Incidental Mutation 'R2351:Olfr2'
Institutional Source Beutler Lab
Gene Symbol Olfr2
Ensembl Gene ENSMUSG00000070417
Gene Nameolfactory receptor 2
SynonymsMOR103-15, I7, I54, Olfr41, GA_x6K02T2PBJ9-9381439-9380456
MMRRC Submission 040333-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.258) question?
Stock #R2351 (G1)
Quality Score225
Status Not validated
Chromosomal Location106995399-107006072 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 107001676 bp
Amino Acid Change Tyrosine to Stop codon at position 61 (Y61*)
Ref Sequence ENSEMBL: ENSMUSP00000150093 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094109] [ENSMUST00000207280] [ENSMUST00000208147] [ENSMUST00000211432] [ENSMUST00000214105] [ENSMUST00000216375]
Predicted Effect probably null
Transcript: ENSMUST00000094109
AA Change: Y61*
SMART Domains Protein: ENSMUSP00000091656
Gene: ENSMUSG00000070417
AA Change: Y61*

Pfam:7tm_4 31 313 9.2e-53 PFAM
Pfam:7tm_1 42 295 3e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000207280
AA Change: Y61*
Predicted Effect probably null
Transcript: ENSMUST00000208147
AA Change: Y61*
Predicted Effect probably null
Transcript: ENSMUST00000211432
AA Change: Y61*
Predicted Effect probably null
Transcript: ENSMUST00000214105
AA Change: Y61*
Predicted Effect probably null
Transcript: ENSMUST00000216375
AA Change: Y61*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217764
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310009B15Rik A T 1: 138,852,108 Y135* probably null Het
2700081O15Rik T C 19: 7,422,244 I247T probably damaging Het
9430007A20Rik A T 4: 144,528,778 Y256F probably damaging Het
Acad10 A T 5: 121,629,927 I820K probably benign Het
Arl8b A T 6: 108,821,523 I178F possibly damaging Het
Asap1 A T 15: 64,135,804 probably null Het
Atp2b2 A T 6: 113,789,757 I552N possibly damaging Het
C130074G19Rik G T 1: 184,882,863 D43E probably benign Het
Ccdc162 C A 10: 41,555,972 probably null Het
Ccdc186 T G 19: 56,798,697 K613T possibly damaging Het
Cggbp1 T A 16: 64,855,683 D37E possibly damaging Het
Cntn3 A T 6: 102,337,383 N123K possibly damaging Het
Col18a1 C T 10: 77,112,704 G325S probably benign Het
Cwc25 G T 11: 97,747,392 T405K probably damaging Het
Cyp4a31 T C 4: 115,571,313 V370A possibly damaging Het
Cyp4f13 T G 17: 32,925,596 I309L probably benign Het
Dap3 A T 3: 88,933,563 probably null Het
Dchs1 G T 7: 105,754,094 D3080E probably benign Het
Ern2 A G 7: 122,171,508 V762A probably damaging Het
Fgr C T 4: 132,997,237 R255C probably damaging Het
Gcm2 A T 13: 41,103,618 D218E probably benign Het
Gfi1 A G 5: 107,721,774 S131P probably damaging Het
Grm8 A T 6: 28,126,119 C3S possibly damaging Het
Gucy2d A G 7: 98,464,019 D840G probably benign Het
H3f3a T C 1: 180,810,158 T81A probably benign Het
Igsf23 C T 7: 19,944,798 W22* probably null Het
Il12rb2 G A 6: 67,361,944 Q3* probably null Het
Ino80d A T 1: 63,085,835 L156H probably benign Het
Kdm2a G A 19: 4,329,126 P554S probably benign Het
Lefty1 T A 1: 180,937,242 L244H possibly damaging Het
Mdn1 T A 4: 32,750,010 S4398T probably benign Het
Myh10 A G 11: 68,793,139 D1126G probably damaging Het
Myo16 G A 8: 10,594,905 D1746N possibly damaging Het
Myom1 A T 17: 71,034,579 D111V probably damaging Het
Naip6 T A 13: 100,283,661 D1367V probably damaging Het
Nbeal1 A T 1: 60,237,098 H666L possibly damaging Het
Nsmaf T A 4: 6,437,921 I77F probably damaging Het
Nvl T C 1: 181,130,792 T231A probably benign Het
Obscn T C 11: 59,112,612 R1287G probably damaging Het
Olfr1058 C T 2: 86,386,127 C97Y probably damaging Het
Olfr1219 C T 2: 89,074,399 G231S possibly damaging Het
Olfr1254 T C 2: 89,789,178 Y58C probably damaging Het
Olfr420 T A 1: 174,158,920 V49D probably damaging Het
Olfr765 A G 10: 129,046,928 V45A probably benign Het
Opn3 T C 1: 175,692,511 D9G probably benign Het
Parp10 A T 15: 76,242,856 S101R probably benign Het
Pdhx T A 2: 103,024,217 K399* probably null Het
Pdia4 A T 6: 47,796,914 probably null Het
Pla2g4f T C 2: 120,300,442 D844G probably benign Het
Prtg C A 9: 72,856,824 D526E probably damaging Het
Rassf6 T C 5: 90,631,559 D5G probably benign Het
Riok3 C T 18: 12,149,667 Q388* probably null Het
Robo4 T A 9: 37,411,660 F825L probably benign Het
Rpl13a-ps1 C T 19: 50,030,429 E103K probably benign Het
Rpl18a A T 8: 70,896,220 H37Q probably benign Het
Ryr1 A T 7: 29,075,293 S2301T probably benign Het
Slc39a9 T A 12: 80,644,886 D2E possibly damaging Het
Slco5a1 C T 1: 12,989,934 V188I probably benign Het
Son T A 16: 91,657,659 M1098K probably damaging Het
Spag9 A G 11: 94,092,900 D701G probably damaging Het
Ssmem1 T C 6: 30,512,496 F46S possibly damaging Het
Sspo C T 6: 48,464,869 R1938W probably damaging Het
Sstr3 T C 15: 78,539,921 I209V probably benign Het
Tlk2 A G 11: 105,209,830 Y87C probably damaging Het
Traf4 G A 11: 78,160,176 R385W probably damaging Het
Triobp G A 15: 79,004,580 V1962M probably benign Het
Tspan12 T G 6: 21,835,507 I56L probably benign Het
Upp2 T A 2: 58,763,662 probably null Het
Vps13b T C 15: 35,869,311 W2654R probably damaging Het
Zc3h18 C T 8: 122,403,187 R435* probably null Het
Other mutations in Olfr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02270:Olfr2 APN 7 107001423 missense probably damaging 1.00
IGL02620:Olfr2 APN 7 107001618 nonsense probably null
IGL02942:Olfr2 APN 7 107001354 missense possibly damaging 0.88
R1171:Olfr2 UTSW 7 107001584 missense probably benign
R1956:Olfr2 UTSW 7 107001135 missense probably damaging 1.00
R2128:Olfr2 UTSW 7 107001248 missense probably damaging 1.00
R2342:Olfr2 UTSW 7 107000909 missense probably benign
R3752:Olfr2 UTSW 7 107001475 nonsense probably null
R4197:Olfr2 UTSW 7 107001038 missense probably damaging 0.97
R4237:Olfr2 UTSW 7 107001329 missense probably damaging 1.00
R4787:Olfr2 UTSW 7 107001086 missense probably benign 0.00
R4795:Olfr2 UTSW 7 107001335 missense probably damaging 1.00
R4796:Olfr2 UTSW 7 107001335 missense probably damaging 1.00
R5268:Olfr2 UTSW 7 107000904 missense probably benign 0.00
R5412:Olfr2 UTSW 7 107001635 missense probably damaging 0.99
R5474:Olfr2 UTSW 7 107001089 missense probably damaging 0.98
R5542:Olfr2 UTSW 7 107001079 missense probably damaging 1.00
R5792:Olfr2 UTSW 7 107001443 missense possibly damaging 0.61
R6149:Olfr2 UTSW 7 107001600 missense probably benign
R7552:Olfr2 UTSW 7 107001327 missense probably benign
R7838:Olfr2 UTSW 7 107001307 nonsense probably null
R8177:Olfr2 UTSW 7 107001456 missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On2014-10-30