Incidental Mutation 'R2296:Iigp1c'
| ID |
245189 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Iigp1c
|
| Ensembl Gene |
ENSMUSG00000073555 |
| Gene Name |
interferon inducible GTPase 1C |
| Synonyms |
Gm4951 |
| MMRRC Submission |
040295-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2296 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
60345152-60380892 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 60378542 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 26
(C26S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031549
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031549]
|
| AlphaFold |
Q3UED7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000031549
AA Change: C26S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: C26S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IIGP
|
34 |
402 |
4.8e-157 |
PFAM |
|
Pfam:MMR_HSR1
|
70 |
198 |
2.8e-8 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
A |
G |
1: 11,582,275 (GRCm39) |
E68G |
possibly damaging |
Het |
| Apob |
A |
G |
12: 8,044,879 (GRCm39) |
D820G |
probably damaging |
Het |
| Bglap3 |
G |
C |
3: 88,276,819 (GRCm39) |
|
probably benign |
Het |
| Calr3 |
C |
T |
8: 73,178,469 (GRCm39) |
|
probably benign |
Het |
| Carmil1 |
A |
G |
13: 24,299,492 (GRCm39) |
L344P |
probably damaging |
Het |
| Cop1 |
G |
A |
1: 159,072,220 (GRCm39) |
V109M |
possibly damaging |
Het |
| Dennd4b |
T |
A |
3: 90,182,821 (GRCm39) |
N879K |
probably damaging |
Het |
| Fam13b |
T |
C |
18: 34,627,814 (GRCm39) |
D129G |
possibly damaging |
Het |
| Fam222a |
C |
A |
5: 114,749,027 (GRCm39) |
H74Q |
possibly damaging |
Het |
| Gata5 |
A |
G |
2: 179,970,113 (GRCm39) |
M278T |
possibly damaging |
Het |
| Grm7 |
G |
T |
6: 110,623,309 (GRCm39) |
V161F |
probably damaging |
Het |
| Inpp5k |
T |
G |
11: 75,530,313 (GRCm39) |
L251R |
probably damaging |
Het |
| Lrrc36 |
T |
G |
8: 106,187,651 (GRCm39) |
D522E |
possibly damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Nras |
T |
A |
3: 102,966,350 (GRCm39) |
|
probably null |
Het |
| Nudt12 |
A |
G |
17: 59,317,044 (GRCm39) |
V201A |
possibly damaging |
Het |
| Phf2 |
T |
C |
13: 48,988,754 (GRCm39) |
E39G |
unknown |
Het |
| Serpinb3a |
A |
T |
1: 106,975,291 (GRCm39) |
V172D |
probably damaging |
Het |
| Stab2 |
T |
A |
10: 86,790,338 (GRCm39) |
|
probably null |
Het |
| Trim3 |
A |
G |
7: 105,262,481 (GRCm39) |
I559T |
probably damaging |
Het |
| Trp53bp1 |
A |
T |
2: 121,039,728 (GRCm39) |
S1304T |
possibly damaging |
Het |
| Xrcc5 |
A |
T |
1: 72,385,485 (GRCm39) |
K525N |
probably benign |
Het |
| Zfp110 |
T |
A |
7: 12,583,467 (GRCm39) |
V705D |
probably damaging |
Het |
|
| Other mutations in Iigp1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00717:Iigp1c
|
APN |
18 |
60,379,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Iigp1c
|
APN |
18 |
60,378,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00956:Iigp1c
|
APN |
18 |
60,379,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01017:Iigp1c
|
APN |
18 |
60,378,508 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01929:Iigp1c
|
APN |
18 |
60,379,554 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02267:Iigp1c
|
APN |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02276:Iigp1c
|
APN |
18 |
60,379,151 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02499:Iigp1c
|
APN |
18 |
60,378,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02538:Iigp1c
|
APN |
18 |
60,378,944 (GRCm39) |
nonsense |
probably null |
|
|
IGL03139:Iigp1c
|
APN |
18 |
60,379,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03209:Iigp1c
|
APN |
18 |
60,379,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Iigp1c
|
APN |
18 |
60,378,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03325:Iigp1c
|
APN |
18 |
60,378,883 (GRCm39) |
nonsense |
probably null |
|
|
Carboniferous
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Oily
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Iigp1c
|
UTSW |
18 |
60,378,489 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2046:Iigp1c
|
UTSW |
18 |
60,378,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4583:Iigp1c
|
UTSW |
18 |
60,379,152 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5500:Iigp1c
|
UTSW |
18 |
60,379,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5532:Iigp1c
|
UTSW |
18 |
60,379,142 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5938:Iigp1c
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6446:Iigp1c
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7191:Iigp1c
|
UTSW |
18 |
60,379,329 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7238:Iigp1c
|
UTSW |
18 |
60,379,355 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7443:Iigp1c
|
UTSW |
18 |
60,379,122 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9261:Iigp1c
|
UTSW |
18 |
60,353,820 (GRCm39) |
intron |
probably benign |
|
|
R9650:Iigp1c
|
UTSW |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Iigp1c
|
UTSW |
18 |
60,379,368 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGATGGTCTCAGCTACCTG -3'
(R):5'- AAGCTGGACTTCCCTGATCCAG -3'
Sequencing Primer
(F):5'- TGGTCTCAGCTACCTGCAGAAAG -3'
(R):5'- ATCCAGTCTCCCCGGTGAGAG -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation