Incidental Mutation 'R2292:Or2w6'
ID 245051
Institutional Source Beutler Lab
Gene Symbol Or2w6
Ensembl Gene ENSMUSG00000049737
Gene Name olfactory receptor family 2 subfamily W member 6
Synonyms GA_x6K02T2QHY8-11577590-11578528, MOR256-12, Olfr1361
MMRRC Submission 040291-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.179) question?
Stock # R2292 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 21842538-21848693 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21843001 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 164 (M164T)
Ref Sequence ENSEMBL: ENSMUSP00000150315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055615] [ENSMUST00000214321]
AlphaFold Q8VFH0
Predicted Effect probably damaging
Transcript: ENSMUST00000055615
AA Change: M164T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000062356
Gene: ENSMUSG00000049737
AA Change: M164T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 30 312 4.2e-10 PFAM
Pfam:7tm_4 36 313 7.7e-52 PFAM
Pfam:7tm_1 46 295 1.5e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214321
AA Change: M164T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik T C 2: 68,562,483 (GRCm39) I370T probably benign Het
A2m A G 6: 121,650,518 (GRCm39) T1209A possibly damaging Het
Als2 T C 1: 59,226,544 (GRCm39) Q920R probably damaging Het
Arhgap20 T A 9: 51,760,743 (GRCm39) Y829N possibly damaging Het
Arhgap35 A T 7: 16,297,476 (GRCm39) F530I probably damaging Het
Arid4a G T 12: 71,108,315 (GRCm39) G40V probably damaging Het
Ascc2 T C 11: 4,629,352 (GRCm39) probably benign Het
Cacna1b C T 2: 24,496,632 (GRCm39) V2312I probably benign Het
Dctn6 T C 8: 34,559,679 (GRCm39) T159A probably benign Het
Ddx55 G T 5: 124,706,140 (GRCm39) A522S probably benign Het
Dnah6 G A 6: 72,998,092 (GRCm39) T4110I probably damaging Het
Dvl1 G A 4: 155,932,273 (GRCm39) V28I possibly damaging Het
Dym A G 18: 75,332,283 (GRCm39) T504A possibly damaging Het
E130308A19Rik T C 4: 59,690,579 (GRCm39) Y138H probably damaging Het
Fgd4 A T 16: 16,253,864 (GRCm39) C568S possibly damaging Het
Fkbp4 A C 6: 128,413,625 (GRCm39) V6G probably damaging Het
Flg2 A T 3: 93,127,984 (GRCm39) S2299C unknown Het
Gdf2 A T 14: 33,667,145 (GRCm39) N289I possibly damaging Het
Gpr182 A G 10: 127,586,051 (GRCm39) I300T possibly damaging Het
Iqcg A G 16: 32,870,253 (GRCm39) V80A probably benign Het
Letm1 A AG 5: 33,926,859 (GRCm39) probably null Het
Lyst T G 13: 13,915,080 (GRCm39) F3258C probably damaging Het
Map3k12 T C 15: 102,408,574 (GRCm39) E870G probably damaging Het
Mphosph10 G A 7: 64,035,519 (GRCm39) P384L probably damaging Het
Ncoa4 T G 14: 31,895,413 (GRCm39) L179R probably damaging Het
Nlrp1c-ps A G 11: 71,137,188 (GRCm39) noncoding transcript Het
Nwd2 A T 5: 63,962,917 (GRCm39) M834L probably benign Het
Or10a49 A T 7: 108,468,223 (GRCm39) M46K probably benign Het
Pccb T C 9: 100,876,685 (GRCm39) E266G probably benign Het
Pcdhb2 T A 18: 37,430,297 (GRCm39) probably null Het
Pramel25 T C 4: 143,520,446 (GRCm39) I66T probably benign Het
Prdm13 A C 4: 21,683,914 (GRCm39) I119S unknown Het
Tchh A G 3: 93,349,689 (GRCm39) Y18C probably damaging Het
Tmem192 T C 8: 65,411,998 (GRCm39) V59A probably damaging Het
Trak2 A T 1: 58,974,916 (GRCm39) F92Y probably damaging Het
Trappc11 C T 8: 47,958,771 (GRCm39) G40D probably damaging Het
Ttc23 A T 7: 67,319,535 (GRCm39) I132F probably benign Het
Ttc9b A G 7: 27,355,405 (GRCm39) D225G probably benign Het
Ubr3 G T 2: 69,727,604 (GRCm39) probably benign Het
Vmn2r75 A C 7: 85,798,144 (GRCm39) C556W probably damaging Het
Zbtb41 T C 1: 139,368,097 (GRCm39) V595A probably damaging Het
Other mutations in Or2w6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01878:Or2w6 APN 13 21,842,953 (GRCm39) missense possibly damaging 0.63
IGL02025:Or2w6 APN 13 21,843,433 (GRCm39) missense possibly damaging 0.92
IGL02275:Or2w6 APN 13 21,843,170 (GRCm39) missense probably benign 0.01
IGL02831:Or2w6 APN 13 21,843,074 (GRCm39) missense probably benign
IGL02932:Or2w6 APN 13 21,843,001 (GRCm39) missense probably damaging 1.00
R0102:Or2w6 UTSW 13 21,842,905 (GRCm39) missense probably damaging 1.00
R0597:Or2w6 UTSW 13 21,843,316 (GRCm39) missense probably damaging 0.96
R1669:Or2w6 UTSW 13 21,843,456 (GRCm39) missense possibly damaging 0.91
R2006:Or2w6 UTSW 13 21,842,642 (GRCm39) missense possibly damaging 0.94
R4894:Or2w6 UTSW 13 21,843,352 (GRCm39) missense probably damaging 1.00
R4919:Or2w6 UTSW 13 21,842,794 (GRCm39) missense possibly damaging 0.59
R5339:Or2w6 UTSW 13 21,843,404 (GRCm39) missense probably benign 0.37
R5815:Or2w6 UTSW 13 21,842,707 (GRCm39) missense probably damaging 1.00
R6248:Or2w6 UTSW 13 21,843,244 (GRCm39) missense possibly damaging 0.72
R8273:Or2w6 UTSW 13 21,843,377 (GRCm39) missense probably damaging 1.00
R8323:Or2w6 UTSW 13 21,843,302 (GRCm39) missense possibly damaging 0.95
R8913:Or2w6 UTSW 13 21,843,274 (GRCm39) missense probably damaging 1.00
R9010:Or2w6 UTSW 13 21,842,681 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GATCCTAAACACTGCTCGGG -3'
(R):5'- GGGTTGTGCTATCCAACTGTAC -3'

Sequencing Primer
(F):5'- TGCTCGGGCAATGTAACCATAG -3'
(R):5'- AACTGTACTTTGTCTTAGCCCTGGG -3'
Posted On 2014-10-30