Incidental Mutation 'R2345:Kynu'
ID 245966
Institutional Source Beutler Lab
Gene Symbol Kynu
Ensembl Gene ENSMUSG00000026866
Gene Name kynureninase
Synonyms L-kynurenine hydrolase, 4432411A05Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2345 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 43445341-43572734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 43471397 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Serine at position 71 (Y71S)
Ref Sequence ENSEMBL: ENSMUSP00000108445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028223] [ENSMUST00000050511] [ENSMUST00000112826]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000028223
AA Change: Y71S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028223
Gene: ENSMUSG00000026866
AA Change: Y71S

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 400 3.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000050511
AA Change: Y71S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061775
Gene: ENSMUSG00000026866
AA Change: Y71S

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 307 7.8e-12 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000112826
AA Change: Y71S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108445
Gene: ENSMUSG00000026866
AA Change: Y71S

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 405 8.4e-17 PFAM
Meta Mutation Damage Score 0.9643 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 100% (30/30)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atxn3 A T 12: 101,914,580 (GRCm39) M48K probably damaging Het
Bnc2 T C 4: 84,210,740 (GRCm39) E638G probably damaging Het
Cdh15 G A 8: 123,583,374 (GRCm39) R59H probably benign Het
Ceacam3 T G 7: 16,888,925 (GRCm39) D231E possibly damaging Het
Ckb G A 12: 111,638,238 (GRCm39) T52I probably damaging Het
Elac2 T C 11: 64,891,900 (GRCm39) M773T probably damaging Het
Fbxw8 A T 5: 118,203,872 (GRCm39) probably benign Het
Hk3 T C 13: 55,156,806 (GRCm39) D582G probably damaging Het
Htt T A 5: 34,983,348 (GRCm39) N982K possibly damaging Het
Jag2 T C 12: 112,872,684 (GRCm39) E1190G probably damaging Het
Kcnc1 A G 7: 46,047,370 (GRCm39) E90G probably damaging Het
Lonrf1 A T 8: 36,690,016 (GRCm39) probably null Het
Mfsd4b3-ps T A 10: 39,824,069 (GRCm39) M64L probably benign Het
Nbea A T 3: 55,992,700 (GRCm39) F302Y probably damaging Het
Ndst4 T C 3: 125,501,769 (GRCm39) S111P possibly damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Or1f19 G A 16: 3,411,003 (GRCm39) V248M probably damaging Het
Or5m8 A G 2: 85,822,166 (GRCm39) T2A probably benign Het
Or8b57 T G 9: 40,003,849 (GRCm39) I138L probably benign Het
Phf3 G T 1: 30,844,432 (GRCm39) S1509* probably null Het
Plekhh1 A T 12: 79,100,421 (GRCm39) I130F probably damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Szt2 A G 4: 118,238,594 (GRCm39) F1953S unknown Het
Togaram1 T A 12: 65,055,406 (GRCm39) S1466T probably benign Het
Tox2 T C 2: 163,161,518 (GRCm39) Y348H probably damaging Het
Vmn2r129 T A 4: 156,689,334 (GRCm39) noncoding transcript Het
Wdr90 G T 17: 26,078,136 (GRCm39) H411N probably benign Het
Yme1l1 C T 2: 23,084,798 (GRCm39) T632I probably damaging Het
Other mutations in Kynu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Kynu APN 2 43,561,394 (GRCm39) missense possibly damaging 0.91
IGL01974:Kynu APN 2 43,571,352 (GRCm39) unclassified probably benign
R0099:Kynu UTSW 2 43,519,065 (GRCm39) critical splice donor site probably null
R0304:Kynu UTSW 2 43,569,893 (GRCm39) missense probably damaging 0.99
R1681:Kynu UTSW 2 43,569,837 (GRCm39) missense probably damaging 1.00
R1799:Kynu UTSW 2 43,494,169 (GRCm39) missense possibly damaging 0.65
R2016:Kynu UTSW 2 43,494,289 (GRCm39) nonsense probably null
R3085:Kynu UTSW 2 43,492,312 (GRCm39) missense probably benign 0.00
R3825:Kynu UTSW 2 43,571,451 (GRCm39) missense probably benign
R4091:Kynu UTSW 2 43,569,884 (GRCm39) missense possibly damaging 0.94
R4241:Kynu UTSW 2 43,571,422 (GRCm39) missense probably benign 0.00
R4594:Kynu UTSW 2 43,569,902 (GRCm39) missense probably benign 0.00
R4673:Kynu UTSW 2 43,569,815 (GRCm39) missense probably damaging 1.00
R4871:Kynu UTSW 2 43,569,830 (GRCm39) missense possibly damaging 0.58
R5371:Kynu UTSW 2 43,479,406 (GRCm39) missense probably benign 0.00
R6272:Kynu UTSW 2 43,525,001 (GRCm39) missense probably benign 0.01
R6342:Kynu UTSW 2 43,571,463 (GRCm39) missense probably benign 0.09
R6866:Kynu UTSW 2 43,453,122 (GRCm39) nonsense probably null
R7203:Kynu UTSW 2 43,571,365 (GRCm39) missense probably damaging 1.00
R8163:Kynu UTSW 2 43,518,966 (GRCm39) missense probably damaging 1.00
R9024:Kynu UTSW 2 43,490,807 (GRCm39) missense possibly damaging 0.62
R9089:Kynu UTSW 2 43,489,620 (GRCm39) missense probably damaging 1.00
R9303:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9305:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9506:Kynu UTSW 2 43,571,414 (GRCm39) missense probably damaging 1.00
R9702:Kynu UTSW 2 43,479,469 (GRCm39) missense probably damaging 1.00
R9759:Kynu UTSW 2 43,569,881 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCCTCCATGTAAAATACAAAAGGTC -3'
(R):5'- ATATGCTAGGGTGTAACTTGTCC -3'

Sequencing Primer
(F):5'- GGTCAAATACTGTTCAGAGCCTG -3'
(R):5'- GCTAGGGTGTAACTTGTCCAAATCAG -3'
Posted On 2014-10-30