Incidental Mutation 'R0284:Or8c11'
ID 24613
Institutional Source Beutler Lab
Gene Symbol Or8c11
Ensembl Gene ENSMUSG00000096757
Gene Name olfactory receptor family 8 subfamily C member 11
Synonyms GA_x6K02T2PVTD-32071567-32072508, Olfr900, GA_x6K02T2MYUG-9124-8183, MOR170-2, MOR170-13, MOR170-15, Olfr251
MMRRC Submission 038505-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R0284 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38289179-38290129 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38289880 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 234 (M234I)
Ref Sequence ENSEMBL: ENSMUSP00000072514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072731] [ENSMUST00000214865]
AlphaFold E9Q891
Predicted Effect probably benign
Transcript: ENSMUST00000072731
AA Change: M234I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000072514
Gene: ENSMUSG00000096757
AA Change: M234I

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 9.8e-50 PFAM
Pfam:7tm_1 47 296 4.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214865
AA Change: M228I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.9%
  • 20x: 92.4%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh6 A G 7: 30,013,413 (GRCm39) T161A probably benign Het
Alox12e A G 11: 70,211,725 (GRCm39) probably benign Het
Ap1g2 A G 14: 55,339,149 (GRCm39) probably benign Het
Arid2 A T 15: 96,276,848 (GRCm39) probably benign Het
Bmp2k A T 5: 97,216,314 (GRCm39) H604L unknown Het
Cacna1a A T 8: 85,338,914 (GRCm39) M1705L probably damaging Het
Cacna1d A T 14: 29,794,062 (GRCm39) D1526E probably damaging Het
Ccdc171 A G 4: 83,467,975 (GRCm39) R107G possibly damaging Het
Cklf T C 8: 104,988,207 (GRCm39) probably benign Het
Crabp1 A G 9: 54,672,210 (GRCm39) K9E probably benign Het
Cspg4 A G 9: 56,793,423 (GRCm39) D386G probably damaging Het
Cyp3a41b G A 5: 145,515,014 (GRCm39) probably benign Het
Dsg1a T A 18: 20,464,684 (GRCm39) V393E probably damaging Het
Ednrb C T 14: 104,057,449 (GRCm39) G371D probably damaging Het
Efcab5 T C 11: 76,994,353 (GRCm39) probably benign Het
Exoc2 A T 13: 31,061,608 (GRCm39) probably benign Het
Fbn2 G A 18: 58,183,362 (GRCm39) probably benign Het
Foxo6 T C 4: 120,126,199 (GRCm39) S199G probably benign Het
Fpr1 T A 17: 18,097,618 (GRCm39) I124F probably damaging Het
Gk5 A T 9: 96,063,823 (GRCm39) probably null Het
Gys1 A T 7: 45,086,143 (GRCm39) probably benign Het
Igfbp1 T C 11: 7,148,103 (GRCm39) S49P probably damaging Het
Incenp A T 19: 9,871,357 (GRCm39) S91T unknown Het
Itpkc G A 7: 26,913,968 (GRCm39) R498* probably null Het
Kat6a A G 8: 23,429,819 (GRCm39) T1725A unknown Het
Kiz T A 2: 146,705,730 (GRCm39) C97S probably benign Het
Kri1 A G 9: 21,187,848 (GRCm39) probably benign Het
Lipn A G 19: 34,058,106 (GRCm39) S276G possibly damaging Het
Llgl1 A G 11: 60,602,967 (GRCm39) T881A probably damaging Het
Man1a2 T C 3: 100,592,102 (GRCm39) H26R probably damaging Het
Map3k5 T A 10: 19,876,359 (GRCm39) F173I probably damaging Het
Miox C T 15: 89,220,477 (GRCm39) L189F possibly damaging Het
Mipol1 A G 12: 57,503,855 (GRCm39) Q341R probably damaging Het
Mllt6 G T 11: 97,569,431 (GRCm39) A928S probably benign Het
Ncoa6 TGC TGCGC 2: 155,250,211 (GRCm39) probably null Het
Nipsnap3a C T 4: 52,997,178 (GRCm39) T150I probably benign Het
Nsl1 A G 1: 190,797,427 (GRCm39) E97G probably damaging Het
Or11j4 G A 14: 50,630,452 (GRCm39) V80M probably damaging Het
Or4f54 T C 2: 111,122,931 (GRCm39) V106A probably benign Het
Or7g18 A T 9: 18,786,848 (GRCm39) Y72F probably benign Het
Pakap T C 4: 57,855,207 (GRCm39) F220L probably damaging Het
Pdcd6ip A G 9: 113,491,572 (GRCm39) L552S probably damaging Het
Plekhf2 T C 4: 10,990,595 (GRCm39) probably benign Het
Prdm1 T C 10: 44,332,622 (GRCm39) E96G probably damaging Het
Prpf40a T A 2: 53,040,659 (GRCm39) E608D probably damaging Het
Prpf40b A T 15: 99,214,274 (GRCm39) probably benign Het
Rag2 T C 2: 101,460,464 (GRCm39) V258A probably damaging Het
S100a5 A G 3: 90,518,881 (GRCm39) I68V probably benign Het
Serpinb8 G A 1: 107,530,648 (GRCm39) probably null Het
Slc24a4 T C 12: 102,226,740 (GRCm39) V492A probably damaging Het
Spag6l T A 16: 16,598,630 (GRCm39) Q287L probably damaging Het
Spmip6 T G 4: 41,507,538 (GRCm39) E150A probably damaging Het
Synpo2 C T 3: 122,873,383 (GRCm39) W211* probably null Het
Tgtp1 A G 11: 48,877,970 (GRCm39) V245A probably benign Het
Tmem144 G A 3: 79,746,580 (GRCm39) probably benign Het
Trerf1 A G 17: 47,630,471 (GRCm39) noncoding transcript Het
Ttn G C 2: 76,677,048 (GRCm39) probably benign Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vps13d A T 4: 144,871,372 (GRCm39) M1900K probably benign Het
Vps41 A T 13: 19,037,610 (GRCm39) D691V probably damaging Het
Zfp518b T C 5: 38,829,083 (GRCm39) Y974C probably damaging Het
Zscan29 A T 2: 120,997,214 (GRCm39) probably benign Het
Other mutations in Or8c11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02013:Or8c11 APN 9 38,289,373 (GRCm39) missense probably benign 0.31
IGL02131:Or8c11 APN 9 38,289,203 (GRCm39) missense probably benign 0.01
IGL02311:Or8c11 APN 9 38,289,194 (GRCm39) nonsense probably null
IGL02377:Or8c11 APN 9 38,289,542 (GRCm39) missense probably damaging 1.00
R0412:Or8c11 UTSW 9 38,290,090 (GRCm39) missense probably damaging 0.98
R0903:Or8c11 UTSW 9 38,290,097 (GRCm39) missense probably benign 0.00
R1664:Or8c11 UTSW 9 38,289,548 (GRCm39) missense possibly damaging 0.93
R2902:Or8c11 UTSW 9 38,289,337 (GRCm39) missense possibly damaging 0.89
R3970:Or8c11 UTSW 9 38,289,222 (GRCm39) missense probably damaging 0.98
R4191:Or8c11 UTSW 9 38,289,648 (GRCm39) missense probably damaging 0.98
R4650:Or8c11 UTSW 9 38,289,699 (GRCm39) missense probably damaging 1.00
R4910:Or8c11 UTSW 9 38,290,038 (GRCm39) missense probably null 0.98
R5256:Or8c11 UTSW 9 38,289,213 (GRCm39) missense probably benign 0.00
R5385:Or8c11 UTSW 9 38,289,281 (GRCm39) missense probably benign
R5386:Or8c11 UTSW 9 38,289,281 (GRCm39) missense probably benign
R6005:Or8c11 UTSW 9 38,289,605 (GRCm39) missense probably damaging 1.00
R6268:Or8c11 UTSW 9 38,289,384 (GRCm39) missense probably benign 0.10
R6486:Or8c11 UTSW 9 38,289,200 (GRCm39) missense probably benign
R7019:Or8c11 UTSW 9 38,290,098 (GRCm39) missense possibly damaging 0.89
R7045:Or8c11 UTSW 9 38,289,729 (GRCm39) missense probably damaging 0.99
R7120:Or8c11 UTSW 9 38,289,945 (GRCm39) missense probably damaging 1.00
R7329:Or8c11 UTSW 9 38,289,456 (GRCm39) missense probably benign 0.00
R7703:Or8c11 UTSW 9 38,289,357 (GRCm39) missense probably benign 0.01
R8333:Or8c11 UTSW 9 38,289,912 (GRCm39) missense probably damaging 0.98
R8352:Or8c11 UTSW 9 38,289,647 (GRCm39) missense probably benign 0.01
R8452:Or8c11 UTSW 9 38,289,647 (GRCm39) missense probably benign 0.01
R8461:Or8c11 UTSW 9 38,289,777 (GRCm39) missense probably damaging 0.96
R8870:Or8c11 UTSW 9 38,289,720 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TTGCTGGTGCCCTGACTCATACAG -3'
(R):5'- TGGCAGTGATCAACATTCTGGAGC -3'

Sequencing Primer
(F):5'- CTCATACAGGGTTTATGATCAGGC -3'
(R):5'- aacaaagagagagaataaaGCAATGC -3'
Posted On 2013-04-16