Incidental Mutation 'R2298:Rps6ka5'
ID 245238
Institutional Source Beutler Lab
Gene Symbol Rps6ka5
Ensembl Gene ENSMUSG00000021180
Gene Name ribosomal protein S6 kinase, polypeptide 5
Synonyms 3110005L17Rik, MSK1, 6330404E13Rik
MMRRC Submission 040297-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2298 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 100514692-100691693 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 100517713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 796 (F796S)
Ref Sequence ENSEMBL: ENSMUSP00000152481 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043599] [ENSMUST00000222731]
AlphaFold Q8C050
Predicted Effect possibly damaging
Transcript: ENSMUST00000043599
AA Change: F861S

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000042987
Gene: ENSMUSG00000021180
AA Change: F861S

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
S_TKc 48 317 1.08e-101 SMART
S_TK_X 318 378 2.45e-13 SMART
S_TKc 425 751 1.1e-75 SMART
low complexity region 812 832 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221246
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221323
Predicted Effect probably benign
Transcript: ENSMUST00000221356
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221379
Predicted Effect probably damaging
Transcript: ENSMUST00000222731
AA Change: F796S

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a mutant allele exhibit altered response to cocaine including decreased hyperlocomotor activity and sensitization at a lower dose. Mice homozygous for a kinase dead allele exhibit altered experience-dependent synaptic plasticity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A G 8: 73,209,247 (GRCm39) D459G probably benign Het
Abhd12 C A 2: 150,743,414 (GRCm39) probably benign Het
Atcay A T 10: 81,046,397 (GRCm39) I309N probably damaging Het
Capn8 T C 1: 182,440,985 (GRCm39) V473A probably benign Het
Cramp1 T C 17: 25,216,454 (GRCm39) I220V probably damaging Het
Creb3l1 G A 2: 91,822,321 (GRCm39) P222S probably damaging Het
Crocc G A 4: 140,752,770 (GRCm39) A1374V probably benign Het
Crybg1 A G 10: 43,875,218 (GRCm39) L630S probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Erbb4 C T 1: 68,081,690 (GRCm39) D1115N probably damaging Het
Fasn T A 11: 120,704,642 (GRCm39) L1314F possibly damaging Het
Galm T A 17: 80,489,126 (GRCm39) C84* probably null Het
H3f3a C T 1: 180,630,703 (GRCm39) R117H probably benign Het
Klf13 T C 7: 63,541,504 (GRCm39) K208E probably damaging Het
Kremen1 AGGCGG AGGCGGCGG 11: 5,151,788 (GRCm39) probably benign Het
Lgmn A G 12: 102,361,937 (GRCm39) F388S probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Msh2 T A 17: 88,015,930 (GRCm39) Y521N probably damaging Het
Myo5b G T 18: 74,758,676 (GRCm39) R219L probably damaging Het
Myzap A T 9: 71,456,039 (GRCm39) M327K probably damaging Het
Ngfr AAGCAGCAGCAGCAGCAGCAGCAG AAGCAGCAGCAGCAGCAGCAG 11: 95,478,316 (GRCm39) probably benign Het
Phf8-ps T C 17: 33,285,752 (GRCm39) E350G probably damaging Het
Srl T C 16: 4,300,762 (GRCm39) I332V probably damaging Het
Stab2 T A 10: 86,790,338 (GRCm39) probably null Het
Tenm2 T C 11: 35,937,604 (GRCm39) T1690A possibly damaging Het
Traf4 T A 11: 78,051,677 (GRCm39) D241V probably benign Het
Trpv6 A G 6: 41,613,010 (GRCm39) I52T possibly damaging Het
Zfp768 T A 7: 126,943,361 (GRCm39) M256L probably benign Het
Other mutations in Rps6ka5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01072:Rps6ka5 APN 12 100,540,157 (GRCm39) missense probably benign
IGL01450:Rps6ka5 APN 12 100,519,250 (GRCm39) splice site probably benign
IGL01586:Rps6ka5 APN 12 100,537,173 (GRCm39) missense probably damaging 0.99
IGL01743:Rps6ka5 APN 12 100,541,892 (GRCm39) critical splice donor site probably null
IGL02995:Rps6ka5 APN 12 100,540,258 (GRCm39) intron probably benign
IGL03051:Rps6ka5 APN 12 100,582,250 (GRCm39) splice site probably null
IGL03190:Rps6ka5 APN 12 100,524,907 (GRCm39) splice site probably benign
chard UTSW 12 100,582,342 (GRCm39) missense probably damaging 1.00
Ramp UTSW 12 100,541,964 (GRCm39) missense possibly damaging 0.85
zwiebel UTSW 12 100,644,797 (GRCm39) missense probably damaging 0.99
R0055:Rps6ka5 UTSW 12 100,644,839 (GRCm39) missense probably damaging 0.97
R0055:Rps6ka5 UTSW 12 100,644,839 (GRCm39) missense probably damaging 0.97
R0067:Rps6ka5 UTSW 12 100,582,342 (GRCm39) missense probably damaging 1.00
R0212:Rps6ka5 UTSW 12 100,519,428 (GRCm39) splice site probably null
R0761:Rps6ka5 UTSW 12 100,537,141 (GRCm39) missense probably damaging 1.00
R0893:Rps6ka5 UTSW 12 100,540,697 (GRCm39) missense possibly damaging 0.71
R1237:Rps6ka5 UTSW 12 100,541,964 (GRCm39) missense possibly damaging 0.85
R1254:Rps6ka5 UTSW 12 100,585,788 (GRCm39) missense probably damaging 1.00
R1447:Rps6ka5 UTSW 12 100,544,084 (GRCm39) missense probably benign 0.02
R1611:Rps6ka5 UTSW 12 100,537,111 (GRCm39) missense possibly damaging 0.77
R2086:Rps6ka5 UTSW 12 100,585,874 (GRCm39) missense possibly damaging 0.67
R2129:Rps6ka5 UTSW 12 100,644,797 (GRCm39) missense probably damaging 0.99
R2432:Rps6ka5 UTSW 12 100,520,664 (GRCm39) missense probably damaging 0.98
R4378:Rps6ka5 UTSW 12 100,564,196 (GRCm39) missense probably damaging 1.00
R4394:Rps6ka5 UTSW 12 100,547,578 (GRCm39) missense probably damaging 0.97
R4461:Rps6ka5 UTSW 12 100,537,123 (GRCm39) missense probably damaging 0.99
R4584:Rps6ka5 UTSW 12 100,547,577 (GRCm39) missense probably damaging 1.00
R4672:Rps6ka5 UTSW 12 100,620,546 (GRCm39) missense possibly damaging 0.93
R4706:Rps6ka5 UTSW 12 100,547,578 (GRCm39) missense probably damaging 0.97
R4706:Rps6ka5 UTSW 12 100,564,144 (GRCm39) splice site probably null
R4707:Rps6ka5 UTSW 12 100,564,144 (GRCm39) splice site probably null
R4966:Rps6ka5 UTSW 12 100,519,325 (GRCm39) missense probably benign 0.01
R5059:Rps6ka5 UTSW 12 100,520,634 (GRCm39) missense probably damaging 0.96
R5404:Rps6ka5 UTSW 12 100,582,352 (GRCm39) missense probably damaging 1.00
R5660:Rps6ka5 UTSW 12 100,585,839 (GRCm39) missense possibly damaging 0.95
R5678:Rps6ka5 UTSW 12 100,691,135 (GRCm39) missense unknown
R5992:Rps6ka5 UTSW 12 100,541,509 (GRCm39) missense possibly damaging 0.68
R6104:Rps6ka5 UTSW 12 100,519,407 (GRCm39) missense possibly damaging 0.84
R6163:Rps6ka5 UTSW 12 100,562,179 (GRCm39) critical splice acceptor site probably null
R6390:Rps6ka5 UTSW 12 100,537,251 (GRCm39) missense probably damaging 0.99
R6599:Rps6ka5 UTSW 12 100,564,168 (GRCm39) missense probably damaging 1.00
R6653:Rps6ka5 UTSW 12 100,517,795 (GRCm39) missense probably damaging 1.00
R6693:Rps6ka5 UTSW 12 100,540,088 (GRCm39) missense probably benign 0.11
R7009:Rps6ka5 UTSW 12 100,585,796 (GRCm39) missense probably damaging 1.00
R7157:Rps6ka5 UTSW 12 100,547,679 (GRCm39) missense probably damaging 1.00
R7196:Rps6ka5 UTSW 12 100,562,123 (GRCm39) missense possibly damaging 0.77
R7510:Rps6ka5 UTSW 12 100,582,327 (GRCm39) missense possibly damaging 0.56
R7565:Rps6ka5 UTSW 12 100,582,342 (GRCm39) missense probably damaging 1.00
R7800:Rps6ka5 UTSW 12 100,524,824 (GRCm39) missense probably damaging 0.97
R7843:Rps6ka5 UTSW 12 100,519,408 (GRCm39) missense possibly damaging 0.92
R8009:Rps6ka5 UTSW 12 100,544,048 (GRCm39) missense probably damaging 0.97
R8057:Rps6ka5 UTSW 12 100,540,055 (GRCm39) critical splice donor site probably null
R8292:Rps6ka5 UTSW 12 100,644,791 (GRCm39) missense possibly damaging 0.83
R8324:Rps6ka5 UTSW 12 100,524,746 (GRCm39) missense possibly damaging 0.92
R8428:Rps6ka5 UTSW 12 100,541,500 (GRCm39) nonsense probably null
R8913:Rps6ka5 UTSW 12 100,520,595 (GRCm39) missense
R9711:Rps6ka5 UTSW 12 100,540,250 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TAACGCTGTCTGTCCAGTGC -3'
(R):5'- GCAGGCCTTTAACAAGTATAAGAG -3'

Sequencing Primer
(F):5'- CCAGTGCTTTTGGACAAGGATAACC -3'
(R):5'- CAGAATGTGGATAAGGCCCCTTTG -3'
Posted On 2014-10-30