Incidental Mutation 'R2274:Gpr155'
ID 244947
Institutional Source Beutler Lab
Gene Symbol Gpr155
Ensembl Gene ENSMUSG00000041762
Gene Name G protein-coupled receptor 155
Synonyms DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2274 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 73171850-73216842 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 73178479 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000076463] [ENSMUST00000112043] [ENSMUST00000112044]
AlphaFold A2AWR3
Predicted Effect noncoding transcript
Transcript: ENSMUST00000048504
SMART Domains Protein: ENSMUSP00000037772
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 1.9e-16 PFAM
Pfam:Mem_trans 187 360 4.9e-12 PFAM
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000076463
SMART Domains Protein: ENSMUSP00000075788
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112043
SMART Domains Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
transmembrane domain 209 231 N/A INTRINSIC
transmembrane domain 241 260 N/A INTRINSIC
transmembrane domain 272 291 N/A INTRINSIC
transmembrane domain 311 330 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 380 402 N/A INTRINSIC
transmembrane domain 415 432 N/A INTRINSIC
transmembrane domain 442 464 N/A INTRINSIC
transmembrane domain 477 499 N/A INTRINSIC
transmembrane domain 519 538 N/A INTRINSIC
transmembrane domain 657 679 N/A INTRINSIC
transmembrane domain 689 711 N/A INTRINSIC
DEP 759 833 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112044
SMART Domains Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
Pfam:Mem_trans 40 205 3.3e-15 PFAM
Pfam:Mem_trans 187 360 8.3e-11 PFAM
transmembrane domain 382 404 N/A INTRINSIC
transmembrane domain 414 436 N/A INTRINSIC
transmembrane domain 449 471 N/A INTRINSIC
transmembrane domain 491 510 N/A INTRINSIC
transmembrane domain 629 651 N/A INTRINSIC
transmembrane domain 661 683 N/A INTRINSIC
DEP 731 805 8.28e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000131430
SMART Domains Protein: ENSMUSP00000114294
Gene: ENSMUSG00000041762

DomainStartEndE-ValueType
transmembrane domain 98 120 N/A INTRINSIC
transmembrane domain 130 152 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184503
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300003K06Rik A T 11: 99,728,667 (GRCm39) C59S possibly damaging Het
Abca5 A T 11: 110,166,107 (GRCm39) N1556K possibly damaging Het
Abcb10 G T 8: 124,709,491 (GRCm39) A21E probably benign Het
Ackr1 T C 1: 173,160,052 (GRCm39) N156D probably benign Het
Adamtsl3 A T 7: 82,255,766 (GRCm39) S1593C probably benign Het
Ank3 T A 10: 69,786,772 (GRCm39) probably null Het
Aqp4 A G 18: 15,526,537 (GRCm39) S315P probably benign Het
Atp7b T C 8: 22,510,848 (GRCm39) I433V probably benign Het
Bco1 G A 8: 117,835,522 (GRCm39) probably null Het
Cacna1g T A 11: 94,306,762 (GRCm39) E1842V probably damaging Het
Calhm3 T A 19: 47,145,986 (GRCm39) Q73L probably damaging Het
Car5a C T 8: 122,671,408 (GRCm39) probably null Het
Cdk11b T A 4: 155,732,051 (GRCm39) probably benign Het
Cdr2 A T 7: 120,557,732 (GRCm39) H264Q possibly damaging Het
Col9a2 C G 4: 120,911,455 (GRCm39) R599G probably damaging Het
D7Ertd443e A G 7: 133,871,930 (GRCm39) S644P probably damaging Het
Dnlz A T 2: 26,241,483 (GRCm39) C82S probably damaging Het
Egr4 A T 6: 85,489,725 (GRCm39) F112I probably damaging Het
Emilin1 C T 5: 31,075,082 (GRCm39) P441L possibly damaging Het
F11 T C 8: 45,705,184 (GRCm39) D119G possibly damaging Het
Fat4 T A 3: 39,050,048 (GRCm39) V3970D possibly damaging Het
Fbxw5 C A 2: 25,394,773 (GRCm39) C222* probably null Het
Fn1 C T 1: 71,653,102 (GRCm39) G1296R probably null Het
Ghr A G 15: 3,349,507 (GRCm39) V557A probably benign Het
Gm11568 A G 11: 99,749,070 (GRCm39) S92G unknown Het
Gpatch1 A T 7: 34,988,103 (GRCm39) S678T probably benign Het
Gucy2f A T X: 140,899,269 (GRCm39) M697K probably benign Het
Hecw1 T C 13: 14,520,653 (GRCm39) T195A probably benign Het
Hoxd1 A G 2: 74,594,501 (GRCm39) K252R probably damaging Het
Iqck G A 7: 118,498,880 (GRCm39) D173N possibly damaging Het
Irf8 A G 8: 121,480,266 (GRCm39) E168G probably damaging Het
Kcnh1 T G 1: 192,019,829 (GRCm39) V358G probably damaging Het
Kifap3 T A 1: 163,696,327 (GRCm39) V652D possibly damaging Het
L3hypdh T C 12: 72,131,632 (GRCm39) Y100C possibly damaging Het
Map4k1 T A 7: 28,701,382 (GRCm39) H729Q probably damaging Het
Marchf1 T A 8: 66,840,151 (GRCm39) N311K probably benign Het
Mier2 T C 10: 79,380,368 (GRCm39) I321V probably damaging Het
Mta1 C T 12: 113,091,770 (GRCm39) S291L probably damaging Het
Myh2 A G 11: 67,081,184 (GRCm39) K1267E possibly damaging Het
Nbea A T 3: 55,895,506 (GRCm39) probably null Het
Nexmif T G X: 103,131,452 (GRCm39) E155A possibly damaging Het
Nkpd1 A G 7: 19,257,822 (GRCm39) I534V probably benign Het
Nxph1 G T 6: 9,247,746 (GRCm39) C239F probably damaging Het
Odc1 A G 12: 17,598,425 (GRCm39) I189V probably benign Het
Or1n1 A T 2: 36,750,113 (GRCm39) N82K probably damaging Het
Or2t44 T C 11: 58,677,492 (GRCm39) V144A probably benign Het
Or5d41 A G 2: 88,055,167 (GRCm39) F70L probably benign Het
Or6c35 T C 10: 129,169,326 (GRCm39) I192T probably benign Het
Pcdhb15 T C 18: 37,608,496 (GRCm39) L576P probably damaging Het
Raph1 T C 1: 60,537,659 (GRCm39) D499G probably damaging Het
Rptor T A 11: 119,647,148 (GRCm39) C246* probably null Het
Rtl1 T C 12: 109,561,101 (GRCm39) E246G unknown Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Slc12a3 T A 8: 95,059,915 (GRCm39) I187N possibly damaging Het
Slc46a1 T G 11: 78,357,249 (GRCm39) S101A probably benign Het
Slc4a8 A G 15: 100,705,283 (GRCm39) M830V probably benign Het
Sned1 T A 1: 93,209,364 (GRCm39) probably null Het
St3gal6 T A 16: 58,309,332 (GRCm39) E34D possibly damaging Het
Tcstv3 C T 13: 120,779,190 (GRCm39) Q30* probably null Het
Tex16 T A X: 111,030,838 (GRCm39) D1112E probably damaging Het
Tmcc3 G A 10: 94,414,777 (GRCm39) V160I probably damaging Het
Tmf1 T A 6: 97,140,547 (GRCm39) L776F probably damaging Het
Tsr1 A T 11: 74,795,653 (GRCm39) probably null Het
Tyrp1 A T 4: 80,755,771 (GRCm39) E180V probably damaging Het
Ubr3 T C 2: 69,846,685 (GRCm39) V1636A probably benign Het
Usp1 T C 4: 98,818,079 (GRCm39) L139P probably damaging Het
Vmn1r232 A G 17: 21,134,465 (GRCm39) L45P probably benign Het
Vmn1r49 G A 6: 90,049,126 (GRCm39) T292I probably benign Het
Wdr19 T A 5: 65,398,334 (GRCm39) M853K possibly damaging Het
Zkscan8 C T 13: 21,705,966 (GRCm39) M265I probably benign Het
Other mutations in Gpr155
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00731:Gpr155 APN 2 73,192,957 (GRCm39) missense probably damaging 1.00
IGL01432:Gpr155 APN 2 73,182,229 (GRCm39) missense possibly damaging 0.51
IGL01528:Gpr155 APN 2 73,192,767 (GRCm39) critical splice donor site probably null
IGL01718:Gpr155 APN 2 73,212,576 (GRCm39) missense probably benign
IGL01733:Gpr155 APN 2 73,183,956 (GRCm39) splice site probably null
IGL03342:Gpr155 APN 2 73,180,022 (GRCm39) missense probably damaging 1.00
PIT1430001:Gpr155 UTSW 2 73,200,482 (GRCm39) missense probably benign 0.08
PIT4810001:Gpr155 UTSW 2 73,178,607 (GRCm39) missense probably benign 0.08
R0226:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R0399:Gpr155 UTSW 2 73,200,346 (GRCm39) missense possibly damaging 0.91
R0445:Gpr155 UTSW 2 73,200,488 (GRCm39) splice site probably benign
R1570:Gpr155 UTSW 2 73,200,382 (GRCm39) missense possibly damaging 0.87
R1598:Gpr155 UTSW 2 73,200,434 (GRCm39) missense probably damaging 0.98
R1647:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1648:Gpr155 UTSW 2 73,194,508 (GRCm39) splice site probably null
R1756:Gpr155 UTSW 2 73,197,921 (GRCm39) missense probably benign 0.00
R1760:Gpr155 UTSW 2 73,212,279 (GRCm39) missense probably damaging 1.00
R2033:Gpr155 UTSW 2 73,178,526 (GRCm39) missense probably benign 0.18
R2044:Gpr155 UTSW 2 73,203,977 (GRCm39) missense probably damaging 1.00
R2145:Gpr155 UTSW 2 73,187,002 (GRCm39) missense probably benign 0.01
R2172:Gpr155 UTSW 2 73,212,471 (GRCm39) missense probably benign 0.00
R3878:Gpr155 UTSW 2 73,198,736 (GRCm39) nonsense probably null
R3924:Gpr155 UTSW 2 73,200,420 (GRCm39) missense probably damaging 1.00
R4910:Gpr155 UTSW 2 73,197,882 (GRCm39) nonsense probably null
R4950:Gpr155 UTSW 2 73,212,529 (GRCm39) missense probably benign
R5337:Gpr155 UTSW 2 73,178,592 (GRCm39) missense probably benign 0.32
R5830:Gpr155 UTSW 2 73,200,433 (GRCm39) missense possibly damaging 0.93
R5887:Gpr155 UTSW 2 73,174,062 (GRCm39) nonsense probably null
R5929:Gpr155 UTSW 2 73,204,011 (GRCm39) nonsense probably null
R6293:Gpr155 UTSW 2 73,204,341 (GRCm39) missense possibly damaging 0.47
R6553:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R6585:Gpr155 UTSW 2 73,179,989 (GRCm39) missense probably damaging 1.00
R7003:Gpr155 UTSW 2 73,173,961 (GRCm39) missense probably damaging 0.99
R7353:Gpr155 UTSW 2 73,197,835 (GRCm39) nonsense probably null
R7506:Gpr155 UTSW 2 73,198,683 (GRCm39) missense probably damaging 0.97
R7631:Gpr155 UTSW 2 73,213,291 (GRCm39) intron probably benign
R7753:Gpr155 UTSW 2 73,212,550 (GRCm39) missense probably benign 0.27
R7810:Gpr155 UTSW 2 73,212,296 (GRCm39) missense probably damaging 0.99
R7813:Gpr155 UTSW 2 73,212,329 (GRCm39) nonsense probably null
R7815:Gpr155 UTSW 2 73,192,904 (GRCm39) missense probably benign
R7873:Gpr155 UTSW 2 73,173,934 (GRCm39) missense possibly damaging 0.51
R8506:Gpr155 UTSW 2 73,173,806 (GRCm39) missense probably damaging 0.99
R8680:Gpr155 UTSW 2 73,174,039 (GRCm39) missense probably damaging 0.99
R8856:Gpr155 UTSW 2 73,203,993 (GRCm39) missense probably benign 0.27
R8872:Gpr155 UTSW 2 73,197,936 (GRCm39) missense probably benign 0.02
R9116:Gpr155 UTSW 2 73,204,109 (GRCm39) missense possibly damaging 0.78
R9683:Gpr155 UTSW 2 73,192,780 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GAAATCTCTTCTGGAGCCGGTG -3'
(R):5'- GTGACAGGTTGTGGATCAGC -3'

Sequencing Primer
(F):5'- TTGTGGGAGACGCTAATGGCC -3'
(R):5'- GGATCAGCCACCTTCTTAAATTCTGG -3'
Posted On 2014-10-30