wnk4 T A 11: 101,159,307 (GRCm39) S575T probably damaging Het
Zscan18 T C 7: 12,509,386 (GRCm39) probably benign Het
Other mutations in Zfp558
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00532:Zfp558 APN 9 18,367,883 (GRCm39) missense possibly damaging 0.72
IGL00722:Zfp558 APN 9 18,367,817 (GRCm39) missense probably damaging 0.97
R0270:Zfp558 UTSW 9 18,379,252 (GRCm39) missense probably damaging 1.00
R0708:Zfp558 UTSW 9 18,368,123 (GRCm39) missense possibly damaging 0.75
R1521:Zfp558 UTSW 9 18,367,859 (GRCm39) missense possibly damaging 0.86
R1618:Zfp558 UTSW 9 18,380,579 (GRCm39) missense possibly damaging 0.73
R2939:Zfp558 UTSW 9 18,367,924 (GRCm39) missense possibly damaging 0.71
R4537:Zfp558 UTSW 9 18,368,798 (GRCm39) missense probably null 0.72
R4569:Zfp558 UTSW 9 18,367,799 (GRCm39) missense possibly damaging 0.72
R4570:Zfp558 UTSW 9 18,367,799 (GRCm39) missense possibly damaging 0.72
R4571:Zfp558 UTSW 9 18,367,799 (GRCm39) missense possibly damaging 0.72
R4619:Zfp558 UTSW 9 18,367,577 (GRCm39) missense possibly damaging 0.96
R5207:Zfp558 UTSW 9 18,368,296 (GRCm39) missense possibly damaging 0.93
R5530:Zfp558 UTSW 9 18,367,669 (GRCm39) missense probably benign 0.05
R6631:Zfp558 UTSW 9 18,368,219 (GRCm39) nonsense probably null
R7892:Zfp558 UTSW 9 18,379,993 (GRCm39) missense possibly damaging 0.73
R8309:Zfp558 UTSW 9 18,368,213 (GRCm39) missense probably benign 0.02
R9006:Zfp558 UTSW 9 18,367,776 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- GGCTGTCTCTCATATCCAAGG -3'
(R):5'- CAGTGTGCATCTTGAAGAAGGC -3'

Sequencing Primer
(F):5'- GTCTCTCATATCCAAGGACCACTGG -3'
(R):5'- GCTGAAAAGGGCTCATCCTC -3'
Posted On 2014-10-30