Incidental Mutation 'R2330:Or2t45'
ID 245846
Institutional Source Beutler Lab
Gene Symbol Or2t45
Ensembl Gene ENSMUSG00000056959
Gene Name olfactory receptor family 2 subfamily T member 45
Synonyms GA_x6K02T2NKPP-630272-629343, MOR278-1, Olfr315
MMRRC Submission 040321-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R2330 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 58668915-58669912 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58669825 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Cysteine at position 291 (S291C)
Ref Sequence ENSEMBL: ENSMUSP00000144944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081533] [ENSMUST00000203256] [ENSMUST00000205189]
AlphaFold Q8VFG7
Predicted Effect probably damaging
Transcript: ENSMUST00000081533
AA Change: S291C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080248
Gene: ENSMUSG00000056959
AA Change: S291C

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 3.5e-51 PFAM
Pfam:7TM_GPCR_Srsx 34 252 1.3e-7 PFAM
Pfam:7tm_1 41 290 6.1e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203256
AA Change: S291C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144944
Gene: ENSMUSG00000056959
AA Change: S291C

DomainStartEndE-ValueType
Pfam:7tm_4 29 126 1.2e-13 PFAM
Pfam:7TM_GPCR_Srsx 35 126 1.8e-5 PFAM
Pfam:7tm_1 41 126 4.4e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205189
SMART Domains Protein: ENSMUSP00000145387
Gene: ENSMUSG00000059504

DomainStartEndE-ValueType
Pfam:7tm_4 26 259 8.9e-42 PFAM
Pfam:7TM_GPCR_Srsx 33 246 9.4e-6 PFAM
Pfam:7tm_1 39 259 1.1e-25 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.1%
Validation Efficiency 100% (31/31)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp9a A G 2: 168,481,849 (GRCm39) S958P probably benign Het
Cdh15 G A 8: 123,583,374 (GRCm39) R59H probably benign Het
Clasp2 T C 9: 113,705,372 (GRCm39) V594A probably damaging Het
Col12a1 A G 9: 79,540,939 (GRCm39) I2396T probably damaging Het
Col1a2 T A 6: 4,528,300 (GRCm39) probably benign Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Dnaja3 T A 16: 4,507,880 (GRCm39) D127E probably benign Het
Etnppl T C 3: 130,424,224 (GRCm39) L332P probably damaging Het
Gm4559 A T 7: 141,827,833 (GRCm39) C90S unknown Het
Gramd1c T C 16: 43,803,566 (GRCm39) N616D probably benign Het
Hmcn1 A G 1: 150,528,429 (GRCm39) probably benign Het
Hydin C A 8: 111,291,641 (GRCm39) Q3378K probably benign Het
Lin7b A G 7: 45,019,337 (GRCm39) probably null Het
Mex3c G A 18: 73,706,799 (GRCm39) V229I probably damaging Het
Micall2 C G 5: 139,703,270 (GRCm39) G189R probably damaging Het
Ncam2 A G 16: 81,309,809 (GRCm39) H433R probably benign Het
Or4c12 T C 2: 89,774,297 (GRCm39) N54S probably benign Het
Or6c5 C T 10: 129,074,908 (GRCm39) Q297* probably null Het
Pml A T 9: 58,141,854 (GRCm39) V326E probably damaging Het
Prl2c5 T A 13: 13,366,378 (GRCm39) M219K possibly damaging Het
Rfc1 A T 5: 65,470,312 (GRCm39) I65N possibly damaging Het
Rsbn1 T C 3: 103,821,816 (GRCm39) L17P probably damaging Het
Serpina3m A G 12: 104,357,963 (GRCm39) K296E possibly damaging Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Spag6l T C 16: 16,646,949 (GRCm39) Q19R probably benign Het
Tgm6 A C 2: 129,985,162 (GRCm39) D344A probably damaging Het
Zfp7 T C 15: 76,775,509 (GRCm39) I517T probably damaging Het
Zfp831 T A 2: 174,489,882 (GRCm39) Y1216* probably null Het
Other mutations in Or2t45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01526:Or2t45 APN 11 58,669,123 (GRCm39) missense probably benign 0.21
IGL03265:Or2t45 APN 11 58,669,697 (GRCm39) missense probably damaging 1.00
R0395:Or2t45 UTSW 11 58,669,195 (GRCm39) missense probably benign 0.05
R1760:Or2t45 UTSW 11 58,669,195 (GRCm39) missense possibly damaging 0.79
R1782:Or2t45 UTSW 11 58,669,631 (GRCm39) missense probably damaging 1.00
R3831:Or2t45 UTSW 11 58,669,571 (GRCm39) splice site probably null
R4898:Or2t45 UTSW 11 58,669,132 (GRCm39) missense possibly damaging 0.60
R5227:Or2t45 UTSW 11 58,669,705 (GRCm39) missense possibly damaging 0.70
R6257:Or2t45 UTSW 11 58,669,829 (GRCm39) missense probably damaging 0.96
R7253:Or2t45 UTSW 11 58,669,822 (GRCm39) missense probably damaging 1.00
R8751:Or2t45 UTSW 11 58,669,213 (GRCm39) missense probably benign 0.00
R9803:Or2t45 UTSW 11 58,669,595 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- ATGTACATCTGCTGCATTCTGATG -3'
(R):5'- GGCAAATTGATTTTCCAAACGC -3'

Sequencing Primer
(F):5'- GATGCTCCTGATCCCGCTG -3'
(R):5'- TAGAAAATGTCAAAGGAGCATCAAAG -3'
Posted On 2014-10-30