Incidental Mutation 'R2317:Nuggc'
ID 245538
Institutional Source Beutler Lab
Gene Symbol Nuggc
Ensembl Gene ENSMUSG00000061356
Gene Name nuclear GTPase, germinal center associated
Synonyms SLIP-GC, Gm600, LOC239151
MMRRC Submission 040312-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R2317 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 65835995-65885980 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 65861591 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 479 (E479G)
Ref Sequence ENSEMBL: ENSMUSP00000118402 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079469] [ENSMUST00000150897]
AlphaFold D3YWJ0
Predicted Effect possibly damaging
Transcript: ENSMUST00000079469
AA Change: E495G

PolyPhen 2 Score 0.805 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000078434
Gene: ENSMUSG00000061356
AA Change: E495G

DomainStartEndE-ValueType
Pfam:Dynamin_N 119 372 2.2e-15 PFAM
low complexity region 406 421 N/A INTRINSIC
Blast:AAA 434 739 4e-14 BLAST
coiled coil region 758 792 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000150897
AA Change: E479G

PolyPhen 2 Score 0.805 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000118402
Gene: ENSMUSG00000061356
AA Change: E479G

DomainStartEndE-ValueType
Pfam:Dynamin_N 103 356 6.1e-16 PFAM
low complexity region 390 405 N/A INTRINSIC
Blast:AAA 418 723 4e-14 BLAST
coiled coil region 742 776 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased somatic mutation frequency immunoglobulin and non-immunoglobulin loci in B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc102a T C 8: 95,634,957 (GRCm39) D327G probably null Het
Cdh15 G A 8: 123,583,374 (GRCm39) R59H probably benign Het
Cfap126 A G 1: 170,953,700 (GRCm39) D134G possibly damaging Het
Cript T C 17: 87,335,139 (GRCm39) L19P probably benign Het
Cwf19l1 A C 19: 44,120,597 (GRCm39) L39V possibly damaging Het
Eif2b4 T C 5: 31,348,920 (GRCm39) probably null Het
Esp16 A G 17: 39,850,738 (GRCm39) N39S probably benign Het
Fbxo30 A G 10: 11,166,078 (GRCm39) N267D probably damaging Het
Gabra6 T C 11: 42,208,607 (GRCm39) probably null Het
Gp1ba A G 11: 70,531,473 (GRCm39) probably benign Het
Klf12 C T 14: 100,179,503 (GRCm39) R279Q probably benign Het
Lats1 C T 10: 7,567,540 (GRCm39) Q104* probably null Het
Myrfl A G 10: 116,675,289 (GRCm39) Y215H possibly damaging Het
Ncoa1 A G 12: 4,325,189 (GRCm39) I963T probably damaging Het
Neurod6 A G 6: 55,655,906 (GRCm39) Y244H probably damaging Het
Nodal T C 10: 61,254,212 (GRCm39) M45T possibly damaging Het
Pdcd6ip T C 9: 113,501,842 (GRCm39) D467G probably benign Het
Pnmt C A 11: 98,277,677 (GRCm39) Q74K probably benign Het
Slc25a36 G A 9: 96,961,235 (GRCm39) T267I probably damaging Het
Slc35e3 A G 10: 117,580,804 (GRCm39) S167P probably damaging Het
Sprr2f C A 3: 92,273,390 (GRCm39) P63H unknown Het
Stt3a T C 9: 36,659,371 (GRCm39) I323V probably benign Het
Tedc2 A G 17: 24,435,358 (GRCm39) S344P probably benign Het
Unc13b A G 4: 43,245,514 (GRCm39) D3722G probably damaging Het
Zfp35 T C 18: 24,136,555 (GRCm39) Y300H probably damaging Het
Zfp959 A G 17: 56,204,326 (GRCm39) D121G possibly damaging Het
Other mutations in Nuggc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01359:Nuggc APN 14 65,860,656 (GRCm39) missense probably damaging 1.00
IGL01403:Nuggc APN 14 65,860,635 (GRCm39) missense probably benign 0.01
IGL01413:Nuggc APN 14 65,876,030 (GRCm39) missense probably benign 0.23
IGL02588:Nuggc APN 14 65,855,226 (GRCm39) splice site probably benign
R0102:Nuggc UTSW 14 65,851,000 (GRCm39) missense probably null 1.00
R0102:Nuggc UTSW 14 65,851,000 (GRCm39) missense probably null 1.00
R0395:Nuggc UTSW 14 65,850,921 (GRCm39) nonsense probably null
R0827:Nuggc UTSW 14 65,846,340 (GRCm39) missense probably damaging 1.00
R1496:Nuggc UTSW 14 65,861,582 (GRCm39) missense probably damaging 0.96
R1861:Nuggc UTSW 14 65,879,450 (GRCm39) splice site probably benign
R1986:Nuggc UTSW 14 65,879,370 (GRCm39) missense probably damaging 0.98
R1995:Nuggc UTSW 14 65,848,623 (GRCm39) missense probably benign 0.02
R2283:Nuggc UTSW 14 65,876,061 (GRCm39) missense possibly damaging 0.89
R3799:Nuggc UTSW 14 65,857,087 (GRCm39) missense probably benign 0.00
R3980:Nuggc UTSW 14 65,856,542 (GRCm39) critical splice donor site probably null
R4303:Nuggc UTSW 14 65,848,621 (GRCm39) missense possibly damaging 0.77
R4431:Nuggc UTSW 14 65,848,659 (GRCm39) missense probably benign 0.19
R4734:Nuggc UTSW 14 65,860,679 (GRCm39) missense probably damaging 1.00
R5095:Nuggc UTSW 14 65,872,539 (GRCm39) nonsense probably null
R5108:Nuggc UTSW 14 65,876,129 (GRCm39) missense probably damaging 0.99
R5360:Nuggc UTSW 14 65,876,075 (GRCm39) missense probably damaging 1.00
R5547:Nuggc UTSW 14 65,879,330 (GRCm39) missense possibly damaging 0.87
R5636:Nuggc UTSW 14 65,885,637 (GRCm39) nonsense probably null
R6494:Nuggc UTSW 14 65,885,671 (GRCm39) missense probably damaging 1.00
R6922:Nuggc UTSW 14 65,855,092 (GRCm39) missense probably damaging 1.00
R6971:Nuggc UTSW 14 65,846,305 (GRCm39) missense probably benign 0.04
R7124:Nuggc UTSW 14 65,846,251 (GRCm39) missense probably damaging 1.00
R7273:Nuggc UTSW 14 65,857,057 (GRCm39) missense probably damaging 0.99
R7282:Nuggc UTSW 14 65,855,072 (GRCm39) missense probably damaging 1.00
R7578:Nuggc UTSW 14 65,885,623 (GRCm39) missense probably damaging 1.00
R7670:Nuggc UTSW 14 65,850,975 (GRCm39) missense probably damaging 1.00
R7780:Nuggc UTSW 14 65,882,490 (GRCm39) missense probably damaging 1.00
R7871:Nuggc UTSW 14 65,860,700 (GRCm39) missense probably benign 0.01
R8250:Nuggc UTSW 14 65,879,318 (GRCm39) missense probably benign 0.10
R8329:Nuggc UTSW 14 65,878,731 (GRCm39) missense probably benign 0.01
R8334:Nuggc UTSW 14 65,882,478 (GRCm39) missense probably benign 0.04
R8463:Nuggc UTSW 14 65,851,011 (GRCm39) missense probably damaging 1.00
R8503:Nuggc UTSW 14 65,878,797 (GRCm39) critical splice donor site probably null
R8737:Nuggc UTSW 14 65,882,535 (GRCm39) missense probably benign 0.00
R8861:Nuggc UTSW 14 65,847,484 (GRCm39) critical splice donor site probably null
R8914:Nuggc UTSW 14 65,879,354 (GRCm39) missense probably benign
R9573:Nuggc UTSW 14 65,848,603 (GRCm39) missense probably benign 0.37
R9666:Nuggc UTSW 14 65,857,045 (GRCm39) missense possibly damaging 0.86
R9792:Nuggc UTSW 14 65,847,345 (GRCm39) missense probably damaging 1.00
R9793:Nuggc UTSW 14 65,847,345 (GRCm39) missense probably damaging 1.00
R9795:Nuggc UTSW 14 65,847,345 (GRCm39) missense probably damaging 1.00
RF019:Nuggc UTSW 14 65,885,713 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAACTGTTTCATTGACTTCC -3'
(R):5'- TCCTAACTTACAGTTGCACAGG -3'

Sequencing Primer
(F):5'- CAACTGTTTCATTGACTTCCTTTATG -3'
(R):5'- GTGAGACAACCCAGGAGCCTTC -3'
Posted On 2014-10-30