Incidental Mutation 'R2351:Myo16'
ID 246138
Institutional Source Beutler Lab
Gene Symbol Myo16
Ensembl Gene ENSMUSG00000039057
Gene Name myosin XVI
Synonyms C230040D10Rik, BM140241, Nyap3
MMRRC Submission 040333-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.325) question?
Stock # R2351 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 10203911-10684742 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 10644905 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 1746 (D1746N)
Ref Sequence ENSEMBL: ENSMUSP00000146796 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042103] [ENSMUST00000207204] [ENSMUST00000207477]
AlphaFold Q5DU14
Predicted Effect probably benign
Transcript: ENSMUST00000042103
AA Change: D1760N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000049345
Gene: ENSMUSG00000039057
AA Change: D1760N

DomainStartEndE-ValueType
ANK 92 121 1.65e-1 SMART
ANK 125 154 3.46e-4 SMART
ANK 158 189 2.11e2 SMART
ANK 221 250 2.85e-5 SMART
ANK 254 283 3.51e-5 SMART
low complexity region 333 349 N/A INTRINSIC
MYSc 394 1144 2.27e-144 SMART
IQ 1144 1166 4.06e-2 SMART
Pfam:NYAP_N 1207 1591 4.1e-135 PFAM
low complexity region 1670 1690 N/A INTRINSIC
low complexity region 1841 1860 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000207204
AA Change: D1746N

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000207477
AA Change: D1802N

PolyPhen 2 Score 0.309 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(2) Gene trapped(1)

Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310009B15Rik A T 1: 138,779,846 (GRCm39) Y135* probably null Het
Aadacl4fm1 A T 4: 144,255,348 (GRCm39) Y256F probably damaging Het
Acad10 A T 5: 121,767,990 (GRCm39) I820K probably benign Het
Arl8b A T 6: 108,798,484 (GRCm39) I178F possibly damaging Het
Asap1 A T 15: 64,007,653 (GRCm39) probably null Het
Atp2b2 A T 6: 113,766,718 (GRCm39) I552N possibly damaging Het
C130074G19Rik G T 1: 184,615,060 (GRCm39) D43E probably benign Het
Ccdc162 C A 10: 41,431,968 (GRCm39) probably null Het
Ccdc186 T G 19: 56,787,129 (GRCm39) K613T possibly damaging Het
Cggbp1 T A 16: 64,676,046 (GRCm39) D37E possibly damaging Het
Cntn3 A T 6: 102,314,344 (GRCm39) N123K possibly damaging Het
Col18a1 C T 10: 76,948,538 (GRCm39) G325S probably benign Het
Cwc25 G T 11: 97,638,218 (GRCm39) T405K probably damaging Het
Cyp4a31 T C 4: 115,428,510 (GRCm39) V370A possibly damaging Het
Cyp4f13 T G 17: 33,144,570 (GRCm39) I309L probably benign Het
Dap3 A T 3: 88,840,870 (GRCm39) probably null Het
Dchs1 G T 7: 105,403,301 (GRCm39) D3080E probably benign Het
Ern2 A G 7: 121,770,731 (GRCm39) V762A probably damaging Het
Fgr C T 4: 132,724,548 (GRCm39) R255C probably damaging Het
Gcm2 A T 13: 41,257,094 (GRCm39) D218E probably benign Het
Gfi1 A G 5: 107,869,640 (GRCm39) S131P probably damaging Het
Grm8 A T 6: 28,126,118 (GRCm39) C3S possibly damaging Het
Gucy2d A G 7: 98,113,226 (GRCm39) D840G probably benign Het
H3f3a T C 1: 180,637,723 (GRCm39) T81A probably benign Het
Igsf23 C T 7: 19,678,723 (GRCm39) W22* probably null Het
Il12rb2 G A 6: 67,338,928 (GRCm39) Q3* probably null Het
Ino80d A T 1: 63,124,994 (GRCm39) L156H probably benign Het
Kdm2a G A 19: 4,379,154 (GRCm39) P554S probably benign Het
Lefty1 T A 1: 180,764,807 (GRCm39) L244H possibly damaging Het
Mdn1 T A 4: 32,750,010 (GRCm39) S4398T probably benign Het
Myh10 A G 11: 68,683,965 (GRCm39) D1126G probably damaging Het
Myom1 A T 17: 71,341,574 (GRCm39) D111V probably damaging Het
Naip6 T A 13: 100,420,169 (GRCm39) D1367V probably damaging Het
Nbeal1 A T 1: 60,276,257 (GRCm39) H666L possibly damaging Het
Nsmaf T A 4: 6,437,921 (GRCm39) I77F probably damaging Het
Nvl T C 1: 180,958,357 (GRCm39) T231A probably benign Het
Obscn T C 11: 59,003,438 (GRCm39) R1287G probably damaging Het
Opn3 T C 1: 175,520,077 (GRCm39) D9G probably benign Het
Or4a81 T C 2: 89,619,522 (GRCm39) Y58C probably damaging Het
Or4c114 C T 2: 88,904,743 (GRCm39) G231S possibly damaging Het
Or6a2 A T 7: 106,600,883 (GRCm39) Y61* probably null Het
Or6c8b A G 10: 128,882,797 (GRCm39) V45A probably benign Het
Or6k2 T A 1: 173,986,486 (GRCm39) V49D probably damaging Het
Or8k24 C T 2: 86,216,471 (GRCm39) C97Y probably damaging Het
Parp10 A T 15: 76,127,056 (GRCm39) S101R probably benign Het
Pdhx T A 2: 102,854,562 (GRCm39) K399* probably null Het
Pdia4 A T 6: 47,773,848 (GRCm39) probably null Het
Pla2g4f T C 2: 120,130,923 (GRCm39) D844G probably benign Het
Prtg C A 9: 72,764,106 (GRCm39) D526E probably damaging Het
Rassf6 T C 5: 90,779,418 (GRCm39) D5G probably benign Het
Riok3 C T 18: 12,282,724 (GRCm39) Q388* probably null Het
Robo4 T A 9: 37,322,956 (GRCm39) F825L probably benign Het
Rpl13a-ps1 C T 19: 50,018,868 (GRCm39) E103K probably benign Het
Rpl18a A T 8: 71,348,864 (GRCm39) H37Q probably benign Het
Ryr1 A T 7: 28,774,718 (GRCm39) S2301T probably benign Het
Slc39a9 T A 12: 80,691,660 (GRCm39) D2E possibly damaging Het
Slco5a1 C T 1: 13,060,158 (GRCm39) V188I probably benign Het
Son T A 16: 91,454,547 (GRCm39) M1098K probably damaging Het
Spag9 A G 11: 93,983,726 (GRCm39) D701G probably damaging Het
Ssmem1 T C 6: 30,512,495 (GRCm39) F46S possibly damaging Het
Sspo C T 6: 48,441,803 (GRCm39) R1938W probably damaging Het
Sstr3 T C 15: 78,424,121 (GRCm39) I209V probably benign Het
Tlk2 A G 11: 105,100,656 (GRCm39) Y87C probably damaging Het
Traf4 G A 11: 78,051,002 (GRCm39) R385W probably damaging Het
Triobp G A 15: 78,888,780 (GRCm39) V1962M probably benign Het
Tspan12 T G 6: 21,835,506 (GRCm39) I56L probably benign Het
Upp2 T A 2: 58,653,674 (GRCm39) probably null Het
Vps13b T C 15: 35,869,457 (GRCm39) W2654R probably damaging Het
Zc3h18 C T 8: 123,129,926 (GRCm39) R435* probably null Het
Zfta T C 19: 7,399,609 (GRCm39) I247T probably damaging Het
Other mutations in Myo16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Myo16 APN 8 10,488,889 (GRCm39) missense probably damaging 1.00
IGL00567:Myo16 APN 8 10,512,154 (GRCm39) missense probably damaging 1.00
IGL00671:Myo16 APN 8 10,411,067 (GRCm39) missense probably damaging 1.00
IGL00897:Myo16 APN 8 10,365,518 (GRCm39) missense probably damaging 1.00
IGL01458:Myo16 APN 8 10,485,853 (GRCm39) missense probably damaging 1.00
IGL01523:Myo16 APN 8 10,420,908 (GRCm39) missense probably damaging 1.00
IGL01532:Myo16 APN 8 10,450,551 (GRCm39) missense probably benign 0.00
IGL01680:Myo16 APN 8 10,322,630 (GRCm39) missense probably damaging 1.00
IGL01747:Myo16 APN 8 10,654,877 (GRCm39) missense probably damaging 1.00
IGL02084:Myo16 APN 8 10,411,088 (GRCm39) missense probably damaging 0.99
IGL02203:Myo16 APN 8 10,620,132 (GRCm39) missense possibly damaging 0.52
IGL02506:Myo16 APN 8 10,440,217 (GRCm39) missense probably damaging 1.00
IGL02819:Myo16 APN 8 10,372,600 (GRCm39) missense probably damaging 1.00
IGL02935:Myo16 APN 8 10,582,990 (GRCm39) missense probably benign 0.41
IGL02943:Myo16 APN 8 10,450,595 (GRCm39) splice site probably benign
IGL03347:Myo16 APN 8 10,426,120 (GRCm39) critical splice acceptor site probably null
3-1:Myo16 UTSW 8 10,488,869 (GRCm39) missense probably damaging 0.99
P0016:Myo16 UTSW 8 10,450,596 (GRCm39) splice site probably benign
R0006:Myo16 UTSW 8 10,525,988 (GRCm39) missense probably damaging 0.98
R0006:Myo16 UTSW 8 10,525,988 (GRCm39) missense probably damaging 0.98
R0033:Myo16 UTSW 8 10,420,955 (GRCm39) missense probably damaging 1.00
R0033:Myo16 UTSW 8 10,420,955 (GRCm39) missense probably damaging 1.00
R0142:Myo16 UTSW 8 10,619,790 (GRCm39) missense probably benign 0.01
R0195:Myo16 UTSW 8 10,365,538 (GRCm39) splice site probably benign
R0418:Myo16 UTSW 8 10,619,918 (GRCm39) missense probably benign 0.01
R0576:Myo16 UTSW 8 10,612,318 (GRCm39) critical splice donor site probably null
R0627:Myo16 UTSW 8 10,489,689 (GRCm39) missense probably benign 0.15
R0826:Myo16 UTSW 8 10,426,285 (GRCm39) splice site probably benign
R0835:Myo16 UTSW 8 10,322,766 (GRCm39) missense probably damaging 1.00
R1015:Myo16 UTSW 8 10,440,183 (GRCm39) missense probably benign 0.17
R1052:Myo16 UTSW 8 10,620,181 (GRCm39) missense possibly damaging 0.92
R1180:Myo16 UTSW 8 10,446,908 (GRCm39) missense probably damaging 1.00
R1185:Myo16 UTSW 8 10,683,624 (GRCm39) missense probably damaging 1.00
R1185:Myo16 UTSW 8 10,683,624 (GRCm39) missense probably damaging 1.00
R1474:Myo16 UTSW 8 10,552,796 (GRCm39) missense probably damaging 1.00
R1484:Myo16 UTSW 8 10,610,145 (GRCm39) missense probably damaging 1.00
R1503:Myo16 UTSW 8 10,552,817 (GRCm39) missense probably benign 0.44
R1733:Myo16 UTSW 8 10,492,283 (GRCm39) missense probably damaging 0.98
R1873:Myo16 UTSW 8 10,322,789 (GRCm39) missense probably damaging 1.00
R1885:Myo16 UTSW 8 10,372,656 (GRCm39) missense probably damaging 1.00
R1943:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2013:Myo16 UTSW 8 10,552,796 (GRCm39) missense probably damaging 1.00
R2019:Myo16 UTSW 8 10,426,260 (GRCm39) missense probably benign 0.05
R2022:Myo16 UTSW 8 10,322,633 (GRCm39) missense probably benign 0.08
R2214:Myo16 UTSW 8 10,488,803 (GRCm39) missense probably damaging 1.00
R2228:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2352:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2357:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2566:Myo16 UTSW 8 10,644,820 (GRCm39) missense probably benign 0.43
R3402:Myo16 UTSW 8 10,434,719 (GRCm39) missense probably benign
R3870:Myo16 UTSW 8 10,492,239 (GRCm39) missense probably benign 0.25
R4080:Myo16 UTSW 8 10,612,240 (GRCm39) missense probably damaging 1.00
R4498:Myo16 UTSW 8 10,485,869 (GRCm39) missense probably benign 0.01
R4631:Myo16 UTSW 8 10,556,984 (GRCm39) missense probably damaging 1.00
R4689:Myo16 UTSW 8 10,488,890 (GRCm39) missense probably damaging 1.00
R4736:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4738:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4739:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4764:Myo16 UTSW 8 10,485,880 (GRCm39) missense probably damaging 1.00
R4778:Myo16 UTSW 8 10,619,694 (GRCm39) missense probably damaging 0.97
R4852:Myo16 UTSW 8 10,423,474 (GRCm39) missense probably damaging 1.00
R4885:Myo16 UTSW 8 10,488,892 (GRCm39) missense probably damaging 0.98
R4993:Myo16 UTSW 8 10,526,094 (GRCm39) missense probably damaging 0.99
R5077:Myo16 UTSW 8 10,372,658 (GRCm39) missense probably damaging 1.00
R5135:Myo16 UTSW 8 10,526,114 (GRCm39) missense probably benign
R5170:Myo16 UTSW 8 10,619,745 (GRCm39) missense probably benign 0.30
R5203:Myo16 UTSW 8 10,410,995 (GRCm39) missense probably damaging 1.00
R5246:Myo16 UTSW 8 10,612,212 (GRCm39) nonsense probably null
R5517:Myo16 UTSW 8 10,610,226 (GRCm39) missense probably benign 0.22
R5567:Myo16 UTSW 8 10,372,676 (GRCm39) missense probably damaging 1.00
R5694:Myo16 UTSW 8 10,619,606 (GRCm39) missense probably benign 0.01
R5749:Myo16 UTSW 8 10,463,245 (GRCm39) missense probably benign 0.01
R6131:Myo16 UTSW 8 10,619,877 (GRCm39) missense probably benign
R6213:Myo16 UTSW 8 10,420,963 (GRCm39) critical splice donor site probably null
R6216:Myo16 UTSW 8 10,365,494 (GRCm39) missense probably benign 0.01
R6240:Myo16 UTSW 8 10,420,930 (GRCm39) missense probably damaging 1.00
R6628:Myo16 UTSW 8 10,620,638 (GRCm39) missense probably damaging 0.99
R6935:Myo16 UTSW 8 10,619,820 (GRCm39) missense probably benign 0.37
R6996:Myo16 UTSW 8 10,619,496 (GRCm39) missense probably damaging 1.00
R7103:Myo16 UTSW 8 10,619,673 (GRCm39) missense unknown
R7164:Myo16 UTSW 8 10,619,585 (GRCm39) missense unknown
R7255:Myo16 UTSW 8 10,549,169 (GRCm39) missense unknown
R7266:Myo16 UTSW 8 10,322,687 (GRCm39) missense unknown
R7319:Myo16 UTSW 8 10,526,185 (GRCm39) splice site probably null
R7398:Myo16 UTSW 8 10,612,183 (GRCm39) missense unknown
R7442:Myo16 UTSW 8 10,322,537 (GRCm39) missense probably damaging 1.00
R7498:Myo16 UTSW 8 10,450,589 (GRCm39) missense unknown
R7539:Myo16 UTSW 8 10,411,095 (GRCm39) critical splice donor site probably null
R7622:Myo16 UTSW 8 10,426,238 (GRCm39) missense unknown
R7794:Myo16 UTSW 8 10,619,913 (GRCm39) missense unknown
R7903:Myo16 UTSW 8 10,426,265 (GRCm39) missense probably null
R8055:Myo16 UTSW 8 10,612,186 (GRCm39) missense unknown
R8078:Myo16 UTSW 8 10,612,078 (GRCm39) missense unknown
R8081:Myo16 UTSW 8 10,372,743 (GRCm39) missense unknown
R8679:Myo16 UTSW 8 10,411,042 (GRCm39) missense unknown
R8700:Myo16 UTSW 8 10,463,172 (GRCm39) missense unknown
R8939:Myo16 UTSW 8 10,524,679 (GRCm39) missense probably damaging 0.99
R8955:Myo16 UTSW 8 10,426,175 (GRCm39) missense probably damaging 1.00
R8968:Myo16 UTSW 8 10,619,700 (GRCm39) missense unknown
R9187:Myo16 UTSW 8 10,492,233 (GRCm39) missense unknown
R9219:Myo16 UTSW 8 10,492,236 (GRCm39) missense unknown
R9287:Myo16 UTSW 8 10,526,114 (GRCm39) missense unknown
R9327:Myo16 UTSW 8 10,489,705 (GRCm39) critical splice donor site probably null
R9763:Myo16 UTSW 8 10,450,528 (GRCm39) missense unknown
R9765:Myo16 UTSW 8 10,620,401 (GRCm39) missense probably damaging 0.97
R9790:Myo16 UTSW 8 10,619,925 (GRCm39) missense unknown
R9791:Myo16 UTSW 8 10,619,925 (GRCm39) missense unknown
X0066:Myo16 UTSW 8 10,426,185 (GRCm39) missense probably damaging 1.00
Z1177:Myo16 UTSW 8 10,524,691 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CAGATTTCACTAAGGATTTTGGGGC -3'
(R):5'- AGGATGCTGACAGTGATGCC -3'

Sequencing Primer
(F):5'- TCCAGTGTTTTACTCAGATTTGAAG -3'
(R):5'- AAGCCACCATGTAGTTGCTG -3'
Posted On 2014-10-30