Incidental Mutation 'R2317:Zfp959'
| ID |
245542 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp959
|
| Ensembl Gene |
ENSMUSG00000003198 |
| Gene Name |
zinc finger protein 959 |
| Synonyms |
BC011426 |
| MMRRC Submission |
040312-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R2317 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
56199093-56205928 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 56204326 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 121
(D121G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000053979
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054780]
[ENSMUST00000224379]
|
| AlphaFold |
Q91VM8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000054780
AA Change: D121G
PolyPhen 2
Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000053979
Gene: ENSMUSG00000003198
AA Change: D121G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
5.28e-14 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
2.57e2 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
1.72e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224294
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224379
AA Change: D118G
PolyPhen 2
Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ccdc102a |
T |
C |
8: 95,634,957 (GRCm39) |
D327G |
probably null |
Het |
| Cdh15 |
G |
A |
8: 123,583,374 (GRCm39) |
R59H |
probably benign |
Het |
| Cfap126 |
A |
G |
1: 170,953,700 (GRCm39) |
D134G |
possibly damaging |
Het |
| Cript |
T |
C |
17: 87,335,139 (GRCm39) |
L19P |
probably benign |
Het |
| Cwf19l1 |
A |
C |
19: 44,120,597 (GRCm39) |
L39V |
possibly damaging |
Het |
| Eif2b4 |
T |
C |
5: 31,348,920 (GRCm39) |
|
probably null |
Het |
| Esp16 |
A |
G |
17: 39,850,738 (GRCm39) |
N39S |
probably benign |
Het |
| Fbxo30 |
A |
G |
10: 11,166,078 (GRCm39) |
N267D |
probably damaging |
Het |
| Gabra6 |
T |
C |
11: 42,208,607 (GRCm39) |
|
probably null |
Het |
| Gp1ba |
A |
G |
11: 70,531,473 (GRCm39) |
|
probably benign |
Het |
| Klf12 |
C |
T |
14: 100,179,503 (GRCm39) |
R279Q |
probably benign |
Het |
| Lats1 |
C |
T |
10: 7,567,540 (GRCm39) |
Q104* |
probably null |
Het |
| Myrfl |
A |
G |
10: 116,675,289 (GRCm39) |
Y215H |
possibly damaging |
Het |
| Ncoa1 |
A |
G |
12: 4,325,189 (GRCm39) |
I963T |
probably damaging |
Het |
| Neurod6 |
A |
G |
6: 55,655,906 (GRCm39) |
Y244H |
probably damaging |
Het |
| Nodal |
T |
C |
10: 61,254,212 (GRCm39) |
M45T |
possibly damaging |
Het |
| Nuggc |
A |
G |
14: 65,861,591 (GRCm39) |
E479G |
possibly damaging |
Het |
| Pdcd6ip |
T |
C |
9: 113,501,842 (GRCm39) |
D467G |
probably benign |
Het |
| Pnmt |
C |
A |
11: 98,277,677 (GRCm39) |
Q74K |
probably benign |
Het |
| Slc25a36 |
G |
A |
9: 96,961,235 (GRCm39) |
T267I |
probably damaging |
Het |
| Slc35e3 |
A |
G |
10: 117,580,804 (GRCm39) |
S167P |
probably damaging |
Het |
| Sprr2f |
C |
A |
3: 92,273,390 (GRCm39) |
P63H |
unknown |
Het |
| Stt3a |
T |
C |
9: 36,659,371 (GRCm39) |
I323V |
probably benign |
Het |
| Tedc2 |
A |
G |
17: 24,435,358 (GRCm39) |
S344P |
probably benign |
Het |
| Unc13b |
A |
G |
4: 43,245,514 (GRCm39) |
D3722G |
probably damaging |
Het |
| Zfp35 |
T |
C |
18: 24,136,555 (GRCm39) |
Y300H |
probably damaging |
Het |
|
| Other mutations in Zfp959 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00698:Zfp959
|
APN |
17 |
56,204,565 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02731:Zfp959
|
APN |
17 |
56,202,956 (GRCm39) |
splice site |
probably benign |
|
|
IGL03206:Zfp959
|
APN |
17 |
56,204,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0141:Zfp959
|
UTSW |
17 |
56,205,139 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0347:Zfp959
|
UTSW |
17 |
56,204,180 (GRCm39) |
nonsense |
probably null |
|
|
R0522:Zfp959
|
UTSW |
17 |
56,203,201 (GRCm39) |
missense |
probably null |
1.00 |
|
R1692:Zfp959
|
UTSW |
17 |
56,205,299 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1771:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
splice site |
probably null |
|
|
R1891:Zfp959
|
UTSW |
17 |
56,204,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1945:Zfp959
|
UTSW |
17 |
56,204,231 (GRCm39) |
nonsense |
probably null |
|
|
R1959:Zfp959
|
UTSW |
17 |
56,204,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4726:Zfp959
|
UTSW |
17 |
56,205,260 (GRCm39) |
splice site |
probably null |
|
|
R4869:Zfp959
|
UTSW |
17 |
56,204,228 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5436:Zfp959
|
UTSW |
17 |
56,204,626 (GRCm39) |
missense |
probably benign |
|
|
R6235:Zfp959
|
UTSW |
17 |
56,204,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6365:Zfp959
|
UTSW |
17 |
56,204,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Zfp959
|
UTSW |
17 |
56,202,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6417:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6420:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Zfp959
|
UTSW |
17 |
56,205,501 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7380:Zfp959
|
UTSW |
17 |
56,205,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7437:Zfp959
|
UTSW |
17 |
56,205,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7568:Zfp959
|
UTSW |
17 |
56,204,886 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8114:Zfp959
|
UTSW |
17 |
56,205,496 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8197:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Zfp959
|
UTSW |
17 |
56,204,299 (GRCm39) |
missense |
probably benign |
|
|
R8970:Zfp959
|
UTSW |
17 |
56,204,836 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9063:Zfp959
|
UTSW |
17 |
56,204,221 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9504:Zfp959
|
UTSW |
17 |
56,204,793 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9648:Zfp959
|
UTSW |
17 |
56,204,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9733:Zfp959
|
UTSW |
17 |
56,204,866 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1088:Zfp959
|
UTSW |
17 |
56,205,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAATCCTCCATAGTGAAGCTAGTGT -3'
(R):5'- TGAAGATACCTGGGATGGGTTA -3'
Sequencing Primer
(F):5'- GTTGTAGTGGAGAAACTTGAATCCC -3'
(R):5'- GGTTAAGCTTTTACTACTTGGCTCAC -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation