Incidental Mutation 'R2351:Triobp'
| ID |
246165 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Triobp
|
| Ensembl Gene |
ENSMUSG00000033088 |
| Gene Name |
TRIO and F-actin binding protein |
| Synonyms |
EST478828, Mus EST 478828, Tara |
| MMRRC Submission |
040333-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2351 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
78831924-78890069 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 78888780 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 1962
(V1962M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105311
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109687]
[ENSMUST00000109688]
[ENSMUST00000109689]
[ENSMUST00000109690]
|
| AlphaFold |
Q99KW3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109687
AA Change: V621M
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000105309
Gene: ENSMUSG00000033088
AA Change: V621M
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
coiled coil region
|
339 |
377 |
N/A |
INTRINSIC |
|
coiled coil region
|
401 |
463 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000109688
|
| SMART Domains |
Protein: ENSMUSP00000105310
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
30 |
47 |
N/A |
INTRINSIC |
|
PH
|
54 |
151 |
6.2e-19 |
SMART |
|
coiled coil region
|
324 |
351 |
N/A |
INTRINSIC |
|
coiled coil region
|
386 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
448 |
510 |
N/A |
INTRINSIC |
|
coiled coil region
|
544 |
623 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109689
AA Change: V1962M
PolyPhen 2
Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000105311
Gene: ENSMUSG00000033088
AA Change: V1962M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
7.43e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
7.43e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1395 |
1492 |
6.2e-19 |
SMART |
|
coiled coil region
|
1665 |
1692 |
N/A |
INTRINSIC |
|
coiled coil region
|
1727 |
1765 |
N/A |
INTRINSIC |
|
coiled coil region
|
1789 |
1851 |
N/A |
INTRINSIC |
|
coiled coil region
|
1885 |
1964 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109690
AA Change: V2008M
PolyPhen 2
Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000105312
Gene: ENSMUSG00000033088
AA Change: V2008M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
9.24e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
9.24e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1441 |
1538 |
6.2e-19 |
SMART |
|
coiled coil region
|
1711 |
1738 |
N/A |
INTRINSIC |
|
coiled coil region
|
1773 |
1811 |
N/A |
INTRINSIC |
|
coiled coil region
|
1835 |
1897 |
N/A |
INTRINSIC |
|
coiled coil region
|
1931 |
2010 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129922
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183598
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229535
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230425
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
PHENOTYPE: Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310009B15Rik |
A |
T |
1: 138,779,846 (GRCm39) |
Y135* |
probably null |
Het |
| Aadacl4fm1 |
A |
T |
4: 144,255,348 (GRCm39) |
Y256F |
probably damaging |
Het |
| Acad10 |
A |
T |
5: 121,767,990 (GRCm39) |
I820K |
probably benign |
Het |
| Arl8b |
A |
T |
6: 108,798,484 (GRCm39) |
I178F |
possibly damaging |
Het |
| Asap1 |
A |
T |
15: 64,007,653 (GRCm39) |
|
probably null |
Het |
| Atp2b2 |
A |
T |
6: 113,766,718 (GRCm39) |
I552N |
possibly damaging |
Het |
| C130074G19Rik |
G |
T |
1: 184,615,060 (GRCm39) |
D43E |
probably benign |
Het |
| Ccdc162 |
C |
A |
10: 41,431,968 (GRCm39) |
|
probably null |
Het |
| Ccdc186 |
T |
G |
19: 56,787,129 (GRCm39) |
K613T |
possibly damaging |
Het |
| Cggbp1 |
T |
A |
16: 64,676,046 (GRCm39) |
D37E |
possibly damaging |
Het |
| Cntn3 |
A |
T |
6: 102,314,344 (GRCm39) |
N123K |
possibly damaging |
Het |
| Col18a1 |
C |
T |
10: 76,948,538 (GRCm39) |
G325S |
probably benign |
Het |
| Cwc25 |
G |
T |
11: 97,638,218 (GRCm39) |
T405K |
probably damaging |
Het |
| Cyp4a31 |
T |
C |
4: 115,428,510 (GRCm39) |
V370A |
possibly damaging |
Het |
| Cyp4f13 |
T |
G |
17: 33,144,570 (GRCm39) |
I309L |
probably benign |
Het |
| Dap3 |
A |
T |
3: 88,840,870 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
T |
7: 105,403,301 (GRCm39) |
D3080E |
probably benign |
Het |
| Ern2 |
A |
G |
7: 121,770,731 (GRCm39) |
V762A |
probably damaging |
Het |
| Fgr |
C |
T |
4: 132,724,548 (GRCm39) |
R255C |
probably damaging |
Het |
| Gcm2 |
A |
T |
13: 41,257,094 (GRCm39) |
D218E |
probably benign |
Het |
| Gfi1 |
A |
G |
5: 107,869,640 (GRCm39) |
S131P |
probably damaging |
Het |
| Grm8 |
A |
T |
6: 28,126,118 (GRCm39) |
C3S |
possibly damaging |
Het |
| Gucy2d |
A |
G |
7: 98,113,226 (GRCm39) |
D840G |
probably benign |
Het |
| H3f3a |
T |
C |
1: 180,637,723 (GRCm39) |
T81A |
probably benign |
Het |
| Igsf23 |
C |
T |
7: 19,678,723 (GRCm39) |
W22* |
probably null |
Het |
| Il12rb2 |
G |
A |
6: 67,338,928 (GRCm39) |
Q3* |
probably null |
Het |
| Ino80d |
A |
T |
1: 63,124,994 (GRCm39) |
L156H |
probably benign |
Het |
| Kdm2a |
G |
A |
19: 4,379,154 (GRCm39) |
P554S |
probably benign |
Het |
| Lefty1 |
T |
A |
1: 180,764,807 (GRCm39) |
L244H |
possibly damaging |
Het |
| Mdn1 |
T |
A |
4: 32,750,010 (GRCm39) |
S4398T |
probably benign |
Het |
| Myh10 |
A |
G |
11: 68,683,965 (GRCm39) |
D1126G |
probably damaging |
Het |
| Myo16 |
G |
A |
8: 10,644,905 (GRCm39) |
D1746N |
possibly damaging |
Het |
| Myom1 |
A |
T |
17: 71,341,574 (GRCm39) |
D111V |
probably damaging |
Het |
| Naip6 |
T |
A |
13: 100,420,169 (GRCm39) |
D1367V |
probably damaging |
Het |
| Nbeal1 |
A |
T |
1: 60,276,257 (GRCm39) |
H666L |
possibly damaging |
Het |
| Nsmaf |
T |
A |
4: 6,437,921 (GRCm39) |
I77F |
probably damaging |
Het |
| Nvl |
T |
C |
1: 180,958,357 (GRCm39) |
T231A |
probably benign |
Het |
| Obscn |
T |
C |
11: 59,003,438 (GRCm39) |
R1287G |
probably damaging |
Het |
| Opn3 |
T |
C |
1: 175,520,077 (GRCm39) |
D9G |
probably benign |
Het |
| Or4a81 |
T |
C |
2: 89,619,522 (GRCm39) |
Y58C |
probably damaging |
Het |
| Or4c114 |
C |
T |
2: 88,904,743 (GRCm39) |
G231S |
possibly damaging |
Het |
| Or6a2 |
A |
T |
7: 106,600,883 (GRCm39) |
Y61* |
probably null |
Het |
| Or6c8b |
A |
G |
10: 128,882,797 (GRCm39) |
V45A |
probably benign |
Het |
| Or6k2 |
T |
A |
1: 173,986,486 (GRCm39) |
V49D |
probably damaging |
Het |
| Or8k24 |
C |
T |
2: 86,216,471 (GRCm39) |
C97Y |
probably damaging |
Het |
| Parp10 |
A |
T |
15: 76,127,056 (GRCm39) |
S101R |
probably benign |
Het |
| Pdhx |
T |
A |
2: 102,854,562 (GRCm39) |
K399* |
probably null |
Het |
| Pdia4 |
A |
T |
6: 47,773,848 (GRCm39) |
|
probably null |
Het |
| Pla2g4f |
T |
C |
2: 120,130,923 (GRCm39) |
D844G |
probably benign |
Het |
| Prtg |
C |
A |
9: 72,764,106 (GRCm39) |
D526E |
probably damaging |
Het |
| Rassf6 |
T |
C |
5: 90,779,418 (GRCm39) |
D5G |
probably benign |
Het |
| Riok3 |
C |
T |
18: 12,282,724 (GRCm39) |
Q388* |
probably null |
Het |
| Robo4 |
T |
A |
9: 37,322,956 (GRCm39) |
F825L |
probably benign |
Het |
| Rpl13a-ps1 |
C |
T |
19: 50,018,868 (GRCm39) |
E103K |
probably benign |
Het |
| Rpl18a |
A |
T |
8: 71,348,864 (GRCm39) |
H37Q |
probably benign |
Het |
| Ryr1 |
A |
T |
7: 28,774,718 (GRCm39) |
S2301T |
probably benign |
Het |
| Slc39a9 |
T |
A |
12: 80,691,660 (GRCm39) |
D2E |
possibly damaging |
Het |
| Slco5a1 |
C |
T |
1: 13,060,158 (GRCm39) |
V188I |
probably benign |
Het |
| Son |
T |
A |
16: 91,454,547 (GRCm39) |
M1098K |
probably damaging |
Het |
| Spag9 |
A |
G |
11: 93,983,726 (GRCm39) |
D701G |
probably damaging |
Het |
| Ssmem1 |
T |
C |
6: 30,512,495 (GRCm39) |
F46S |
possibly damaging |
Het |
| Sspo |
C |
T |
6: 48,441,803 (GRCm39) |
R1938W |
probably damaging |
Het |
| Sstr3 |
T |
C |
15: 78,424,121 (GRCm39) |
I209V |
probably benign |
Het |
| Tlk2 |
A |
G |
11: 105,100,656 (GRCm39) |
Y87C |
probably damaging |
Het |
| Traf4 |
G |
A |
11: 78,051,002 (GRCm39) |
R385W |
probably damaging |
Het |
| Tspan12 |
T |
G |
6: 21,835,506 (GRCm39) |
I56L |
probably benign |
Het |
| Upp2 |
T |
A |
2: 58,653,674 (GRCm39) |
|
probably null |
Het |
| Vps13b |
T |
C |
15: 35,869,457 (GRCm39) |
W2654R |
probably damaging |
Het |
| Zc3h18 |
C |
T |
8: 123,129,926 (GRCm39) |
R435* |
probably null |
Het |
| Zfta |
T |
C |
19: 7,399,609 (GRCm39) |
I247T |
probably damaging |
Het |
|
| Other mutations in Triobp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01634:Triobp
|
APN |
15 |
78,877,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01904:Triobp
|
APN |
15 |
78,851,564 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01957:Triobp
|
APN |
15 |
78,856,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02085:Triobp
|
APN |
15 |
78,858,497 (GRCm39) |
splice site |
probably benign |
|
|
IGL02260:Triobp
|
APN |
15 |
78,850,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Triobp
|
APN |
15 |
78,845,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02551:Triobp
|
APN |
15 |
78,857,689 (GRCm39) |
missense |
probably benign |
|
|
IGL02740:Triobp
|
APN |
15 |
78,850,889 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02810:Triobp
|
APN |
15 |
78,886,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03063:Triobp
|
APN |
15 |
78,875,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4304:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
FR4340:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4342:Triobp
|
UTSW |
15 |
78,877,592 (GRCm39) |
unclassified |
probably benign |
|
|
FR4449:Triobp
|
UTSW |
15 |
78,877,589 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
R0276:Triobp
|
UTSW |
15 |
78,857,876 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0309:Triobp
|
UTSW |
15 |
78,860,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Triobp
|
UTSW |
15 |
78,852,401 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0464:Triobp
|
UTSW |
15 |
78,851,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0525:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0665:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0689:Triobp
|
UTSW |
15 |
78,844,188 (GRCm39) |
nonsense |
probably null |
|
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1151:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1152:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1510:Triobp
|
UTSW |
15 |
78,887,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Triobp
|
UTSW |
15 |
78,857,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Triobp
|
UTSW |
15 |
78,886,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Triobp
|
UTSW |
15 |
78,851,428 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1755:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1975:Triobp
|
UTSW |
15 |
78,850,908 (GRCm39) |
missense |
probably benign |
|
|
R2051:Triobp
|
UTSW |
15 |
78,888,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Triobp
|
UTSW |
15 |
78,858,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2260:Triobp
|
UTSW |
15 |
78,875,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2902:Triobp
|
UTSW |
15 |
78,857,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3801:Triobp
|
UTSW |
15 |
78,857,900 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3959:Triobp
|
UTSW |
15 |
78,886,589 (GRCm39) |
nonsense |
probably null |
|
|
R4003:Triobp
|
UTSW |
15 |
78,844,177 (GRCm39) |
unclassified |
probably benign |
|
|
R4084:Triobp
|
UTSW |
15 |
78,857,871 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4482:Triobp
|
UTSW |
15 |
78,850,763 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4592:Triobp
|
UTSW |
15 |
78,851,295 (GRCm39) |
missense |
probably benign |
|
|
R4662:Triobp
|
UTSW |
15 |
78,877,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4789:Triobp
|
UTSW |
15 |
78,875,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Triobp
|
UTSW |
15 |
78,850,816 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4990:Triobp
|
UTSW |
15 |
78,851,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5129:Triobp
|
UTSW |
15 |
78,845,296 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5181:Triobp
|
UTSW |
15 |
78,851,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5279:Triobp
|
UTSW |
15 |
78,878,591 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5584:Triobp
|
UTSW |
15 |
78,852,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5601:Triobp
|
UTSW |
15 |
78,857,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Triobp
|
UTSW |
15 |
78,852,467 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5969:Triobp
|
UTSW |
15 |
78,851,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6722:Triobp
|
UTSW |
15 |
78,885,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Triobp
|
UTSW |
15 |
78,850,566 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6810:Triobp
|
UTSW |
15 |
78,850,815 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7011:Triobp
|
UTSW |
15 |
78,862,923 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Triobp
|
UTSW |
15 |
78,878,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7200:Triobp
|
UTSW |
15 |
78,851,042 (GRCm39) |
small deletion |
probably benign |
|
|
R7294:Triobp
|
UTSW |
15 |
78,858,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Triobp
|
UTSW |
15 |
78,845,311 (GRCm39) |
splice site |
probably null |
|
|
R7805:Triobp
|
UTSW |
15 |
78,858,204 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7972:Triobp
|
UTSW |
15 |
78,852,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Triobp
|
UTSW |
15 |
78,844,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Triobp
|
UTSW |
15 |
78,842,475 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8348:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8446:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8448:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8469:Triobp
|
UTSW |
15 |
78,851,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8491:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8492:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8493:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9424:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9495:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9514:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Triobp
|
UTSW |
15 |
78,886,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Triobp
|
UTSW |
15 |
78,858,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9576:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Triobp
|
UTSW |
15 |
78,887,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Triobp
|
UTSW |
15 |
78,851,227 (GRCm39) |
small insertion |
probably benign |
|
|
RF005:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
RF022:Triobp
|
UTSW |
15 |
78,858,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
RF028:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Triobp
|
UTSW |
15 |
78,851,263 (GRCm39) |
small insertion |
probably benign |
|
|
RF049:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Triobp
|
UTSW |
15 |
78,851,234 (GRCm39) |
small insertion |
probably benign |
|
|
RF058:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
X0026:Triobp
|
UTSW |
15 |
78,844,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Triobp
|
UTSW |
15 |
78,886,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGACAATGAAATCTCCATCACTGG -3'
(R):5'- CTGGGGACAAACATGCACAG -3'
Sequencing Primer
(F):5'- CTACCAGCAGGGGCAAAGTG -3'
(R):5'- CATGCACAGGTTGACAGAAC -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation